Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 68852 | Collagenase and its natural inhibitors in relation to the rheumatoid joint. | 1977 | This report attempts to summarize our present knowledge of rheumatoid synovial collagenase and its natural serum inhibitors, beta1-anticollagenase and alpha2-macroglobulin, in relation to cartilage collagen resorption in the rheumatoid joint. Immunolocalization of collagenase across the cartilage/pannus junction is described, and in the light of the finding of the specific, small molecular weight beta1-anticollagenase we propose a model of cartilage erosion based on the interaction between collagenase and its natural inhibitors. | |
| 6151882 | The long term effects of sulphasalazine in the treatment of rheumatoid arthritis and a com | 1984 Dec | The long term efficacy and tolerability of sulphasalazine (SASP) in the treatment of 21 patients with active classical or definite rheumatoid arthritis (RA) were examined and compared with the effects of penicillamine in a similarly active group of RA patients. Nineteen of the 21 patients treated with SASP improved during the first 6 months as shown by significant changes in the clinical and laboratory variables. Clinical improvement was maintained for the remainder of the year. Improvement in laboratory variables was maintained at 9 months but showed some deterioration at 1 year. Six patients went into remission by the ARA criteria, and 16 were able to continue the drug at the end of 1 year. In addition SASP had a steroid-sparing effect in 4 of the patients on systemic steroids. No potentially dangerous side effects were encountered by the end of the first year, although 5 patients were withdrawn. Dyspepsia, nausea and abdominal discomfort were the most common side-effects, although rashes (3) and macrocytosis (2) also occurred. Eighteen of the 21 patients treated with penicillamine improved during 9 months, although there was some deterioration at 1 year. Eight patients were withdrawn because of side-effects - thrombocytopenia (5), nephrotic syndrome (1) and proteinuria (2). This study suggests that SASP has a disease modifying action maintained over a year and associated with low toxicity. It is a useful addition to the small number of second-line drugs with a possibly different mode of action. | |
| 6400518 | A double-blind comparison of tenoxicam (Tilcotil, Mobiflex) at two doses against ibuprofen | 1984 | Tenoxicam (Tilcotil, Mobiflex), a new non-steroidal anti-inflammatory agent of the oxicam group, has been compared at two dose levels (20 mg/day and 4 mg/day) to ibuprofen 800 mg t.d.s. in a double-blind parallel group study of four weeks duration in rheumatoid arthritis. Efficacy results showed no significant difference between the three treatments at two or four weeks though clinical assessments slightly favoured groups treated with tenoxicam in this 30 patient study. No patients withdrew from tenoxicam because of side-effects and there were no withdrawals because of inefficacy. The higher dose (40 mg) of tenoxicam was as well tolerated as the lower dose (20 mg) though plasma levels of tenoxicam suggested that at the lower dose this drug had barely reached optimum plasma levels in a study of relatively short duration. | |
| 6419595 | Comparison of auranofin, gold sodium thiomalate, and placebo in the treatment of rheumatoi | 1983 Dec 30 | A comparison of placebo, auranofin, and parenteral gold sodium thiomalate therapy in 209 patients with active rheumatoid arthritis was performed in a 21-week prospective, controlled, double-blind multicenter trial. When the 161 patients who completed at least 20 weeks of treatment were analyzed for different degrees of response, no remissions were identified. When 50 percent or greater improvement of pain/tenderness scores were compared for end of trial versus entry values, 9 percent of placebo-treated patients, 34 percent of auranofin-treated patients, and 48 percent of gold sodium thiomalate-treated patients showed important improvement that was statistically significant for both gold treatments. When 50 percent improvement for joint swelling was analyzed, 12 percent of the placebo-treated group, 28 percent in the auranofin-treated group, and 37 percent in the gold sodium thiomalate-treated group showed this degree of improvement. Auranofin almost achieved statistical significance for improvement in joint swelling when compared with placebo (p = 0.07), but gold sodium thiomalate was much better than placebo (p = 0.009). There was no statistically significant difference between the two gold treatments. Thus it appears that a subset of patients had an important response to gold therapy that would not be evident by the usual analyses of mean or median changes. Analysis for predictors of response did not discriminate between responders and nonresponders. Because the trial was limited to 21 weeks of therapy, no prediction of the longer-term-effects, especially for auranofin, should be inferred. | |
