Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6838672 | Morphologic observations in the early phase of the cartilage-pannus junction. Light and el | 1983 Apr | The early phase of cartilage destruction by active cellular pannus in rheumatoid joints was observed under light and electron microscopy. In the early phase of pannus formation, cartilage was covered by several layers of fibroblast-like cells. This was also the case at the advancing edge of the pannus. Invasion of the cartilage by macrophage-like cells has been observed to start beneath this layer. Observations under electron microscope demonstrated that the main cells participating in the cartilage destruction at the cartilage-pannus junction were either fibroblast-like or macrophage-like cells, and suggested the possibility that these two types of cells were derived from synovial type A and type B cells. Morphologic observations also suggested a possibility of transformation of the fibroblast-like cell into the macrophage-like cell at the cartilage-pannus junction. | |
| 3936927 | Histochemical study of the vascular endothelium of the synovial membrane of rheumatoid art | 1985 Oct | The Ulex europaeus agglutinin-I binding sites were significantly more distributed on the capillary endothelium of the synovium of rheumatoid arthritis (12 of 24 cases, positive) than of osteoarthritis (2 of 14 cases, positive). The distribution was not related to that of factor VIII related antigen nor IgG or IgM. | |
| 6146295 | Outcome of attempts to treat rheumatoid arthritis with gold, penicillamine, sulphasalazine | 1984 Jun | The outcome of attempts to continue treatment indefinitely with either gold, penicillamine, sulphasalazine, or dapsone was studied in 240 patients with rheumatoid arthritis (RA). The usual reason for discontinuing treatment was the occurrence of an adverse effect. This led to 53% of patients stopping gold, 33% sulphasalazine, 32% penicillamine, and 17% dapsone. The next most frequent reason was that the drug was ineffective, leading to discontinuation in 37% of patients having dapsone, 24% sulphasalazine, 19% penicillamine, and 16% gold. Other reasons for stopping treatment were infrequent. The high discontinuation rate of these drugs over 2 years in part accounts for the conflict of opinion on whether they can alter the course of RA; their efficacy must to a large extent be governed by their acceptability. | |
| 1257706 | Enzymes in intestinal mucosa from patients with rheumatoid diseases. | 1976 | Jejunal mucosa from arthritic and control subjects was obtained by intraluminal biopsy or at operation and analysed for eight different enzymes. Histidinemethyl-esterase showed 6 to 10 times higher values in patients uith rheumatoid arthritis on comparison with control individuals in respective series. A disturbance in the histidine metabolism in these patients, possible depending on their intestinal flora, is discussed. | |
| 3887928 | The Canadian collar: a new cervical spine orthosis. | 1985 Mar | We developed a cervical collar (the Canadian collar) in response to the requirements of occupational therapists who manage arthritis patients. This orthosis overcomes the problems of heat and inadequate support common to many soft collars. The collar is constructed from nylon and polyvinyl chloride tubing, clipped together by nylon junctions, and from chin and breastplate supports of molded nylon rod. Preliminary clinical trials have been conducted on 20 patients, 15 of whom had arthritis. An additional 60 patients with various disabilities have been fitted. The collar has been readily accepted by patients, therapists, orthotists, and physicians. | |
| 6825543 | Polymorphonuclear leukocyte function in ulcerative colitis and Crohn's disease. | 1983 Mar | The aim of this study was to determine whether polymorphonuclear leukocyte chemotaxis, adhesion, and electrophoretic mobility were altered in inflammatory bowel disease and whether such alterations could be related to prior ingestion of immune complexes. Polymorphonuclear leukocytes from patients with ulcerative colitis and Crohn's disease showed significantly impaired stimulated migration (P less than 0.05), increased adhesiveness (P less than 0.01 in ulcerative colitis, P less than 0.001 in Crohn's disease), and reduced electrophoretic mobility (P less than 0.02 in ulcerative colitis, P less than 0.001 in Crohn's disease) compared with healthy controls. The disease control of patients with rheumatoid arthritis demonstrated reduced stimulated migration (P less than 0.025) but normal adhesion. Preincubating normal cells in inflammatory bowel disease sera suggested that the altered migration and adhesion were due to circulating serum factors. Circulating immune complexes, detected by the C1q PEG binding assay, were present in 12.5% of patients with ulcerative colitis and 30% with Crohn's disease. Direct immunofluorescence of polymorphonuclear leukocytes suggested binding and/or ingestion of complexes in 57% of patients with ulcerative colitis, and 67% with Crohn's disease. There was a direct correlation between positive immunofluorescence and impaired cell migration in ulcerative colitis (P less than 0.05), but no such relationship was found in the other parameters of polymorph function. | |
