Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6225084 | [Inflammatory rheumatism in children. Definitions and nosology]. | 1983 Sep 3 | In this critical nosological study of chronic juvenile rheumatoid arthritis, the author opposes his own pluralist concept based on a longitudinal analysis of the overall development to the conventional unicist concept in which the three forms of the disease are regarded as initial presentations of one single entity. The relationship between the systemic form and the abarticular hyperimmune syndromes previously described by Wissler and Fanconi is stressed. Similarities between juvenile rheumatoid arthritis and reactional inflammatory joint diseases of well defined aetiology are discussed; both are considered articular immune reactions to more or less demonstrable antigens. In the absence of specific laboratory tests, the disease can only be defined on clinical grounds. Without being exceedingly wide, this definition should be less restrictive than that based on currently accepted criteria. | |
| 4083017 | Analysis of rheumatoid factors by a biotin-avidin based isotype-specific ELISA. | 1985 Oct | A one day enzyme immunoassay for the detection of rheumatoid factors of the IgG, IgM, and IgA class is described. The assay utilizes rabbit IgG as solid-phase reactant and the biotin-avidin interaction for the coupling of enzyme to indicator antibody. Three different indicator antibodies discriminated effectively between rheumatoid arthritis patients and normal subjects. F(ab')2 fragments of goat antibodies were found best suited for the test. Rheumatoid factor activity was expressed in U/ml by comparing samples to an internal standard, which was related to the WHO international reference serum for rheumatoid arthritis. Rheumatoid factor activity (U/ml) in the IgM-specific assay showed a close correlation to the latex agglutination titer. Avidity indices estimated from the slopes of the dose response curves of test sera were significantly higher for rheumatoid arthritis patients than for a group of healthy persons, indicating a higher avidity of the rheumatoid factors in the patients' sera. | |
| 808780 | Characteristics of juvenile rheumatoid arthritis: its medical and orthopedic management. | 1975 Jul | The characteristics of juvenile rheumatoid arthritis have been presented and the important features of its medical and orthopedic management described. Surgical experience in a carefully studied group of 200 patients has been recounted. The increasing importance of reconstructive joint surgery is noted, preferably performed after growth has stopped. | |
| 6973386 | [Juvenile rheumatoid arthritis and HLA-B27]. | 1980 Sep 6 | Forty children with juvenile rheumatoid arthritis were studied to determine the frequency of the histocompatibility antigen HLA [human leukocyte antigen)-B27 in this disease and to characterize the arthropathy associated with this antigen. HLA-B27 was detected in four patients (10%). Its presence was associated in a statistically significant manner with sacroiliitis demonstrated radiologically and with a greater age at the time symptoms in the joints first appeared; this age was, on average, 10 years, compared with 6.29 years for the children without HLA-B27. | |
| 1257705 | Arthritis and hypogammaglobulinaemia. A. Family survey. | 1976 | 1. Hypogammaglobulinaemic patients admitted to the Medical Research Council's immunoglobulin therapy trials up to 1963 were examined for evidence of arthritis and were compared with population samples from Leigh, Wensleydale and Watford which were used as controls. 2. Four out of 60 males had inflammatory polyarthritis compared with an expected 0.4. In addition, 3 had synovitis limited to the knees and 4 had had polyarthritis in the past, the expected figures being 0.12 and 2.4 respectively. None of the patients had definite rheumatoid arthritis as defined by the American Rheumatism Association Criteria, though one satisfied the New York Criteria for Still's disease. All were seronegative and none of the patients with polyarthritis had radiological evidence of arthritis. None of the 18 female patients had arthritis. The prevalence of arthritis of synovitis in males was 29% in 1964, but in the following 3 years varied between 8 and 11%, suggesting a strong environmental influence. 3. All of the 7 males with inflammatory polyarthritis had levels of IgG, IgA, IgM and IgD, which were less than 30% of the standard normals and steatorrhoea was present in three. Steatorrhoea was also noted in 2 of 5 patients wih arthritis who died before the start of the survey, compared with 7% of all the males. 4. Clinical inflammatory polyarthritis was no more common in the first-degree relatives of patients with hypogammaglobulinaemia than in the population as a whole and they had no excess of erosive arthritis visible in X-rays of the hands or feet nor was sacro-iliitis excessively frequent. 5. Positive tests for rheumatoid factor were found in only 2 of the patients with hypogammaglobulinaemia and the first-degree relatives had no more positive sheep cell agglutination or latex fixation tests than expected in random population samples. 6. It is concluded that the seronegative polyarthritis which occurs in patients with hypogammaglobulinaemia is unrelated genetically to rheumatoid arthritis or Still's disease. | |
