Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6470496 | Comparative investigations of various immunoregulatory substances in the delayed type hype | 1984 | The substances D-penicillamine, auranofin, chloroquine, levamisole, BM 41.332, azimexone, bestatin, methisoprinol (inosiplex), thymosine (fraction 5), indomethacin and cyclophosphamide were examined comparatively in the delayed type hypersensitivity test after oxazolone sensitisation in mice. It was found, that only the basal antirheumatic drugs D-penicillamine, auranofin, chloroquine and levamisole and also BM 41.332 led to a potentiation of the DTH reactions. Methisoprinol, bestatin, azimexone, thymosine fraction 5 and indomethacin had no effect on the DTH, whilst the immunosuppressant cyclophosphamide led to an inhibition of the DTH reaction. It is concluded that this pharmacological model is suitable for screening of new basal drugs for rheumatoid arthritis. | |
| 6318334 | [Generalities on clinical trials of the effectiveness of non-steroidal anti-inflammatory a | 1983 Dec 12 | Non-steroidal antiinflammatory drugs represent a strictly symptomatic treatment since they act mainly on pain and act fast. One week cross-over study models confirm the intrinsic pharmacodynamic effect of the test product, specify daily doses and optimal dosage regimens and enable comparison of the product with a reference drug. These studies must be conducted in out-patients, by an experienced investigator, using a double-blind design in a sufficiently large number of patients. Rheumatoid arthritis, ankylosing spondylitis and osteoarthritis of the hip and knee are the most suitable models for such studies. A long-term efficacy study is best done by analyzing the rate of withdrawals from treatment as a function of time. | |
| 7418262 | Radioconglutinin-binding azssay for circulating immune complexes: a new method. | 1980 Jun | A new method for the detection of circulating immune complexes using radiolabelled conglutinin as a marker for complement-bound complexes precipitated in low concentrations (3.5%) of polyethylene glycol is described. The optimal laboratory conditions for the test have been defined and certain limitations studied. The technique is simple with good reproducibility and high degree of specificity. In a double-blind study of eighty-seven samples of sera from normals, patients with glomerulonephritis, post-renal transplantation, rheumatic diseases, breast tumours, multiple sclerosis and infections the method was compared and correlated to the Clq-binding assay and the Raji cell test. The radioconglutinin-binding assay was most discriminative for cases of glomerulonephritis, renel transplantation, breast carcinoma and multiple sclerosis and least for rheumatoid arthritis. | |
| 7408290 | Arthroplasty of the wrist. | 1980 Jun | The history of the artificial wrist joint is brief and begins as recently as 1971. The prosthesis is designed as a ball-and-socket joint. The metallic trunnion component is cemented into the radius and the metallic cup component into the carpal and metacarpal II and III bones. There is a central articulating polyethylene ball. The surgical technique itself requires only a few special instruments. The centering of the prosthesis is of utmost importance and requires great care. The fixation stems of the prosthesis can and must be bent and adapted to the skeletal conditions of the individual. The wrist joint prosthesis is indicated for the treatment of severe painful wrist joint destruction--mainly rheumatoid arthritis or degenerative osteoarthritis--in patients not concerned with heavy manual work. Clinical experience over a period of 8 years with 41 wrist arthroplasties has shown that although initially technical errors resulted in a number of re-operations, in almost all cases, however, the final outcome was satisfactory. When necessary, a change of prosthesis or a subsequent arthrodesis of the wrist was always possible. | |
| 7009760 | Immunokinetics of a single dose of thymopoietin pentapeptide. | 1980 | 14 patients with classical or definite rheumatoid arthritis and a low number of E-rosette forming cells were given single doses of 5 mg and 50 mg of thymopoietin intravenously. Thymopoietin pentapeptide produced a dose-related sustained increase in E-rosette forming lymphocytes as shown by the decrease of thymopoietin dependent rosetting ratio. A single dose of 50 mg restored the number of E-rosette forming cells to normal after 12 h and this effect lasted 60 to 7 days. With the administration of 5 E-rosette forming cells markedly increased after 12 h and returned to the pretreatment level on the 2nd day. These immunokinetic data clarify some aspects of the clinical pharmacology of thymopoietin pentapeptide and must be considered for a rational schedule of treatment with the drug. | |
