Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 851102 | Rheumatoid esophageal disease. | 1977 Jan | Esophageal diameters were measured in the roentgenogram in 43 patients with rheumatoid arthritis and in 43 healthy subjects matched by sex and age. The incidence of esophageal dilatation in rheumatoid patients was significantly higher than that of healthy subjects (P LESS THAN 0.01). Higher incidence of esophageal dilatation was seen in groups with pulmonary fibrosis and with subcutaneous nodules (P less than 0.01, P less than 0.05 respectively). An orderly relationship between the incidence of esophageal dilatation and the grades of RA test, stage of joint x-ray, or duration of disease were shown. These results suggest the existence of "rheumatoid esophageal disease". | |
| 6750772 | High incidence of spontaneous Ig-producing lymphocytes in peripheral blood and synovial fl | 1982 Jul | Numbers of in vitro spontaneous IgG, IgM and IgA plaque-forming cells (PFC) as assessed by a modification of the protein A haemolytic plaque assay were determined in the blood and synovial fluid of patients with seropositive rheumatoid arthritis (RA) and compared with those of control groups. The total numbers of PFC were significantly higher in the peripheral blood of patients with active seropositive RA than in that of normal controls. In addition, most B lymphocytes in the synovial fluid of patients with active seropositive RA were active immunoglobulin (Ig) producers, whereas synovial fluid lymphocytes from patients with inactive seropositive RA and seronegative arthritis were not. In general, IgA PFC were relatively high in blood, whereas IgG PFC dominated in the synovial fluid. IgM PFC appear to be relatively low in blood and synovial fluid. However, a relative increase of IgG PFC was noted in the peripheral blood of patients with active RA. To test for polyclonality of the increased Ig synthesis, we tested the sera of patients and controls for the presence of polyclonal antibodies against sheep erythrocytes (SRBC) and SRBC modified by fluorescein isothiocyanate (FITC) and trinitrophenyl (TNP). No differences were observed with SRBC and TNP-SRBC agglutinin titres between patients and controls, but patients with RA had higher titres of FITC-SRBC agglutinins than normal sera. This finding supports the concept of a polyclonal nature of antibody production in RA patients. | |
| 454498 | Increased C1q binding immune complexes in Felty's syndrome: comparison with uncomplicated | 1979 Jul | Sera from patients with Felty's syndrome (FS) and rheumatoid arthritis (RA) were examined for the presence of circulating immune complexes (IC) by using the 125I-C1q binding and monoclonal rheumatoid factor (mRF) techniques. Of 15 patients with FS, 9 (60%) had high 125I-C1q binding as compared to 3 of 26 RA patients (12%). The average C1q binding was significantly higher in the FS patients than in the RA patients without FS. C1q binding in both FS and RA patients was significantly higher than a group of 90 normal controls. In addition, serum C4 levels were significantly lower in the FS patients than in the RA patients. In contrast to these findings, IC levels in FS and RA patients were very similar when measured by the mRF technique. These studies indicate that FS patients have higher levels of complement-fixing IC in their sera than RA patients without FS. These findings raise the possibility that the complement-fixing IC found in these patients may play a role in the pathogenesis of neutropenia of FS. | |
| 7375981 | Decompression without synovectomy in rheumatoid extensor tenosynovitis. | 1980 May | Fifteen wrists in 11 patients with rheumatoid tenosynovitis involving the extensor tendons were treated by decompression alone, without synovectomy. The results were not unlike those obtained by the more traditional operation of tenosynovectomy. Alleviation of the retinacular compression appears to have a beneficial local effect to reduce synovitis and to arrest tendon attrition and pain. Removal of the synovium is not required in the treatment of such cases. | |
| 3920314 | Increased proliferation of human synovial fibroblasts treated with recombinant immune inte | 1985 May | Because immune lymphocytes are commonly found in inflamed rheumatoid synovium, we tested the hypothesis that immune or gamma-interferon, a product of activated lymphocytes, may modulate synovial cell growth. Using a cell culture model, we found that addition of gamma-interferon at 10 to 100 antiviral units/ml to cultures of human synovial fibroblasts or human foreskin fibroblasts resulted in a two- to threefold increase in proliferation, measured by incorporation of [3H]thymidine and cell number. The proliferative effect was abrogated if the gamma-interferon was neutralized with a specific monoclonal antibody. Increased proliferation induced by gamma-interferon was antagonized by all-transretinoic acid but was enhanced by prednisolone. Our data indicate that the T cell product, gamma-interferon, can directly modulate synovial cell function and suggest that this interaction may play a role in the proliferative lesion of rheumatoid arthritis. | |
| 7432760 | Arthrography of the shoulder. | 1980 Apr | Arthrography of the shoulder is a most effective diagnostic tool in evaluating the shoulder joint. The technique is easily mastered with practice. A knowledge of shoulder anatomy is imperative in order to fully understand the normal as well as abnormal shoulder arthrogram. | |
| 7369250 | Dissected popliteal cyst: an unusual presentation of acute gout. | 1980 Jan | A 46-year-old man with acute gout and a dissected popliteal cyst presented with clinical features which mimicked rheumatoid arthritis and thrombophlebitis. The clinical and laboratory diagnosis of the case are presented and similar cases previously reported are briefly reviewed. | |
