Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4078264 | Radiolunate arthrodesis. | 1985 Nov | The procedure of radiolunate arthrodesis was suggested by spontaneous radiolunate arthrodesis that resulted in painless, satisfactory function. Ulnar translation down the inclined slope of the radius is accelerated by dorsal dislocation of the ulnar head, ulna minus variance, and triangular fibrocartilage resorption and may be an inducement to increased ulnar deviation of the fingers as well as disintegration of the proximal carpal row. Twenty-two radiolunate arthrodeses were performed, 16 by a corticocancellous slotted graft and six by a modified Lauenstein procedure in 17 rheumatoid and five traumatic cases. Nineteen wrists were available for follow-up at an average of 28 months. Average range of motion was 25 degrees of extension, 30 degrees of flexion, 5 degrees of radial deviation, and 15 degrees of ulnar deviation. Subjective evaluation was good in 14 wrist, fair in three, and poor in two. Relief of pain was generally satisfactory, and preoperative grip strength was slightly improved. Progressive degeneration of the midcarpal joint tends to be minimal. If further spontaneous arthrodesis occurs, the wrist remains in satisfactory position. Carpal ulnar translation, midcarpal angulation, and radial angulation are corrected. Loss of carpal height is partially corrected in most instances. | |
| 314294 | T lymphocyte subpopulations in synovial fluid of patients with rheumatic disease. | 1979 Sep | The proportion of T lymphocytes with receptors for the Fc portion of IgG (TG cells) of IgM (TM cells) was determined in synovial fluid and blood of 16 patients with various rheumatic diseases including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. The percentage of TG cells was low in all synovial fluid samples, whereas in the patients' blood the percentage was higher than or equal to the level found in the blood of healthy subjects. Eight patients also had a lower level of TM cells in synovial fluid as compared to the percentage found in the blood of healthy donors. In the patients' blood the percentage of TM cells was usually within the normal range. Thus the proportion of T cells lacking either receptor (Tnull cells) was higher in synovial fluid than in blood. This pattern of low TG cell and high Tnull cell percentages was found in the synovial fluid of patients with various rheumatic diseases and thus seems to be a general feature of chronic inflammatory joint exudates. | |
| 6524029 | [Quantitative determination of spongiosa formation of tibial cortical bone following knee | 1984 Nov | Cancellization always occurs following implantation of total knee joint replacements. In the study reported here the extent of the cancellization process at the tibia corticalis was investigated; it was found that the extent of cancellization differs according to the height and the time factor. The danger of cancellization as a risk to the joint prosthesis is pointed out with reference to a case in which a fracture occurred. The problem of isoelastic joint prostheses as alternatives for avoiding cancellization is discussed. | |
| 901181 | Total ankle joint replacement. | 1977 Sep | The ankle is an inherently stable, kinematically simple joint that bears tremendous compression forces with relative ease because of a large load-bearing surface area. Disabling disease of the ankle is less common than at the hip or knee joints, but is not rare. Ankle arthrodesis seems less than ideal as a technique of surgical treatment. Total ankle joint replacement seems to be a clinically possible alternative on the basis of experience with 76 procedures performed during a 31-month period. Continuing clinical experience is resulting in more gratifying results by the avoidance of technical errors and better selection of patients. | |
| 6607499 | [The reactive arthritis syndrome. Rheumatological limits]. | 1983 Nov | The term reactive arthritis (RA) refers to an inflammatory joint disease in the absence of bacteria in the joint, but which is caused by a distant extra-articular infection. They occur as a result of a variety of infections, which are essentially genital or gastro-intestinal in subjects with a particular genetic predisposition characterized by the presence of the HLA-B27 antigen or one of the CREG group of antigens (B7 - B27 - BW22 - BW42). The most complete clinical expression of reactive arthritis is the Fiessinger-Leroy-Reiter syndrome. Apart from the reactive arthritis with a generally accepted aetiology such as those following infections of the genital tract (Chlamydia trachomatis, Ureaplasma urealyticum or of the gastrointestinal tract: Yersinia enterocolitica and pseudotuberculosis, Shigella flexneri, Salmonella minor, Campylobacter jejuni), the authors discuss the possibility of including, in a broader definition of RA, post-streptococcal arthritis and cases of arthritis following gonococcal, meningococcal and Brucella infections. RA does not always have a favourable clinical course. It is not exceptional to see a picture of recurrences with progression towards chronic inflammatory rheumatism. | |