| 7014533 | [Pyoderma gangraenosum]. | 1981 Apr | Pyoderma gangrenosum is a relatively rare, destructive, inflammatory disease of unknown cause which may present as a purely cutaneous disorder or may be associated with an underlying internal disease (ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple myeloma, lymphoma and others). Four selected patients are described which reflect the clinical spectrum of this condition; these cases and a review of the literature serve as a background for analysis of pyoderma gangraenosum as an entity and a discussion of its pathogenesis. | |
| 6605767 | Serum concentrations of lipid bound sialic acid and acute phase proteins in patients with | 1983 | Levels of serum lipid bound sialic acid (LSA) were determined in lung cancer and the inflammatory reaction associated with pneumonia, rheumatoid arthritis and surgical wounding. The mean levels of serum LSA were raised in all these disorders and levels were closely correlated with serum alpha 1-acid glycoprotein (AGP) r = 0.9. Levels of AGP and LSA rose and fell in parallel following cholecystectomy. The major influence on the concentration of serum lipid bound sialic acid is the intensity of the response to inflammation. | |
| 3878007 | [Spontaneous secretion of antinuclear factors in systemic lupus erythematosus, rheumatoid | 1985 | The authors studied the ability of non-stimulated short-term cultures of peripheral lymphocytes of SLE, RA and rheumatic fever patients to spontaneously produce antibodies to DNA and other antinuclear factors. To demonstrate antibodies to DNA, use was made of the radioimmunoassay and the passive hemagglutination test. ANF-test of indirect immunofluorescence. The nosological and clinical features of secretory ANF were explored in the diseases in question. It was established that patients with the main rheumatic diseases are different as regards the rate of demonstration, level and spectrum of secretory ANF. They also differ from the group of donors in terms of the same characteristics. The culture of peripheral lymphocytes of SLE patients has the greatest ability to secrete antibodies to DNA and ANF of the primarily marginal and homogenous types of fluorescence. This characteristic correlates with SLE activity before the disease onset and over time as well as with lupus nephritis. In RA and rheumatic fever, this characteristics correlates with the disease activity, the presence of visceritis in RA. The clinicopathogenetic importance of secretory ANF in rheumatic diseases is discussed. | |
| 6190486 | High serum beta-2-microglobulin levels and circulating immune complexes containing beta 2m | 1983 Jun | Serum beta-2-microglobulin (beta 2m) levels, incidence and levels of anti-beta 2m autoantibodies, and quantity of circulating macromolecular complexes containing beta 2m were studied in patients with Felty's syndrome (FS), joint-restricted rheumatoid arthritis (RA), and healthy controls. The serum beta 2m concentrations detected in the FS group (6.95 +/- 2.9 mg/liter) greatly exceeded those of the RA group (3.4 +/- 1.2 mg/liter) and the control group (1.42 +/- 0.69 mg/liter). Autoantibodies to beta 2m were frequent in the FS group. Circulating complexes containing beta 2m, prepared by precipitation in 3% polyethylene glycol, were detected in 65% of FS and 35% of RA patients. In the majority of these cases the solid-phase C1q purified immune complexes also contained beta 2m. Detection of anti-beta 2m antibodies in a significant part of complexes containing beta 2m suggests the presence of specific immune complexes in this fraction of FS and RA patients. | |
| 161063 | [In vitro study of the primary antibody response of circulating lymphocytes in patients wi | 1979 Dec | We have studied the in vitro antibody response to a hapten of peripheral blood lymphocytes from 26 patients with rheumatoid arthritis and 7 ankylosing spondylitis. These patients had never received immunosuppressor drugs before or corticosteroids during the month before the test. They had failed to receive aspirin or non-steroid anti-inflammatory drugs for 72 hours before blood sampling. The control groups included respectively 38 healthy subjects and 24 patients hospitalized for non inflammatory disease. The antibody response of ankylosing spondylitis patients is comparable to that of controls ; on the opposite the response of patients with rhumatoid arthritis is significantly depressed in comparison with the three other groups. The weak response of lymphocytes in arthritis is not due to increased cell death in culture or to modified kinetics of the antibody response or to the appearance of a IgG secondary type response or a in vivo pre-activation. The lymphocytes of arthritis patients do not inhibit the response of normal lymphocytes when they are co-cultured. The observed response is identical to that obtained when control patient lymphocytes are co-cultured with normal lymphocytes. The function of suppressor T cells induced by Con A seems normal in spondylitis and arthritis. | |
| 6373089 | Reconstruction of the acetabular wall with bone graft in arthroplasty of the hip. | 1984 Jun | The fate of autologous bone grafts under a layer of methylmethacrylate cement, previously investigated in dogs, was observed in eight patients. The grafts were incorporated into the acetabular bone within six to ten months. Reinforcement of the inadequate acetabulum with autologous bone graft is necessary in order to withstand the long-term repetitive loading in patients with total hip arthroplasties. Reconstruction of the medial acetabular wall (using autologous bone chips), combined with fixation of the socket with methylmethacrylate, was successful in all eight patients with a follow-up period of two to six years. | |
