Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 549807 | [Kessler arthroplasty of the carpometacarpal joint of the thumb in arthrosis and arthritis | 1979 | Early results of the KESSLER-Implant in 11 patients are presented. 7 patients suffered from rheumatoid arthritis, 1 from psoriatic arthropathy. For technical reasons this endoprosthesis seems to be especially suitable for patients with rheumatoid disease. By remodelling the articular surface of the trapezium corresponding to the implant, it is possible to reestablish stability even in cases with severe destruction and subluxation of the CM joint. | |
| 434066 | Lysozyme content of tears in patients with Sjögren's syndrome and rheumatoid arthritis. | 1979 Feb | In 37 patients and 143 control patients we estimated tear fluid lysozyme content by the Micrococcus lysodeikticus agar diffusion assay. We found no correlation between the titer of lysozyme in tear fluid and the rate of tear flow. Decrease in lysozyme production was found to be a sensitive indicator of the involvement of the lacrimal system in Sjögren's syndrome. | |
| 329399 | [Cellular immunity in rheumatoid arthritis. Effect of therapy]. | 1977 May | In 89 cases of rheumatoid polyarthritis the number of B lymphocytes was shown by an immunofluorescence technique and the number T lymphocytes by a rosette test. 30 untreated polyarthritics were distinguished into two groups: in one there was no change in the number of T cellules; in the other there was a reduction in the number of T cells and lymphopenia. The same differences were found under corticotherapy (10 cases), antimalarial drugs (8 cases), penicillamine (21 cases), chrysotherapy (11 cases) and levamisole (9 cases). Levamisole only infrequently increases the number of T cellules (2/9). No relation with any developmental parameter was found in any group. | |
| 915010 | Lymphocyte tubular structures in rheumatoid arthritis. | 1977 Sep | Two types of lymphocyte tubular structures were studied by electron microscopy in 80 patients with classic or definite rheumatoid arthritis (RA). Fifteen patients with unequivocal systemic lupus erythematosus (SLE) and 10 healthy persons were studied as controls. Lymphocyte tubulo-reticular structures were found in 13 of the 80 patients with RA and in 10 of the 15 patients with SLE. No tubuloreticular structures were found in any of the healthy subjects. In the RA patients antinuclear antibodies, LE cell phenomenon, and chlorambucil treatment were associated significantly with these inclusions but disease activity was not related to their presence. In cases in which tubuloreticular structures were present the number of cells containing inclusions was on average much lower in patients with RA than in those with SLE. Lymphocyte tubular parallel arrays were found in all the patients with RA and SLE and in all the healthy persons. In all three groups the average number of cells containing parallel tubular arrays was similar. | |
| 789133 | [Studies on the secretion of gonadotropins in patients with collagen diseases]. | 1976 Feb 20 | It is well known that majority of patients with collagen diseases are women and that collagen diseases take turn for the worse or the better when the secretion of sex hormones changes greatly at menarche, pregnancy, delivery or menopause. These facts suggest that sex hormones are involved in the pathophysiology of collagen diseases. In the present study, the responses of plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels following the intravenous injection of 100 mug luteinizing hormone-releasing hormone (LR-RH) were investigated in 34 patients with systemic lupus erythematosus (SLE) and in 15 patients with rheumatoid arthritis (RA). The results obtained were as follows: 1) The magnitude of plasma LH response to LH-RH in 29 mature female patients with SLE was significantly greater than that in normal subjects. 2) On the other hand, the magnitude of plasma FSH response to LH-RH in patients with SLE was comparable to that in control subjects. 3) In patients with RA who have normal menstrual cycles, the magnitude of increase in plasma LH and FSH levels after the injection of LH-RH was the almost same as that in normal subjects. Increased responses in plasma LH and FSH levels to LH-RH were observed in 7 patients with RA who were 3 menopausal females and 4 aged males. These findings suggest that the secretion of LH, but not FSH, in response to LH-RH might augment in patients with SLE. On the other hand, in RA patients the function of the pituitary-gonadal axis might maintain within normal limits. For that reason, I guess the following possibilities: 1) In patients with SLE the pathological changes of the disease reached to the ovary and ovarial function was slightly suppressed and then a hypersecretion of LH was observed, 2) the hypothalamus was attacked with the disease and then an unknown mechanism caused the hypersecretion of LH. | |
