Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6828259 | [Serum ferritin in rheumatoid arthritis: an acute phase protein or indication of iron depo | 1983 Feb 25 | Serum ferritin was determined in 24 menopausal women who did not have any iron metabolic disorders but were suffering from RA. We furthermore investigated its correlation to various clinical and laboratory indexes of activity. The regression analysis revealed significant coefficients of direct correlation between serum ferritin, ESR, and Ritchie's index as well as an indirect correlation to the hematic haemoglobin and to serum iron. These data would apparently be in agreement with the hypothesis that, during the course of RA, serum ferritin assumes the significance of an acute phase protein; nonetheless, in spite of this, these data would induce one to believe that the serum ferritin levels closely reflect that RES iron deposits, the extent of which is influenced by chronic phlogosis. | |
| 6791165 | Cellular, molecular, and genetic characteristics of T cell reactivity to collagen in man. | 1981 Jun | Rheumatoid arthritis is significantly associated with the HLA determinant HLA-DRw4 and cell-mediated reactivity to collagen. To determine if genes linked to those coding for HLA-DRw4 constituted immune response genes for collagen reactivity, peripheral blood mononuclear cells from 20 individuals with rheumatoid arthritis, 13 individuals with other arthropathies, and 41 normal individuals were compared for their ability to synthesize the lymphokine leukocyte inhibition factor in response to denatured bovine collagen. All individuals were responsive to the control antigen Candida albicans. While 90% of the patients with rheumatoid arthritis responded to collagen, so did 30% of the individuals without rheumatoid arthritis. This included 15 normal individuals without any evidence of arthritis. Collagen responsiveness was dependent on interactions between T cells and macrophages was dependent on interactions between T cells and macrophages and was directed against determinants expressed by primary amino acid sequences in the synthetic polypeptide (Gly-Pro)n. HLA-DRw typing of 59 individuals revealed a highly significant relationship (P less than 0.0001, chi 2 = 33.7) between HLA-DRw4 and collagen responsiveness, irrespective of whether or not rheumatoid arthritis was present. All normal individuals who were HLA-DRw4-positive were collagen responders. These studies demonstrate that the cellular, molecular, and genetic characteristics of collagen reactivity in man parallel those documented for the T cell-dependent response to antigens under immune response gene control in rodents. | |
| 6389322 | [A solid-phase ELISA with specificity for rheumatoid factors of classes IgA, IgG and IgM]. | 1984 Oct | A solid phase ELISA was developed for the simple and rapid determination of rheumatoid factors (RF) of all major immunoglobulin classes. Micro-ELISA-plates were coated with human Fc-fragments and incubated with various dilutions of serum samples as well as with an international RF reference serum. Rheumatoid factors were quantitatively detected by rabbit antibodies (RaHIgA(alpha), RaHIgM(mu), RaHIgG(Fab] conjugated with alkaline phosphatase. The specificity of the ELISA was proved by means of binding inhibition of all rheumatoid factor classes by heat aggregated human IgG. A comparison of the IgM-RF titres of the latex fixation test with the IgM-RF concentration values of the ELISA yielded high correlation (r = .81). | |
| 6573513 | Leukemia and arthritis: including reports on light, immunofluorescent, and electron micros | 1983 Feb | Leukemia is a well described cause of arthritis. Articular manifestations may be present for months before the diagnosis of leukemia becomes evident. Leukemic arthritis may mimic other diseases. The etiology of leukemic arthritis can be diverse, but is often attributed to leukemic involvement of synovium. We describe a case where evaluation, including immunofluorescent and electron microscopy of open synovial biopsy specimens, revealed no obvious cause of the arthritis. | |
| 6488121 | Polyarthritis associated with gastric carcinoma. | 1984 Oct 15 | In a 68-year-old man who had polyarthritis associated with gastric carcinoma surgical resection of the tumour was accompanied by prompt resolution of the arthritic syndrome. In 11 years of follow-up the arthritis has remained in complete remission and there has been no recurrence of the carcinoma. An awareness that polyarthritis may be a presenting manifestation of an underlying carcinoma may, especially in an elderly person, lead to early recognition and treatment of the malignant disease. | |