| 535273 | Compression arthrodesis of finger joints. | 1979 Nov | Compression arthrodesis is useful for treatment of finger and thumb joints in arthrosis, scleroderma, hypermobile joints, paralytic deformities, and rheumatoid arthritis. A dorsal incision exposes the joint. Its surfaces are prepared in a ball-and-socket arrangement using a high-speed burr. A longitudinal pin 1.1 mm in diameter is passed distally and then retrograde to determine the angle of fusion and to prevent migration of bone ends as the longitudinal compression is applied. Transverse pins 1.5 mm in diameter are put in one-third of the distance from the joint. A Charnley clamp, as modified by Micks and Hager, is applied and tightened. At 6 weeks, the arthrodesis is checked for solidity and, if stable, X-rays are examined for new bone. When solid, the joints should be protected by external splinting for an additional 2 weeks to be sure that the fusion is complete. Compression arthrodesis was obtained in 49 of 54 joints. Solid fusion was usually attained within 6 weeks, without loss of mobility of other joints. | |
| 642189 | A clinicopathological study on pericardial heart disease in the aged. | 1978 Feb | A total of 87 cases of pericardial heart disease (73 of pericarditis and 14 of hemopericardium) among 870 consecutive autopsies of aged patients was studied. Fibrinofibrouspericarditis was found in 80.8% of pericarditis, neoplastic in 13.7% and purulent in 5.5%. Representative cases of each type of pericarditis were illustrated. Among fibrinofibrous pericarditis, idiopathic was the most common and the other causes included irradiation, myocardial infarction, renal failure, rheumatoid arthritis and hypothyroidism. Frequent association of congestive heart failure or anasarca with mild to moderate fibrinofibrous pericarditis was noted. Clinical and morphologic evidences of pulmonary tuberculosis were present in nearly one third of cases with fibrinofibrious pericarditis, but actual incidence of tuberculous pericarditis could not be determined. Incidence of clinical signs and symptoms of acute pericarditis was evaluated with the stress on the relatively high incidence of supraventricular tachyarrhythmias, especially in cases with histological evidence of sinus node involvement in aged cases. | |
| 132609 | [The clinical importance of tissue antigens (HL-A) in man (author's transl)]. | 1976 May 7 | The HL-A system is part of the main histocompatibility complex of man which is located on chromosome A6. The clinical importance of this antigen system lies in its application in the immunological choice of donor for transplantations, it being clear that still other important transplantation systems must be located on chromosome 6. The fact that in many diseases certain HL-A antigens occur more frequently has acquired a certain diagnostic significance in ankylosing spondylitis, iritis and juvenile rheumatoid arthritis. The associations with HL-A observed can best be explained by the assumption HL-A-coupled defective immunoresponse genes which are partly responsible for sensitivity to disease. | |
| 6635733 | Urinary complications of cyclophosphamide therapy: etiology, prevention, and management. | 1983 Nov | Cyclophosphamide is a well established cytotoxic drug used in the treatment of lymphoproliferative disorders, certain solid tumors, and nonneoplastic disorders such as the nephrotic syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Hemorrhagic cystitis can be a complication of this drug in from 2% to 40% of patients so treated. At times, the hemorrhage may be severe, protracted, and life-threatening. Cyclophosphamide therapy has also been implicated as the causative agent in 32 cases of carcinoma of the bladder and three cases of carcinoma of the renal pelvis. | |
| 7146267 | International comparison of the prevalence of psychosomatic disorders in schizophrenic pat | 1982 | An epidemiological survey was carried out in Montreal (Canada). Plattsburgh (USA) and Lodz (Poland) to test the hypothesis that certain psychosomatic disorders show a low lifetime prevalence in schizophrenic patients (total n = 665). The same method for collection and evaluation of demographic and clinical data was used in order to establish the lifetime prevalence of peptic ulcer (PU), bronchial asthma (BA), neurodermatitis (ND) and rheumatoid arthritis (RA) in the patients as well as in their nuclear families. Low values of lifetime prevalence were found in schizophrenic patients in chronic hospitals as compared with those in general-university hospitals. Similarities were found in age- and sex-related patterns of these psychosomatic disorders in both samples. However, PU showed higher prevalence, and BA, ND and RA showed lower prevalence in the Polish sample. | |