| 4057193 | Relation between meteorological factors and pain in rheumatoid arthritis in a marine clima | 1985 Aug | Reports indicate that weather conditions may affect some symptoms of rheumatoid arthritis (RA) but not the disease itself. Eighty-eight patients living in the marine climate of the Dutch coastal provinces scored their pain symptoms daily during a full year. Correlation analyses of monthly patient averaged pain scores against each of 6 weather factors indicated that RA pain associates positively and quite significantly (p less than 0.01) with temperature and with vapour pressure, negatively and significantly (p less than 0.02) with relative humidity and not with any of the other factors. The fact that the relation between the temperature/vapour pressure complex and RA pain is stronger in summer than in winter is discussed. | |
| 7230165 | Results of surgical treatment of nonambulatory rheumatoid patients. | 1981 Mar | Total joint replacements were performed in 37 nonambulatory rheumatoid patients. Postoperatively, 35 patients regained the ability to walk. Our accumulated clinical experience indicates that such operations should be performed only when at least all of the following criteria are satisfied: 1) strong motivation for restoration of walking ability; 2) good relationship between physician and patient; 3) absence of severe systemic complications, and 4) the rheumatoid arthritis can be controlled by medication. | |
| 4582051 | Method for assessing therapeutic potential of anti-inflammatory antirheumatic drugs in rhe | 1973 Jun 23 | A 14-day, single-blind trial of prednisone, aspirin, and placebo was carried out in 128 patients suffering from rheumatoid arthritis, using subjective criteria only (severity of pain daily on a pain chart and assessment of the drug for effectiveness). The average treated pain rating, mean patient satisfaction rating, and mean number of days withdrawn from each drug all showed significant differences between prednisone, aspirin, and placebo. Of various pretreatment observations, only the initial pain score and articular index of joint tenderness were significantly related to the average treated pain rating.The trial method is simple and allows many patients to participate without being time consuming for patient or physician. The method seems to have potential in comparing the comparative effectiveness of anti-inflammatory analgesics used in the treatment of patients with rheumatoid arthritis. | |
| 7001616 | An evaluation of two methods for detection of circulating immune complexes in patients wit | 1980 | Immune complexes were detected by Clq-binding activity (Clq-BA) in 58% of 107 patients with seropositive rheumatoid arthritis (RA), and in 24% of 31 patients with seronegative arthritis. The difference is significant. Immune complexes were detected by the anticomplementarity test (AC) in approximately half of the patients without significant inter-group differences. No correlation was observed between the two methods. In 35 randomly selected patients with seropositive RA, a significant correlation was observed between Clq-BA and the functional class and the latex titre for rheumatoid factor. In patients with seronegative RA, the Clq-BA was significantly correlated to the number of joints with impaired mobility. The AC test was correlated to the erythrocyte sedimentation rate and the concentration of hemoglobin and gammaglobulin in patients with seropositive RA. As regards the clinical activity of disease, erythrocyte sedimentation rate and hemoglobin seem better parameters than the Clq-BA and AC tests. | |
| 6683487 | Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis. | 1983 Jul | Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine. After discontinuation of the drug, plasmapheresis and steroid therapy led to a sustained remission. To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported. | |
| 7394586 | Synovectomy of the elbow and excision of the radial head in rheumatoid arthritis. | 1980 Jun | Twenty-two patients with rheumatoid arthritis who had partial synovectomy and excision of the radial head were reviewed at an average of five years and four months after operation. Of these, 84% obtained satisfactory pain relief and 76% had improved range of motion postoperatively. Eighty-eight percent were satisfied with the final outcome. We believe satisfactory results can be expected even in the late stages of the disease. | |