| 6318346 | [Double-blind comparative study of Bi-Profenid tablets and Profenid capsules in inflammato | 1983 Dec 12 | The effectiveness of Bi-Profenid tablets and Profenid capsules was studied comparatively in patients with inflammatory joint disease. 43 patients with rheumatoid arthritis or various chronic inflammatory joint diseases were given 300 mg of Bi-Profenid in 2 daily oral doses and 300 mg of Profenid in 3 daily oral doses, for two consecutive 7 day periods. This double blind cross-over study was carried out in two rheumatology centers. Effectiveness of the two forms of ketoprofen on morning stiffness and pain scale was found to be comparable. However, patients more often preferred Bi-Profenid (15 cases) to Profenid (10 cases); 12 patients reported no difference. Tolerance was excellent in 92.7% of cases under Profenid capsules and in 94.8% of cases under Bi-Profenid tablets. | |
| 6770953 | Adverse reactions to D-penicillamine after gold toxicity. | 1980 Jun 21 | The incidence of adverse reactions to D-penicillamine in 155 patients with rheumatoid arthritis was analysed and compared with their history of adverse reactions to gold. Out of 125 patients who took only D-penicillamine, 45 developed side effects from the drug, whereas of 27 patients with a history of gold toxicity, 18 also reacted adversely to D-penicillamine. All patients who took D-penicillamine within six months after an adverse reaction to gold developed side effects from D-penicillamine. Fourteen patients developed similar adverse reactions to D-penicillamine and gold, and the interval between treatments in this group was significantly shorter (p less than 0.01) than in those who developed either differing adverse reactions to both drugs or no reaction to D-penicillamine after treatment with gold. An interval exceeding six months between treatment with gold and treatment with D-penicillamine in patients who have developed adverse reactions to gold apparently reduces the risk of adverse reactions to D-penicillamine. | |
| 7191312 | [Study of the dose-reducing effect of acemetacin on prednisolon (author's transl)]. | 1980 | The dose-reducing effect of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy[ acetic acid (acemetacin, TV 1322, Rantudil¿) on prednisolon was studied on 22 patients suffering from rheumatoid arthritis. The average prednisolon-saving was 4.33 mg; in 31.8% of the patients it was possible to dispense with prednisolon completely (in 6 cases the reduction was 5 mg and in 1 case 7.5 mg). During the short test period the medication was well tolerated. Undesired gastro-intestinal drug reactions were not recorded for any of the patients. None of the investigated laboratory parameters revealed any pathological changes which were attributable to Acemetacin, but in one patient getting a long-term treatment with gold a decrease of lymphoid cell count was observed. | |
| 7020705 | Enhanced neutral protease activity in proliferating rheumatoid synovial cells. | 1981 Jul | Proteolytic enzymes associated with rheumatoid synovial cells (RSC) have been implicated in the degradation of articular cartilage. Proteases have been measured in proliferating rheumatoid synovial cells (P-RSC), proliferating nonrheumatoid synovial cells (P-NSC), and their nonproliferating counterparts (NP-RSC and NP-NSC). The P-RSC and P-NSC exhibit enhanced total surface-associated plus secreted neutral protease activity, as compared with NP-RSC and NP-NSC. The P-RSC exhibited significantly higher protease activity in this category compared to P-NSC. The RSC also secreted higher levels of secreted proteases alone compared to NSC. The secreted protease activity alone was not related to the proliferative state of the cells. Extractable protease activity was measured in early-passaged and serially-passaged P-RSC, NP-RSC, P-NSC, and NP-NSC. Extractable cellular protease activity measured at pH ranges from 5.0 through 8.0 was not significantly different between P-RSC and NP-RSC or between P-NSC and NP-NSC. The RSC contained elevated extractable cellular protease activity measured at pH ranges from 5.0 through 8.0 compared to extracts from later-passaged cells. The neutral protease activity in the early-passaged RSC was also higher than that measured at pH 6.0 or 8.0. In synovial cells cellular protease activity was related to the proliferative state and the origin of the cells. The P-RSC exhibited the highest levels of surface associated plus secreted neutral protease activity. The RSC also possessed the highest levels of extractable protease activity compared to NSC. | |
