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PMID	Title	PublicationDate	abstract
3157276	[Local and systemic parameters in the synovial milieu].	1985 Jan	Our own results as well as recent data from the literature confirm the already long known fact, that synovial fluid analysis allows only in very few diseases as for example a crystal synovitis a definite diagnosis in the individual case. In the majority of the patients this technique permits only to differentiate between inflammatory and non-inflammatory joint disease as well as an estimation of the local inflammatory activity of joint. The simultaneous histologic examination of synovial membrane according to our experience seems to bring no major additional information which exceeds the information given by each technique alone.
54937	Radionuclide joint imaging.	1976 Jan	Modern radionuclide techniques of joint imaging involve the use of either 99mTc-pertechnetate or 99mTc-phosphate compounds in conjunction with the Anger camera. In general, images obtained with both types of radiocompound are nonspecific--although increased uptake of 99mTc-pertechnetate usually denotes the presence of synovitis. The most popular uses of the technique are in documenting the extent and severity of inflammatory joint disease, assessing the effect of therapy, and establishing the diagnoses of Legg-Perthes disease and septic arthritis. The method is also useful in judging the extent of involvement in osteoarthritis of the knee prior to surgical intervention. Radionuclide joint imaging is more sensitive than clinical or radiographic techniques in detecting early joint involvement but usually it must be supplemented by other techniques to establish a specific diagnosis.
735458	[Aliphatic diamines and histamine in the serum of patients with chronic polyarthritis].	1978 Sep	The concentration of histamine, cadaverine, putrescine as well as spermidine and spermine was measured in blood serum of patients with rheumatoid arthritis (RA). In comparison to normals there is no statistically significant difference in the concentration of putrescine and spermidine in blood serum of RA patients. Spermine which could be detected in all samples too did not show distinct abnormalities from healthy subjects. Histamine and cadaverine present in measurable amounts were only in particular cases. A relation between increased histamine and basophile count was not demonstrable. There is apparently no correlation between histidinemia which is reported in the literature for RA patients in blood serum and plasma, and histamine production in the blood.
6623118	Sex differences in illness incidence, prognosis and mortality: issues and evidence.	1983	This paper reviews current research and presents new evidence concerning sex differences in morbidity and mortality. Attention is focused primarily on the following topics: (1) sex differences in incidence, prognosis and mortality for several major types of chronic disease, (2) causes of sex differences in morbidity and mortality, (3) sex differences in physician visits and (4) a methodological issue, whether there are sex differences in reporting morbidity. Relationships between sex differences in incidence, prognosis and mortality have been analyzed for various types of cancer, ischemic heart disease and rheumatoid arthritis. There was little or no correlation between sex differences in incidence and sex differences in prognosis. Sex differences in prognosis were generally smaller than sex differences in incidence. In most cases, sex differences in prognosis made a relatively small contribution to sex differences in mortality, and sex differences in incidence were the primary determinant of sex differences in mortality. These patterns indicate that the causes of sex differences in incidence frequently have little effect on sex differences in prognosis. Reasons for this are discussed in the text. The causes of sex differences in morbidity and mortality are discussed, with attention to the contributions of genetic and environmental factors, sex roles, sex differences in stress responses and sex differences in risk-taking and preventive behaviors. One conclusion is that, although men take more risks of certain types, there does not appear to be a consistent sex difference in propensity to take risks or to engage in preventive behavior. Rather sex differences in risk-taking and preventive behavior vary depending on the specific behavior and the culture considered. Sex differences in physician visit rates are influenced by a variety of biological and cultural factors. For example, women's more complex and demanding reproductive functions are a major reason for women's higher rates of physician visits, at least in Western countries. The importance of cultural factors is indicated by the cross-cultural and historical variation in sex differences in physician visit rates. In order to test whether there are sex differences in the reporting of health and illness, discrepancies between self-report and medically-evaluated morbidity measures have been assessed for males and females in twelve studies. These data indicate that sex differences in reporting vary depending on the particular type of morbidity measure considered. For example, for self-ratings of general health women may be more predisposed than men to rate their health poor, but no significant sex differences were observed in reporting of physician visits or hospital admissions. The evidence discussed in this paper illustrates the diversity and complexity of factors that influence sex differences in morbidity and mortality...
