Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 975663 | A statistical evaluation of geometric total knee arthroplasties. | 1976 Oct | Seventy-five knees in 56 patients were examined preoperatively and at two years after geometric total knee surgery. Thirty-three knees were in 28 patients with osteoarthritis. Fourty-two knees were in 28 patients with rheumatoid arthritis. Pain was significantly decreased and the use of aids was significantly decreased in both groups. The distance walked increased significantly for the osteoarthritic group but not for the rheumatoid group. Rheumatoid patients did not fare as well as osteoarthritic patients in distance walked and use of aids. Knees with osteoarthritis had more evidence of lucent lines and implant loosening than did the rheumatoid patients. | |
| 6882031 | The occurrence of malignancies in patients with rheumatoid arthritis treated with cyclopho | 1983 Aug | In a retrospective follow-up we compared the incidence of malignancies in patients with rheumatoid arthritis treated with cyclophosphamide with that in another group of patients with rheumatoid arthritis and also with the incidence of malignancies in the general population. Among 81 patients treated with cyclophosphamide in the past decade 15 malignancies occurred. This was 4.1 times the expected number obtained from a closely matched control group of patients with rheumatoid arthritis not treated with cytotoxic drugs (95% confidence interval 1.5 to 19.0), and 3.7 times the expected number calculated from general population rates (95% confidence interval 2.1 to 5.9). The increase in haematological and lymphoreticular malignancies was specially notable. The data also indicate that the development of malignancies after the start of cyclophosphamide therapy necessitates a certain induction time and that it is to some extent dose-dependent. | |
| 7461559 | [Antirheumatics - Which to choose]. | 1980 Nov 13 | The vast amount of so-called antirheumatics that have flooded the pharmaceutical market in recent time makes it practically impossible for the physician to distinguish between positive and negative therapeutical effects of these drugs. We have therefore tried, based upon the pharmaco-dynamical and pharmaco-kinetical results as well as clinical experience, to give rational advice as to application of antirheumatic substances in general practice. It has shown, that as in all of the subdivisions of pharmatherapeutics the best therapy is to treat patients with only a small contingent of name drugs, whose side-effects and dangers are exactly known. | |
| 3901571 | [Ultrasonic diagnosis in orthopedics]. | 1985 May | Ultrasonics in medicine and especially ultrasonics in orthopedics are an essential enrichment of our ways of making a diagnosis. The development of modern diagnosis instruments in addition to the systematic research of the skeletal system and soft tissues have made it possible that this method can now also be employed in the special field of orthopedics. That doesn't mean that other imaging methods should be given up but rather that this new way of imaging should be seen as a completion and a screening method for the other procedures. Because of the easiness of applying ultrasonics there is also the danger of overestimating the extent to which this method can be used and the danger of misinterpreting findings because of a lack of knowledge. Both risks should be kept in mind when using ultrasonics so that this harmless method doesn't became dangerous to the patients after all. | |
| 6388188 | [Arthrosonography--a new additional image-producing procedure in the detection of diseases | 1984 Jul | Ultrasonic examination of the knee joint is a non invasive reliable technique without disadvantages to the patients. It should be used supplementary to usual X-ray pictures of the popliteal space. Ultrasonography is a fast and accurate method to detect a wide variety of disorders, describing their exact location and calculating their volume. It produces supplementary diagnosis of extraarticular findings like popliteal cysts (Baker's cysts), aneurysms of popliteal artery, soft-tissue lesions, abscesses, hematomas, bursitis and varicosis, and of intra-articular disorders like effusion and synovial edema. | |
| 1088036 | Arthritis and heart lesions. A study of 25 cases with pericarditis or valvular lesions ass | 1976 | Clinical and laboratory data of 25 patients with inflammatory joint disease and pericarditis or valvular heart disease are reviewed. The patients were divided in two groups: 11 presented pericarditis and 14 valvular heart disease. The patients studied presented a spectrum of diseases ranging from classical sero-positive rheumatoid arthritis to ankylosing spondylitis. Acute rheumatic fever was in no case the actual joint disease. In contrast to the patients with valvular heart disease nearly all patients with pericarditis were rheumatoid arthritis factor positive and signs of a generalized systemic disease with vasculitis were also more frequent. In the pericarditis group there was no sex difference in contrast to the valvular group where females were more often affected. The heart lesions were usually detected late in the course of the chronic joint disease. Valvular heart disease occurs not only in ankylosing spondylitis but also in rheumatoid arthritis, usually the sero-negative type. In the light of a survey of the literature, the pertinent findings are discussed. | |