| 6406594 | High incidence of free monoclonal lambda light chains in the sera of patients with Sjogren | 1983 Jun | Sjogren's syndrome presents a wide spectrum of disease manifestations ranging from benign to malignant lymphoproliferation. Sera from 21 patients with primary Sjogren's syndrome, 63 patients with other autoimmune rheumatic diseases, and 140 normal controls were studied by using high-resolution gel electrophoresis combined with immunofixation and specific absorption studies. Two-thirds of the sera from Sjogren's syndrome patients contained free monoclonal lambda light chains. In addition, one patient with Sjogren's syndrome and pseudolymphoma had a circulating monoclonal IgM-lambda immunoglobulin. In contrast, only 16% of the patients with other autoimmune diseases and 5% of normals had monoclonal bands; none of the other patients studied exhibited monoclonal-free lambda light chains in their serum. Our findings suggest that the monoclonal process in Sjogren's syndrome starts early in the disease process in a subset of B cells. | |
| 7451524 | Total condylar knee replacement in rheumatoid arthritis. A review of one hundred and seven | 1981 Jan | Total condylar tricompartmental total knee replacement was performed in ninety-one patients (117 knees) with seropositive rheumatoid arthritis, all of whom were followed for at least two years postoperatively. Angular deformities of as much as 35 degrees of varus and 20 degrees of valgus angulation were seen preoperatively; postoperatively 85 per cent of the knees had alignment of between zero and 5 degrees of valgus angulation. One hundred and ten knees had less than 5 degrees of varus-valgus laxity on postoperative stress roentgenograms. The range of motion was not statistically increased except in those patients in whom there had been a severe flexion contracture preoperatively. Eighty-six per cent of the patients were either completely free of pain or had only mild barometric discomfort postoperatively, and 88 per cent had markedly increased walking ability after surgery. The majority of complications were related to problems with soft-tissue healing. Postoperative stability to anterior-posterior and valgus-varus stresses was obtained through a combination of implant design and soft-tissue ligament balancing. | |
| 3921298 | Interleukin-2 in rheumatoid arthritis: production of and response to interleukin-2 in rheu | 1985 Mar | Several aspects of interleukin-2 (IL-2) generation and function were studied employing mononuclear cells from synovial fluid (SF), synovial tissue (ST) and peripheral blood (PB) of patients with rheumatoid arthritis (RA). Decreased PHA stimulated IL-2 production by lymphocytes from rheumatoid ST, SF (P less than 0.02), and PB (P less than 0.01) was observed when compared to normal blood and SF of patients with gout. The proliferative response of rheumatoid lymphocyte blasts exposed to exogenous IL-2 was also defective (P less than 0.05-0.001). This defect was greater in SF than in rheumatoid PB (P less than 0.05-0.001). In addition to the proliferative response, the effect of IL-2 on interferon-gamma (IFN-gamma) production was also examined. Rheumatoid lymphocytes from both PB and SF produced less IFN-gamma after overnight treatment with IL-2 than did normal PB lymphocytes. This decreased IFN-gamma induction was discordant with the excellent enhancement by IL-2 of natural killer activity. Removal of adherent cells in synovial fluid did not correct this deficit. Abnormalities in the biology of IL-2 and IFN-gamma suggest that impaired T cell function could contribute to the immunopathogenesis of RA. | |
| 6466393 | Articular mastocytosis in rheumatoid arthritis. | 1984 Aug | The number and distribution of mast cells were assessed in 116 synovial membranes from patients with rheumatoid arthritis and in 30 control specimens. Rheumatoid synovial membranes contained a mean of 48.5 mast cells per 20 high-power fields (HPF) (range 0-252), and control synovial membranes had a mean of 3.9 mast cells per 20 HPF (range 0-13) (P less than 0.001). In a comparison of high and low mast cell subgroups in rheumatoid arthritis, counts were directly related to the intensity of clinical synovitis in the affected joint, but not to hemoglobin concentration or erythrocyte sedimentation rate. Joints excised from 5 patients with rheumatoid arthritis were characterized by active bone remodeling with increased osteoid, active resorption by osteoclasts, and trabecular osteoporosis. Mast cells were prominent in both extraosseous pannus and intraosseous invasive tissue. The possible roles of mast cells in the pathogenesis of rheumatoid arthritis are discussed. | |
