Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4464498 | Periodic synoviosis (intermittent hydrarthrosis) with observations and studies on a patien | 1974 Jan | More than 200 instances of periodic synoviosis have been recorded. It is related to periodic oedema (hereditary angioedema). Various autonomic disturbances accompany episodes. Confusion with rheumatoid arthritis persists. Theoretically an inherent rhythm or feedback mechanism operates as the cause. The disorder in several observed patients has persisted for decades, worsened or abated. In one instance, contraceptive medication failed to suppress episodes in contrast to the effect of pregnancy in some patients. E-aminocaproic acid disturbed the rhythm and gave mild relief. A few episodes were suppressed after two surgical operations. The inhibitor of Cl esterase in one patient lacked as much as it does in periodic oedema. | |
| 4075618 | Anti-inflammatory therapy during pregnancy and lactation. | 1985 | Acetylsalicylic acid (ASA), other nonsteroidal antiinflammatory drugs (NSAID) and corticosteroids are not known to be teratogenic in humans. Congenital defects have been reported with chloroquine but not in association with gold or D-penicillamine therapy. Likewise, several immunosuppressive agents have been incriminated but azathioprine may be safe to use during pregnancy. Acetylsalicylic acid is considered to be the antiinflammatory drug of choice in pregnancy because of greater experience than with other nonsteroidal antiinflammatory drugs. However adverse effects of acetylsalicylic acid in pregnancy includes prolonged gestation and labour and increased blood loss during delivery. Other nonsteroidal antiinflammatory drugs have been less well studied. Despite the relatively low risks with current antiinflammatory drugs, unnecessary exposure should be avoided in the first trimester and all such medication reduced to a minimum throughout pregnancy. | |
| 6295771 | Immunopathogenesis of rheumatoid arthritis. | 1982 | Three distinct groups of phenomena occur in the rheumatoid joint. The synovial lining cells proliferate and hypertrophy; the sublining or deep layer becomes infiltrated by mononuclear cells; and fluid, which is rich in polymorphonuclear cells, collects in the synovial space. As a result, there is a polymorphonuclear inflammatory reaction in the rheumatoid effusion and a chronic inflammatory reaction in the sublining layer of synovial membrane. In spite of their divergent histologic character, these two inflammatory reactions appear to be interrelated immunologically. In this review, we describe these two types of inflammation, trace their interrelationship and consider possibly underlying mechanisms for the inflammation. | |
| 6344196 | The role of the MA-sensitive leukocyte chemotaxis in rheumatoid arthritis. A randomized do | 1983 | Polymorphonuclear leukocyte (PMN) chemotaxis is thought to play an essential role in the pathogenesis of rheumatoid arthritis. PMN chemotaxis is in part sensitive to microtubule antagonists (MAs), e.g. colchicine. The antimycotic antibiotic griseofulvin inhibits the MA-sensitive PMN chemotaxis in vitro in concentrations far below those obtained in serum during antimycotic therapy. The role of the MA-sensitive chemotaxis in rheumatoid arthritis could thus be elucidated by a clinical trial of griseofulvin treatment. Griseofulvin (n = 20) was tested in a randomized double-blind study versus placebo (m = 19) during one year in patients with rheumatoid arthritis of mild-moderate activity. No beneficial effect of griseofulvin treatment was noted on clinical symptoms or laboratory parameters of rheumatoid arthritis. Moreover, the placebo-treated patients showed more improvement than the griseofulvin-treated patients. It is therefore suggested that the MA-sensitive chemotaxis plays a reparative role in the inflammatory lesions of rheumatoid arthritis. | |
| 7419291 | Determination of rheumatoid factor by means of thin layer immunoassay. | 1980 | Thin layer immunoassay (TIA), a solid phase immunoassay based on a technically simple visualization method, was adapted for quantitative determination of rheumatoid factor (RF) in blood serum. The influence of various factors of possible significance for accurate quantitation of RF by TIA was studied. Comparison between TIA and the Waaler-Rose test for determination of RF was performed on 335 patient sera. The results obtained by the two methods agreed reasonably well. Preliminary experiments were also performed concerning the use of TIA for differentiation of RF with regard to the immunoglobulin class. It is concluded that, because of its simplicity and screening capacity, TIA could be an attractive method for detection and quantiation of RF. | |
