Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6226252 | Immunoblastic sarcoma in patients with systemic lupus erythematosus-like disorders. | 1983 Nov | Five patients, predominantly older men, had abnormal immune states for prolonged periods of time with manifestations of multisystem involvement, including features of systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome. In the course of their disease, all had malignant lymphoma (immunoblastic sarcoma) develop. The development of lymphoma was associated with generalized lymphadenopathy in four cases. | |
| 6752406 | Anticentromere antibody and primary pulmonary hypertension. | 1982 Jul | A patient is described with pulmonary hypertension complicating rheumatoid arthritis. Anticentromere antibody, a test of high specificity for the CREST syndrome, was present in the serum. Confirmation of this observation may lead to an improved classification of "primary" pulmonary hypertension. | |
| 4218655 | [Inflammatory rheumatism and Waldenström's macroglobulinemia]. | 1974 Oct | Painful articular manifestations occured in 6 out of 256 patients with Waldenström's macroglobulinaemia: in all the cases they took the form of subacute oligoarthritis unrelated to rheumatoid illness or gout. Although these 6 cases would appear to be associated, the total number is too small to exclude the possibility of coincidence. In any case, if such articular manifestations do occur, their rarity makes it impractical to use them as a positive diagnostic aid. | |
| 725551 | HLA antigens in females with ankylosing spondylitis and other forms of seronegative rheuma | 1978 | A total of 222 female patients with seronegative rheumatic diseases were investigated by sacroiliac joint X-ray and HLA-A, B and Ctyped. The frequency of the B27 antigen was significantly increased in the following groups: definite pelvospondylitis (26 patients and relative risk (RR) = 99), possible pelvospondylitis (20 patients, RR=4.5), definite sacroiliitis (14 patients, RR-20.1) and uroarthritis (8 patients). When 24 B27 negative patients from these B27 associated diseases were analysed, significantly increased frequencies of the BW22 (RR=16.7) and CW1 (RR=14.4) antigens were found. There were no significantly deviating HLA frequencies in the following diagnostic groups: clinical sacroiliitis (20 patients), polyarthritis with clinically silent sacroiliitis (12 patients), polyarthritis without sacroiliitis (47 patients), arthralgia preceded by beta-streptococcal infection (17 patients), other arthralgia (33 patients), osteo-arthritis (13 patients) and other arthritis (12 patients). | |
| 1105240 | [Pharmacological and clinical aspects of S-adenosylmethionine (SAMe) in primary degenerati | 1975 Dec 5 | After some preliminary remarks of a biochemical and pharmacological nature, the authors have started a clinical study to test the antiinflammatory activity of the S-adenosyl-methionine (SAMe). An open trial, carried out on 90 patients with severe degenerative arthropathies has shown that 30 mg SAMe intravenously twice a day for 14 days have a marked anti-inflammatory effect a rather term and no side-effects. In a "double-crossover" investigation, SAMe was next compared to indomethacin by i.m. administrations to 15 arthropathic patients. The therapeutic responses of the two drugs proved exactly alike, whereas the side-effects following indomethacin administration were not present after SAMe. In 9 patients affected with rheumatoid arthritis administrations of SAMe have proved less effective, although some clinical parameters showed improvements. | |
| 593547 | Visualization of the craniocervical subarachnoid spaces. | 1977 Dec 14 | A very simple procedure is described which leads to adequate visualization of the structures in the craniocervical area that are otherwise often very insufficiently investigated during myelography routinely performed with metrizamide. | |
| 4085166 | D-penicillamine-induced acute hypersensitivity pneumonitis and cholestatic hepatitis in a | 1985 Oct | Acute hypersensitivity pneumonitis is not a known side effect of D-penicillamine. Also, there are only a few reports of cholestatic hepatitis caused by this drug. The present report describes a case of rheumatoid arthritis where these manifestations appeared in the same patient ten days after the institution of D-penicillamine therapy. The etiological relationship with the drug was established, inadvertantly, by its accidental intake by the patient 5 months later with the reproduction of the same manifestations. | |
