Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6982336 | Overlap syndrome of juvenile rheumatoid arthritis and systemic lupus erythematosus. | 1982 Jul | Two children with an overlap syndrome of juvenile rheumatoid arthritis (JRA) and systemic lupus erythematosus (SLE) are described. Both developed SLE years after presenting with typical JRA. | |
| 7223078 | A study of rheumatoid factors in juvenile rheumatoid arthritis (chronic polyarthritis) by | 1981 Jan | The photometric latex test (PLT) for the detection of rheumatoid factors (RF), developed and clinically evaluated in adult rheumatoid arthritis, was applied in a study of juvenile rheumatoid arthritis (JRA). A total of 40 individuals with JRA, 27 with other collagen diseases and 24 in a control group were examined. The incidence of seropositives by PLT was 50% in JRA, 33% in collagen diseases and 17% in controls. The percentage of JRA was significantly higher than in the controls, and also higher than values in the literature claiming that only about 20% of JRA patients are seropositive. These findings were discussed concerning the diagnostic capability of PLT as compared with other serologic tests for RF. The increase in PLT titer values was found to indicate an aggravation of the inflammatory process and could help estimate the clinical stage of the disease. A follow-up of patient titer values could be of great diagnostic value. The data on serum immunoglobulins and complement fractions levels could not confirm the findings on a significant increase in JRA patients, but following of "level profiles" of each patient could add to the estimation of patient's clinical status. In cases of seropositives when other laboratory parameters did not indicate a clear transition from the chronic active to acute stage of disease, the only parameter which often showed such a transition is the RF titer determined by PLT testing, which could be of importance for a timely change of the therapy. | |
| 6868560 | [Viremia in children with rheumatoid arthritis]. | 1983 Mar | The blood specimens from 22 children with rheumatoid arthritis, 57 children with other chronic diseases and 30 apparently normal children were tested for the presence of Coxsackie A and B, adeno, and rubella viruses by the method of co-cultivation of patient's lymphocytes with continuous HEp-2 cell culture. Children with chronic diseases were found to have viremia much more frequently than normal children. The frequency of finding of different viruses in patients with rheumatoid arthritis (86.4%) significantly exceeded that in healthy children (20%). These patients had rubella and adeno 5 viruses in their blood more frequently than children in the other groups under study. Repeated examinations of 14 patients with rheumatoid arthritis at intervals of 1 year or longer revealed in 11 of them the same viruses as those identified in initial examinations. Persistence of some viruses in patients with rheumatoid arthritis is discussed. | |
| 299941 | Juvenile rheumatoid arthritis. | 1977 Jan | Juvenile rheumatoid arthritis is a diverse group of diseases that includes systemic-onset, polyarticular, and pauciarticular types. Appreciation of the different types and their hallmarks is particularly important to accurate diagnosis, which is determined by exclusion of other known disease entities in children with chronic arthritis (more than three months' duration). Therapy should be directed at the arthritis per se (synovitis), at the extra-articular manifestations, and at the whole child. Salicylates provide the most satisfactory control of the arthritis per se and of the systemic manifestations in most cases. Iridocyclitis should be managed in consultation with an ophthalmologist. Patients should not be regarded as invalids or restricted needlessly. The prognosis for children with juvenile rheumatoid arthritis is good. In most patients, the disease remits without causing permanent joint damage. | |
| 1163505 | Increased circulating basophils in juvenile rheumatoid arthritis. A preliminary report. | 1975 Aug | Basophil counts were done in children with rheumatoid arthritis, using a special staining method. Basophils were increased in absolute number and in percentage in 11 of 16 patients with juvenile rheumatoid arthritis. This increase was particularly significant in children with active polyarticular arthritis. | |