| 6857177 | Pleurisy in rheumatoid arthritis. | 1983 | In 157 women and 77 men with rheumatoid arthritis, observed for a mean of 5.7 years, the annual incidence of pleural effusion was found to be 0.34% in the women and 1.54% in the men. In 4 pleural fluids the fluid-to-serum ratio for Waaler-Rose titres was 1:4, which agrees with the ratios for other proteins and does not suggest a pathogenetic role of the rheumatoid factor. In two other pleural fluids the findings suggested immune mechanisms implicating the rheumatoid factor. In general, the data, both clinical and any other, was compatible with the possibility of multiple etiological and pathogenetic factors in rheumatoid pleural effusions. These were: extrinsic factors causing pleural thickenings in 25% of non-rheumatoid men and in less than 10% of non-rheumatoid women aged more than 50 years; preceding lung disorder; particular inflammatory responsiveness due to rheumatoid disease, related or unrelated to rheumatoid factor; and some degree of transudation. | |
| 6758794 | [Proteolytic occurrences in the metabolism of cartilage and their modification by antirheu | 1982 | Rheumatic diseases are characterized by the progressive loss of articular cartilage. According to a well established hypothesis proteolytic enzymes take part in these events. The initial attack in an normal cartilage can be exerted by proteoglycanases originating from either chondrocytes or cells from outside the cartilage like neutrophilic granulocytes or macrophages. In rheumatoid arthritis these latter cells are found in immediate vicinity to cartilage and it is assumed that they release their enzymes directly into the cartilage. Lysosomal elastase from neutrophilic granulocytes is a key enzyme made responsible for the degradation of cartilage, since it is able to soften up this tissue and thereby to deprive it of its normal mechanical properties. Therefore the pharmacological inactivation of elastase bears a therapeutic potential for rheumatic joint disease. The ultimate value of enzyme inhibitory antirheumatic drugs needs, however, further investigation since also enzyme independent variables play an important role in maintaining normal function of cartilage. | |
| 324154 | [Leukocyte agglomeration as an activity criterion of inflammatory processes]. | 1977 Feb 15 | The agglomeration of leucocytes serves for the proof of activation of the leucocytic system, the so-called leucergia, which among other occurs in inflammatory diseases of different genesis. On the basis of 1,000 examinations in patients with rheumatoid arthritis the sensitivity of the method was tested compared with the usual criteria of inflammation. In agroup of patients with slight activity with the agglomeration of leucocytes an inflammatory activity could be proved in 67.5% (electrophoresis 53.5%, BSR 49.2%, CrP 35.4%, leucocytosis 27.9%). The chi2-test resulted in a significant correspondence between the examinations mentioned and the agglomeration (p less than 0.001). In contrast to the usual criteria of activity the proof of leucergy is a new principle ofthe diagnostics of activity. High sensitivity and simple methodics recommend the use of the agglomeration of leucocytes in routine diagnostics. | |
| 3874417 | [Muscular scanning in polyarthritis and rheumatology]. | 1985 May | Atypical features were observed in 7 out of 120 cases of rheumatoid arthritis and in 3 out of 4 cases of polymyositis. A vermicular image was observed burrowing into the muscles, which head a "worm eaten" appearance. This series is too small to allow definitive conclusions, but this appearance is very different from the other features observed in muscular pathology such as myopathy or neurogenic amyotrophy. A "combed" appearance of the paravertebral muscles was also observed in 4 cases of rheumatoid pelvispondylitis. The authors also present several examples which illustrate the value of the CT scan in focal disease (lipomas, hydatid cysts, muscle angiomas). | |
| 322585 | [Involvement of lymphocyte populations in rheumatoid synovial lesions]. | 1977 Jan | T and B lymphocyte proportions have been studied in synovial fluid and peripheral blood from 70 patients with classical or definite rheumatoid arthritis (RA). The results have shown that T-cell numbers assessed by E-rosettes and anti-HTLA antiserum, B-cell numbers detected by membrane immunofluorescence and EAC-rosettes from peripheral blood were similar in RA and in a control group. Conversely, "active" E-rosettes which detected a subset of mature T cells, were decreased in blood and very increased in synovial fluid. Furthermore, the percentages of mononuclear cells bearing a Fc-receptor for IgG (EA-rosettes) were higher in synovial fluid than in RA peripheral blood. These data could be in favour of the cell-mediated immunity in rheumatoid arthritis lesions. | |