1082850	[Possible role of immune-phenomena in the pathogenesis of rheumatoid arthritis (author's t	1976 Feb	The R.A. is accompanied by a variety of different immune-phenomena. These are not restricted to the well known and diagnostically exploited IgM-rheumatoid factors in serum, but involve also rheumatoid factors of the Ig-classes G and A, which, at least partially are produced by lymphoid cells, which infiltrate the synovial membranes. These cellular infiltrations consist of macrophages, B and T lymphocytes, the latter being in excess. There is now good evidence that locally deposited, complement activating immune-complexes participate in the inflammatory lesions of the R.A.-joints by inducing the release of hydrolases from phagocytic cells. This event is also mediated by lymphokines and complement factors. Is is suggested that the pathogenicity of the immunoreactions occuring within the synovial tissue and fluid is a quantitative rather than a qualitative problem. In contrast to other tissues, the anatomy of the joint may favour the local accumulation of the immune-complexes. Moreover abundant immuno-reactions may be provided by a defective T-cell mediated control. Thus there is strong indication that immune-phenomena play an important role in the pathogenesis of R.A. This does not exclude the significance of metaboltic disturbances of the connective tissues for this disease.
3989961	Radiology of disorders of the sacroiliac joints.	1985 May 17	Differentiation of the many disorders that affect the sacroiliac joints can often be accomplished by attention to radiographic detail. By evaluating the distribution of disease, the presence of erosions and other changes as noted herein, and the course of disease over a period of time, a specific diagnosis can often be made, or at the very least, suggested (Table).
4093914	Prosthetic synovitis: clinical and histologic characteristics.	1985 Dec	Our study of 20 patients correlates the clinical picture of each patient with the pathology of synovial tissue obtained at the time of revision arthroplasty. While 12 patients had rheumatoid arthritis and 8 had osteoarthritis, the histopathology was identical. Additionally, while 15 of the 20 had an etiology for the revision, 5 patients were revised for pain alone with no explanation other than the synovitis. The characteristic histologic findings included lining cell hyperplasia, vascular congestion, giant cells, brightly birefringent high density polyethylene chards and cysts that represented ghosts of methyl methacrylate debris.
237492	Lymphocyte proliferation to artery antigen as a positive diagnostic test in polymyalgia rh	1975 Apr	The transformation response of peripheral blood lymphocytes in vitro to human arterial and muscle antigen has been studied in patients with polymyalgia rheumatica, polymyositis, rheumatoid arthritis, and polyarteritis, and polyarteritis nodosa and in unrelated controls. Lymphocytes from patients with polymyalgia rheumatica showed transformation responses significantly higher to artery antigen than those in the other disease and control groups. The highest responses were found in patients with evidence of the most active clinical disease at the time of testing. It is suggested that the transformation response to arterial antigen might aid the diagnosis of polymyalgia rheumatica.
4049928	[Side effects of nonsteroidal and steroidal anti-inflammatory drugs on cartilage metabolis	1985 Jul	On the base of experiments with laboratory animals and in the clinical practice existing results confirmed that steroidal and any non-steroidal antiphlogistic drugs have antianabolic and catabolic side effects on the connective tissue--and special articular cartilage metabolism. Biochemical and pharmacological investigations have shown that any of these drugs excert inhibitory effects on synthesis special of proteoglycans of ground substance in the cartilage. The use of such drugs in therapy of osteoarthrosis should be short-timed and limited to the treatment of patients with a so called activation of osteoarthrosis. For the long-term pharmacotherapy of osteoarthrosis should be used such antiphlogistic drugs without inhibitory side effects on the cartilage metabolism. The risk in occurrence of progressive articular cartilage damage in the therapy, special long-term therapy, with antiphlogistic drugs and the existence of pathological metabolic changes as a favourable factor for aseptic osteochondronecroses respectively as praearthrotic deformity is probably greater as in normal metabolic situations. The application of steroidal antiphlogistic drugs lead initial to good therapy results with reference to objective and subjective disease signs. These drug-therapy should be succombed an account of the severe negative side effects on cartilage metabolism (risk of osteochondronecrosis) a strict diagnosis and limited for the therapy of patients with rheumatoid arthritis (acute phase).
6411401	Immune complexes in Hodgkin's disease: isolation, immunochemical and physico-chemical anal	1983 Aug	Immune complexes (IC) present in sera from patients with Hodgkin's disease (HD) were isolated using three different affinity columns: C1q-degalan, anti-C1q sepharose and conglutinin (K)-degalan. The isolated IC were analysed by immunoprecipitation, SDS-PAGE and sucrose density gradients and compared with IC similarly isolated from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and in vitro prepared BSA-anti-BSA complexes. Isolated material from each disease, and BSA-anti-BSA complexes contained proteins compatible with true immune complexes--IgM, IgG, C1q and C3 breakdown components. Albumin, fibronectin and CRP, whose affinity for IgM, C1q and C3 are known, were co-isolated along with IC material. The size of isolated IC in HD ranged from 8-40S on sucrose density gradients. Despite the operational difference in detecting and isolating HD complexes via the C1q ligand (C1q-degalan or anti-C1q column) and C3bi (K-degalan), material purified by both methods showed remarkable similarity on SDS-PAGE and immunoprecipitation analysis. Although IC isolated from different diseases showed disparate banding patterns on SDS-PAGE this was attributed to a variation in the relative concentrations of constituent proteins--IgM, IgG and C3 breakdown products. IgM, IgG and C3 bind loosely, and non-specifically, to macromolecular aggregates formed around immune complexes. Using the anti-C1q column, most of this material could be eluted using 0.02M EDTA. Least protein, yet the most specific for antigen and antibody was eluted at pH 3.0.