| 308274 | Rheumatoid granuloma of kidney. | 1978 Jul | A seventy-year-old black man with long-standing rheumatoid arthritis who had been treated with corticoids presented with painless hematuria originating from the kidney. The clinical findings were suggestive of a renal cell carcinoma. The resected kidney was markedly enlarged, scarred, and disclosed a necrotic rheumatoid granuloma surrounded by chronic inflammatory reaction. The mechanism of hematuria and the clinical significance of the rheumatoid granulomatous involvement of the kidney are discussed. | |
| 7345216 | [Transformation of connective tissue cells by pathological altered synovial fluid as demon | 1981 Oct 1 | Joint cavities and tendon sheaths are fissurations in the mesenchyme. The coating synovial lining cell layer is caused through the environment of the synovial fluid. The pathologically altered synovial fluid initiates the transformation and proliferation of the marginal connective tissue cells. Evidence for this thesis are the synovial transformatory processes of the cutaneous connective tissue in the area of a synovial fistula and the formation of synovial like structures in the subcutaneous fatty tissues of the rat following the application of synovial fluid from patients with rheumatoid arthritis. | |
| 1198074 | Death rate and causes of death in patients with rheumatoid arthritis. | 1975 | Patients with rheumatoid arthritis, 500 males and 500 females, aged 40 years or over, and an age- and sex-matched control population were observed over a 3-year period. During the follow-up, 122 RA patients and 69 controls had died. The most common causes of death in RA patients were cardiovascular diseases (57 patients), renal failure (27 patients), infections (19 patients), and malignant neoplasms (11 patients); in the controls, the respective data are: cardiovascular diseases (35 people), malignant neoplasms (21 people), accidents (7 people), and infections (5 people). | |
| 6170755 | Inosiplex: a novel treatment in rheumatoid arthritis? | 1981 Jul | In an open study inosiplex, a new synthetic immunomodulatory drug, was given to 15 patients with rheumatoid arthritis (RA) 3 g daily until clinical improvement occurred and then tapered. Nine of 15 patients experienced clinical benefit evidenced by a reduction of morning stiffness, fewer tender joints, decreased proximal interphalangeal joint circumference, and decreased sedimentation rate and fibrinogen level. Three patients responded rapidly to inosiplex (in two weeks) and a clear cut improvement was noticed within 1 month by all the responders. Two patients showed an exacerbation of the disease. No toxic drug effect was noticed. Although the mode of action of inosiplex in RA appears unclear, its rapidly of action and high rate of response should encourage further study of its use in the treatment of RA. | |
| 1210795 | [Management of para-articular cysts in progressive chronic polyarthritis]. | 1975 Nov | Peri-articular cysts complicating rheumatoid arthritis give rise to a difficult therapeutic problem. The origin of these cysts is discussed with particular reference to Baker's cyst. In principle, treatment is identical with that used in chronic joint effusions. The authors have noted satisfactory results with a steroid-synoviorthesis using triamcinolone acetonide (Kenalog, Squibb, Volon, Heyden). Best results have been achieved by injecting triamcinolone into both the cyst and the corresponding joint. The total effect of intraarticular use of this drug is discussed. | |
| 1105332 | [Tetrazolim nitroblue reduction test. Influence of the latex on the reliability of the res | 1975 May | The finding of sudden variations in the results of the N.B.T. reduction test, using Baehner and Nathan's technique, depending on the latex used, led the authors to doubt the quality of this latex. A comparative study was carried out on adult controls with two different types of latex. With the new type of latex, the results were more reproducible and the sensitivity of the technique was increased. A study in rheumatoid arthritis confirmed these two findings and showed that the new latex was more reliable using the N.B.T. reduction test. | |
| 520872 | Habitual extensor tendon dislocation. | 1979 Oct | Dislocated tendons are frequently seen in the rheumatoid hand. Habitual dislocation is rare. Five patients, all sero-negative with this problem, are described. The causation of the deformity and its treatment is discussed in relation to other cases reported in the literature. An extensor loop operation is recommended. | |
| 700301 | [Rheumatoid heart: report of a case with endomyocardial injury and severe arrhythmias (aut | 1978 | The Authors describe the case of a 61 year old man suffering from rheumatoid arthritis; the diagnosis of "rheumatoid heart" was made on the basis of the humoral findings and of the clinico-ecgraphic picture of endocardial (mitral incompetence) and myocardial injuries. The different complications impairing the heart rhythm (FA, tachycardia S.V., and episodes of tachycardia V., torsade de pointes type) and the A-V and the I.V. conduction (RBBB phase 3, LBBB phase 4, BAV 1st, 2nd and 3rd degree) which determined the recurrence of episodes of heart block and required adequate intensive cardiological treatment, are described. In conclusion, the significance of the persistance of the L.A.D. in the course of complete LBBB and the discovery of an unusual type of escape-capture bigeminy in the course of 2nd degree BAV is discussed. | |