| 1094764 | [Electron-microscopic demonstration of virus-like structures in the synovial membrane in c | 1975 Mar | The recent demonstration of ultramicroscopic "virus-like" cell inclusions in various organs in patients with collagen and autoimmune diseases suggest that viruses may play an aetiological role in these diseases. This paper reports briefly on some of the evidence for such "virus-like" structures in different cells of the synovial membrane from two patients with rheumatoid arthritis. The inclusions were localised in the vaculoes of the endoplasmatic reticulum of endothelial cells, lymphocytes, macrophages, fibroblasts and perithelial cells. They appear as tubular bodies of approximately 250 A. diameter. The tubules join together so that they form a 3-dimensional network. The possible viral or non-viral nature of these inclusions is discussed. A ultramicroscopical resemblance to the RNA-containing paramyxo-viruses suggests their virus nature. However, the negative results in testing with serum antibodies and immunofluorescence techniques argue against this. The authors suggest that the demonstration of these inclusions in other than collagen diseases points more in the direction of the correlation of these inclusions with immune globulin synthesis rather than the presence of a virus. | |
| 534786 | Immune complexes and complement in rheumatoid arthritis. | 1979 Sep | Immune complexes have been shown to occur frequently during rheumatoid arthritis. They have been found in blood, in the synovium and in other extravascular lesions. The recent development of methods for the quantitation of immune complexes provided new tools to evaluate the possible role of immune complexes in rheumatoid arthritis. Immune complexes which appear in synovial fluid are in higher concentration than in serum and have particular physicochemical properties. They likely result from a local formation in the synovium and seem to be directly involved in the generation of the local inflammation. High levels of circulating immune complexes are usually associated with the development of extra-articular vascular lesions. One of the major biological activity of immune complexes is to activate the complement system. There is indeed evidence of complement activation in circulating blood as well as in synovial fluid in patients with rheumatoid arthritis. The presence and the concentration of complement breakdown products in these fluids correlates with the clinical activity. Therefore, the analysis of immune complexes and of complement components appears useful for diagnosis and follow-up, and for the understanding of the pathogenesis of the disease. | |
| 7077223 | A spontaneous rheumatoid arthritis-like disease in MRL/l mice. | 1982 Jun 1 | MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with significant levels of IgMRF had synovitis and/or arthritis. | |
| 716428 | [Lymphocyte response to mitogens in serum-free and serum-containing medium in patients wit | 1978 Oct 27 | Mitogenic transformation of lymphocytes from patients with rheumatoid arthritis (RA) has revealed divergent results in different laboratories. Since the sera used for medium supplementation in these previous studies might have influenced the results, we investigated lymphocyte transformation in serum-free medium in 28 RA-patients and 25 controls. It was shown that a majority of patients with RA responded weakly to PHA. Comparing some of these serum-free cultures with cultures that were set in parallel in 10% ABserum, no difference between patients and controls was observed after transformation in supplemented medium. It is concluded that lymphocyte reactivity to PHA (however not to ConA and PWM) is diminished in patients with RA and that this defect--at least partially--is reversible by addition of serum. The use of parallel cultures in serum-free and serum-containing medium is recommended for evaluation of the lymphocyte mitogenic response. | |
| 781226 | Fenoprofen calcium therapy in rheumatoid arthritis. | 1976 | Fenoprofen calcium (FC) was compared to aspirin (ASA) in 20 patients with rheumatoid arthritis in a double-blind parallel study. The average daily dose was 2.0 gm of FC, or 3.6 gm of ASA. Most patients on FC therapy responded similarly to those receiving ASA, but FC was slightly better in reducing morning stiffness, walking time, fatigue severity, and activity index. More FC treated than ASA treated patients became worse when placebo was substituted after one year of therapy, with a greater increase in the number and severity of painful and swollen joints, in addition to the above mentioned parameters. This suggests a greater suppression of the inflammatory process during FC therapy. FC was well tolerated and had a greater antirheumatic effect than aspirin. Both drugs were superior to placebo. |