Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6612371 | Observer variation in skeletal radiology. | 1983 | The factors that affect observer variation in bone radiology are analysed from data in the literature and on the basis of studies carried out at McMaster University on the hands and sacroiliac joints. A plea is made for presenting results in terms of Kappa statistics so that agreement due purely to chance is eliminated. In the conclusions the main variables that affect concordance are listed so that strategies can be developed to reduce observer variation. This is important in serial studies to ensure that the observer variations are smaller than the effect one wishes to measure. | |
| 3927859 | Gm and Km allotypes in rheumatoid arthritis. | 1985 Aug | Immunoglobulin heavy chain (Gm) and kappa light chain (Km) allotype and phenotype frequencies were compared in 173 patients with rheumatoid arthritis (RA) and in 798 controls. No significant differences were found between allotype or phenotype frequencies in overall RA and control groups. However, the Gm(zaxfngb) phenotype and G1m(x) allotype were increased in HLA-DR4 positive RA patients compared with DR4 negative patients and controls, suggesting that immunoglobulin heavy chain genes interact with HLA in the pathogenesis of RA. All four patients with pulmonary fibrosis were Km(1) positive suggesting a possible role for immunoglobulin kappa light chain genes in the pathogenesis of pulmonary fibrosis found in rheumatoid patients. | |
| 6722416 | Cause of death in rheumatoid arthritis. | 1984 May | A series of 489 consecutive patients with definite or classical rheumatoid arthritis was followed for a mean of 11.2 years. Cohort-analysis of the series showed a three-fold increase in mortality overall in comparison with age- and sex-specific rates in the general population. In patients first seen in hospital early in the course of the disease (less than 5 years from onset), the excess of deaths from circulatory, respiratory and musculoskeletal disorders was highly significant. Malignant disease and digestive system disorders accounted for a small excess of borderline significance. Patients who were referred later (greater than 5 years from onset) experienced, in addition, a highly significant excess of deaths from infections and disorders of the digestive and genito-urinary system but not from malignant neoplasms. | |
| 6813483 | Auranofin and sodium aurothiomalate in the treatment of rheumatoid arthritis. A double-bli | 1982 Jul | Auranofin (AF), a new gold compound, has been suggested as an alternative to parenteral gold in the treatment of rheumatoid arthritis (RA). This hypothesis has been tested within a double-blind comparative study and to date 103 patients have been enrolled. Forty-one RA patients have been treated for longer than 6 months. The patients were randomly allocated to treatment with either AF or sodium aurothiomalate (GSTM) and serial comparison of changes within the articular index, grip strength, pain, morning stiffness, and global assessment during treatment were measured. Improvement was noted within both treatment groups. Diarrhea as a side effect was most commonly seen during treatment with AF while rash often combined with pruritus was most commonly reported with GSTM; withdrawal from treatment as the result of this was nevertheless uncommon. | |
| 1105742 | Production of MIF-like supernatants by rheumatoid arthritis lymphocytes stimulated by immu | 1975 | Patients with rheumatoid arthritis (RA), patients with positive tuberculin (PPD) skin-tests and controls were studied. The lymphocytes from these groups were cultured in serum-free medium to obtain cell-free supernatants. These lymphocyte cultures were pre-incubated with the appropriate antigen or reconstituted after removal of the cells. Supernatants from RA lymphocytes stimulated in vitro by IgG induced an inhibition of the leucocyte migration, as well as the supernatants from tuberculin-sensitized lymphocytes. However, supernatants from non-RA lymphocytes or tuberculin-unsensitized lymphocytes did not show such an inhibition. These MIF-like supernatants have been studied by Sephadex G-100 gel filtration. A MIF activity has been found for PPD and IgG supernatants between the chymotrypsinogen (MW 23,000) and the lysozyme (MW 17,000). This seems to agree with the classical region where MIF can be usually isolated. | |