| 6497918 | Small airways function in nonsmokers with rheumatoid arthritis. | 1984 Nov | To evaluate the possible relationship between rheumatoid arthritis (RA) and airways dysfunction independent of cigarette smoking, we studied 19 lifetime nonsmokers with RA and 47 healthy nonsmokers. Ten tests of small airways function were administered to the subjects. In addition, diffusing capacity and static lung compliance were measured, and upstream airway conductance at mid-to-low lung volumes was calculated. Mean values were not significantly lower in the RA group than in the control group in any of the tests of small airways function. Three of the 19 (16%) patients with RA versus 15 of the 47 (32%) control subjects had abnormal findings on greater than 2 tests of small airways function (P greater than 0.1). Although mean diffusing capacity and static lung compliance were both within normal limits in each group, the former tended to be lower, while the latter was significantly lower, in the RA subjects. We conclude that airways dysfunction in RA, if present, is probably related to factors other than the underlying disease; if an association between RA and small airways abnormality is present in some patients, its prevalence is too small to have been detected in our sample. | |
| 7406520 | Multiple keratoacanthomas associated with steatocystoma multiplex and rheumatoid arthritis | 1980 Aug | Keratoacanthomas have been associated with multiple carcinomas, discoid lupus erythematosus, and multiple sebaceous gland tumors with colonic and gastric carcinoma. Steatocystoma multiplex has been associated with ichthyosis and koilonychia, pachyonychia congenita, multiple hairs and acrokeratosis verruciformis of Hopf, hypertrophic lichen planus, hypohidrosis, hypothyroidism, hidradenitis suppurativa, and hypotrichosis. We report a case of multiple keratoacanthoma associated with steatocystoma multiplex and rheumatoid arthritis. | |
| 1216948 | [Effect of long term treatment with trenimon in chronic progressive polyarthritis]. | 1975 Oct 15 | It is reported on the therapeutic effects with trenimon in patients with rheumatoid arthritis half a year and one year after the end of the treatment. When critically judged the quota of success was 32.5% for the total judgement after half a year. Significant relations dosis-effect could be ascertained only for the parameters of clinical activity up to 1 year and humoral inflammatory signs after half a year. When the therapeutic success is assessed in any case the additional therapeutic expenditure must be taken into consideration. Before the beginning of the therapy there was no ascertained relation between success of therapy and duration of the disease, sex, age, activity and function. | |
| 7352902 | Middle ear immittance in rheumatoid arthritis. | 1980 Feb | Audiologic and electroacoustic immittance measurements were obtained from each ear of 23 patients with rheumatoid arthritis and 13 normal control subjects. Audiologic findings revealed 14 patients with rheumatoid arthritis with hearing loss of either conductive (three patients) or sensorineural (11 patients) type, while only two control subjects demonstrated hearing loss, both of sensorineural type. Immittance data revealed abnormal findings in 59% of the patients with rheumatoid arthritis as compared to only 4% of the control subjects. The increased incidence of sensorineural hearing loss in the sample with rheumatoid arthritis could not be readily explained. The observed prevalence of abnormal immittance findings in patients with rheumatoid arthritis suggested either increased middle ear stiffness or increased stiffness associated with decreased stability of ligamentous anchorage. | |
| 6602374 | Autonomic nerve function in rheumatoid arthritis of varying severity. | 1983 | Autonomic nerve function was evaluated by deep breathing and tilt table tests in 17 patients with rheumatoid arthritis (RA) and in 24 healthy control subjects. The results showed that all RA patients had increased heart rates at rest, irrespective of the severity of the disease. Patients with severe RA had increased systolic and diastolic blood pressures before and after tilting. Pronounced abnormalities in the immediate heart rate reaction to tilting indicating autonomic neuropathy (AN) were also demonstrated in patients with severe RA. The abnormal immediate reaction to tilting was mainly the result of vagal neuropathy. From the present study it is evident that severe RA may be accompanied by AN and the consequences need to be elucidated. | |
| 787518 | Night medication in rheumatoid arthritis. | 1976 Aug | The efficacy of indomethacin 100 mg, diazepam 10 mg, and placebo in producing sleep, relieving night pain, and reducing the severity of morning stiffness, was compared in 18 patients in hospital with active classical or definite rheumatoid arthritis.There was no statistically significant difference in the preference of patients or sleep score among the three forms of treatment. Both indomethacin and diazepam were more effective than placebo in relieving night pain. Indomethacin decreased, but diazepam increased, morning stiffness in comparison to placebo. Neither active therapy produced significant side-effects. |