Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4036917 | Reye syndrome and juvenile rheumatoid arthritis in Michigan. | 1985 Sep | Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy. We reviewed all cases of RS reported to the Michigan Department of Public Health during 1982 and 1983. Three of the 36 patients were receiving aspirin for the treatment of juvenile rheumatoid arthritis. All three patients had clinical courses characteristic of RS and two had supportive histologic findings on liver biopsy. The incidence of RS among children with juvenile rheumatoid arthritis is significantly greater than the incidence of RS among children who do not have juvenile rheumatoid arthritis. These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS. Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses. | |
| 1008941 | [Juvenile rheumatoid arthritis, Report of 12 cases]. | 1976 Nov | This report includes 12 cases of juvenile rheumatoid arthritis seen through a period of 4 years of Unidad de PediatrÃa del Hospital General de México, S.S.A. An analysis is made on the etiology, prevalence, clinical symptoms, laboratory findings, radiology and treatment. The youngest patient was 3 years old and the oldest 14. Three groups were formed on the basis of the mode of onset; 4 patients were included in the systemic group, 7 in de polyarthritis and one in the monoarticular. All patients showed arthralgias and flogosis with joint disability in one or more joints; eleven patients developed joint deformity; 4 patients had fever and rheumatoid rash was detected during the course of the disease. Subcutaneous nodules were detected in one patient. Radiological abnormalities, compatible with juvenile rheumatoid arthritis, were found in all patients. Laboratory findings are discussed and a clinical correlation is made in order to emphasize the differences with adult disease. The principles of general treatment are analyzed including, medical, phychologic and rehabilitation programs. Pertinent literature is reviewed. | |
| 7247594 | Juvenile rheumatoid arthritis with pericardial tamponade in an adult. | 1981 Jul | A 25-year-old man was initially seen with pericardial tamponade as a manifestation most probably of juvenile rheumatoid arthritis that had been quiescent for 18 years. A pericardial window relieved the tamponade. Immunofluorescence studies of the pericardial tissue disclosed no deposits of immunoglobulin of complement. | |
| 6354195 | Probable depiction of juvenile arthritis by Sandro Botticelli. | 1983 Oct | There is a question whether rheumatoid arthritis is a disease of recent or ancient onset since it was only first described in 1800. In support of its earlier appearance are depictions of rheumatoid hands in Flemish paintings of the fifteenth through eighteenth centuries. The first description of juvenile arthritis is attributed to Cornil in 1864, making the question of its antiquity also pertinent. We show here that the "Portrait of a Youth," painted in 1483 by the Florentine artist Sandro Botticelli, has features of rheumatoid arthritis in the hand of the subject, who would be young enough to be considered as having juvenile arthritis. A review of all of Botticelli's paintings revealed that these changes could not be attributed to stylistic traits. Neither could they be attributed to lack of technique, for he has been considered a superb artist. If the "Portrait of a Youth" does indeed represent juvenile arthritis, it would mean that this disease is older than its initial description would indicate. | |
| 6610463 | Prognostic factors in palindromic rheumatism. | 1984 Apr | Thirty-eight patients with palindromic rheumatism were reviewed. A questionnaire was compiled to elucidate prognostic factors in the pattern of disease. Over the period of follow-up 6 patients had developed rheumatoid arthritis, 25 remained palindromic, 3 were in remission of symptoms for over a year, 1 developed ankylosing spondylitis, 1 systemic lupus erythematosus and 2 a non-specific polyarthritis. The duration and interval between attacks was variable and did not differ significantly between the palindromic and rheumatoid groups. All patients who developed rheumatoid had a combination of morning stiffness and pain in several joints at once, whereas only 28% of the palindromics did so, (p <0.01). There was a tendency for episodes of joint pain to occur with increasing frequency and for the plasma viscosity to be persistently elevated in those who developed rheumatoid arthritis. Neither a family history of rheumatoid arthritis nor a positive serum rheumatoid factor test at presentation were of prognostic significance. Oral analgesics or symptomatic measures for the relief of joint pain were effective in the majority of patients. | |
| 4087814 | [Genetic aspects of Behçet's disease and juvenile rheumatoid arthritis]. | 1985 Nov | Diagnosis of Behçet's disease in a subject implies that the monosymptomatic aphthae in other members of the family, which are also caused by genetic factors, should be considered as malignant aphthosis. In seronegative juvenile rheumatoid arthritis without common symptoms with anterior uveitis, genetic factors also play an important role. | |
