Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6802914 | Degradation of amyloid by a serum component and inhibition of degradation. | 1982 May | ADA of human serum was demonstrated and investigated with an agar gel diffusion technique using amyloid-impregnated agar plates. Sera of 20 healthy adults, 40 patients with AA-amyloidosis, and 86 nonamyloidotic patients were tested. The presence of an ADF, showing enzymatic properties and strongly bound to albumin, was demonstrated in normals and amyloidotic and nonamyloidotic patients. ADA in the serum of amyloidotic and cirrhotic patients was markedly decreased due to the presence of an inhibitor of ADF. ADA of amyloidotic sera was restored to normal by EDTA, citric acid, and ascorbic acid. The ADA of 16 FMF patients and four of 34 patients with rheumatoid arthritis without amyloidosis was intermediate between normal and amyloidotic values, indicating the presence of lADF at low concentrations in these patients. These findings suggest that amyloid is a normal protein metabolite, possibly with a high metabolic turnover. Accumulation of amyloid may be caused by decrease of the ADA of the serum by its inhibitor, rather than by accelerated production. | |
| 1085236 | A double antibody solid phase assay for DNA autoantibodies for clinical use. | 1976 Aug | DNA antoantibodies in serum will bind to antigen-coated polystyrene tubes and can be detected by radiolabelled anti-immunoglobulin. The method is quantitative, gives information on the antibody class and is not readily subject to interference by factors such as the size of the DNA, minor contamination of double-stranded with single-stranded DNA and the presence of materials which can combine "non-specifically" with the antigen. Double-stranded DNA gave good discrimination between SLE and rheumatoid arthritis but with single-stranded preparations approximately 40% of the RA patients showed elevated antibody values. Individual results obtained with the two antigens were compared and correlated with the Farr test and ANA titres. Surprisingly, a proportion of the SLE sera gave high background binding to tubes coated with gelatine. | |
| 3002449 | Synthetic substrates of vertebrate collagenase. | 1985 Nov 5 | The active site specificity of vertebrate collagenase was mapped with the synthesis of a variety of peptides, peptolides, and peptide esters. The enzyme was found to prefer very lipophilic sequences, and it was also found to be an esterase. The thio peptolide Ac-Pro-Leu-Gly-SCH[CH2CH(CH3)2]CO-Leu-Gly-OC2H5 was found to be an exceptional substrate. High-performance liquid chromatography and tandem mass spectrometry were used to unambiguously establish the cleavage site in several peptide substrates. | |
| 901179 | New concepts in arthroplasty of the hand and wrist. | 1977 Sep | Clinical trials with cemented polyethyiene and metal total joint arthroplasties were initiated in 1973. Replacements have been developed for the wrist, carpometacarpal joint of the thumb, metacarpophalangeal joints of the thumb and fingers, and the proximal interphalangeal joints of the fingers. Results, evaluated by pain relief and joint stability, were excellent at all sites. Motion, however, averaged only 50% of normal. Significant problems included abnormal posture in the wrist, roentgenographic evidence of loosening in the finger metacarpophalangeals, extensor lag in the metacarpophalangeal of the thumb, and lack of motion in the proximal interphalangeal joint of the finger. | |
| 134533 | Stimulation of the phagocytic activity of the reticuloendothelial system in adjuvant arthr | 1976 Apr | The administration of mycobacterial adjuvant produced a stimulation of the reticuloendothelial system (RES) phagocytic function. The degree of such a stimulation was greater in Lewis than in AVN inbred strain of rats. There was no relationship between the degree of RES stimulation and clinical signs of adjuvant-induced arthritis. | |
| 962423 | 4-nitro-2-phenoxymethanesulfonanilide (R-805): a chemically novel anti-inflammatory agent. | 1976 May | The anti-inflammatory activity of the sulfonanilide, 4-nitro-2-phenoxymethanesulfonanilide (R-805) has been demonstrated in conventional models (carrageenan-induced edema of the rat's paw, UV-induced erythema of guinea-pig skin, adjuvant-induced arthritis of the rat). R-805 differs from most currently available acidic anti-inflammatory drugs in that its functional acidic group is not carboxyl. The relative anti-inflammatory potency of R-805 is comparable to indomethacin. Calculation of acute therapeutic indices (LD50/ED50) for 8 acidic anti-inflammatory drugs show R-805 to possess a more favourable index than the other drugs examined. | |
| 6985649 | Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization | 1980 Jan 1 | The Ia antigens, usually expressed primarily on B lymphocytes, are found on a small percentage of normal peripheral blood T cells (average 2.6% by fluorescence and 10.8% by rosette assay). Elevated levels up to 40% by both assays were observed in a high proportion of patients with rheumatoid arthritis. Increases also were found in patients with systemic lupus erythematosus and various types of infections. The increases were evident with a specific heteroantiserum, a hybridoma reagent, and DR specific alloantisera. Normal levels were present in multiple sclerosis and an assortment of metabolic and other disorders. A rise in similarly positive T cells occurred in normal individuals after immunization with tetanus toxoid or PPD. The cells primarily involved in all of these instances were small lymphocytes, which stained relatively weakly with the fluorescent reagents and were readily distinguishable from T-cell blasts. They were found to be enriched in isolated T gamma fractions but were also found in other T cells. The accumulated evidence indicated that these cells represent an expansion of one or more subsets of T cells found in normal individuals, and that their level in the peripheral blood may serve as an index of immunological stimulation. | |