| 821403 | Comparative toxicity of gold preparations in treatment of rheumatoid arthritis. | 1976 Apr | Patients with rheumatoid arthritis have been treated alternately with aurothioglucose and aurothiomalate. In the earlier part of the study an oily suspension of aurothioglucose and an aqueous solution of aurothiomalate were used, but later an aqueous solution of aurothioglucose was alternated with the oily suspension and an oily suspension of aurothiomalate with the aqueous solution. Skin eruptions, stomatitis, and albuminuria were significantly more common in patients treated with the aqueous solution than with the oily suspension. | |
| 6601817 | [Significance of reduced complement level in the articular fluid. 81 cases]. | 1983 Jan | Based on their own experience, the authors report that a fall in the complement level of joint fluid, which is particularly common in rhumatoid arthritis, is also seen in cases of systemic lupus eryrthematosis and a variety of arthritis: infectious arthritis, gout, articular chondrocalcinosis and psoriatic rheumatism. This should be taken into account when evaluating the diagnostic value of this test in rheumatoid arthritis. | |
| 7022484 | Sodium meclofenamate ('Meclomen') in the treatment of rheumatoid arthritis: a double-blind | 1981 | The therapeutic efficacy of sodium meclofenamate (300 mg per day) was compared with that of aspirin (3.6 g per day) and placebo in 317 patients with active rheumatoid arthritis. The 8-week double-blind treatment period was preceded by a 2-week washout period on aspirin. A smaller proportion of patients on sodium meclofenamate (11%) withdrew for a lack of efficacy than did patients on aspirin (18%) or placebo (40%). Analyses of measures of tenderness, total joint involvement, duration of morning stiffness, and patient condition and global improvement revealed that the therapeutic effectiveness of 300 mg sodium meclofenamate daily and 3.6 g aspirin daily were equivalent and significantly superior to that of placebo. The principal adverse reactions with sodium meclofenamate were gastro-intestinal symptoms of which diarrhoea was the most frequently reported. The rates of adverse reaction withdrawals were similar in the three treatment groups. Sodium meclofenamate showed good control of disease activity and was generally well tolerated in the treatment of rheumatoid arthritis. | |
| 7244583 | Common serological features in rheumatoid arthritis and yersinia arthritis. Demonstration | 1981 | Sera from 31 patients with rheumatoid arthritis (RA) and from 49 patients with Yersinia enterocolitica 0:3 infection were examined for the presence of rheumatoid factors (RF) and antibodies against denatured (ss) DNA and Y. enterocolitica 0:3 lipopolysaccharide (LPS), by using enzyme-linked immunosorbent assays. Anti-ssDNA antibodies of IgG class were found equally often in the RA as in yersinia patients. The IgM-anti-ssDNA antibody levels were also elevated in the yersinia patients, whereas the RA patients had elevated levels of IgA-anti-ssDNA antibodies. High levels of RF were seen in the RA patients and an increase in IgA-RF activity was observed during the acute stage in the yersinia arthritis patients. An overlap in the serological profiles of RA and yersinia arthritis was further seen in th results of the anti-Y. enterocolitica LPS determinations, a anti-LPS antibodies of IgG class were present not only in yersiniosis but also in 16% of the RA patients. | |
| 6216579 | Autologous mixed lymphocyte reactions in patients with rheumatoid arthritis and juvenile r | 1982 Sep | The lymphocyte responses in autologous mixed lymphocyte reactions (AMLR) between irradiated non-T and T lymphocytes from the peripheral blood (PB) of rheumatoid arthritis (RA) and juvenile RA (JRA) patients were decreased compared with the AMLR responses of normal PB lymphocytes. Normal AMLR responses were seen in synovial tissue and the synovial fluid lymphocytes from RA and JRA patients. The lymphocyte responses were also decreased in AMLR between irradiated non-T cells from peripheral blood and T cells from synovial tissue (ST) in RA patients and between irradiated non-T from PB and synovial fluid (SF) T cells in JRA patients. However, when irradiated non-T cells from ST of RA patients or from SF of JRA patients were mixed with autologous PB T lymphocytes, increased lymphocyte responses were observed. SF T lymphocytes and ST T cells were also shown to stimulate autologous PB T lymphocytes. | |