| 3875718 | Serum IgG and IgM rheumatoid factors and complement activation in extraarticular rheumatoi | 1985 Apr | Rheumatoid factors (RF) may participate in both synovial and extraarticular (EA) inflammation in rheumatoid disease (RD). The relative roles of serum IgG RF and IgM RF in extraarticular rheumatoid disease (EARD) are unclear, as is the importance of complement (C) activation by these proteins. To investigate the relation of C activating properties of IgM RF (RF CAP) and total IgG RF and IgM RF to EARD we compared 18 patients with only articular disease to 27 patients with various EA manifestations (nodules, cutaneous vasculitis, neuropathy, Felty's syndrome) using radioimmunoassays for IgG and IgM RF and an established hemolytic assay for C activation by IgM RF. We calculated RF CAP by determining the mean hemolysis of sensitized SRBC/ml of RF serum (MH/ml). Normal volunteers and patients with other inflammatory arthritides served as controls. Controls had negligible amounts of IgG RF, IgM RF, and RF CAP. Mean IgG and IgM RF levels and RF CAP values were significantly higher in patients with EARD than those in the arthritis-only (AO) group. Mean IgM RF concentrations and IgM RF CAP correlated with each other and EARD. IgG RF also correlated with IgM RF and EARD, but did not contribute to RF CAP or EARD when adjusted for IgM RF. Further, some patients had high RF CAP values despite modest IgM RF levels. These data suggest that quantitative differences in IgM RF CAP and total IgM RF may be more important than IgG RF as determinants of EARD. | |
| 7310774 | Levamisole - a possible alternative to gold and penicillamine in the longterm treatment of | 1981 Sep | One hundred and twenty-three patients with rheumatoid arthritis were studied to compare different dose regimens of levamisole with gold and penicillamine. In the first study, in 75 patients, 450 mg of levamisole weekly was found to be as effective as gold or penicillamine, but considerably more toxic. In the second study, in 48 patients, 150 mg of levamisole weekly was found to be less toxic than 450 mg, but when compared with gold, no significant benefit could be demonstrated after 6 months of therapy. | |
| 6316601 | Immunoelectronmicroscopic characterization of intracellular inclusions in synovial fluid c | 1983 Jul | Qualitative immunoelectronmicroscopic (IEM) analysis of intracellular inclusions in synovial fluid (SF) cells in rheumatoid arthritis (RA) was performed using the peroxidase-antiperoxidase (PAP) method. Cells from patients with chronic RA were fixed in glutaraldehyde containing 0.05% saponin to permeabilize membranes before immunologic treatments. Intracellular inclusions of IgG, IgM, and C3 were observed in vacuoles of greater than 75% of both polymorphonuclear leukocytes (PMNs) and mononuclear phagocytic cells. IgA- and fibrinogen-containing inclusions were less frequent. Intracellular staining for albumin was minimal. Other membranous, vesicular, and granular unstained materials of potential importance were also often present in the same vacuoles. Stained inclusions were clearly distinct from lipid bodies, which were negative for immunostaining. Control samples had only occasional, scattered and weak stain that was easily recognizable as nonspecific and thus established the specificity of the reactions. A few lymphocytes in 2 patients showed positive staining for IgG in vacuoles. Extracellular staining of clumps of immunoglobulins, C3, and fibrinogen was also present. The various materials phagocytized by the different SF cells may be important in perpetuation of joint inflammation. | |
| 6415954 | [Morphology and pathogenesis of glomerular renal lesions in gold nephropathy]. | 1983 | Histological, immunofluorescent and electron microscopical investigations on the glomerular renal lesions in gold-induced nephropathy were performed by analyzing biopsy materials from 9 patients with rheumatoid arthritis treated by Sanocrysin (gold sodium thiosulfate). The morphological and immunofluorescent main changes consisted in the characteristic pattern of immune complex nephritis as membranous glomerulonephritis on the one hand (4 cases) and as mesangioproliferative glomerulonephritis (4 cases) on the other hand; in one case there could be demonstrated a focal proliferative glomerulonephritis similar to that observed as visceral manifestation of rheumatoid arthritis in the kidney. These different types of glomerular alterations in gold nephropathy evidently are related to th duration and immunological activity of the main disease and to the individual immune reactivity of the body as a whole determined by this, and not at all, by the combination of gold additionally with other antiinflammatory, especially antirheumatic drugs. The possible pathogenesis of nephropathy is discussed with special regard to definite effects of gold on the immune system. | |