| 6973957 | [Cellular immunity deficiency and chemotaxis deficiency in children with rheumatoid arthri | 1980 Sep | Some immunological parameters have been examined in eleven children with juvenile rheumatoid arthritis. A quantitative and functional defect in T lymphocytes has been observed associated with defective chemotaxis of neutrophils. High levels of circulating immune-complexes were detected in sera of 5 out 11 patients. 1 patient showed high levels of antinuclear antibodies and positivity for the rheumatoid factor. Immunological pathogenesis of juvenile rheumatoid arthritis is discussed. | |
| 7054755 | Role of self-esteem and autonomy in determining medication compliance among adolescents wi | 1982 Jan | This study was designed to improve understanding of adolescents' compliance with medical regimens. Compliance with salicylate therapy among adolescents with juvenile rheumatoid arthritis was examined in relationship to two of the most important issues of adolescent psychosocial development--self-image and autonomy. Standardized instruments that assessed these variables were administered to 38 adolescents with juvenile rheumatoid arthritis during the year in which compliance was determined, utilizing serum salicylate measurements. Patients and disease-related characteristics were also recorded, and interactions with personality variables were examined. The data show that adolescents with juvenile rheumatoid arthritis who comply with their medical regimen are those who have high self-esteem and are allowed more autonomy than the noncompliers. The longer the duration of the illness and the more symptoms present at onset, the poorer was self-concept, and hence compliance, at adolescence. | |
| 7246137 | Transient remission of juvenile rheumatoid arthritis after measles. | 1981 | A 4-year-old Japanese girl with systemic juvenile rheumatoid arthritis had an attack of measles. On the day following the first signs of measles she became afebrile and free of joint pain even though aspirin therapy was discontinued. The remission lasted for 10 days. It appears that the measles virus infection may have been responsible for the brief remission in this patient. The observation of a remission of juvenile rheumatoid arthritis after measles is extremely rare. | |
| 7447961 | Carpal ankylosis in juvenile rheumatoid arthritis. | 1980 Nov | Forty-seven of 100 consecutive juvenile rheumatoid arthritis patients with wrist arthritis were found to have ankylosis at the carpal joints. this finding was significantly more frequent in juvenile than in adult rheumatoid arthritis patients. The carpometacarpal wrist segment was the most frequently ankylosed. Ankylosis was not related to any particular feature of the disease, but disease duration was longer in patients with ankylosis. A significant association was found between carpal ankylosis and cervical apophyseal joint fusion. | |
| 6256964 | [Cyclic 3',5'-adenosine monophosphate in the liver of rats with experimental rheumatoid ar | 1980 Nov | Content of cAMP was distinctly decreased in rat liver tissue within the first days of development of experimental rheumatoid arthritis (adjuvant arthritis). Within 6 days the content of cAMP was slightly increased in liver tissue of the arthritic rats but it was lowered 2-fold as compared with controls. The content of cAMP was quite unaltered during subsequent course of the impairment (within 25 days). In blood plasma of patients with rheumatoid arthritis the content of cAMP was decreased more than 2-fold as compared with its concentration in blood of donors. Possible importance of cAMP deficiency in pathogenesis of rheumatoid arthritis is discussed. | |
| 177792 | Coxsackievirus and adenovirus infection. Association with acute febrile and juvenile rheum | 1976 Jun 7 | The prearthritic manifestations of juvenile rheumatoid arthritis in a 16-year-old boy were associated with a rise in coxsackievirus B3 and A9 neutralizing antibody titers from 1:16 to larger than or equal to 1:512, and 1:64 to 1:512, respectively. Recurrent polyarthritis followed and has persisted for three years. Adenovirus 7 was isolated from the pericardial fluid of a 9-year-old girl in whom juvenile rheumatoid arthritis then developed. Of 11 patients with acute, nonspecific, febrile arthritis subsequently studied, fourfold or greater antibody elevations occurred against coxsackieviruses in five, and against rubella and varicella-zoster virus in two. Antibody titers against other viral (and Mycoplasma) antigens remained stable. These findings suggest that coxsackieviruses, as well as other common viruses, may cause acute, nonspecific, febrile arthritis. In certain instances, such infection may be related to the development of juvenile rheumatoid arthritis. | |