| 6116431 | Sural nerve biopsy in systemic necrotizing vasculitis. | 1981 Oct | This study of 17 patients with vasculitic neuropathy (polyarteritis nodosa in 11, rheumatoid arthritis in five, and systemic lupus erythematosus in one) revealed the following: (1) Polyneuropathy is the most common manifestation of peripheral neuropathy in polyarteritis nodosa. (2) Peripheral neuropathy is more common in systemic necrotizing vasculitis than physical evaluation alone suggests. Adequate electrophysiologic tests can detect asymptomatic peripheral neuropathy in a substantial number of patients. (3) Abnormal sural nerve condition is a prerequisite to the demonstration of vasculitis on biopsy of this nerve. Thus, in using abnormal sural nerve conduction as a guide in nerve biopsy, the diagnostic yield of sural nerve biopsy will be greatly enhanced. | |
| 7230154 | Local hyperthermia and cartilage breakdown: histochemical and metabolic studies on rabbit | 1981 Mar | The hypothesis that local hyperthermia generated in inflamed joints may cause damage to the articular cartilage was tested in vitro using histochemical and isotopic methods. We found that this could be the case. Incubation temperatures above 38 degrees C in experiments of longer duration and 39 degrees C during shorter incubation times induced a loss of metachromasia, decreased rates of synthesis, and increased degradation of cartilage matrix macromolecules. It is postulated that local synovial hyperthermia might partly account for the cartilage degeneration that frequently occurs in rheumatoid arthritis as a result of a decreased synthesis and increased catabolism of matrix macromolecules. | |
| 6970414 | Cefamandole failure in ampicillin-resistant Haemophilus influenzae b pneumonia. | 1981 Feb | A woman with rheumatoid arthritis and ampicillin-resistant Haemophilus influenzae type b (Hib) pneumonia complicated by bacteremia and empyema is reported. Initial therapy with cefamandole failed to eliminate bacteria from the pleural space and did not substantially affect the clinical course. However, cultures became negative and fever resolved when therapy was changed to chloramphenicol. Ampicillin-resistant Hib pneumonia in adults is an increasing problem and may be a difficult diagnosis to establish initially. Counterimmunoelectrophoresis may be useful in adults with pneumonia. If Hib antigen is detected, or if H influenzae is suspected on the basis of Gram stains and cultures, chloramphenicol should be given until the isolate is shown to be sensitive to ampicillin. | |
| 7006876 | Identification of biliary antigens in circulating immune complexes in primary biliary cirr | 1980 Oct | The presence of biliary tract antigens in circulating immune complexes from patients with primary biliary cirrhosis (PBC) was investigated. Concentrations of immune complexes in PBC sera, measured by the Raji cell immunoassay, ranged from 58 to greater than 1,000 microgram/ml, but did not correlate with disease activity. Immunofluorescent staining of complexes bound to Raji cells was carried out with guinea-pig antiserum raised against biliary tract antigens. Positive staining reactions were observed with complexes obtained from PBC patients, but not with those obtained from patients with systemic lupus erythematosus or rheumatoid arthritis, indicating that in PBC antigenic components associated with the biliary tract are contained within the complexes. | |
| 7413421 | The halo-shoulder brace and the mandibular-shoulder brace as postoperative supports follow | 1980 Aug | Bracing of the cervical spine in patients with rheumatoid arthritis, ankylosing spondylitis and instability due to metastases poses special problems. Because of asymmetry, a tender bony or cutaneous swelling or tender skin, difficulties arise in fitting a mass-produced brace. In order to overcome these difficulties a carefully moulded made-to-measure halo-shoulder brace and also a mandibular-shoulder brace were developed. The halo-shoulder brace (a halo connected with 4 rods to a shoulder girdle) provides an effective means of postoperatively controlling the unstable cervical spine until the graft unites. The brace is well tolerated by the patient and facilitates early postoperative mobility. The mandibular-shoulder brace (a similar shoulder girdle with a mandibular and an occipital part), also well tolerated by the patient, is used after the halo-shoulder brace during consolidation of the graft and also to support the neck in patients who for other reasons require a collar but who cannot tolerate a normal readymade appliance. The manufacture of the braces, their effectiveness and a series of 13 patients are described. | |