| 331502 | Bumadizone calcium in the treatment of rheumatoid arthritis. | 1977 Aug 27 | A double-blind crossover trial of bumadizone calcium (Eumotol), a non-steroidal anti-inflammatory drug, has been carried out in 56 patients with rheumatoid arthritis. On both objective and subjective criteria bumadizone was superior to placebo and paracetamol at a statistically highly significant level (P less than 0,01). When tested against acetylsalicylic acid, bumadizone was more effective in 13 patients and less effective in 4 patients. Although this does not represent a statistically significant difference it does suggest that its anti-inflammatory and analgesic qualities are at least equal to those of salicylate in high dosages. There were no serious side-effects in the patients who received bumadizone and the drug was better tolerated than either acetylsalicylic acid or paracetamol. | |
| 6978853 | Anti-DNA, anti-deoxyribonucleoprotein and rheumatoid factor measured by ELISA in patients | 1982 | Serum concentrations of anti-DNA and anti-deoxyribonucleoprotein (NP) antibodies were measured in parallel by standardized ELISA methods with a polyvalent anti-immunoglobulin conjugate in patients with systemic lupus erythematosus (SLE), Sjögren's syndrome (SS) and rheumatoid arthritis (RA). High levels of these antibodies predominated in systemic lupus erythematosus. While an appreciable incidence of antibodies also occurred in SS and RA, they were mostly at lower levels. By using heavy chain-specific anti-immunoglobulin conjugates, IgG antibodies to both DNA and NP were found in SLE more frequently and at higher levels than were IgM antibodies. In contrast, IgM antibodies to DNA and NP predominated in SS and RA. The immunoglobulin class of the anti-DNA and anti-NP responses in a given SLE patient were not infrequently different. For example, a patient might show a very high IgG but low IgM anti-DNA value, with the reverse being true for anti-NP. IgG anti-DNA antibodies were significantly associated with depressions of C3. During changes in SLE serology, normalization of DNA binding by Farr radioimmunoassay and/or complement was most frequently associated with normalization of the IgG anti-DNA antibody concentrations. In patients simultaneously possessing elevated levels of anti-DNA, anti-NP and rheumatoid factor (RF), absorption with aggregated human IgG usually decreased only the RF activity. In some, however, such absorption decreased all three antibody values simultaneously. The latter findings support observations that some RF possess antinuclear properties. | |
| 168697 | [Compression arthrodesis of the knee joint]. | 1975 Feb | The results of 42 cases of compression arthrodesis of the knee joint during a 5.5 years period are reviewed. Main indications were degenerative, rheumatoid and posttraumatic arthrosis and tuberculosis of the knee joint. Other differential indications and the operative procedure following the Charnley-Müller method are described. The complications - pseudarthrosis, infection, false rotation - are discussed. | |
| 5040309 | The concentrations of the fourth component of complement and of the C1 inactivator in syno | 1972 Jun | The concentration of the fourth component (C4) of complement (C) in synovial fluid was immunochemically determined in forty-nine cases of arthritis. The lowest C4 values were found in the patients with rheumatoid arthritis (RA), in particular those with depressed synovial fluid C values (and positive rheumatoid factor tests), whereas the highest were obtained in cases of non-rheumatoid arthritis (pelvospondylites ossificans, Reiter's disease and psoriasis arthropathica) and in the majority of the sero-negative RA patients. Low C4 values also proved closely associated with low values for the third component (C3), and with pronounced conversion of this component. The C[unk] inactivator (immunochemically determined) of the synovial fluid which was correlated with the albumin concentration, did not vary with total C, C4 or C3. | |
| 79218 | Collagenase in synovial fluid. | 1978 | Free collagenase activity was demonstrated in all 13 normal, 5 osteoarthrotic and 54 rheumatoid synovial fluids studied. Osteoarthrotic, normal, and rheumatoid fluids showed a free collagenase content increasing in that order. However, the total activities after trypsin activation did not differ significantly. The concentrations of alpha1-at and alpha2-M in synovial fluids reflected those in sera. The complex interactions between serum inhibitors, and free or latent collagenase released from both synovial cells and leukocytes are discussed. | |
| 866648 | Radiosensitization of normal tissue by chloroquine. | 1977 Jul | Severe radiation reaction with chest wall necrosis occurred following 5,000 rads of 60Co irradiation. The patient was arthritic and on chloroquine therapy. This delayed reaction was due to chloroquine radiosensitization. Rats treated with combined chloroquine and chest wall irradiation were compared to rats receiving irradiation alone. The acute radiation reaction was greater in the drug treated animals. | |