| 6867521 | [A new case of rheumatoid nodulitis]. | 1983 Mar | A new case of rhumatoid nodulitis is reported in à 28 year old man presenting with rapidly regressive arthralgia, numerous rhumatoid nodules and metatarsal lesions without signs of associated arthritis. The biochemical profile was non-specific; serology was weakly positive for rhumatoid factor; there was no obvious immunological disorder (no circulating immune complexes, total complement and its various fractions within normal limits). The clinical findings, treatment and classification of this condition are discussed with reference to six other published cases with a similar clinical and paraclinical features. | |
| 219811 | Immunological experimental arthritis in pigs. II. The level of complement in the pigs immu | 1978 | The level of complement was studied in 3 groups of pigs. One group was immunized with Erysipelothrix rhusiopathiae and two remaining groups with virus of Aujeszky's disease. The lowest titers, irrespective of the starting level were shown to exist in all the studied groups in the third week after the last dose of the virus. | |
| 6731501 | Renal amyloidosis associated with crescentic glomerulonephritis. | 1984 | A case of renal amyloidosis coincidentally associated with crescentic glomerulonephritis is described. A 59-year-old female with 30 years' history of rheumatoid arthritis developed nephrotic syndrome followed by rapid deterioration of renal function. Among 28 glomeruli in a kidney biopsy specimen, glomerular amyloid deposition was present in 17 and crescent formation in 20. Only one glomerulus was free from amyloid deposition or crescent. The amyloid deposition was clearly demonstrated by congo red, thioflavin-T staining as well as electron-microscopic examination. Glomerular deposition of immunoglobulins and/or complements were not noted. While cyclophosphamide, dipyridamole, and heparin followed by pulse methylprednisolone were given, the renal function deteriorated progressively and dialysis was initiated. Renal function, however, recovered partially without medication after peritoneal dialysis of 3 months' duration. The second renal biopsy revealed the progression of glomerular amyloid deposition and the increase in fibrous component of crescent. | |
| 7023571 | An autoantibody reactive with nuclei of polymorphonuclear neutrophils: a cell differentiat | 1981 Oct | An autoantibody that reacted with nuclei of polymorphonuclear neutrophils (PMN) was detected at titers of greater than 10 in sera of 25 of 50 patients with rheumatoid arthritis and 36 of 50 with autoimmune chronic active hepatitis but in none of 160 controls comprising 24 patients with alcoholic cirrhosis, 36 with multiple myeloma, and 100 healthy subjects. Through the use of enriched populations of hemopoietic cells, this antibody was shown to be cell-specific, reacting only with the nucleus of the mature neutrophil. It was unreactive with nuclei of progenitor cells in the myeloid series and with nuclei of eosinophils, monocytes, lymphocytes, and thymocytes. It reacted with a determinant that appeared to be a differentiation antigen. This cell-specific autoantibody may prove to be of value in analytical studies of granulocyte maturation. | |
| 812287 | [Antigens of the synovial fluid. I. Immunodiffusion and electrophoretic studies]. | 1975 Sep | 9 rabbits were immunized with the synovial fluid of patients with rheumatoid arthritis. The antisera thus raised contained antibodies against 18 serum proteins and against fibrinogen. After full absorption of the antisera with human blood plasma a maximum of 5 and average of 3 typically synovial antigens could be detected in the synovial fluid by immunodiffusion. One antigen (SF1) was present in all studied human organs and connective tissue extracts. It is thermostable, insoluble in alcohol, but soluble in 0,3 N perchloric acid. The two other antigens had a lipid character, one of them was also thermostable and insoluble in alcohol and smaller amounts there-of were found in organ extracts. The antigens could also be detected in synovial effusions caused by trauma, whereas normal synovial fluid contained only two unidentified antigens in low titre. Using immunodiffusion the antisera did not show any cross reaction with synovial fluids and organ extracts of other species. Immuno-electrophoretically only the line of the SF1 in the alpha1/alpha2 area could be definitely localized. | |