| 114646 | Metabolism and distribution of gold compounds. | 1979 | The pharmacokinetics of gold in blood and urine are compared during intramuscular and oral chrysotherapy for rheumatoid arthritis. Blood gold levels are 3 to 10 fold higher with injectable aurothioglucose and gold sodium thiomalate (50 mg/week) than with oral auranofin (6 mg/day). But, the serum half-life of the parenteral compounds is significantly shorter (5.5 days) than the oral agent (14-21 days). The gold content of urine is nearly 10 times higher with the intramuscular compounds than with the oral drug. The excretory pathways and tissue distribution of gold during conventional intramuscular chrysotherapy are reviewed. Forty percent of a 50 mg injection of gold sodium thiomalate is excreted in 7 days, of which 70% is recovered in the urine. Highest gold concentrations are found in the reticuloendothelial system, adrenal glands and kidneys, while the bone marrow, liver, skin and bone contain the greatest quantities of gold. | |
| 6606513 | Binding of immunoglobulins and immune complexes to cartilage derived extracts. | 1983 Dec | Cartilage extracts with affinity for heat aggregated immunoglobulins were prepared from human articular and bovine nasal cartilage. These extracts, containing predominantly collagen, also bound both to immune complexes (IC) prepared in vitro and to immunoglobulins from sera of many patients with rheumatoid arthritis (RA). Cryoprecipitation of rheumatoid sera removed material reacting with the extract and density gradient fractionation of a positive serum showed correlation between binding to the extract and to C1q. These results indicate that the binding materials in rheumatoid sera were likely to be IC. We suggest that some assays which apparently demonstrate anti-collagen autoantibodies in fact measure IC. These findings also have implications for models of the pathogenesis of RA. | |
| 930424 | [Modification of a rheumatoid model disease using a benzopyron preparation]. | 1977 Sep | The influence of a benzopyrone-preparation on the process of an experimental erysipelas in the rat, an animal model for the human rheumatoid arthritis, was studied. By plethysomometric determination of the paw volume it was shown that the swelling of the paw was significantly smaller in the benzopyrone-group than in the control-group. Furthermore it was observed that the administration of benzopyrones significantly reduced cornea-oedemas, a characteristic of the erysipelas model. The reduction of body weight, occurring during erysipelas disease, is not significantly improved by benzopyrone administration. The mortality, which is much smaller in the benzopyrone-group (30%) than in the matened control group (60%), demonstrates the good tolerance of the drug. The revealed results are described and the influence of benzopyrones on this rheumatoid disease is discussed. | |
| 901177 | Status of total shoulder arthroplasty. | 1977 Sep | Some patients with degenerative, rheumatoid, and traumatic diseases of the glenohumeral joint require treatment primarily to relieve pain. In the absence of complete knowledge of basic mechanical requirements, clinical trials with both constrained and resurfacing prosthesis were initiated. Three types of constrained prostheses were placed in 23 patients. Pain relief was satisfactory, but six reoperations were necessary and motion greater than 90 degrees was rarely achieved. Twenty-five prostheses that were used to replace the glenohumeral articulation, but were not stable by virtue of design, were implanted. Again, pain relief was excellent; mechanical problems were not present, and motion was almost always greater than 90 degrees. Achieving stability by capsular-muscle cuff repair has not been as great a problem as anticipated. These results suggest that more emphasis should be placed on repair of the glenohumeral stabilizing structures than on their replacement. | |
| 6974844 | Nonspecific alpha-naphthyl acetate esterase activity of T-lymphocytes: study in healthy ne | 1981 Sep | The aim of this study was to compare the E rosette-forming cells and nonspecific alpha naphthyl esterase (ANAE)-positive lymphocyte values in normal and pathologic situations. In newborns, the ANAE-positive lymphocytes represented less than 60% of the E rosette population. During the first year of life, E rosette-forming cells (E-RFC) reached normal values as soon as one month whereas only three-fourths of the T cells exhibited an ANAE-positive staining. In adult T cell populations, nearly 90% were ANAE-positive. Our observations of immune deficiencies suggested that the relative proportions of E-RFC and ANAE-positive lymphocytes were generally comparable to normal values. However, in the majority of the patients with very low or absent E-RFC (severe combined immune deficiencies, Di George syndrome, and congenital rubella), some ANAE-positive lymphocytes could be detected. Our immunologic survey shows that the ANAE-positive lymphocytes were in a normal range 2 years after a bone marrow transplantation in severe combined immune deficiencies patients. One child who exhibited a normal amount of E-RFC and whose lymphocytes failed to respond in vitro to mitogens had practically no ANAE-positive lymphocytes. An elevated amount of ANAE-positive cells in juvenile rheumatoid arthritis may reflect an augmentation of the T helper functions which permanently stimulated in vivo immunoglobulin production. | |