| 3977974 | Evidence for intravascular coagulation in systemic onset, but not polyarticular, juvenile | 1985 Mar | After observing a child with systemic onset juvenile rheumatoid arthritis (S-JRA) who developed purpura fulminans in association with disseminated intravascular coagulation, with subsequent gangrene and autoamputation, we undertook a prospective study of coagulation parameters in children with JRA. Ten consecutive children with S-JRA, 10 children with rheumatoid factor-negative, polyarticular juvenile rheumatoid arthritis (P-JRA), and 10 age- and sex-matched controls were studied. Routine coagulation screening tests were performed, as were tests for plasma fibrinopeptide A (a sensitive measure of intravascular thrombin generation), factor VIII-related antigen (an endothelial cell protein), and platelet factor 4 (a platelet-secreted protein). Our studies suggest that activation of intravascular coagulation is common in systemic onset JRA, but not in rheumatoid factor-negative, polyarticular disease. The coagulopathy may cause severe morbidity. In addition, marked elevations of plasma factor VIII-related antigen suggest perturbation of endothelial cells and vascular involvement in S-JRA, but not in P-JRA. Normal ranges of platelet factor 4 indicate that intravascular platelet consumption does not occur in either type of JRA, despite the thrombocytosis common in both. | |
| 6617001 | The cervical spine in juvenile rheumatoid arthritis. | 1983 Oct | Clinical and roentgenographic follow-up examinations of patients with juvenile rheumatoid arthritis (JRA) suggest that neurologic complications are less likely to develop in these patients than in patients with adult rheumatoid arthritis (RA). A review of the charts of 92 patients treated for JRA during the period from 1970 to 1976 revealed that 29 (31%) had clinical evidence of cervical spine involvement. Follow-up examinations in 15 of these 29 patients revealed that all had limited cervical spine motion, 14 had neck pain and stiffness, and two had torticollis. Roentgenographic evidence of atlantoaxial subluxation was present in five patients and ankylosis of the facet joints in four. Two patients with atlantoaxial subluxation had hypereflexia and clonus, but both long tract signs and subluxation spontaneously resolved in one of these patients. None of these patients had basilar invagination or subaxial instability, which can occur in adult RA. | |
| 7247445 | Rubella and juvenile chronic arthritis. | 1981 Apr | A 9-year-old boy with a clinical illness similar to juvenile rheumatoid arthritis was found to have rubella virus in the synovial fluid. There was complete remission of symptoms after 3 months. The role of rubella virus as a possible possible aetiological agent in juvenile rheumatoid arthritis is discussed. | |
| 1221374 | Pulmonary lesions in the course of rheumatoid arthritis in children. | 1975 May | Pulmonary morphological lesions are described in 16 children who died of rheumatoid arthritis. In all of them the disease had a stormy course. Generalized amyloidosis was the most frequent cause of death. The majority of cases showed clinical and morphological lung lesions. The lung lesions were only rarely the chief cause of death. There were no formations of the type of rheumatoid nodule nor diffuse lung fibrosis. There was only peribronchial and perivascular fibrosis as well as thickening of interalveolar septa. The most frequent abnormalities, namely lung congestion and edema could result from extrapulmonary causes or agony. Although the observed lung lesions are nonspecific, they can reflect the generalization of the disease. | |
| 324479 | Lymphocytes eluted from synovial tissue of juvenile rheumatoid arthritis patients. | 1977 Apr | Synovial tissues from 11 patients with juvenile rheumatoid arthritis were investigated. The elution of lymphocytes was performed according to a procedure previously described for synovial tissue of adult rheumatoid arthritis patients (1). The T lymphocytes were pre dominant (mean: 71%) in all cell suspensions studied, whereas the average proportion of B lymphocytes was 4%. In addition, Fc-receptor-bearing lymphocytes were demonstrable (mean: 8%). Transformation of the lymphocytes was induced by the unspecific mitrogens phytohemagglutinin, pokeweed mitogen, and concanavallin A, whereas antigens such as ppd and candida albicans antigen were usually ineffective. | |
| 159607 | Antigammaglobulin antibodies in experimental adjuvant arthritis. | 1979 | Several-fold administration of complete Freund's adjuvant in rat provoked acute arthritis accompanied by production of antigammaglobulin antibodies in a high percentage from the animals studied; their sera precipitate homologous and heterologous aggregated IgG and demonstrate hemagglutination titers up to 1 : 1792. To confirm the Ig type of the studied antibodies, rat sera were fractionated by gel filtration on Sephadex G200 by pH = 4.0 and by preparative ultra-centrifugation by pH = 3.6. It was established that the antibodies are of IgM type. - The presence of autoantibodies in an autoimmune disease, such as experimental adjuvant arthritis similar to the rheumatoid factors in human rheumatoid arthritis gives support to the statement that autoimmune processes are involved in the etiology of rheumatoid arthritis in men. | |
| 6269326 | [Profilographic studies with 99mTc-pertechnetate in joint diseases in children]. | 1981 May | The inflammatory activity of joints can be stated after intravenous administration of 99mTc-pertechnetate by demonstration of an enrichment of isotope. In 85 out of 111 patients (77%) a good accordance between profilogram and clinical finding could be seen. "False positive" results could be found in juvenile rheumatoid arthritis, ulcerative colitis, reactive arthritis and juvenile gout. In some cases of juvenile rheumatoid arthritis the clinical finding is later obvious than the demonstration by nuclear medicine. "False negative" results mainly can be seen at the wrists of patients with juvenile rheumatoid arthritis and tendosynovitis as well as in already existing radiological changes of the bones. Differential diagnostical evidences of profilography cannot be expected with the investigation technique used here. It, however, may contribute to assure the diagnosis in non-inflammatory joint diseases ("psychogenic rheumatism", lymphatic oedema). | |