6970643	Naturally occurring human antibodies to the F(ab')2 portion of IgG.	1980 Nov	Antibodies to the F(ab')2 portion of IgG were detected in the sera of patients and normals using a heat-aggregated F(ab')2 fragment in a liquid-phase radioimmunoassay. The antibodies were found in 72% of 82 rheumatoid arthritis patients, in less than 20% of patients with other diseases and in a few normal subjects. Anti-F(ab')2 antibodies were distinct from previously described anti-Fc antibodies and 'serum agglutinators'. They reacted with intact IgG, F(ab')2 and IgM in binding and inhibition assays and they appeared to have specificity for the Fd portion of IgG molecules, possibly to the VH region. The anti-F(ab')2 antibodies were of both 7S IgG and 19S IgM classes and were found in sera as components of intermediate size (between 7S and 19S) and large size (greater than 19S) immune complexes. The possible contribution of autologous anti-F(ab')2 to abnormal immunoregulation is discussed.
975669	Duo-condylar knee arthroplasty: hospital for special surgery design.	1976 Oct	This is a report of 94 knees in 88 patients with the duo-condylar type of knee arthroplasty. The follow-up period of time was between 2 to 4 years with an average of 3 years. The rheumatoid to osteoarthritic patient ratio was 3 to 1. The overall results were excellent in 37.5 per cent, good in 37.5 per cent, fair in 16 per cent, and poor in 9 per cent. The main causes of failure and poor results were: (1) under or over correction of deformity leading to subluxation and/or instability of the knee; (2) loosening of the tibial component, and (3) symptoms arising from the patellofemoral joint. The revision rate is 5.5 per cent. The progressive radiolucency at the cement bone bond is 26 per cent of which 16 per cent is up to 1 mm and 10 per cent is between 1.5 to 3 mm. To further improve the results of arthroplasty, one should take into consideration (1) replacement of the patellofemoral joint, (2) insertion of the prosthesis in the proper anatomical location under correct tension of the ligaments and capsule with the help of proper instrumentation and (3) improvement in fixation of the tibial component.
942503	The role of osmic acid in the treatment of immune synovitis.	1976 Jul	Thirty-seven New Zealand rabbits were observed for up to 1 year after their knee joints were instilled with 1 ml of 1% osmic acid. A selective destruction of synovial lining cells occurred with a concurrent synovitis, but lining cell regenerated by the eighth week. Nonprogressive abnormalities were also present in the cartilage. When an immune synovitis was induced in both knees of 16 rabbits, the osmic acid treated joint demonstrated a significantly greater synovitis and progressive aberrations compared to the untreated knee.
6705356	The posterior cruciate condylar total knee prosthesis. A five-year follow-up study.	1984 Apr	Remarkable results were demonstrated for the nonlinked, semiconstrained total condylar knee prosthesis in the first long-term follow-up study. The posterior cruciate condylar prosthesis, a variation of the basic design, leaves the posterior cruciate ligament intact. Ninety-four consecutive knees were observed for a minimum postoperative follow-up period of five years. Apart from this design modification and a slightly different program of postoperative care, the methods and techniques used were identical to those used with the total condylar knee prosthesis. By the same method of assessment (The Hospital for Special Surgery Knee Rating Scale), 54 of the ninety-four knees (57.4%) were rated excellent; 37 (39.4%), good; two (2.1%), fair; and one (1.0%), poor. The average preoperative score was 48 points, and the average postoperative score was 81 points (85-100 points = excellent). The posterior cruciate condylar total knee prosthesis represents an excellent prosthetic design for a wide variety of knee deformities and maintains the posterior cruciate ligament for supplementary posterior support.