| 956219 | A comparison of four models of total knee-replacement prostheses. | 1976 Sep | Twenty-nine knees with unicondylar, sixty-four with duocondylar, fifty with Guepar, and fifty with geometric prostheses were studied. The follow-up ranged from two to three and one-half years. The unicondylar prosthesis was used in the mildest cases and gave the least complications, but the quality of results was not superior to that achieved with the other prostheses. The duocondylar model was best suited for knees with rheumatoid arthritis and mild deformity. The geometric prosthesis was the best condylar prosthesis for osteoarthritis with moderate to severe deformity, but gave the worst results in knees with rheumatoid arthritis. The Guepar prosthesis was used in the worst knees and gave the best results, but it had the highest infection rate and was the most difficult to salvage. A radiolucency was observed in about 60 per cent of the condylar replacements around the tibial component and in 45 per cent of the Geupar replacements around the femoral component. The significance of this cannot yet be determined but it suggest that the fixation may not be ideal. In all types, residual pain was most frequently attributed to the patellar compartment. Patellectomy was not a solution. | |
| 793644 | Immunofluorescence of synovial membrane multifactorial analysis of the results. | 1976 Nov 10 | Synovial membrane taken by needle biopsy from the knee joint of 61 patients with various rheumatic diseases were studied using immunofluorescence methods. Staining techniques and their controls were detailed. Classical statistical tests and principal components multifactorial analysis of the data emphasized some differences between the pathological groups. Connective tissue diseases seemed to be characterized by plasma cells fluorescence and mixed immunoglobulins and complement deposits. These were mostly localized to extracellular spaces in sero-positive rheumatoid arthritis and to blood vessels in sero-negative rheumatoid arthritis and systemic lupus erythematosus. On the contrary, isolated immunoglobulins without complement were mostly found in the other inflammatory arthritis, while negative results were obtained in non inflammatory arthropathy. Immunoglobulin classes did not seem to have any diagnostic value. On the contrary, rheumatoid factor was specific for rheumatoid arthritis, whatever the serological pattern was, and it was particularly frequent in patients suffering from rheumatoid arthritis associated with a Sj5AOGREN SYNDROME. A strict relationship between classical histological findings and immunofluorescence results was not always found; so, immunological methods can be aquivocal. | |
| 3984747 | Amyloid-related serum protein (SAA) during and after pregnancy in healthy women and women | 1985 Feb | The usefulness of amyloid-related serum protein (SAA) as an indicator of disease activity has been evaluated in 11 patients with rheumatoid arthritis (RA), 2 patients with psoriatic arthritis (PA) and 13 patients with ankylosing spondylitis (AS) prospectively studied during and after pregnancy. For comparison, SAA levels were recorded serially during and after pregnancy in 28 healthy pregnant women. SAA levels were unaltered by gestation and thus within the normal range during normal pregnancy, but were raised in healthy pregnant women with episodes of intercurrent infections. In RA and AS patients, SAA concentrations correlated to disease activity during and after pregnancy. Serial levels of SAA and C-reactive protein in healthy women and patients paralleled each other with the most pronounced inflammatory response displayed by SAA. We conclude that SAA is a sensitive and reliable indicator of inflammatory events both in the pregnant and non-pregnant state. | |
| 6629328 | The covalent structure of amyloid-related serum protein SAA from two patients with inflamm | 1983 Aug | The complete covalent structure of an amyloid-related serum protein SAA from a patient (Jen.) with severe rheumatoid arthritis, is presented. The structure was elucidated by N-terminal analyses of the protein as well as on peptides derived from tryptic digestion and after cleaving the protein with BNPS-skatole. The characterization of tryptic peptide T-9 revealed a polymorphism similar to that seen in protein AA. Structural studies performed on another protein SAA, isolated from a patient (Mik.) with acute systemic lupus erythematosus, indicated that this protein is homologous to that from patient Jen. The formation and deposition of the protein AA-containing amyloid fibrils is discussed. | |