| 3997313 | A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid art | 1985 | A male aged 72 years suffering from erosive seropositive rheumatoid arthritis developed jaundice after one month on D-penicillamine after a cumulative dose of 5.625 g. The biological abnormalities were characteristic of cholestasis. There were no gall-stones. The liver biopsy showed severe intrahepatocellular cholestasis with a slight degree of cellular cholangitis and with eosinophils in the portal tracts. There was no sign of cellular necrosis. After cessation of D-penicillamine, the jaundice cleared within three weeks and the enzymes were normalized within two months. The aetiology is discussed and the cases of the literature are reviewed. This case represents a further instance of D-penicillamine-induced cholestatic hepatitis. | |
| 7337961 | Fc receptors on lymphocytes from the blood of rheumatoid arthritis patients and normal con | 1981 Sep | Peripheral blood lymphocytes (PBL) from rheumatoid arthritis (RA) patients and healthy controls (NC) were assayed for Fc receptors by four methods. Three of the four assays showed RA PBL to contain a greater proportion and number of Fc receptor-bearing cells than PBL from healthy controls. This confirmed our earlier report and indicated that the proportion of Fc receptor-bearing cells detected can be influenced by the test system. Neither the proportion of B, nor the non-B, non-T lymphocytes was consistently increased in RA PBL, suggesting that the increase found results from an increase in Fc gamma receptor-positive T cells. | |
| 7206401 | The relationship between D-penicillamine--induced proteinuria and prior gold nephropathy. | 1981 Feb | Twenty-five patients with rheumatoid arthritis treated with D-penicillamine were retrospectively reviewed for signs of drug intolerance. Nine patients (36%) developed adverse drug reactions, the most common of which was proteinuria in six patients (24%). Comparative analysis of patients with and without penicillamine-induced proteinuria revealed the only significant correlate to be a previous history of gold nephropathy. Five (83%) of six patients who developed penicillamine-induced proteinuria had had gold-induced proteinuria; in contrast, only three (20%) of 19 who tolerated penicillamine had prior gold-induced proteinuria (p less than .01). HLA typing performed in five of the six patients with penicillamine nephropathy revealed DRw4 at a prevalence less than that expected for a population with rheumatoid arthritis, with DRw3 and/or B8 present in four patients. Further studies are in progress to determine whether a genetic predisposition is present. These data suggest that cautious observation is warranted in rheumatoid patients receiving D-penicillamine who have a prior history of gold nephropathy. | |
| 7424199 | [D-penicillamine and wound healing in patients with rheumatoid arthritis]. | 1980 Jan | The inhibiting effect of D-penicillamine on the collagen metabolism in animal experiments and in some published clinical observations appear to confirm the assumption that this drug might retard the wound healing after surgery. Therefore the authors studied wound healing following 107 orthopedic operations in 49 RA patients: 36 operations on patients without any basic treatment, 48 during D-PA, 18 during gold, 4 during azathioprine and 1 during Resochin. Retarded wound healing (up to 4 weeks after the date of the operation) was observed 6 times: in 2 out of 36 operations (5.5%) in those without basic treatment, in one out of 48 (2.1%) during D-PA (600 mg/day), in 3 out of 18 (16.6%) during gold therapy. Operative re-interventions because of disturbances in the wound healing or infections were not needed. Based on these observations and the fact that authors who have observed an inhibition of the collagen synthesis have used an uncomparibly higher dosage per kilogram of body weight, the authors of this report are so far of the opinion that the dosage they are using (300-600 mg/day) does not significantly influence the speed of wound healing. Thus the basic treatment must not be interrupted before or after an operation. | |