| 6401327 | Auranofin in the treatment of juvenile rheumatoid arthritis. | 1983 Jan | Auranofin (triethylphosphine gold) was administered to 21 patients with juvenile rheumatoid arthritis during an open-ended, open-label, noncontrolled trial designed to establish safety and preliminary efficacy. Initial dosage was 0.1 mg/kg/day; incremental increases to 0.2 mg/kg/day were allowed. Aspirin (80 mg/kg/day), tolmetin (20 to 40 mg/kg/day), and naproxen (400 to 600 mg/m2/day) were allowed as rapidly acting anti-inflammatory agents. All patients attained measurable plasma concentrations of gold during the study. Clinically significant improvement (greater than 25%) occurred in more than half the patients with regard to the number and severity of joints with swelling, pain on motion, and tenderness. The number of joints with active arthritis decreased by at least 25% in nine of the 19 patients. Group mean changes between the initial and final visit indicated improvement in all articular disease indices measured. Eleven of 16 patients with an elevated erythrocyte sedimentation rate showed decreases of at least 25%. The group given the higher dosage had a greater proportion of responders with decreases in erythrocyte sedimentation rate. Four of six patients whose sera contained rheumatoid factor showed decreases in its titer. Discontinuation of auranofin was necessary in two patients because of headaches and because of hematuria and anemia associated with a severe flare of polyarticular disease, respectively. The results from this trial are sufficiently encouraging to merit a double-blind trial of auranofin in children with juvenile rheumatoid arthritis. | |
| 6462810 | Late sequelae of juvenile rheumatoid arthritis of the hip: a follow-up study into adulthoo | 1984 | A 4-13 year follow up study of 29 patients with juvenile rheumatoid arthritis into adulthood revealed several structural deformities of the hips: coxa magna, short femoral neck, subluxations associated with large cyst-like erosions of femur and acetabulum near the ligamentum teres and a flattened, wide femoral head (without steroid treatment). The deformities evoke the possibility of ischemia of the femoral head in the presence of active, compressive synovial proliferation during the growth period in a joint with largely intra-articular nutrient vessels. | |
| 646890 | [Juvenile rheumatoid arthritis. Study of 46 cases]. | 1978 Jul | Forty-six children with the diagnosis of juvenile rheumatoid arthritis (JRA) were studied according to the criterion of the American Rheumatism Association (ARA). No predominance was seen in terms of sex. Preschool age was preferably affected and the poliarticular form was the most frequent at the initiation. Sixty per cent of the cases followed a recurrent course. The routine clinical manifestations were fever, arthralgia, visceromegalia and exanthema. The knees were found to be the joints most frequently affected in one half of the cases. The laboratory tests showed in all of the cases, increased sedimentation rate, hypergammaglobulinemia and in 33% of the cases, the rheumatoid factor was positive. The most frequent X-ray changes were: increase of soft parts and osteoporosis in 38% of the cases, without radiological changes in 25% of them. Thirty-four percent of the patients remained without articular sequelae and approximately in one half of the cases, functional incapacity was minimal. | |
| 7092005 | Mumps arthritis: unusual presentation as adult Still's disease. | 1982 Jul | The clinical spectrum of Still's disease suggests disseminated infection. Although the cause of this syndrome remains unknown, recent case reports have noted its association with various viruses. Increased antiviral titers to rubella, coxsackieviruses, and adenovirus have been noted in patients with syndromes similar to juvenile rheumatoid arthritis. We describe a patient with apparent adult Still's disease in whom a significant rise in mumps antibody titers was observed. Arthritis in association with mumps infection is a relatively rare condition. To our knowledge, this is the first report of mumps virus infection related to a disorder similar to juvenile rheumatoid arthritis. | |