| 6644712 | Carcinoma polyarthritis: role of immune complexes in pathogenesis. | 1983 Oct | Rapid onset of an additive inflammatory arthritis was observed in a patient with newly-diagnosed carcinoma of the lung. Serological studies revealed antinuclear antibodies and evidence of circulating immune complexes (CIC) by Raji cell assay. Synovial fluid was inflammatory and synovial biopsy showed chronic synovitis, but immunofluorescence and electron microscopy of tumor and synovium failed to reveal evidence of immune complex deposition. These findings suggest that CIC may not be the cause of carcinoma polyarthritis. | |
| 340113 | Drug trial in rheumatoid arthritis: a new design. | 1978 Feb | The comparative efficacy and safety of naproxen and ibuprofen were studied in 64 patients with rheumatoid arthritis. A new trial design with three aspirin periods interspersed during the study was used. By passing a smooth curve through the values obtained for the various measures of disease activity during the aspirin periods, one could calculate the difference between what would have been expected on aspirin therapy and what was found during therapy with the two trial drugs. These differences, or "incremental values," allowed each patient's variations to be analyzed individually, thus eliminating the necessity of assuming that a patient's disease was constant. Napoxen and ibuprofen were comparable in efficacy to each other and to aspirin, but both drugs caused significantly less severe side effects than aspirin. Although analysis of the incremental values showed essentially the same results as a standard analysis of the raw data with only a modest increase in sensitivity in this particular study, the novel trial design may prove useful in future drug studies in patients with rheumatoid arthritis and other chronic but fluctuating diseases. | |
| 737001 | Ocular chrysiasis correlated with gold concentrations in the crystalline lens during chrys | 1978 Jul | The eyes of 11 patients with rheumatoid arthritis (RA) who received extended chrysotherapy (mean cumulative dose greater than 7 grams during a mean 6-year period) were examined biomicroscopically. Minute reddish-purple particles were seen in the cornea (corneal chrysiasis) in 5 and in the lens (lens chrysiasis) in 4 patients. Particulate deposits were absent in 11 other RA patients who had not received gold treatment. Seven crystalline lenses from 5 gold-treated patients were removed surgically because of incidental cataract formation and analyzed for gold content using neutron activation analysis. Although the mean lens gold concentration was higher in these patients than in non-gold-treated controls without RA (0.0073 microgram/grams versus 0.001 microgram/grams), the absolute gold level was markedly lower than that found in 25 diverse tissue analyzed previously. This finding is compatible with the absence of clinical gold-related lens disease or visual impairment. | |
| 7014876 | The metabolism and pharmacology of D-penicillamine in man. | 1981 Jan | D-penicillamine is rapidly absorbed from the intestine and appears in plasma as free penicillamine, cysteine-penicillamine disulfide, and penicillamine disulfide. Penicillamine binds firmly to serum and tissue proteins. The urinary excretion of S-methyl-D-penicillamine, cysteine-penicillamine disulfide, penicillamine disulfide, and a newly identified metabolite, homocysteine-penicillamine disulfide, has been quantitated for patients with rheumatoid arthritis, cystinuria, and Wilson's disease. Fifty percent of an oral dose is excreted in the feces, but the metabolites have not yet been fully characterized. The pharmacologic effects of D-penicillamine are associated with disulfide bond formation or cleavage, thiazolidine formation, and metal chelation. | |
| 7011116 | [The search for circulating immune complex (IC) (author's transl)]. | 1980 | There are at present a large number of methods of searching for circulating immune complexes. No method is totally satisfactory, but the use of several methods simultaneously now permits us to draw a few conclusions. The very frequent presence of circulating immune complexes in the serum during systemic lupus erythematous, rheumatoid arthritis, and acute glomerulonephritis, is further evidence in favour of circulating immune complexes in these diseases. Furthermore, circulating IC may be observed in numerous circumstances, without causing obvious pathological consequences. It is nevertheless possible that they may play a role in the control mechanisms of immune function. | |
| 6156970 | Radioimmunoassay for immunoconglutinins. | 1980 | A competitive radioimmunoassay for immunoconglutinin (IK) was developed using isolated antostimulated rabbit IK labelled with 125I and glutaraldehyde-fixed sheep erythrocytes coated with fixed complement (EAC). IKs in test sera of human or animal origin produced specific inhibition of uptake of [125I]IK onto EAC and this was quantitated by reference to a calibration curve established with pure rabbit IK. Among 20 normal human sera the IK levels were: median 62 microgram/ml, range 41-170 microgram/ml and in 7 rat sera the levels were: median 71 microgram/ml, range 58-80 microgram/ml. Preliminary studies showed raised IK levels in the sera of patients with rheumatoid arthritis and with Crohn's disease. | |