| 6098047 | [Circadian rhythm of the pituitary-adrenal system in rheumatoid arthritis]. | 1984 | Two hundred and fifty-five patients with rheumatoid arthritis (RA) were examined for the levels of free cortisol and corticotrophin as well as for their circadian rhythms. It was established that the lowering of the daily average cortisol level and corticotrophin elevation in the blood as well as the desynchronization types of circadian rhythms depended on the RA gravity and the disease clinical variety. The most pronounced decrease in the cortisol level and destabilization of pituitary-adrenal function were found in the visceral RA pattern, particularly in subjects treated with corticosteroids and in those with hormone-dependent RA. Triamcinolon gave rise to a more substantial lowering of free cortisol as compared to prednisolone. It is assumed that impairment of the synchronization role of hypothalamic formations is of importance in the genesis of neuroendocrine dysfunction in RA patients. | |
| 7377855 | Plasma steroid levels after intra-articular injection of prednisolone acetate in patients | 1980 Feb | Eight patients with rheumatoid arthritis received an intra-articular injection of either 50 mg or 100 mg of prednisolone acetate into the knee joint. After the injection plasma levels of prednisolone were measured by radioimmunoassay and plasma cortisol levels were estimated fluorimetrically. Peak prednisolone levels were reached at between 2 and 4 hours after the intra-articular injection at both dosage levels, though the peak was higher with the larger dose. The 50 mg dose did not have any effect on the plasma cortisol level at 24 or 48 hours, but there was some suppression of plasma cortisol levels for up to 48 hours after the 100 mg dose. | |
| 1097682 | Nuclear antigens and antinuclear antibodies-their role in joint inflammation. | 1975 Jun | Nuclear antigens, including native DNA, denatured single-stranded DNA and soluble nucleoprotein are found in synovial effusions from a majority of all types of inflammatory joint disease. On the other hand, antinuclear antibodies are rarely detected in joint fluids, except in rheumatoid arthritis. Evidence that nucleoprotein and DNA immune complexes contribute to rheumatoid joint inflammation is reviewed. | |
| 6604603 | C1 inactivator-C1s complexes in inflammatory joint disease. | 1983 Sep | A newly developed enzyme linked immunosorbent assay for the quantitation of C1 inhibitor (C1In)-C1s complexes was used to study activation of the classical pathway of complement in inflammatory joint diseases. Synovial fluid (SF) specimens were obtained from patients with rheumatoid arthritis (RA), other arthritides and non-inflammatory joint effusions. Paired serum (S) samples were obtained in 17 cases. Immune complexes (IC) were measured by the staphylococcal binding assay. C1In-C1s were higher in RA SF samples than in paired RAS samples (P less than 0.01). IC were higher in RA SF than non-RA SF. There was a significant inverse correlation between SF C1In-C1s complexes and SF total haemolytic complement. For all SF samples there was a correlation between IC and C1In-C1s complexes, but for RA SF alone there was no significant correlation between these parameters. There was no correlation between titre of rheumatoid factor and C1In-C1s complexes. These results demonstrate that activation of the classical pathway of complement is the hallmark of rheumatoid synovitis, yet also suggest functional heterogeneity of both circulating and intra-articular IC. | |
| 1251008 | Periostitis and pseudoperiostitis. | 1976 Mar | Increased metabolic activity with the periosteum is demonstrated radiographically by the presence of a linear shadow of bone paralleling the cortex, most commonly reflecting increased osteoblastic activity and thus representing periosteal new bone. This is frequently seen in psoriatic arthritis and Reiter's syndrome. A similar picture occurs with increased osteoclastic activity and reflects rapid demineralization, simulating periostitis. This change must be recognized as a reflection of osteoporosis, lest the condition be misdiagnosed as inflammatory disease. | |
| 6302817 | Epstein-Barr virus-specific cytotoxic T cell responses in rheumatoid arthritis patients. | 1982 | The level of Epstein-Barr (EB) virus-specific cytotoxic T cell responsiveness was measured in 21 patients with active, progressive rheumatoid arthritis (RA). A significant number (8 out of 20) of EB virus sero-positive patients showed a markedly impaired responsiveness when compared with a control group of healthy individuals. Serological responses of the RA patients to EB virus antigens were not significantly different from the control group. The defect in EB virus-specific cellular immunity shown by these results is of interest in the light of previous evidence of an alteration in the virus-host balance in RA patients. | |
