Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 23788 | Drugs affecting the release of rheumatoid factor in a plaque-forming cell assay. | 1978 Jan | Addition of propranolol to the agarose phase of a plaque-forming cell (PFC) assay for rheumatoid factor (RF) caused reduction in the number of plaques seen. This reduction in rheumatoid factor plaque-forming cell (RF PFC) did not depend upon an effect at the beta-adrenergic receptor, since d- and 1-propranolol reduced equally well. Furthermore, in a series of polycyclic compounds with varying beta-receptor blocking capabilities there was no agreement between plaque reduction and blocking. When propranolol was tested in the agarose in an anti-sheep erythrocyte (SRC) plaque assay (anti-SRC PFC), it had no inhibitory effect, but it was capable of inhibiting the generation of new anti-SRC PFC in an in vitro culture. Propranolol is thought to exert these effects through its membrane stabilizing (anesthetic) properties. | |
| 6360284 | Clinical aspects of juvenile and adult ankylosing spondylitis. | 1983 Nov | Ankylosing spondylitis (AS) is a heterogeneous and systemic rheumatic disorder that is characterized primarily by inflammation of the spine and sacroiliac joints. Consequently, back pain is a frequent presenting complaint although the disease can begin with peripheral arthritis as well as acute anterior uveitis. Unlike men, however, women appear to have milder or atypical AS that may go unrecognized for years. Moreover, the presentation in children rests on the recognition of two distinct subgroups that may be indistinguishable from juvenile chronic polyarthritis. The more frequent subgroup includes primarily teenage boys who present initially with an asymmetric peripheral pauciarthritis that most often affects lower-limb joints. Only some years later does sacroiliitis evolve, and, much later still, back complaints or other clinical and radiographic features typical of AS. A second subgroup includes mostly girls with a polyarticular onset that is subsequently characterized by cervical fusion, micrognathia, acute anterior uveitis, sacroiliitis, spondylitis, and rheumatoid-like hands that persist into adulthood. | |
| 6710254 | Juvenile chronic arthritis in black and Indian South African children. | 1984 Mar 31 | Although juvenile chronic arthritis (JCA) has been studied extensively in Whites in Western countries, very few data exist on JCA in children in developing countries and particularly in Africa. Accordingly, a retrospective study of 60 Black and Indian children with JCA was undertaken. The main findings were predominance of JCA of polyarticular onset with a relatively low occurrence of JCA of pauci-articular onset, a high prevalence of positive rheumatoid factor tests and a very low number of patients positive for antinuclear factor, and an equal overall sex ratio (however, there was a preponderance of males in the subgroup with JCA involving only 2 - 4 joints). Moreover, the vast majority of patients initially had a low haemoglobin concentration, a normal white cell count, an elevated erythrocyte sedimentation rate and a positive antistreptolysin O titre. The main differences between Black and Indian South African children with JCA and White children with the disease in Europe and North American appear to be the high prevalences of polyarticular onset and seropositivity, the equal sex ratio and the absence of a specific subgroup with pauci-articular onset and a positive antinuclear factor test. | |
| 4094907 | [Juvenile chronic arthritis]. | 1985 Mar | Juvenile chronic arthritis is the most common connective tissue disease in children. It is of great social and clinical interest for its chronicity, for the often unpredictable response to pharmacological treatment; for the spontaneous evolution toward infirmity and often blindness. The English classification of the disease is here been adopted. There are 3 different types of onset: systemic, poliarticular and pauciarticular. Large joints such as the knees, wrists and ankles are involved more often than small joints. Also the cervical spine is frequently affected. Systemic disease is accompanied by high spiking fever, rash, lynphoadenopathy, pericarditis and hepatosplenomegaly. Chronic uveitis is a feature of JCA, more frequently observed in pauciarticular than in the other types of onset, and it is almost always associated with antinuclear antibody seropositivity. Rheumatoid factor (RF) and subcutaneous nodules are unusual in JCA. Diagnosis is often not easy and it is essentially clinical. The diagnostic criteria adopted have been proposed by ARA in 1977. In the majority of children treatment with ASA is successful. Sometimes other types of more toxic drugs such as gold salts or penicillamine are needed. Their use is best confined to reference centers. Orthopedical and physiotherapic treatments are complementary to the pharmacological one. Multidisciplinary centers are therefore necessary for the total management of these children also to stress the importance of furthering physical and psychological growth. | |