| 6766468 | Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four fami | 1980 Mar | The occurrence of a chronic seronegative polyarthritis has been studied in four families in which the proband presented with some form of juvenile rheumatoid arthritis. In these families, histocompatibility testing suggested that susceptibility to arthritis was controlled by a dominant allele with variable penetrance and expressivity at the rheumatoid-like arthritis, first locus (RLA-1). The combined lod scores for the four families (2.70) indicated that the odds in favor of genetic linkage between the major histocompatibility complex and the postulated disease susceptibility gene, RLA-1, were 500:1. In one family, a recombinant event permitted localization of RLA-1 centromeric to HLA-D. Of major interest was the fact that there was significant pleomorphism in the clinical manifestations of arthritis in affected individuals. In some, symptoms first occurred in childhood and in others, in adult life. Even among those with childhood-onset arthritis, different types of juvenile rheumatoid arthritis were observed within the same family. | |
| 471556 | The triad of pneumonitis, pleuritis, and pericarditis in juvenile rheumatoid arthritis. | 1979 Jul 24 | There are few reports of pleuroparenchymal and pericardial involvement secondary to juvenile rheumatoid arthritis (JRA) in the literature. This article presents two such cases and gathers scattered information about this combination previously reported by few others. We wish to emphasize that the combination of pericardial and pleuropulmonary involvement in a youngster may be the only presenting clinical manifestations of rheumatoid arthritis, whereas in others, it may be associated with arthritic symptoms at the same time. | |
| 6968108 | Cellular immunity to secretory IgA (as a common duct antigen of exocrine glands) in Sjögr | 1980 Apr | Autoimmunity to salivary duct cells has been suggested in Sjögren's symdrome (SjS). We were interested in the secretory component (SC) of secretory IgA (s-IgA) as a common duct cell antigen of systemic exocrine glands because of the possible analogy between SC in SjS and thyroglobulin in Hashimoto's thyroiditis. Therefore, we isolated s-IgA as a source of SC from human milk and investigated lymphocyte responses to s-IgA in patients with SjS. Higher mitogenic indices against s-IgA were demonstrated in SjS than in rheumatoid arthritis, other autoimmune diseases and normal persons. In addition, mitogenic indices in patients with SjS alone were significantly higher than those in SjS patients with associated diseases. These results suggest both the role of SC as a common antigen of exocrine glands in the pathology of SjS, and the presence of an etiologically different subgroup in patients with SjS. | |
| 4047803 | Transient thrombocytopenia in systemic onset juvenile rheumatoid arthritis. | 1985 Oct | Three children have been presented who have had long-standing, typical systemic juvenile rheumatoid arthritis. They also had a transient illness with thrombocytopenia, antiplatelet antibodies, and the simultaneous appearance of anti-DNA antibodies and hypocomplementemia. Other single abnormalities included the development of a positive ANA, Coombs, and lupus bands test. All responded to high-dose steroid therapy. Their similar clinical and serologic findings are noteworthy and represent one of the numerous complications seen in patients with systemic juvenile rheumatoid arthritis. | |
| 303520 | Circulating immune complexes and antinuclear antibodies in juvenile rheumatoid arthritis. | 1977 Nov | Materials with the Clq binding properties of soluble immune complexes (IC) were found in sera from 11 of 51 consecutive (22%) children with juvenile rheumatoid arthritis (JRA) and in 17 of 20 adults with active seropositive rheumatoid arthritis (RA). IC appeared more frequently in children with systemic onset disease whereas antinuclear antibody (ANA) was found more frequently in sera from those with pauciarticular disease. Only 3 JRA sera contained anti-immunoglobulin (rheumatoid factor); those 3 also had high Clq binding activities. Seven of 50 patients (14%) carried HLA-B27 but B27 was not associated with high Clq binding activity or presence of ANA. The presence of free ANA more frequently in children with mild disease and IC more frequently in children with relatively severe disease suggests that children with systemic JRA may have a relative defect in antibody-forming capacity or reticuloendothelial function which results in decreased clearance of circulating IC. Alternatively, systemic, polyarticular, and pauciarticular JRA may represent a spectrum of clinically similar diseases resulting from different etiologic agents. | |