| 7025259 | Fenbufen as a single daily dose in the treatment of rheumatoid arthritis. | 1981 Sep 5 | Fenbufen (3(4-biphenyl-carbonyl) propionic acid) (Cinopal; Lederle) was administered as a single daily dose of 1000 mg for 4 weeks to 20 patients with rheumatoid arthritis. At 2 weeks, and again at the end of the trial, patients were assessed for duration of morning stiffness, number of painful and/or swollen joints, grip strength, walking time, and subjective response to treatment. Four patients failed to complete the trial, 2 because of inability to control symptoms and 2 because of severe rash attributed to the drug. The remaining 16 patients showed some improvement in most of the recorded parameters, with statistically significant reduction of morning stiffness and walking time. Apart from a maculopapular rash, which occurred in 4 patients and cleared up on stopping the fenbufen, side-effects were minimal. No patient complained of dyspepsia or epigastric pain. | |
| 1150711 | Plantar fasciitis. The painful heel syndrome. | 1975 Jul | Of 116 patients with pain in the plantar portion of the heel, nineteen proved on follow-up to have systemic disease as the etiology. Of these treated with phenylbutazone, 71 per cent showed good results and a similar percentage benefited equally from injections of cortisone derivatives. Only two patients required surgical procedures, and these were successful in both. | |
| 192857 | The scintigraphic investigation of sacroiliac disease. | 1977 Jun | Bone scintigraphs obtained with both Technetium-99m polyphosphate and Technetium-99m pyrophosphate have been abnormal at the sacroiliac joints of 44 patients with definite ankylosing spondylitis (AS). Because of the normal registration of the sacroiliac joints on bone scintigraphy, it has been necessary to develop a profile-scan technique to quantify the abnormality that proves to be significantly different from the normal finding. In 17 patients with a strong clinical suspicion of AS but normal radiographs, the sacroiliac joints have frequently been abnormal. This finding is meaningful because there is a common occurence in this group of the histocompatibility antigen HL A-B27, known to be a marker of AS. We also note the frequency of abnormal sacroiliac scinitigrams in 26 patients with rheumatoid arthritis and in a group of other diseases-Crohn's disease, uveitis, psoriasis, ulcerative colitis, and Reiter's disease-all of which share some of the manifestations of AS. | |
| 6723130 | Total condylar knee arthroplasty. A five-year follow-up study of 33 knees. | 1984 Jun | The authors report the results of a consecutive series of 37 total condylar prostheses inserted between 1975 and 1977 in 31 osteoarthritic and six rheumatoid arthritic knees. Prostheses were inserted in 33 usually low-activity patients with an average age of 65 years. There was a five-year minimum follow-up period for 33 knees. The clinical results, according to the Hospital for Special Surgery's knee rating system, were 21 excellent (64%), 7 good (21%), 3 fair (9%), and 2 poor (6%). The two poor results were due to tibial component aseptic loosening. The comparison between the tibial radiolucencies at two and five years showed only minor variations. At five years 75% of the knees had an absent or less than 30% lucency. Most of the mechanical problems occurred after a technically incorrect operation. Varus alignment was not well tolerated with the passage of time. There were no problems caused by the routine use of a patellar component. | |
| 3965357 | Treating joint inflammation in the elderly: an update. | 1985 Jan | The abrupt onset of monoarthritis in an older patient--especially knee, but also wrist, elbow, ankle, or shoulder--should alert the clinician to the possibility of pseudogout. Joint damage or synovitis may predispose aged patients to sepsis. Rheumatoid synovium, for example, has altered synovial resistance to bacterial seeding; thus, septic arthritis in rheumatoid patients may be polyarticular. | |
| 7350870 | Adverse effects of D-penicillamine in rheumatoid arthritis. | 1980 Jan | Adverse effects to D-penicillamine were studied prospectively over 3 years in 259 patients with rheumatoid arthritis. Ninety-five percent had had gold therapy previously, yet 70% benefited from D-penicillamine therapy. Of the 275 courses given, 160 (58%) were complicated by at least one reaction, including rashes (44%), dysgeusia (20%), gastrointestinal upset (18%), stomatitis (10%), proteinuria (7%), thrombocytopenia (3%), and leukopenia (2%). Their occurrences peaked in the first 6 months of treatment, except for proteinuria and thrombocytopenia, which peaked in the second 6 months. Reactions were commoner at daily doses above 250 mg; mean daily doses for proteinuria, thrombocytopenia, and leukopenia were higher (approximately 600 mg/d) than for the others (approximately 500 mg/d). Of 114 discontinued courses, 73 (27%) were due to adverse reactions. The remaining reactions were controlled by altering dosages and symptomatic treatment. Only obliterative bronchiolitis (two cases) was irreversible; it resulted in the only death in our series, possibly attributable to penicillamine. | |
| 6423349 | Bronchoalveolar lavage in gold lung. | 1984 Apr | We report the results of bronchoalveolar lavage in a patient with gold salt-induced interstitial pneumonitis. The presence of elevated numbers of lymphocytes in the lavage specimen supports a hypersensitivity-related pathogenesis of this disease. Such findings may help distinguish pulmonary complications of gold therapy from interstitial disease due to rheumatoid arthritis. |