| 791783 | [Alrheumum in the daily practice]. | 1976 Nov 11 | The new antirheumatic drug Ketoprofen (Alrheumun) has been tested by an open trial in 100 out-patients and the activity and tolerance have been evaluated under practice conditions. A daily dose of 3 capsules Alrheumun proved to have a good activity in patients with rheumatoid arthritis, osteoarthrosis and soft tissue conditions. 80% of all patients did not show to have any side-effects. Among all groups of patients, treatment had to be interupted because of side-effects in two patients only. A negative influence on any of the laboratory tests used was not found. | |
| 6238046 | The relationship between strategies of coping and perception of pain in three chronic pain | 1984 Sep | Examined the relationship between perception of pain, personality, coping and the reactions of family members in three chronic pain groups (sickle cell anemia, arthritis, and low back pain). Sixty black Ss equally distributed in the three medically diagnosed pain groups completed the McGill Pain Questionnaire, Maudsley Personality Inventory, a self-control measure, and the modified spouse response questionnaire. Nonsignificant association was detected between measures of pain and neuroticism; a significant inverse relationship was found between self-controlling behaviors and the affective dimension of pain; the relationship between perceived solicitous behavior and intensity and quality of pain differentiated the sickle cell and arthritic groups from the low back pain group; for the low back pain group, intensity of pain was related significantly to solicitous behaviors of family members, but the reverse was true for the arthritic and sickle cell groups. | |
| 6217789 | Spondyloarthritis and enthesopathy. Current concepts in rheumatology. | 1983 Jan | Spondyloarthritis (Sp) is newly defined as arthritis that is clinically, pathologically, and genetically related to and predisposed to ankylosing spondylitis (AS) and Reiter's syndrome (RS) rather than to rheumatoid arthritis (RA). A diagnosis of Sp does not necessarily imply arthritis of the spine and does not depend on the demonstration of roentgenographic sacroiliitis that, in this conceptualization, is recognized not as the essential hallmark, but rather merely as a diagnostic "way station" on a continuum of disease, which may (but need not necessarily) begin with RS or be complicated during its course by AS or RS. Spondyloarthritis is distinctively characterized morphologically and clinically by disproportionate inflammation at the entheses, the sites of attachment of tendons and ligaments to bone. Family history or presence of enthesopathic pain, psoriasis, inflammatory bowel disease, uveitis, recurrent urethritis, prostatitis or cervicitis, keratoderma blennorrhagicum, HLA-B27, and asymmetric pauciarticular lower lower extremity arthritis without rheumatoid factor or rheumatoid nodules suggests a diagnosis of Sp rather than RA. | |
| 3927888 | Gold-induced bone marrow aplasia: successful treatment with antithymocyte globulin. | 1985 Apr | A patient receiving gold treatment for rheumatoid arthritis developed sudden severe pancytopenia secondary to bone marrow aplasia. She required extensive hematological support but was unsuitable for bone marrow transplantation. Although early use of large doses of a chelating agent did not change the hematological parameters, subsequent use of antithymocyte globulin has been associated with substantial hematological improvement. | |
| 903755 | Joint pain of recent onset. | 1977 Sep | A joint pain of recent onset is a common and often challenging problem to the family physician. The many etiologies of acute arthritis require a systematic approach to a careful definition of the problem which is essential to safe and effective therapy. The proper evaluation of joint pain of recent onset requires a detailed history and physical examination as well as a rationally selected battery of laboratory studies. This paper provides the busy physician with a specific approach to the diagnosis of acute joint pain as the basis for precise management. | |