| 7459014 | [Evaluation of some inflammatory and immune parameters in juvenile rheumatoid arthritis du | 1980 Mar 31 | A serologic study was carried out in 27 children.-- 12 females and 15 males -- affected with juvenile rheumatoid arthritis (JRA), systemic and polyarticular type, in active phase and in remission. Beside the routine assays (ESR and haemometry), a dosage of serum immunoglobulins (IgA, M, G) and complement components (C3 and C4) was carried out; antinuclear antibodies with immunofluorescence, rheumatoid factors with classical method (latex test and Waaler-Rose reaction) and antigamma factors (AGGF) according to modified Schur's method were looked for. Polymorphonuclear function was assayed employing NBT test, phagocytosis and killing with Klebsiella. The results confirmed that the most reliable activity index is the ESR, while the WBC count is move variable and that the rheumatoid factors according to the usual techniques are almost always absent. As a whole, in JRA the levels of IgM, IgG, IgM-AGGF, C4 assayed higher than in controls. In the different subgroups, the systemic disease is characterized by higher serum IgA and IgG-AGFF. The PMN function was globally normal. | |
| 6990934 | Culture-negative septic arthritis and bacterial endocarditis. Diagnosis by synovial biopsy | 1980 May | The capacity of bacterial endocarditis to mimic other systemic illnesses is well known. This report describes a patient with blood culture-negative bacterial endocarditis who presented with features suggestive of rheumatoid arthritis. Despite sterile synovial fluid, synovial biopsy culture resulted in identification of the causative organism and led to specific antibiotic therapy and cure. This is the first report of such a case. | |
| 24822613 | Fatigue fracture of the femoral neck after total knee arthroplasty a case report. | 1984 Jan 1 | Prolonged immobility predisposes to a multitude of medical problems. In the rheumatoid patient, immobility contributes to a preexisting problem of osteoporosis. Our patient with longstanding rheumatoid arthritis underwent total knee arthroplasty and subsequently developed a fatigue fracture of the ipsilateral femoral neck. To our knowledge, this is the first such case to be reported in a patient with rheumatoid arthritis. | |
| 886550 | Adult sexuality and juvenile rheumatoid arthritis. | 1977 Spring | Fifty-eight adults, 37 females and 21 males, were examined and interviewed in a follow-up study, an average of 14.5 years from the onset of juvenile rheumatoid arthritis. Sexual activities of 52 patients were found similar to their peers in the general population. Thirty-eight per cent expressed a need for sexual counselling. Activity of disease rather than severity of joint deformity was found to be the more inhibiting factor in sexual activity. Sexual counselling can help to combat some of these limitations. Sexual counselling should be an integral part of the total treatment provided these patients. | |
| 607392 | Platelet count and disease activity in juvenile rheumatoid arthritis. | 1977 | Blood samples from 41 children with juvenile rheumatoid arthritis (JRA) were studied. The platelet count was tested for possible relationship and correlation with a number of clinical and laboratory parameters. High platelet count was associated with active disease, presence of secondary amyloidosis, and poor functional capacity. The platelet count was positively correlated with the erythrocyte sedimentation rate, anemia, and granulocytosis. The platelet count thus seems to provide an additional parameter of disease activity in patients with JRA. | |
| 6335856 | Yersinia antibodies in inflammatory joint diseases. | 1983 Jul | The occurrence of IgM, IgG and IgA class Yersinia antibodies was studied at the beginning of an inflammatory joint disease and one year later in 354 adult patients using an ELISA technique. The control groups consisted of age and sex matched healthy persons living in the same geographical area as the patients, and of 64 patients with chronic rheumatoid arthritis. Yersinia antibodies of any Ig class were found in 9.0% of all the patients at the beginning of the disease, in 4.0% of the healthy controls and in 1.6% of the patients with chronic rheumatoid arthritis. Patients with ankylosing spondylitis, Reiter's disease or other reactive arthritis showed the highest prevalence (19.4%) of Yersinia antibodies, but in the whole material one half of the patients with Yersinia antibodies were clinically classified as rheumatoid or nonspecific arthritis. The elevated prevalence of Yersinia antibodies in patients with probable rheumatoid or nonspecific arthritis may indicate a reactive etiopathogenesis of arthritis also in some cases without previous evidence of gastrointestinal infection. Quantitation of IgG and IgA antibodies to Yersinia is important in the diagnosis of Yersinia arthritis. These antibodies may not be detected by the generally used agglutination test. | |