| 6364998 | Synovial protease/inhibitor ratios in erosive and nonerosive arthropathies. | 1984 Feb | Although rheumatoid joint fluids contain numerous polymorphs capable of secreting neutral proteases known to be able to digest cartilage, the high level of inhibitors (mainly alpha 1-antitrypsin and alpha 2-macroglobulin) has always been considered to be more than sufficient to inhibit their activity completely. Consequently little interest has been paid to the potential role of these enzymes in cartilage damage. Four arthropathies of different erosive potential are here compared: spondyloarthropathies, rheumatoid arthritis with and without gold or D-penicillamine therapy, and septic arthritis. The synovial concentration of the inhibitors alpha 1-antitrypsin and alpha 2-macroglobulin has been compared with the polymorph enzyme output, as measured by beta-glucuronidase. Total haemolytic complement, white cell count, and C-reactive protein have also been measured in the joint fluid. The range of white cell count and inhibitors was the same in all 4 groups, while the enzyme output varied substantially from low levels in the spondyloarthropathies to very high levels in the septic joints. The higher the erosive potential of the disease, therefore, the more disadvantageous is the inhibitor/enzyme ratio. It is also pointed out that cartilage has physiochemical properties which facilitate and enhance polymorph enzyme output while severely curtailing the activity of the inhibitors. The observation that synovial fluid is inhibitory in vitro may therefore bear little relationship to the situation at the cartilage surface in vivo. | |
| 238648 | The characterisation and function of the polysaccharidases of human synovial fluid in rheu | 1975 Jul 14 | A potential enzymic mechanism for the degradation of glycosaminogly cans was characterised using enzymes found in rheumatoid synovial fluid from the knee joint. This mechanism involves a true hyluronidase together with the concerted action of beta-glucuronidase and beta-N-acetylhexosaminidase. The contribution of the exopolysaccharidases to hyaluronate degradation was demonstrated by the use of specific inhibitors, while the distinct identity of a true hyaluronidase was shown by ammonium sulphate and agarose gel column fractionations. Only the hyluronidase fraction was capable of degrading high molecular weight hyaluronate. The exopolysaccharidase activities were shown to be markedly elevated in rheumatoid as compared to osteoarthritic synovial fluid and also normal serum. On the other hand, hyluronidase was similarly active in rheumatoid and osteoarthritic synovial fluids; both these levels were lower than that of normal human serum. Hyaluronidase in synovial fluid may thus be derived by diffusion from serum, since it is of relatively low molecular weight (60 000). The pH requirements of this enzyme system and the strong inhibition of hyaluronidase by synovial fluid make it unlikely that the mechanism operates extracellularly. It is proposed that as a lysosomal mechanism, however, it is an important contributing factor in the chronic erosion process characteristic of rheumatoid arthritis. | |
| 4094963 | Arthroscopy and arthroscopic surgery of the elbow. | 1985 Oct | Arthroscopy and arthroscopic surgery of the elbow were performed in 45 cases of 3,300 arthroscopic procedures between 1974 through 1984. The indications established are: loose body removal, treatment of osteochondritis dissecans, synovectomy for non-specific and rheumatoid synovitis, treatment of some selected fractures, debridement of specific cases of degenerative arthritis, excision of osteophytes and for evaluation and treatment of the undiagnosed painful elbow. The choice of two different methods is described; one with the arm on an arm table as for hand surgery, and the other with the arm suspended overhead for easier access to the medial side. Normal arthroscopic anatomy of the elbow joint is described. The instruments have been classified as those most commonly used, those of special use, those instruments rarely or never used, and some special instruments introduced more recently. Eight approaches to the elbow joint for viewing and instrumentation are illustrated. The technique for entering the joint, distending and placing the scope, establishing drainage, probing and instrumentation is shown and illustrated. Immediate postoperative care and complications are shown. Seven representative cases are presented. Results of this small number of cases clearly indicate that there is a need for diagnostic and operative arthroscopy of the elbow. | |
| 7004084 | Smooth-muscle antibodies in rheumatoid arthritis. | 1980 Jun | Smooth-muscle antibodies (SMA) detected by the indirect immunofluorescence method were found more often in rheumatoid arthritis (RA) patients (15.3%) than in normal controls (7.6%) (0.02 > p > 0.01). The increased frequency was due to IgG-antibodies which occurred in 12.2% of RA patients, in 4.1% of normal controls and in 7.3% of patients with other arthritic diseases. Eight of 9 IgG-SMA-positive RA sera reacted with F-actin, and one serum contained non-actin antibodies. In RA, ANA were found in 35.7%, glomerular antibodies in 1.0%, parietal cell antibodies in 4.1% and mitochondrial antibodies in 2.0%. SMA were associated with the occurrence of rheumatoid factors and mitochondrial antibodies (0.02% > p and 2p = 0.04, respectively). In the SMA-positive group the erythrocyte sedimentation rate was higher and elevated serum alkaline phosphatase values were found more often than in the SMA-negative group. | |