| 100352 | Experience with high doses of ibuprofen in the long-term treatment of rheumatoid arthritis | 1978 | Ibuprofen (Brufen) is a non-steroidal anti-inflammatory drug well-established in the symptomatic treatment of rheumatoid arthritis. In view of its exceptionally good tolerance it has become fashionable to prescribe increasingly large doses for severe cases or in those patients unable to tolerate other anti-rheumatic compounds. This study illustrates the sustained therapeutic benefit and almost complete lack of toxicity in fify-nine rheumatoid patients treated with up to 1,600 mg ibuprofen daily over six months. Significant improvement occurred in all clinical parameters and gastro-intestinal upset leading to discontinuance of therapy was reported in just two patients. There were no abnormalities in any of the biochemical tests performed. | |
| 336886 | Effect of auranofin on DNA and protein synthesis in human lymphocytes. | 1977 Autumn | The effect of auranofin-a new oral gold compound for the treatment of rheumatoid arthritis-and gold sodium thiosulphate on DNA and protein synthesis, as well as their effect on membrane transport in stimulated lymphocytes was studied. It was found that only auranofin in the given concentrations inhibits the incorporation of 3H thymidine and 14C amino acids. The studies on membrane transport present evidence that the pharmacological action of auranofin might be mediated through its action at the cellular membrane level. | |
| 6966151 | Depressed T cell colony growth in systemic lupus erythematosus. | 1980 Apr | Phytohemagglutinin-stimulated peripheral blood T lymphocytes, plated in agar, are capable of forming discrete lymphoid colonies. In 35 normal subjects, the average number of colonies was 6,020 +/- 351 (SEM). By contrast, in 39 patients with systemic lupus erythematosus (SLE), the mean colony number was 2,774 +/- 384, a value significantly less than controls (P less than 0.001). Normal responses were measured in 5 patients with progressive systemic sclerosis and in 7 of 8 patients with rheumatoid arthritis. Colony growth in SLE showed a strong correlation with disease activity but did not correlate with responses of blood lymphocytes to phytohemagglutinin in suspension cultures, the number of circulating T cells, or serologic abnormalities. | |
| 6474334 | Acrylic reconstruction of an arthritic cervical spine using the transcervical-transclival | 1984 Oct | We describe the use of a transcervical-transclival approach in the treatment of an ascending luxation of the odontoid by rheumatoid arthritis. We favor this approach and use of methylmethacrylate in this rare condition. Other applications of this route which gives access to the craniocervical junction are discussed. | |
| 514939 | Motor polyneuroapthy and nystagmus associated with chloroquine phosphate. | 1979 Sep | A 49-year-old woman with rheumatoid arthritis developed a motor polyneuropathy and nystagmus after 5 months' treatment with chloroquine phosphate. The peripheral neuropathy resolved after the chloroquine was discontinued. | |
| 6282982 | Collagenases and collagen degradation. | 1982 Jul | Degradation of interstitial collagens probably takes place through different enzymatic mechanisms than degradation of basement membrane and pericellular collagens. Interstitial collagens are resorbed under pathological and physiological conditions by collagenases which function extracellularly and cleave polypeptide chains in the collagen triple helix at specific loci resulting in solubilization from the fibril. Production of collagenase in humans is ascribable to fibroblast-like cells which can be stimulated to synthesize new enzyme for release outside of the cell. In several inflammatory conditions, such as rheumatoid synovitis, modulation of collagenase production is mediated by interactions with surrounding inflammatory cells. Monocyte-macrophages produce a stimulatory factor, which has homologies with interleukin 1, which not only increases collagenase synthesis but also PGE2 synthesis. The PGE2 in turn has profound effects on cellular function. Production of the mononuclear cell factor is modulated by several interactions including T lymphocytes and T lymphocyte products, collagen of the extracellular matrix and the Fc portion of immunoglobulins. It is probable, from analogies with other stimulants such as phorbol myristate acetate, that the increase in collagen synthesis is controlled at the level of transcription. Further regulation of collagenase action outside of the cell is probably accomplished by proteolytic activation of a latent collagenase zymogen and interactions with inhibitory proteins also produced by cells in the local environment of the resorptive process. | |
| 819381 | Reevaluation of inguinal lymph node injection for production of adjuvant arthritis in the | 1976 | An experiment was designed to compare the efficiency of lymph node injection for the induction of adjuvant arthritis (AA) with that of conventional footpad injection in the rat. Quantitative studies revealed that the minimal dose required for induction of AA by the lymph node route is one fifth of that by the footpad route. Thus, the lymph node route was found to be more efficient than the footpad method in terms of higher incidence and earlier onset of AA. PPD in Freund's incomplete adjuvant was able to produce tuberculin sensitization in the rat. The lymph node route again proved to be superior in terms of consistent appearance of the 24-hour reaction on days 8 and 14 and prolongation of the skin reaction over 48 h. These findings show that the lymph node method is so efficient in the rat that it will be especially useful for the trial induction of AA with various materials of unknown potency as well as for production of delayed hypersensitivity. In addition, this injection method appears to be a simple and efficient technique for assay of other immunological reactions. | |