| 6972050 | Radiologist's guide to the use of the laboratory in diagnosing rheumatic diseases. | 1981 Jun | Laboratory tests that are commonly used in the evaluation of rheumatic diseases are described. The techniques for performing these tests; their use in screening, diagnosis, and follow-up; and the pitfalls in interpreting their results are discussed to provide the radiologist with an understanding of the current technology relating to rheumatic disorders. | |
| 6681126 | High C-reactive protein response in lupus polyarthritis. | 1983 Jan | Five out of 6 patients with systemic lupus erythematosus (SLE) and chronic polyarthritis were found to have significantly raised (greater than 20 mg/l.) C-reactive protein (CRP) levels. In contrast, slight elevations in CRP levels were present in only 5 of 16 SLE patients without chronic polyarthritis. Thus, an elevated CRP level might be a distinctive feature of SLE patients with chronic polyarthritis. | |
| 6786024 | Skeletal findings in progressive systemic sclerosis (scleroderma). | 1981 Jun | Radiographs were reviewed of the chest, hands, and feet of 55 patients with progressive systemic sclerosis. These patients had been selected so as to exclude overlap syndromes, particularly mixed connective tissue disease. Soft tissue changes included flexion deformities, generalized or localized atrophy, and dystrophic calcifications. While resorption of distal phalanges was the most common bony change, osteolysis in other sites (feet, ribs, and mandibles) was also frequent. Twelve of 55 patients showed radiographic evidence of inflammatory arthritis, ranging from isolated to generalized joint destruction, that could not be attributed to overlap with rheumatoid arthritis or mixed connective tissue disease. | |
| 6691849 | Clinical spectrum of connective tissue disease after cosmetic surgery. Observations on eig | 1984 Jan | Connective tissue disease has been reported to occur following cosmetic surgery with injection of the foreign substances paraffin and silicone (human adjuvant disease). The clinical findings in 18 such patients and a review of 28 additional cases from the Japanese literature are presented. The patients were classified into 2 major groups: group I consisted of 24 patients with definite connective tissue disease--12 with scleroderma, including 8 with progressive systemic sclerosis (PSS), 6 with rheumatoid arthritis, 5 with systemic lupus erythematosus, and 1 with polymyositis; group II consisted of 22 patients with human adjuvant disease with some symptoms, signs, and laboratory abnormalities suggestive, but not diagnostic of a connective tissue disease. The occurrence of PSS is approximately three-fold greater than expected for all women believed to have undergone such surgery, and PSS developed primarily in individuals injected with paraffin. Prolonged exposure to the injected substance may play a role in the induction of these immunologic disorders. | |
| 6182890 | Skin response to intradermal DNA and RNA in systemic lupus erythematosus. | 1982 Nov | The local response of 18 patients with active systemic lupus erythematosus to 0.1 ml of intradermally injected 0.1% polymerized calf thymus DNA and synthetic double-stranded polyinosinic-polycytidylic acid was studied. In 14 patients positive for DNA, 61 +/- 8% of the inflammatory cells in the subepidermis at 24 hours were acid alpha-naphthyl acetate esterase-positive T lymphocytes. A leukocytoclastic vasculitis was observed in the deeper dermis. Rheumatoid arthritis patients and acne patients had negative responses. These results indicated an abnormal cellular and humoral in vivo response by patients with systemic lupus to DNA. It is suggested that the epidermal Langerhans cells were responsible for the topographic dichotomy of the local DNA response. Test results were positive for polyinosinic-polycytidylic acid in 12 patients, for DNA in 14 patients, and for both in 9 patients. In the 9 patients with positive results for both tests, comparison of responses to each test indicated that the reaction intensity was dependent on the patient and not on the type of polynucleotide acid that was injected. | |
| 4026887 | In vitro production and scavenging of hydrogen peroxide by D-penicillamine. Relationship t | 1985 Aug | The capacity of D-penicillamine (DP) to produce or scavenge hydrogen peroxide was investigated. DP added to copper produced H2O2. Greater production was observed with copper sulfate than with copper bound to ceruloplasmin. In contrast, DP in the absence of copper scavenged H2O2, as measured in a direct assay. Furthermore, DP or D-cysteine alone reversed H2O2-mediated inhibition of concanavalin A-stimulated mononuclear cell proliferation. These opposing immunomodulating properties of DP may be relevant to its toxic or therapeutic actions in rheumatoid arthritis. | |
| 3159999 | Self-concept: an outcome of a program for spinal pain. | 1985 May | Changes in self-concept were studied in 50 patients with chronic spinal pain who underwent a 4 week inpatient program. Treatment included increasing quotas for activity and walking, patient education, reduction in pain medications, and reinforcement of non-pain behaviors. The instrument used to measure change was the counseling form of the Tennessee Self-Concept Scale (TSCS). The test was administered upon admission to the program, at discharge, and at 1, 3, and 6 months following discharge. TSCS scores were also compared with those of patients who failed to complete the program and of a quasi-control group of patients with rheumatoid arthritis. The spinal pain group improved significantly on 8 scales of the TSCS, while scores for the arthritis patients were constant over the 6 month period. The program had a positive effect on self-concept and thus should be considered for patients with chronic spinal pain. | |