| 3901585 | [Active stabilization of the acetabular floor by auto-/homologous bone transplantation in | 1985 Jul | Inflammatory changes of the hip joint in rheumatoid arthritis often lead to secundary protrusio acetabuli. Total joint replacement may lead to problems, especially in mounting the acetabular component firmly to the pelvis. For about 7 years we have been using the so-called "active stabilisation of the acetabular floor" by implantation of autologeous bone prepared from the resected femoral neck. In changing the artificial joint homologeous bone from our bone bank was used. Up to Dec. 31, 1983 neither graft versus host reactions nor failure in healing were seen. 107 total joint replacements with bone transplantation in rheumatoid arthritis were performed. In all cases we could see optimal growing in of the transplanted bone, often confirmed by X-ray tomograms, with good support of the acetabular component. So far we have not seen any negative results. The active stabilisation of the acetabular floor seems to be a worthwhile addition to known surgical possibilities. | |
| 1101907 | [Comparison of the effects of niflumic acid and aloxiprin in patients with progressive chr | 1975 Aug | The effects of niflumic acid (trifluoro-methyl-3-phenylamino-2-nicotinic acid) and of aloxiprin (aluminium acetyl-salicylate) in patients with rheumatoid arthritis were compared in a double-blind cross-over trial. Check-up examinations prior to the institution and after the termination of the therapy, as well as after individual treatment periods of two weeks with alternating sequential administration of the two drugs, were carried out with a standardized method. The assessment included subjective (pain intensity) and objective criteria (Lansbury's index), as well as laboratory results (erythrocyte sedimentation rate, uricaemia). With the exception of the articular index disclosing a superior effect of niflumic acid, the other criteria showed no statistically significant differences between the effects of the two drugs. | |
| 6726715 | Efficacy of combined therapy with plasmapheresis and immunosuppressants in rheumatoid vasc | 1984 Apr | The combined effects of plasmapheresis and immunosuppressive therapy in the treatment of rheumatoid vasculitis was evaluated in 8 patients. These modalities, in combination, proved to promote rapid healing of cutaneous ulcers. In addition, it appeared that this aggressive therapy can occasionally reverse early gangrenous lesions involving extremities. By contrast, little change occurred in longstanding neuropathic manifestations. Our preliminary results suggest that plasmapheresis, used as an acute treatment modality, and combined with prolonged therapy with immunosuppressive drugs, may reduce the morbidity associated with certain manifestations of rheumatoid vasculitis. | |
| 228408 | [D-penicillamine in rheumatoid arthritis : hematological incidents and accidents (author's | 1979 Sep 8 | From literature data and their own experience, the authors comment hematological complications, related to the use of D-penicillamine, mainly in theumatoïd arthritis. Hypereosinophilia is more common than thrombopenia, but, both complications are usually benign. Anemia alone is very rare. Leukopenia appears in 6% of treated patients, but pancytopenia is rare. Leukopenia and pancytopenia are the most severe complications, even fatal in some cases. The safest dose of D-penicillamine seems to be between 600 and 900 mg per day, provided that, however, regular hematological controls may be achieved. | |
| 6752878 | [Comparative therapeutic activity of pirprofen and acetylsalicylic acid in rheumatoid arth | 1982 Aug 28 | This double-blind cooperative study comparing pirprofen and acetylsalicylic acid (ASA) in the treatment of rheumatoid arthritis was conducted in 12 centres and involved 342 patients distributed throughout the United States. The patients were randomized to either pirprofen 200 mg four times a day or ASA 900 mg four times a day. The drugs were administered for 52 weeks. Nine standard clinical criteria were used for assessment of the therapeutic results by the investigators and by the patients themselves. Fifty-five % of the total patient population reported that they were highly satisfied with pirprofen, as against 47% with ASA. The investigators preferred pirprofen in 51% of the cases and ASA in 38% (p less than 0.05). Side effects (tinnitus, gastrointestinal disorders) were more frequent in the ASA group than in the pirprofen group. During the 52-week treatment-period, biological alterations were only observed in two patients (1 on pirprofen, 1 on ASA). |