| 6442056 | [Undesirable effects of gold therapy]. | 1984 | In about 20 to 30% of patients receiving intramuscular gold salts untoward side-effects of variable severity are known to occur with resultant discontinuation of treatment in a high percentage of cases to be on the safe side. Among the most common, albeit harmless side-effects are those affecting the skin and the mucous membranes. These are followed by renal symptoms. Grave complications affecting the hemopoietic system (leucopenia, thrombocytopenia, aplastic anaemia) are rarely seen. Other potential side effects (pulmonary fibrosis, liver damage, neuropathies, vasomotor reactions, loss of hair, nail changes) are extremely uncommon or no more than anecdotal). Meticulous follow-ups at regular intervals are imperative to minimize the associated risks. | |
| 6776698 | [Functional diagnostics of the adrenal cortex following long term treatment with prednisol | 1980 Jun 1 | Promounced cases of disturbances of the function of the adrenal cortex may more certainly be found out with the help of the enlarged sinacthen test than after a stimulation done only but once. In a long-term prednisolone therapy of 10 mg/a day we could observe signs of disturbances of the function of the adrenal cortex. A clear evidence in the estimation of the individual value is possible only in decreased plasmacortisol levels which are during the whole course of the experiment. When a prednisolone therapy is established for a longer time apart from the sequels at the adrenal cortex should be thought also of the great number of the side effects caused by the catabolic properties of the cortico-steroids. | |
| 6850197 | Problems for rheumatic patients in opening dispensed drug containers. | 1983 May | The ability of 50 rheumatoid arthritis patients with hand involvement and 50 normal control subjects to open a range of reclosable tablet containers and unit dose packs was tested. Child-resistant containers, particularly the clic-loc type, proved the most difficult for patients and control subjects to open. Smaller containers were less easy to open than comparable ones of a larger size. Only 54% patients were able to remove a suppository from its wrapping. Blister packs and conventional screw-capped tablet bottles were easiest to open. Dispensing of drugs for rheumatic patients in child-resistant containers should be limited to those without hand involvement. | |
| 735455 | Acute autoimmune collagen-induced arthritis in rabbits. | 1978 Sep | Three groups of rabbits were investigated: I. 9 rabbits, immunized with rabbit collagen type I, received 1 intraarticular injection of same antigen in the right knee, and control preparations in the left knee. II. 4 rabbits, immunized with calf collagen type I, received the same intraarticular injections as in group I. III. 2 non-immunized rabbits received also the same intraarticular injections. Synovial fluid and synovium were obtained in all groups 18 hours after intraarticular injection. Knee-joints of all animals immunized and challenged intraarticularly with rabbit collagen showed strong cellular exsudation (mean 1.800 X 10(3) cells,) in contrast to control joints (mean 21 to 484 X 10(3) cells). Histologic investigation of synovium of group I animals showed in rabbit collagen injected knees in contrast to controls, vascular reactions with enlargement of small vessels, thikening of endothelial cells, perivascular infiltration and aggregation of polymorphonuclears in lumen of vessels. Intraarticular injection of rabbit collagen in calf collagen immunized rabbits, induced a limited cellular exsudation, (mean 670 X 10(3) cells) which was lower than in rabbit collagen immunized animals, however also more pronounced than in control joints. Whilst results after intraarticular injection of rabbit collagen in rabbit collagen immunized animals are interpreted as early signs of autoimmune arthritis, results after intraarticular injection of rabbit collagen in calf collagen immunized animals are regarded as milder symptoms of synovitis induced by crossreactivity of antigens. | |
| 6447962 | [The suppressor cell activity in rheumatoid arthritis]. | 1980 May | The rate of 3H-thymidine incorporation into peripheral blood lymphocytes was determined immediately after the addition of 1 microgram of Con A and after 24 h of preincubation period the stimulation in normal controls was 3 times higher than after the immediate addition of mitogen. In rheumatics the increase was 1,7-fold only. The results were interpreted as indicating a lack of suppressor cell activity in the patients with rheumatoid arthritis. | |
| 6311224 | Human alpha-interferon enhances in vitro IgM rheumatoid factor synthesis by lymphocytes fr | 1983 Sep | Alpha-interferon (alpha-IFN) was added to pokeweed mitogen (PWM) or Epstein-Barr virus stimulated human peripheral blood mononuclear cell cultures from normal subjects or patients with rheumatoid arthritis (RA). Alpha-IFN enhanced in vitro production of PWM induced IgG and IgM, and significantly enhanced PWM induced IgM rheumatoid factor (IgM-RF) production by lymphocytes both from normal subjects and RA patients. Enhancement was recorded whether cells were preincubated with alpha-IFN for 16 hours or with alpha-IFN present throughout the culture period. Alpha-IFN did not enhance IgM-RF production in the absence of PWM or T cells. Enhancement of IgM-RF production was not seen in Epstein-Barr virus stimulated cultures. |