| 6978420 | Juvenile rheumatoid arthritis with IgA deficiency and appearance with febrile episode. | 1981 Jul | A 24-year-old female had juvenile rheumatoid arthritis since the age of 3, with systemic manifestations such as fever, polyarthralgia, micrognathia, splenomegaly, hepatomegaly, lymphadenopathy, subcutaneous nodules, hidden rheumatoid factor of IgG type. Particularly noteworthy is selective IgA deficiency in this patient, with increases in concentration up to 50 mg/dl in the serum concurrently with the repeated febrile attacks in the clinical course. | |
| 6968511 | The CREST syndrome: a distinct serologic entity with anticentromere antibodies. | 1980 Oct | The CREST syndrome is a variant of systemic sclerosis characterized by the presence of calcinosis. Raynaud's phenomenon, esophageal motility abnormalities, sclerodactyly and telangiectasia. The serums of 27 patients with the CREST syndrome have been examined for the presence of antinuclear antibodies. Twenty-six of 27 (98 percent) serums contained high titers (> one:80) of an antibody that produces a discrete speckled pattern of immunofluorescence on a human laryngeal carcinoma cell line (HEp-2). The antibody has been shown to react with the centromeric region of metaphase chromosomes. This antibody was also found in three of 14 patients with Raynaud's disease, in one of 60 patients with systemic lupus erythematosus, in three of 26 patients with systemic sclerosis with diffuse scleroderma and in one of 15 patients with mixed connective tissue disease. The antibody was not detected in the serums of patients with rheumatoid arthritis. Sjögren's sicca complex or linear scleroderma. Patients with osteoarthritis who were age- and sex-matched to the group with the CREST syndrome did not have anticentromere antibodies. Autoantibodies found in other connective tissue diseases (anti-DNA, anti-RNP, Sjögren's syndrome antigen B (anti-SS-B) were not found in serums from patients with the CREST syndrome. A case report illustrating the appearance of the anticentromere antibody at a time when Raynaud's phenomenon antedated the clinical diagnosis of CREST syndrome is presented. | |
| 911449 | [Juvenile rheumatoid artritis (a single or various diseases?]. | 1977 Jul | Some characteristics of juvenile rheumatoid arthritis that appeared in recent literature have led us to think that it can be divided into the following four groups: I. Seronegative poliarthritis, with more or less systemic symptoms. With the same characteristics it may appear in adulthood. II. Seropositive poliarthritis, identical to the adult rheumatoid arthritis. III. B-27 negative oligoarthritis, complicated frequently with chronic uveitis and autolimited course. IV. B-27 positive oligoarthritis evolving to ankylosing spondylitis. These groups may represent different diseases. | |
| 7396611 | An adult form of juvenile rheumatoid arthritis. | 1980 Aug | The conditions of five adults were eventually diagnosed as juvenile rheumatoid arthritis (Still's disease). Prolonged hospitalization, repetitive roentogenographic examinations, biopsies, laparotomies, and therapeutic trials with toxic agents preceded the establishment of the final diagnosis. Common early findings in all cases were prolonged "septic fever," polyarthralgia, and an elevated ESR. Three patients had a rash, four had splenomegaly, three had a vague history of a similar disease, and four had leukocytosis. Some of the patients were older than others described in the literature. Two received immunosuppressive agents and did relatively well. In view of our experience and the few reports in the literature, we concluded that juvenile rheumatoid arthritis in adults has to be seriously considered in the presence of prolonged septic fever, polyarthralgia, rash, and splenomegaly, before harmful drugs are given or risky procedures are performed. |