| 6802142 | Gold inhibition of the production of the second complement component by lymphokine-stimula | 1982 Mar | The ability of gold sodium thiomalate to inhibit production of the second complement component (C2) by monocytes stimulated by a lymphokine (monocyte complement stimulator is demonstrated. This gold salt inhibits C2 production irreversibly if monocytes are incubated with it before or during lymphokine stimulation. Thiomalic acid is not inhibitory. Monocytes already stimulated by lymphokine are resistant to inhibition of C2 production by gold sodium thiomalate. Gold salts do not reduce monocyte viability, phagocytic ability (latex heads) accessory cell function (as measured by the ability to present antigen to autologous lymphocytes), or capacity to act as stimulating cells in mixed leukocyte culture. Gold sodium thiomalate's inhibition of monocyte responsiveness to lymphokine may be significant in explaining the therapeutic benefit of gold salts in rheumatoid arthritis. | |
| 6969028 | Systemic involvement and immunologic findings in patients presenting with Raynaud's phenom | 1980 Nov | Systemic involvement and spectrum of autoantibodies were evaluated in 91 patients presenting with Raynaud's phenomenon. Decreased pulmonary diffusing capacity was observed in 23 percent, esophageal hypomotility in 14 percent and renal involvement in 5 percent of the patients, all without clinical symptoms. Arthralgia or a history of arthritis was present in 27 percent and skin abnormalities in 30 percent. Extent of systemic involvement was correlated with the severity of Raynaud's phenomenon, as measured by photoelectric plethysmography (r = 0.38; p < 0.01). In addition, both the variety of different autoantibodies in the serum of individual patients and the titer of antinuclear antibodies were positively correlated with the number of affected organ systems (r = 0.63; p < 0.01 and r = 0.65; p < 0.01, respectively). Raynaud's phenomenon is an important clinical sign of asymptomatic systemic disease. Measurements of its severity and serologic parameters are helpful in predicting the extent of systemic involvement. | |
| 6216285 | Direct demonstration of the human suppressor inducer subset by anti-T cell antibodies. | 1983 Jan | Prior studies indicated that sera of patients with active juvenile rheumatoid arthritis (JRA) contain anti-T cell antibodies reactive with the T4+ inducer population. More important, depletion of this T cell subset with JRA anti-T cell antibodies (JRA+ T cells) and C abrogated T5/T8+ suppressor T cell function. In the present study, we utilized Ig-coated plate techniques and JRA anti-T cell antibodies to fractionate the T4+ population into T4+JRA+ and T4+JRA- subsets and characterize the individual T4+ inducer subset. It was shown that whereas only the T4+JRA- population responded maximally to the soluble antigens, TT and mumps, both T4+JRA+ and T4+JRA- subsets proliferated equally well to mitogens and alloantigens. Furthermore, B cell immunoglobulin production induced by T4+JRA- T cells was approximately twice that induced by the reciprocal T4+JRA+ subset. In contrast, the T4+JRA+ subset alone activated T8+ T cells to become suppressor effector cells. These results suggest that the T4+JRA+ subset is the inducer of suppressor subpopulation whereas the T4+JRA- subset functions maximally as the inducer of B cells. It is believed that the suppressor inducer population may have a central role in the immunoregulatory network in man. | |
| 6449760 | Typing for HLA-D/DR associated DP-antigens with the primed lymphocyte typing (PLT) techniq | 1980 May | A total of 74 healthy unrelated random individuals and 36 patients with juvenile rheumatoid arthritis (JRA) were typed for HLA-D antigens with the homozygous typing cell technique and typed for HLA-D/DR associated DP-antigens with the primed lymphocyte typing (PLT) technique. All patients and some of the controls were also HLA-DR typed with a limited battery of anti-DR sera. Selected PLT-cells, specific for the HLA-D/DR antigens D/DRw1-8 and the local specificity D"H" were used. The results of the PLT-experiments were evaluated with the Normalized Median Response (NMR) method and the further procedure of DP-antigen assignment was analyzed. The DP-antigen assignments could be done solely according the NMR-values in approximately two thirds of the individuals. In the remaining individuals, further interpretation of the experimental data had to be done for the assignment of DP-antigens. The correlation coefficients were estimated between the HLA-D assignments and (i) the individual PLT-cell NMR-values with a fixed cut-off for positive reactions and (ii) the DP-antigen assignments. These coefficients were 0.79 and 0.92, respectively. The correlations between HLA-D, -DR and DP-antigen assignments of the specificities HLA-D, -DR and DP1, 2, 3, 4, 7 and 8 were analyzed in 42 controls and 36 JRA patients. The total correlation coefficients were: (i) HLA-D/DR: r = 0.78; HLA-DR/DP: 0.77; and HLA-D/DP: 0.96. The DP-antigen assignments correlated significantly better with HLA-D than with the HLA-DR antigen assignments, which does not agree with other studies. The DP-antigen frequencies among the controls were calculated and the estimated sum of gene frequency corresponding to definable DP-antigens was 0.94 indicating that about 12% of random individuals possess as yet undefined DP-antigens. | |