| 216183 | Purification and some properties of collagenase proenzyme activator from rheumatoid synovi | 1978 Nov | 1. An activator of leucocyte latent collagenase has been extracted from rheumatoid synovial fluid by a preparative method consisting of six steps including precipitation by ammonium sulphate and chromatography on Sephadex G-100, QAE-Sephadex and SP-Sephadex C-50. The purification factor was nearly 1000 and the activator isolated could be shown to have a high degree of homogeneity.--2. Gel chromatography indicated a molecular weight of ca. 60 000.--3. Kinetic studies of the activation and inactivation of the activator during incubation at higher temperatures demonstrated its enzymic nature.--4. Activation of latent collagenase was partially inhibited by iPr2P-F and KCN. Soybean trypsin inhibitor, iodoacetamide, TosLysCH2Cl and TosPheCH2Cl had no effect.--5. Leucocyte latent collagenase was also activated by an excess of trypsin and p-hydroxymercuribenzenesulphonic acid, but only to the extent of about 40% of its activation capacity. Purified neutral protease from human leucocyte granules had no effect on latent collagenase.--6. Several typical substrates for proteases, peptidases, esterases and glycosidases were not attacked by the activator. The possibility that the activator is a known enzyme, such as kallikrein, urokinase or cathepsin B1, could be excluded. | |
| 6726210 | "Chronic pain as a variant of depressive disease". A critical reappraisal. | 1984 Jul | This paper critically examines the hypothesis that chronic pain is the physical manifestation of an underlying depressive disorder, as proposed by Blumer and Heilbronn in 1982 ( Blumer , D., and Heilbronn , M. Chronic pain as a variant of depressive disease. The pain-prone disorder. J. Nerv . Ment . Dis., 170: 381-406, 1982). The logic of this argument and the empirical evidence provided by Blumer and Heilbronn to support their hypothesis are discussed and their validity challenged. Alternative interpretations for the results as well as for the relationship between pain and depression are noted. Although it may be plausible to view a small subset of chronic pain patients as manifesting a " muted depressive state," the burden of proof still lies with those theorists who adhere to this formulation. | |
| 6582276 | Problems in examination surveys of the rheumatic diseases. | 1983 Nov | Examination surveys to document the frequency and distribution of the rheumatic diseases in populations were largely pioneered by the efforts of Kellgren and Lawrence in England starting in the 1950s. The purpose of these surveys was primarily to gain insight into the extent and types of rheumatic diseases and their associated morbidity in representative population samples. From such studies the relative frequency of the common rheumatic diseases was defined and their occurrence in relation to their age and sex distribution within the population described. The methodologies devised for this purpose contained detailed historical, clinical, radiological, and serological components which were then applied by a number of investigators in different countries. The results of these surveys raised questions concerning diagnostic criteria, and led to the realization that diagnostic categorization in the population at large was often more difficult than in the rheumatology clinic. | |
| 349679 | Antibodies against microfibrils of developing connective tissue in patients with inflammat | 1978 Mar | Sera from patients with chronic inflammatory disease were tested for the presence of connective tissue antibodies. Fetal human skin was used as a substrate in an indirect immunofluorescence assay. Histological staining for connective tissue fibres, antibodies to connective tissue components and immunoelectron microscopy were used to identify the antigenic structures. Some antigenic fibrils were associated with elastin. By immunoelectron microscopy antigenic extracellular microfibrillar structures were identified. Antibodies against these microfibrils were detected in higher titres only in chronic inflammation (14%). Our results suggest that antibodies against connective tissues microfibrils may occur in human sera. | |
| 6095870 | IgG and IgM antibody to native type II collagen in rheumatoid arthritis serum and synovial | 1984 Dec | Levels of IgG and IgM antibody to native type II collagen, a component of articular cartilage, were measured by a specific solid-phase radioimmunoassay, in 48 rheumatoid arthritis patients. Good correlations were found between the levels in sera and those in synovial fluids. Collagenase digestion caused a significant rise in specific antibody levels in synovial fluids, indicating the presence of intraarticular collagen-anticollagen complexes. These immune complexes may be one mechanism for perpetuation of inflammation in some rheumatoid arthritis patients. |