| 6142706 | [Morphology of immune inflammation in rheumatic diseases]. | 1983 | The results of combined histochemical, immunomorphological, and immunological studies on biopsy, operation, and autopsy materials from 184 patients with rheumatoid arthritis, 41 patients with systemic lupus erythematosus, 66 patients with systemic sclerodermia. 35 patients with periarteritis nodosa are summarized. The main morphological changes in rheumatic diseases were found to be due to immunopathological reactions manifested as immune inflammation. According to the pattern of immunopathological mechanism, early and late immune inflammation manifested by humoral and cellular immunopathological reactions are distinguished. The predominant localization of lesions typical of each rheumatic disease, and the chronic self-maintaining pattern of inflammation are discussed. | |
| 498500 | Rate nephelometric measurement of rheumatoid factor in serum. | 1979 Nov | We describe the measurement of rheumatoid factor in human sera with a rate nephelometer. The National Reference Preparation for Rheumatoid Factors is used to calibrate the assay in International Units. We used Hyland Positive Control, Level I, as a secondary standard. The standard curve is exponential, but is linear when plotted on log-log graph paper. Aggregated immune globulin (IgG) is the antigen used to detect rheumatoid factor (IgM-class antibody to IgG). The rate reaction measures the rate of increase in light-scatter by the antigen-antibody complexes; the reaction takes place in 17 to 20 s. Precision, linearity, and accuracy are excellent. Results agree well with those for a commonly used latex precipitation test. The advantages of speed, quantification in International Units, and superior discrimination of concentration as compared to serological titration provide a more reliable test for use in the diagnosis and treatment of rheumatoid arthritis. | |
| 308254 | [Circulating immune complexes and anti-IgG antibodies in rheumatoid arthritis]. | 1978 Jun | Anti-IgG antibodies were studied in 222 patients hospitalized in a Rheumatology service using "radio-immuno-precipitation-PEG-assay" (RIPEGA), The presence of anti-IgG antibodies was observed in 94 per cent of sero-positive rheumatoid arthritis (RA+), 88 percent of seronegative rheumatoid arthritis (RA--), 50 percent miscellaneous chronic inflammatory rheumatisms (CIR) and 77 percent of no-classifiable chronic inflammatory rheumatisms. The study of circulating immune complexes (CIC) using the CIC-125 I linkage tests, carried out on 101 RA cases, demonstrated their presence in 80 per cent of RA+ and 85 per cent of RA--. The comparison of these two factors during RA showed a concordant relationship that was statistically significant. The presence of the rheumatoid factor (RF) in the form of complexes in the blood stream, is discussed. | |
| 106982 | [Criteria for the evaluation of the antirheumatic (antiinflammatory) drugs in man]. | 1978 Oct 23 | Comparison of 5 antiinflammatory drugs and placebo in a double blind, short term, cross-over trial conducted in patients suffering from rheumatoid arthritis. 15 measurements were used and studied. With classical unidimensional statistical tests it was not possible to discriminate active drugs between them. Multidimensional analysis (correspondance analysis and discriminant analysis) are more sensitive and allow us to distinguish active drugs with only 11 criterion. | |
| 532372 | [Venous pseudothromosis of the lower leg after popliteal cyst rupture in rheumatoid arthri | 1979 Nov | During the course of only one year popliteal cyst ruptures simulating deep venous thrombosis were diagnosed in six patients with rheumatoid arthritis. The characteristic history and some specific physical findings are reported which are indicative of a pseudo-thrombophlebitis. Laboratory investigations were of limited value whereas a simplified contrast-arthrography demonstrated the synovial ruptures. In the rheumatoid patient a synovial cyst rupture rather than deep venous thrombosis should be primarily suspected and arthrography should be the first radiographic measure. | |
| 6528683 | [Case report on osteoarthropathy following frostbite]. | 1984 Dec 1 | On the basis of a casuistics of a 38-year-old male is reported on osteoarticular changes after local congelation. 10 years after a second- to third-degree injury of the right hand the patient was admitted to the dispensary for rheumatism under suspicion of a rheumatoid arthritis. Differential-diagnostic aspects and reports in literature on the clinical as well as radiological variation of the course of local congelations are discussed. Here the large temporary intervals between local frost injury, early and late clinical and radiological symptoms with 3 and 10 years, respectively, are conspicuous and little known. |