| 3925680 | Another immune-mediated disease associated with hairy cell leukemia: chronic active hepati | 1985 | This report describes a case of hairy cell leukemia (HCL) occurring with autoimmune chronic active hepatitis (CAH). A 74-year-old woman presented with typical clinical and histologic features of HCL for which splenectomy was performed. 2 years later she developed abnormal liver function tests due to auto-immune CAH. The liver function tests improved promptly after prednisolone therapy. HCL has been reported to occur with several immune-mediated diseases including polyarteritis nodosa, rheumatoid arthritis, hemolytic anemia, cutaneous vasculitis and monoclonal gammopathy with amyloidosis. This report adds a further example of HCL coexisting with an immune-mediated disease, in this case autoimmune CAH. | |
| 6861388 | Survival of patients and prostheses after total hip arthroplasty. | 1983 Jul | The survival statistics of 695 patients who had 803 total hip arthroplasties (THA) were correlated with the incidence of aseptic loosening using standard actuarial methods. Follow-up periods ranged from three to 11 years. High patient mortality was associated with factors that lower physical fitness: old age, bilateral hip disease, excessive obesity, diagnosis of rheumatoid arthritis, and post-traumatic changes. Patients in whom revision procedures were done due to prosthetic failure experienced a very low mortality. The factors associated with aseptic loosening were unilateral hip disease, defective surgical technique, and excessive body weight (greater than 80 kg). The increased rates of aseptic loosening that have been observed during the later years of follow-up evaluation were attributable to higher survival rates of the more physically fit individuals in the population at risk. | |
| 6212656 | Deposition of immunoglobulin and complement in mucocutaneous lesions related to treatment | 1982 Jun | A 23-year-old man suffering from sero-negative rheumatoid arthritis developed severe penicillamine-induced mouth ulcerations and erythematous macules. Immunohistochemical staining in a biopsy specimen from the affected lingual mucosa showed substantial deposition of IgM and C3 in vessel walls below the necrotic epithelium. In the affected skin, irregular granular staining for IgG and IgM along the epidermal basement membrane zone was noted, and granular deposits of IgM were present in small vessels of dermal papillae. The mouth ulcerations healed promptly after withdrawal of the drug, whereas the macules persisted for some months. The immunohistochemical findings indicated that the drug eruptions were related to a vasculitis induced by deposition of immune complexes. | |
| 6263092 | Proliferative diseases. | 1981 Jun | A unifying concept that excessive proliferation of cells and turnover of cellular matrix contribute significantly to the pathogenesis of several diseases, including cancer, atherosclerosis, rheumatoid arthritis, psoriasis, idiopathic pulmonary fibrosis, scleroderma and cirrhosis of the liver, is presented. As corollaries to this concept, the following topics are considered: (1) the role of polypeptide hormones and hormone-like mediators in the initiation, promotion and maintenance of proliferative responses; (2) alterations in collagen metabolism and collagenase activity; (3) the role of proteinases; (4) the potential use of inhibitors of proteinases for prevention of disease; and (5) the potential use of inhibitors of proliferative polypeptide hormones for prevention of disease. As specific proteolytic and proliferative biochemical mechanisms which contribute to the pathogenesis of disease become identified, there is a unique opportunity to develop new pharmacologic methods of prevention. | |
| 7256731 | Excretion pattern of urinary glycosaminoglycans from orthopedic patients. | 1981 Apr | To obtain a clue for the metabolic disorder of glycosaminoglycans (GAG) in connective tissue diseases, a screening test for excretion pattern of urinary GAG was applied to urines from orthopedic patients. The results showed a wide variety of excretion pattern of urinary GAG from various orthopedic patients. Several cases gave irregular bands. Also, most cases of bone tumor showed abnormal excretion patterns different from the normal range of percent distribution of bands 1, 2 and 3. The data suggested abnormal metabolism of GAG in these diseases. Percent distribution of band 1 or bands 1 + 2 tended to increase in rheumatoid arthritis (RA), suggesting an elevation of the metabolic rate of chondroitin sulfates in RA. In cases of other orthopedic diseases, a half of them showed an abnormal excretion pattern of urinary GAG, but the excretion pattern of the remaining ones was within the normal range. |