| 3933866 | Therapeutic uses of trace elements. | 1985 Aug | The properties of trace elements which feature in their therapeutic activity are: binding to macromolecules (enzymes, nucleic acids, etc.) with disturbance of biological function, and interaction with other elements. These properties, particularly the binding to large molecules, are far from specific, an observation which is reflected in the very wide range of diseases in which trace elements are employed. While metal compounds have been administered for several centuries, the scientific basis for treatment with trace elements began with the use of gold compounds, initially in patients with tuberculosis and later those with rheumatoid arthritis. Although many other drugs have been developed, some of which also include metal complexes, gold has retained an important position in the treatment of this condition. The gold-induced effects upon the immunological aspects of RA are also observed in other conditions with autoimmune involvement. The antineoplastic potential of metal complexes will be further exploited by the development of less toxic compounds--of platinum and possibly also of other metals. At the same time there are improvements in the protocols for administration which increase the range of cancers responding to treatment. Perturbation of gastrointestinal activity represents another area where trace elements have an important therapeutic role, both in the control of intraluminal acidity and in the adjustment of nutrient availability. A fourth significant area of trace element therapeutics involves the central nervous system where the use of lithium has provided spectacular results in the treatment of affective and other disorders. With a very wide range of other conditions in which they are employed, therapeutic uses provide somewhat unusual illustrations of the importance of trace elements in human disease. | |
| 40306 | Prednisone effect on microvascular permeability in patients with inflammatory rheumatic di | 1979 | The transcapillary escape rate of albumin was measured in 27 consecutive patients with inflammatory rheumatic diseases before and after 1 and 7 days of prednisone treatment in doses of 45 mg/day. The transcapillary escape rate decreased from 7.33%/h (range 5.11-9.55) before prednisone treatment to 3.11%/h (0.04-6.18) (p less than 0.05) after 1 day of treatment and 5.80%/h (4.36-7.24) after 7 days of treatment. It is concluded that prednisone inhibits vascular permeability in patients with inflammatory rheumatic diseases. | |
| 6335597 | Inflammatory cell infiltrate in labial salivary glands of patients with rheumatoid arthrit | 1984 Dec | The labial salivary glands of 81 patients with rheumatoid arthritis (RA) and those of 45 control (CO) patients were biopsied. Mast cell counts were compared with the number of other inflammatory cells (B- and T-lymphocytes and mononuclear phagocytes, stained with acid-alpha-naphthyl acetate esterase technique (ANAE) and to fatty change and fibrosis. Mast cells were directly related to the amount of fibrosis and fatty change in both series, supporting the recent theory that these changes are age-related phenomena and not caused by RA per se. Mast cell counts increased slightly with increasing inflammatory cell infiltration, but no correlation could be found between mast cell counts and B or T cells. Mononuclear phagocyte system (MPS) cells were fewer in the RA group than in CO patients, possibly suggesting an impaired phagocytizing capacity in their salivary glands. In many respects the results are consistent with the known functions of tissue mast cells. Their role in the labial salivary glands is discussed in the light of current immunopathologic concepts of RA and lesions associated with it, i.e. Sjögren's syndrome. | |
| 1235781 | Comparative morphological studies on adjuvant arthritis induced in the extremities of rats | 1975 | Forty rats, 60 mice, and 60 golden hamsters were administered complete Freund's adjuvant by intracutaneous injections in an attempt to produce the clinical picture of arthritis. 90% of the rats, 25% of the mice, and 40% of the golden hamsters developed swollen extremities similar to those observed in rats affected by adjuvant arthritis. 12 animals of each of the 3 species included in this investigation, which showed macroscopically visible swellings of their extremities, were used for comparative histological studies in order to find out whether the swellings of the extremities of mice and golden hamsters are real inflammations of joints and identical with rat adjuvant arthritis. The animals were killed, at 4-day intervals, between the 8th and the 44th days from administration of the adjuvant. Whereas rats showed the full clinical picture of adjuvant arthritis, mice and hamsters exhibited only inflammatory pedal edema without florid arthritis. The involvement of the joints was confined to a minor focal reaction of the synovial membranes of small individual joints. The results obtained support the view of rat adjuvant arthritis being a species-specific reaction rather than corresponding to a species-dependent, universal principle of reaction. |