| 7465103 | [Comparison of the Waaler-Rose reaction and the optimized Singer-Plotz reaction]. | 1981 Jan 14 | The latex reaction according to Singer & Plotz, an optimised version of the same employing heating at 56 degrees C for 24 hr, and the modified Rose-Waaler test were used to determine rheumatoid factor in the serum of 65 subjects, including 33 with rheumatic and joint diseases, 22 with liver diseases, and 10 presumed to be normal. This optimised latex test is put forward as a supplement to high sensitivity of the simple latex test, and the high specificity of the Rose-Waaler test. In the series examined, it gave results whose clinical comparability was at least on a par with that provided by the Rose-Waaler test. | |
| 7428225 | Synovial biopsy by Franklin--Silverman needle. | 1980 Jul | Franklin-Silverman needles, commonly used for liver biopsies, were used for biopsy of synovia of 75 joints. The results indicate a higher percentage of success in obtaining pathologic specimens than with previously reported instruments. Complications were rare, with only milk transient hemarthrosis being found in 5 cases. For an accurate diagnosis, multiple specimens should be obtained since single specimens are too small to interpret histopathologically. Being simpler and safer, the Franklin-Silverman needle biopsy is recommended as a routine procedure for early diagnosis of synovial diseases of the joint in conjunction with joint aspiration. The success rate depends not only on the type of needle used but also on the proper selection of the biopsy site. | |
| 6603011 | Spontaneous DNA synthesis in rheumatoid arthritis: evidence of enhanced circulating non-T- | 1983 Jun | 3H-thymidine incorporation in cultures of peripheral blood mononuclear cells from patients with seropositive rheumatoid arthritis (RA) and healthy controls was measured in vitro in the absence of added stimulants. A significantly higher level of spontaneous DNA synthesis was found in cultures of mononuclear cells from patients with clinically active RA than from patients with inactive disease and normal controls. This activity was more apparent in 24-h cultures than in 72-h cultures. There was no correlation between DNA levels and IgM rheumatoid factor (RF) titres. When T- and non-T-cell populations were separated and cultured simultaneously with unfractionated cells, only non-T cells maintained high levels of DNA synthesis, and enrichment of surface membrane Ig+ (SmIg) cells was generally associated with enhancement of 3H-thymidine incorporation. Furthermore, no difference was found in spontaneous DNA synthesis between cultures either containing or depleted of phagocytic cells. Moreover, the addition of graded numbers of autologous monocytes to highly purified T- and non-T-cell populations did not alter the background DNA synthesis. Thus, endogenously activated cells in RA patients are neither T lymphocytes nor monocytes. A regulatory influence by monocytes could not be demonstrated. It is suggested that cells actively engaged in DNA synthesis in RA blood are non-T cells in origin, most probably B lymphocytes. | |
| 631181 | Jaccoud's arthropathy in patients with chronic rheumatic valvular heart disease. | 1978 Feb | In a prospective study over a period of 3 yr, involving all patients with rheumatic valvular heart disease seen at our hospital, we found the diagnostic signs of Jaccoud's arthropathy in 17 of 400 cases (4.2%). All 17 patients had a past history of acute arthritis involving the joints and showed deformities at the time of diagnosis. The valvular lesions were mitral and aortic in 11 cases, mitral in 5 cases and aortic in 1 case. The most frequent joint deformities were: ulnar deviation at the metacarpo-phalangeal joints (12 cases), lateral deviation at the metatarso-phalangeal joints (12 cases), and hammer toe deformity (6 cases). The deformities were reducible in all of them. None of the patients had pain or signs of acute inflammation and functional capacity was normal. Other causes of joint deformity were ruled out by means of radiographic and serologic studies. Jaccoud's arthropathy is not a rare entity and its recognition is important for a differential diagnosis with chronic arthritis of other etiologies, also associated with valvular heart lesions. | |
| 157890 | Two cases of penicillamine-induced pemphigus erythematosus. | 1979 | 2 women, 62 and 69 years old, both suffering from rheumatoid arthritis, were treated for 1 and 1 1/2 years, respectively, with penicillamine. Both developed a bullous eruption which according to clinical and histological picture, immunofluorescence studies and to light provocation, as well as in 1 case to antinuclear antibody findings corresponded to pemphigus erythematosus. In spite of treatment with prednisone and azathioprine, they still keep developing bullae. |