| 7340449 | Effect of levamisole on leukocyte adherence inhibition. | 1981 Dec | The leukocyte adherence inhibition test can serve as an in vitro model to investigate the cellular cooperation between T cells, monocytes and polymorphonuclear cells (PMN) but also the mechanism of cell adherence. Therefore, the effect of levamisole on the production of PMN activating factors by mononuclear cells and on cell adherence was studied with leukocytes from polyarthritic patients. Levamisole at concentrations ranging from 10(-9) M to 10(-4) M did not seem to affect the production of activating factors. These results differentiate levamisole from anti-inflammatory drugs which are potent inhibitors. On the other hand, levamisole increased markedly the adherence of leucocytes, mainly mononuclear cells, obtained from polyarthritic patients, or normal cells preincubated in a polyarthritic serum. This could be related to a direct effect of levamisole on the leukocyte membrane. | |
| 74919 | [Resection arthroplasty of the metatarsophalangeal joints after Clayton (10 years of clini | 1977 Dec | 57 resection arthroplasties of the metatarsophalangeal joints using the method of Clayton were performed in arthritic and arthrotic deformities of the forefoot. 43 feet were controlled after an average of 5 years postoperatively. The good postoperative position of the toes changes into a progressive shortening, dorsal transposition and frequently valgus direction of the toes during the first year after operation. The deformity is much less than preoperatively. Passive mobility is good, but there is little active motion. The splay foot deformity is reduced in 50% of the cases. No arthritic recurrences were observed, callosities, clavi and mild pain were rarely found. Foot movements, walking ability was improved in all patients and 50% were wearing standard shoes. The results are influenced negatively by errors in resection technique, particularly lack of plantar rounding, exaggerated resection and unfavourable differencies in length of the metatarsal bones, and occasionally by secondary ossifications. | |
| 2983739 | Autoantibody specificities of immune complexes sequestered in articular cartilage of patie | 1985 Mar | To define autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis, extracts were obtained from articular cartilage specimens from 16 patients with rheumatoid arthritis, 11 patients with osteoarthritis, and 6 normal controls. Radioimmunoassays of the extracts revealed that rheumatoid cartilage contained 37 times more IgM and 14 times more IgG than did normal cartilage extracts. In addition, osteoarthritic cartilage contained 3 times more IgM and IgG than the normal tissues. IgM rheumatoid factor was found in 13 of 16 rheumatoid cartilage extracts but in none of 11 osteoarthritic or 6 normal control extracts. IgG rheumatoid factor was detected in 4 of 7 seropositive rheumatoid but in none of 5 osteoarthritic cartilage extracts. More than 60% of the rheumatoid cartilage extracts were positive for native and denatured collagen II antibodies. Surprisingly, 50% of the osteoarthritic specimens also contained significant titers of collagen antibodies. Similar results were obtained with osteoarthritic menisci extracts. These findings indicate that the immune complexes sequestered in rheumatoid cartilage contain autoantibodies that are probably synthesized locally by cells infiltrating the inflamed synovium. If immune complexes trapped in cartilage play an important role in cartilage damage, our findings would provide a possible pathogenic mechanism that explains the self-perpetuating and chronic nature of cartilage degradation in rheumatoid arthritis and osteoarthritis. | |
| 6129465 | Penicillamine nephropathy and iron. | 1982 Dec 18 | 7 of 16 patients with rheumatoid arthritis in whom penicillamine glomerulonephritis had developed had been taking oral iron, usually without the knowledge of their hospital clinician, while the dose of penicillamine was being gradually increased to an effective level. In 4 patients glomerulonephritis had appeared after the patients had stopped iron, with proteinuria developing with 2-5 months of discontinuation. Chelation of penicillamine by iron in the gut reduces its absorption, and in these 4 patients toxicity only became apparent after iron was stopped and there was a sudden increase in penicillamine absorption. | |