| 7282430 | Comparison between three radiographic techniques for examination of the temporomandibular | 1981 | Comparison between orthopantomography, conventional radiography and lateral tomography for diagnosing arthritic lesions in the temporomandibular joints of 42 children with juvenile rheumatoid arthritis showed that each method seems to have diagnostic limitations. Concordance values of about 70 per cent were obtained. Most often destructive lesions of both the mandibular head and the fossa were observed at tomography. Secondary arthrosis, particularly sclerosis of the fossa, was most often diagnosed at conventional radiography. A combination of radiographic techniques seems to be most reliable for diagnosing arthritic joint abnormalities in children. | |
| 6880414 | [Serum ferritin as an indicator for iron substitution in patients with chronic polyarthrit | 1983 May | 20 patients with rheumatoid arthritis were treated with oral iron for 6 months and hematological parameters including serum ferritin levels and iron absorption were studied. 13 patients (group 1) had iron deficiency as estimated by low serum ferritin concentration (less than or equal to 30 micrograms/l); the other 7 patients (group 2) revealed normal ferritin levels. After treatment with oral iron, patients of group 1 show a significant increase in serum ferritin, serum iron, hematocrit, erythrocytes, and hemoglobin, a significant decrease in transferrin, and diminished iron absorption. In contrast, in group 2 there was no change in the above-mentioned parameters. The evaluation of iron stores by serum ferritin levels is limited to patients with inactive rheumatoid arthritis. Patients with active disease show hyperferritinemia which no longer represents the iron stores. In this case patients with active rheumatoid arthritis and iron deficiency could reveal normal serum ferritin values. | |
| 526114 | [Acute leukemia in 3 children with chronic juvenile arthritis treated with chlorambucil]. | 1979 Jun | Three children out of a total of 40 who had been treated with chlorambucil for juvenile rheumatoid arthritis developed acute leukaemia. No malignancy was detected in 160 patients in those treated with steroids and/or other anti-inflammatory drugs. Chlorambucil may have induced the malignancies and its use should be avoided in rheumatoid arthritis. | |
| 7226636 | Severe generalized (Charcot-like) joint destruction in juvenile rheumatoid arthritis. | 1981 Mar | Although severe polyarticular joint destruction is rarely observed in children with juvenile rheumatoid arthritis (JRA), it occurred in two patients, a 5-year-old girl and an 11-year-old boy. Histopathologic examinations revealed changes typical of JRA with fragments of cartilage imbedded in synovial membrane. Such fragments are usually seen in adults with neuropathic joint disease. Steroid hormone treatment may be implicated in the pathogenesis of joint destruction in children. | |
| 1088366 | Psyche and rheuma. | 1976 | The paper is based on discussions which took place in a seminar at the European League against Rheumatism Meeting in Helsinki in 1975. The importance of assessing the emotional response in rheumatoid disease, as well as the disease process, is stressed. It is important to consider the effect of the discovery by the patient that severe disease is present. Considerable support by general practitioners and consultants may be necessary at this time. There has been much discussion as to whether patients suffering from rheumatoid arthritis have a different type of personality than other subjects. The evidence is not convincing. The role of stress in the aetiology of rheumatoid arthritis is not properly understood. Anxiolytic and antidepressant drugs may help patients to overcome the anxiety and depression associated with rheumatoid arthritis. Children suffering from the disease present a special problem. The incapacity and isolation, especially in old age, which osteo-arthritis brings may lead to depression and antidepressant therapy is often required. When rheumatic pain seems out of proportion to the physical findings, psychogenic rheumatism should be considered. Rheumatic pains occur in masked depression and low backache may be a depressive equivalent. Pain may be used by some patients to communicate distress. |