| 321183 | Comparison of sulindac and aspirin in rheumatoid arthritis. | 1977 | Thirty-one out-patients with rheumatoid arthritis took part in a 10 week double-blind comparison of sulindac (cis-5-fluoro-2-methyl-1-[p-(methylsulphinyl)-benzylidene]-indene-3-acetic acid) 200 mg twice daily and aspirin 3.6 g daily, with a 2-week placebo control period. Both drugs were superior to placebo. The incidence of side-effects was approximately the same on the two drugs, but there was a higher drop-out rate due to side-effects on aspirin. | |
| 7216511 | Early rheumatoid-like joint lesions in rabbits injected with foreign serum. IV. Influence | 1981 | Intradermal injection of rabbits with lipid-coupled bovine serum proteins or bovine serum itself prior to a regimen of intravenous injections of bovine serum enhanced the incidence of joint lesions over that seen in animals receiving the intravenous regimen only. This increased of synovial lesions appeared, however, to be unrelated, either to the state of delayed hypersensitivity or to the concentration of passive haemagglutinating antibodies to bovine serum proteins in these animals. Lipid-coupled bovine serum, given as a first course in a regimen of intravenous injections, was no more arthritogenic than the native proteins and, as a second course series of intravenous injections, was definitely less arthritogenic. | |
| 6146412 | Glycylprolyl-diaminopeptidase in human leukocytes: selective occurrence in T lymphocytes a | 1984 Jun 13 | Using biochemical methods glycylprolyl-diaminopeptidase (GP-DAP, EC 3.4.14.5) was measured in purified leukocyte subpopulations and found selectively in T lymphocytes. In 129 subjects with normal hepatic function a significant correlation was observed between the serum GP-DAP activity and the peripheral blood lymphocyte count. In four patients suffering from rheumatoid arthritis, four weeks of thoracic duct drainage resulted in a reduction of the peripheral blood lymphocyte count and a concomitant decrease of the serum GP-DAP activity. These observations suggest that lymphocytic GP-DAP may contribute to the total serum GP-DAP activity. | |
| 1270463 | Secondarily infected total joint replacements by hematogenous spread. | 1976 Jun | Three fatal cases of infections that followed total joint replacement are repoarted, in each of which a hematogenous source of infection was identified. There also were five non-fatal cases presumable arising hematogenously which were reported in the literature. It is emphasized that concomitant disease, including active rheumatoid arthritis, may predispose to this complication. | |
| 6409636 | Clinical significance of serum hydroxyproline-containing peptides with special reference t | 1983 Apr | Serum hydroxyproline-containing peptides were separated into three fractions, i.e. large protein, polypeptide and smaller peptides, by gel filtration on Sephadex G-200. The large protein was presumed to be the C1q subunit of the first component of complement by an immunological analysis. The polypeptide had an electrophoretic mobility corresponding to beta-globulin and its molecular weight was estimated between 35000 and 45000 by gel filtration analysis. The polypeptide might well be defined as hyproprotein. The molecular weight of smaller peptides was estimated between 1400 and 3000. As compared with the control value, hyproprotein levels were significantly increased in rheumatoid arthritis, systemic lupus erythematosus and chronic liver disease. C1q levels were slightly lowered in rheumatoid arthritis and systemic lupus erythematosus, and were slightly increased in chronic liver disease but were not significant. In all patient groups smaller peptides levels remained in the normal range. These results suggest that serum hyproprotein levels are raised in some fibroproliferative disorders, probably reflecting collagen metabolism. | |
| 1023845 | [Heparin tolerance in relation to age and the presence of amyloidosis]. | 1976 Oct | Clotting time under basal conditions and 30', 60' and 120' after 100 I.U. heparin/kg i.v. was determined in four groups:1) 15 healthy subjects aged less than 50 yr; 2) 27 "healthy" subjects over 65 yr; 3) 20 subjects with either myeloma (7 cases), benign monoclonal gammopathy (7) or rheumatoid arthritis (6); 4) 4 subjects with amyloidosis (2 primary, 1 secondary to rheumatoid arthritis, and 1 secondary to myeloma). Rectal biopsy and a histological search for amyloid substance were carried out in all subjects from the 3rd and 4th groups. Heparin tolerance was too widely scattered to enable statistically significantly means to be deduced. Comparison between the arithmetical means of the four groups, however, showed a greater resistance in aged opposed to young subjects, and in patients with amyloidosis as opposed to those in the other three groups. This was constant and marked after 60' and 120', suggesting that this test may offer indirect evidence in support of a diagnosis of amyloidosis. |