| 187398 | [Nasal application of a synthetic alpha1-18 corticotropin: an effective form of ACTH treat | 1976 Dec 3 | The absorption of a synthetic ACTH-peptide (alpha1-18 corticotropin, Ba 41.795) via the nasal mucosa was investigated in twelve probands. After application of 1 mg into each nostril a rapid increase of the plasma cortisol was observed which returned to the initial value only after 7 hours. In two patients with rheumatoid arthritis and two patients with bronchial asthma who had been treated with regular steroid injections an attempt was made to replace the injections by nasal application. The same therapeutic effects could be obtained, but larger doses were required than when using injection therapy. | |
| 4089773 | [Nature of physico-chemical changes in the membranes and chromatin of the lymphocyte nucle | 1985 | Functional activity of lymphocytes, revealed by means of fluorometric study of the physicochemical properties of the membranes (according to the degree of binding with MBD) and nuclei (according to the degree of AO adsorption on chromatin DNA) was different in patients suffering from rheumatoid arthritis with different blood titers of RF determined by Vaaler-Rose's test. The lowered lymphocyte count in blood plasma was coupled with high functional activity of genome in patients with seronegative RA and with low in seropositive RA patients. Changes in the fluorescence of MBD bound with the membrane differed from those in the fluorescence of AO bound with lymphocyte chromatin. The DNA level in blood plasma of patients with seropositive RA was higher as compared with its levels seen in seronegative patients and healthy subjects. | |
| 6376381 | Cutaneous immunofluorescence studies in adult rheumatoid arthritis in sun-exposed and non- | 1984 May | The incidence and significance of positive cutaneous immunofluorescence findings were assessed in biopsy specimens of both sun-exposed and non-sun-exposed skin of 34 adult patients with rheumatoid arthritis (RA) who were not receiving systemic corticosteroids. The incidence of lupus erythematosus (LE)-band was low (8.6%) in both groups. Twenty-eight percent of the patients had perivascular IgM and/or C3 deposits, and 74% had cytoid bodies in the papillary dermis. These studies indicate that the incidence of LE band is low in RA and that the detection of such a band in normal skin warrants close follow-up of RA patients for possible development of LE. | |
| 7033015 | A double-blind comparison of flurbiprofen and indomethacin suppositories in the treatment | 1981 | Forty patients with osteoarthrosis or rheumatoid arthritis were entered in a 4-week double-blind trial to compare the efficacy, safety and tolerance of a flurbiprofen 100 mg suppository formulation with indomethacin 100 mg suppositories. There were twenty patients each on indomethacin and flurbiprofen. Statistically significant improvements were reported for both treatments during the study with respect to morning stiffness, night pain and the overall progress of the patients. Both treatments were equally effective with respect to the amount of improvement shown for the parameters. No improvement was noted on either treatment with respect to grip-strength, functional capacity or the daily intake of analgesic therapy, while a marginally significant decrease in the erythrocyte sedimentation rate was noted on indomethacin. Both treatments were well tolerated with only a few transient and mild side-effects being reported. On the basis of this trial, flurbiprofen and indomethacin suppositories have equal therapeutic effects in the treatment of night pain and morning stiffness. | |
| 946213 | Plantar pressure measurements. Rational shoe-wear in patients with rheumatoid arthritis. | 1976 Mar 15 | Objective measurements of forefoot plantar pressures were taken on 25 patients with rheumatoid arthritis. The Harris mat footprint test and the Brand slipper sock test were used to assess both compressive shearing forces. The Harris mat footprint test is a static used when the patient is unshod. The Brand slipper sock test is a dynamic test used while the shoe is worn. An experimental sandal was designed and used for the treatment of symptomatic forefoot callosities. The Harris mat footprint test results improved dramatically after the patients had worn an experimental sandal for six months. The Brand slipper sock test results showed marked diminution in the pressure profile while the patients wore the experimental sandal. All of the patients improved in their functional abilities while wearing the experimental sandal. |