| 4058984 | Childhood sarcoidosis manifesting as juvenile rheumatoid arthritis. | 1985 Nov | Sarcoidosis in childhood may manifest primarily as arthropathy and uveitis, mimicking juvenile rheumatoid arthritis. The characteristic appearance and course of the inflammation at these sites, particularly the uveitis, is often a major clue to correct diagnosis. These children generally do not have the fulminant systemic manifestations such as pulmonary disease usually ascribed to sarcoidosis. | |
| 6689990 | Diaphragmatic weakness and myositis associated with systemic juvenile rheumatoid arthritis | 1984 Jan 1 | An unusual presentation of systemic juvenile rheumatoid arthritis in a young adult is reported. Among the major manifestations were severe muscle weakness and dyspnea, which were found to be due to myositis and diaphragmatic weakness. The evolution of the disease and its response to therapy are described. | |
| 629596 | Synovial cysts in juvenile rheumatoid arthritis. | 1978 Feb | In a case of juvenile rheumatoid arthritis with large synovial cysts, cyst fluid aspiration was performed to relieve pain, but recurrence was prevented with salicylate therapy alone. The mechanism of formation of synovial cysts is discussed. | |
| 1248485 | Corticosteroid treatment of juvenile chronic polyarthritis over 22 years. | 1976 Jan 2 | Between the years 1952 and 1974, 1293 children aged from 1-14 years with the adult type of rheumatoid arthritis and Still's disease were admitted, of whom 793 or 61.2% received oral corticosteroids, mostly in the form of continuous therapy. In all children with Still's syndrome (476 cases, of whom 84.4% received corticosteroid therapy), as well as in 75% of the children with rheumatoid arthritis (817 cases, 47.1% under corticosteroid treatment) the therapy had already been initiated by the referring institutions. The mortality and morbidity of corticosteroid treated children is compared with the results from the precortisosteroid era. The influence upon rheumatic activity as well as on joint pathology was compared in groups of patients with rheumatoid arthritis with and without steroid therapy. Corticosteroid therapy led to a significant reduction in the early mortality from myo- and pericarditis in Still's syndrome. On the other hand, the late mortality of 5% was encumbered with a high incidence of direct sequelae of longterm corticosteroid therapy and secondary diseases, especially amyloidosis. Furthermore, more than half of the children on longterm treatment had severe irreversible, and partially fatal lesions. The results of the present investigation strongly suggest that the indications for and the manner of using corticosteroids in treating rheumatoid arthritis and Still's syndrome ought to be revised. | |
| 23952277 | Occupational therapy intervention for the adolescent with juvenile rheumatoid arthritis. | 1985 | Juvenile Rheumatoid Arthritis (JRA) is a chronic disease capable of producing significant physical and psychosocial disabilities. Consequently, the achievement of the normal developmental tasks of adolescence is often laborious and delayed in the young person with JRA. Literature has documented this delay but has not proposed intervention strategies specific to this population. This paper will discuss psychosocial and role adjustment problems typical of the adolescent with Juvenile Rheumatoid Arthritis, then present treatment strategies to facilitate the acquisition of selected developmental tasks as defined by Havighurst. | |
| 737017 | Complement-fixing hidden rheumatoid factor in juvenile rheumatoid arthritis. | 1978 Nov | Fifteen to twenty percent of patients with juvenile rheumatoid arthritis (JRA) have positive latex fixation tests (LFT), whereas approximately 46% have previously been demonstrated to have hidden rheumatoid factors (RF), i.e., 19S IgM RF which can be detected by the LFT after acid separation of the IgM-containing fraction from serum. In this study, hidden RF were found in 59% of patients with seronegative JRA by use of a complement-dependent hemolytic assay. The median titer of JRA patients was 1:42, and in healthy and disease controls it was 1:7. The difference was significant at P less than 0.001. When data from patients with active disease were analyzed separately, the median titer for polyarticular JRA was 1:97 and for pauciarticular JRA, 1:91. The differences due to active disease were significant at P less than 0.001 and P less than 0.005, respectively. The results demonstrate that the hemolytic assay is more sensitive than the LFT in determining the presence of hidden RF, and activity of disease correlates well with high hemolytic RF titers. | |
| 6408097 | Ectopic ossification following total hip replacement in juvenile chronic arthritis. | 1983 Jul | Of twenty-one patients with juvenile chronic arthritis (seventeen with juvenile rheumatoid arthritis and four with juvenile ankylosing spondylitis) who had total hip replacement before the age of thirty years, thirteen patients (62 per cent) showed different degrees of ectopic ossification: nine (53 per cent) of the seventeen with juvenile rheumatoid arthritis and all four of those with juvenile ankylosing spondylitis. Human leukocyte antigen B5 was found with an increased frequency in the patients with ectopic ossification. Functional capacity was not impaired regardless of the severity of the ectopic ossification. As in patients with adult-onset disease, ectopic ossification after total hip replacement occurred with a higher frequency in the patients with juvenile-onset ankylosing spondylitis than in those with juvenile-onset rheumatoid arthritis. |