| 315612 | [Absence of circulating immune complexes and of serum anti-IgG antibodies during ankylosin | 1979 Jun | The sera of 161 subjects hospitalized in a rheumatology department were tested for anti-IgG antibodies using a "PEG radioimmunoprecipitation assay" (RIPEGA), for circulating immune complexes using the liaison test with Clq 125I, and dosage of complement and its metabolites. No significant difference was found between the group of 37 ankylosing spondylitis and the group of 44 control subjects. The results were identical, whatever the form of the disease, be it peripheral or central, and evolutive or non evolutive. On the contrary, the study of the rheumatoid arthritis (47 seropositive and 34 seronegative) provided results in conformity to previous works. The different physiopathogenic origin of these two chronic inflammatory rheumatisms is discussed by the authors. | |
| 760401 | Fatal renal vasculitis and minimal change glomerulonephritis complicating treatment with p | 1979 | Two cases with different and not previously described fatal renal complications during treatment with penicillamine are reported. A man with seronegative rheumatoid arthritis with features of systemic lupus erythematosus was treated with penicillamine for six months and developed a mild membranous glomerulonephritis and a severe renal vasculitis leading to uremia and death. A woman with primary biliary cirrhosis was treated with penicillamine for nine months and developed a nephrotic syndrome, the renal biopsy showing minimal change glomerulonephritis. The nephrotic syndrome responded to prednisone but the patient died, probably from septicemia. Penicillamine may thus cause glomerular damage without deposition of immune complexes. A restricted use of the drug is recommended. | |
| 114191 | Correlation between antiinflammatory activity and inhibition of prostaglandin biosynthesis | 1979 | The effect of several non-steroidal antiinflammatory agents (some of them original from our laboratory) on prostaglandin biosynthesis in guinea pig lung (biological method) and in bovine seminal vesicles (spectrophotometric method) has been studied. When this effect is compared with the in vivo antiinflammatory activity determined in the rat carragenin foot edema and with the recommended clinical daily dose in rheumatoid arthritis, a good correlation between these properties was observed. Only mefenamic acid showed a clear discordance. The experience shows that inhibitory effect of antiinflammatory drugs on prostaglandin synthetase in vitro may be used to predict, in most cases, their antiinflammatory activity in vivo in the pharmacological screening of the new compounds. Structure-activity relationship in the UR-series is also discussed. | |
| 581451 | The Churg-Strauss granuloma: cutaneous, necrotizing, palisading granuloma in vasculitis sy | 1978 Nov | The cutaneous, necrotizing, palisading granuloma (Churg-Strauss granuloma) was observed on histopathologic study of skin specimens from seven patients. Two patients had Wegener's granulomatosis and one patient each had allergic granulomatosis, limited Wegener's granulomatosis, bacterial endocarditis, systemic lupus erythematosus, and rheumatoid arthritis. The microscopic picture consists of extravascular, palisading, dermal granuloma. The center of the granuloma consists of basophilic fibrillar necrosis in which linear bands of destroyed tissue are interspersed with masses of polymorphonuclear leukocytes and leukocytoclastic debris. This necrotic leukocytic mass is surrounded by histiocytes and some lymphocytes. The clinical lesions are symmetric, erythematous papules or nodules on the extremities. The histopathologic picture of the Churg-Strauss granuloma is unique and, as demonstrated in these cases, indicates the presence of systemic vasculitis. | |
| 669201 | Nodular regenerative hyperplasia of the liver. Report of six cases and review of the liter | 1978 Aug | The authors report the cases of 6 adult patients suffering from nodular regenerative hyperplasia of the liver, an uncommon lesion characterized by small-sized hepatocytic nodules scattered throughout the liver, with no or slight fibrosis. The histological recognition of nodular regenerative hyperplasia of the liver was easy on large specimens taken intraoperatively, but was difficult or impossible on small specimens such as those provided by needle biopsy. In all of the patients of this series, the main consequence of nodular regenerative hyperplasia of the liver was portal hypertension. In this series, nodular regenerative hyperplasia of the liver was not associated with rheumatoid arthritis, whereas such an association has been noted in most of the cases previously reported. The etiology and pathogenesis of nodular regenerative hyperplasia of the liver is unknown. |