6447635	A monitored-release study of methrazone in general practice.	1980	Methrazone, a non-steroidal anti-inflammatory drug, was used on a monitored release study in general practice to treat 2,693 patients with rheumatoid or osteoarthritis. In a dose of 200 mg three times daily, it appeared to produce clear benefit in between 50% and 60% of patients. Adverse reactions such as dyspepsia and skin rash led to the drug being withdrawn in 11% of patients. There were three major adverse reactions possibly due to the drug (haematemesis, rectal bleeding and acute purpura), but no cases of severe leucopenia or thrombocytopenia. Methrazone is a useful anti-inflammatory agent. In particular, it is unlikely to cause interactions with other drugs, including cardiac glycosides such as digoxin.
4087268	Elevated granulocyte manganese in rheumatoid arthritis and other connective tissue disease	1985 Oct	Higher than normal amounts (p less than 0.001) of manganese were found in granulocytes isolated from patients with rheumatoid arthritis, other inflammatory arthritides, and scleroderma, while erythrocytes and platelets contained normal amounts of manganese. The cause of manganese accumulation is not known but evidently is linked to the intensity of the inflammatory process since significant positive correlations (p less than 0.001) were seen between erythrocyte sedimentation rate or serum haptoglobin and granulocyte manganese. During corticosteroid therapy granulocyte manganese started to return to normal levels but the relative changes were modest. Strong positive correlations (p less than 0.001) were found between granulocyte manganese and granulocyte stores of calcium and iron, suggesting a close relationship in the cellular regulation of these elements in chronic inflammatory conditions.
7381214	A comparison of two techniques for the detection of an antibody in human serum to Chang li	1980	The antibody-dependent cell-mediated cytotoxicity technique (ADCC) and an isotopic antiglobulin technique have been compared for their abilities to detect human serum antibodies to Chang liver cell membrane antigens. The optimal conditions were established for the latter technique, which was found to be superior with respect to reproducibility and sensitivity. Also, unlike ADCC, the isotopic antiglobulin technique was unaffected by other factors, such as immune complexes present in pathological sera.
2578705	Clinical manifestations of erythema chronicum migrans Afzelius in 161 patients. A comparis	1985	Clinical symptoms were studied in 161 consecutive patients with erythema chronicum migrans Afzelius and in a follow-up study signs of late manifestations were investigated. General symptoms such as headache, fever, myalgia and/or arthralgia were found in about half of the patients with a disease duration of less than or equal to 3 weeks. Three patients had coexisting lymphadenosis benigna cutis. Two untreated patients developed meningitis/meningoradiculitis and one untreated patient arthritis. The importance of a sufficient antibiotic therapy to prevent late manifestations is stressed. Although there are many similarities between erythema chronicum migrans Afzelius and Lyme disease, the results of the present study also point to differences. Multiple skin lesions, pronounced general symptoms, laboratory abnormalities and major symptoms from the joints were less common in patients with erythema chronicum migrans Afzelius than reported in patients with Lyme disease, but a prolonged course of the skin eruption was more common.
6318347	[Double-blind comparative study of slow-release ketoprofen and a placebo in chronic inflam	1983 Dec 12	Twenty-five inpatients with chronic inflammatory rheumatic disease were entered into a double blind crossover trial. Consecutive treatment regimens consisted of a single daily dose of Bi-Profenid 150 mg at 8 pm for 3 days and a single placebo tablet at 8 pm for 3 days. Order of treatment regimens was randomly assigned. Bi-Profenid proved highly superior to placebo with a very significant (p less than 0.01) difference in effectiveness on nocturnal pain, morning stiffness and pain evaluated on the pain scale. During the short treatment period no significant clinical side-effects were recorded. The authors conclude that Bi-Profenid is effective at a daily dosage of 150 mg, thus enabling to adjust prescriptions to actual needs when pain is not continuous throughout the 24 hours.
32614	Electrocardiographic findings in patients with connective tissue disease.	1978	ECG changes in 49 patients with rheumatoid arthritis, 18 with ankylosing spondylitis, 47 with systemic lupus erythematosus, 17 with dermatomyositis, 21 with scleroderma and 7 with polyarteritis nodosa were compared with ECG changes in 106 control subjects. The classification of ECG findings was based mainly on the Minnesota Code. Compared with control subjects, pathological Q--QS, ST segment and T wave patterns were more common in all patient groups--including dermatomyositis, in which cardiac involvement has rarely been reported. P terminal force (PTF) was higher in the patient group. Conduction defects were probably more common in connective tissue diseases, whereas differences in ectopic beats, arrhythmias, QRS duration and QRS axis and R wave amplitude were not significant. The only significant difference between the steroid-treated patients and those without such treatment was the higher frequency of ST changes in the steroid-treated group. The results imply that heart affection is common in all connective tissue diseases. The several mechanisms underlying the cardiac involvement are reflected in many ways in the electrocardiograms of these patients, including an increased frequency of ECG changes mimicking those met in coronary heart disease.