Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 970999 | Improvement in lacrimal and salivary secretions after alkali therapy in Sjøgren's syndrom | 1976 Aug | A patient with Sjøgren's syndrome developed renal tubular acidosis which led to systemic acidosis and potassium depletion. Treatment with Shohl's solution and potassium supplements was followed by subjective improvement in tear flow, salivary flow, and by disappearance of bronchitic symptoms. Detailed objective assessments were then made during the next year, twice on treatment and twice without. These confirmed the subjective impression of improvement. | |
| 6838673 | Clinical and serologic study of Sjögren's syndrome in patients with progressive systemic | 1983 Apr | Fifty-eight patients with progressive systemic sclerosis (PSS) were evaluated clinically and by biopsy of the minor salivary glands of the lips for the presence of Sjögren's syndrome. Clinical findings included dry eyes in 38%, dry mouth in 32%, parotid enlargement in 4%, and an abnormal Schirmer's test in 34%. Histologic changes in lip biopsies included lymphocytic infiltrates characteristic of Sjögren's syndrome in 17 individuals (29%). In 19 (33%) there was periglandular and intraglandular fibrosis (PSS-fibrosis) without significant inflammation, an alteration characteristic of PSS per se. In the remaining 22 patients (38%) with PSS, no abnormality was found. Of those with PSS and Sjögren's syndrome, 53% had serum antibodies to SS-A and/or SS-B, while only 1 patient with a normal biopsy had either of these antibodies. Anti-SS-A and anti-SS-B were not detected in patients with glandular fibrosis alone. The mortality rate of the PSS-fibrosis group was higher due to a variety of severe internal manifestations related to PSS. Antibodies to SS-A and SS-B are useful serologic markers of the presence of Sjögren's syndrome in patients with PSS. | |
| 6600593 | Sjögren's syndrome: association of anti-Ro(SS-A) antibodies with vasculitis, hematologic | 1983 Feb | The clinical significance of autoantibodies to Ro(SS-A) and La(SS-B) in Sjögren's syndrome was examined in a retrospective evaluation of 75 patients with symptoms of the sicca complex who had either primary Sjögren's syndrome or Sjögren's syndrome associated with another connective tissue disease. The clinical, hematologic, and serologic features associated with autoantibodies to the small molecular weight ribonucleoproteins Ro(SS-A) and La(SS-B) were ascertained. A striking clinical association of anti-Ro(SS-A) antibodies (found in 33 patients) with extraglandular disease (vasculitis, purpura, and lymphadenopathy) was seen. Hematologic abnormalities (anemia, leukopenia, and thrombocytopenia) were also associated with the presence of anti-Ro(SS-A) antibodies. Furthermore, anti-Ro(SS-A) antibody was associated with hyperglobulinemia, increased serologic reactivity in terms of rheumatoid and antinuclear factors, cryoglobulinemia, and hypocomplementemia. The presence of anti-Ro(SS-A) antibodies defines a subset of patients with Sjögren's syndrome who have systemic clinical manifestations including vasculitis, hematologic abnormalities, and serologic hyperreactivity. | |
| 6190225 | Serum isoamylases in Sjögren's syndrome. Concentration levels and intra-individual variat | 1983 | A study of isoamylase in serum from 53 patients with Sjögren's syndrome demonstrated that the levels of both pancreatic type and salivary type amylases remain within reference value limits in most cases. However, abnormal low or high values for pancreatic type amylases were seen more frequently than in the control groups. The intra-individual variation in concentration levels of both isoenzymes among patients with Sjögren's syndrome were significantly greater than in the control groups. These observations are interpreted as signs of subclinical lesions of the pancreas and the salivary glands occurring during the course of the disease. Sjögren's syndrome should be borne in mind and sought in cases of unexplained hypo- or hyperisoamylasemias. | |
| 7435511 | Neutrophil kinetics in Felty's syndrome. | 1980 Nov | In 19 patients with Felty's syndrome, marrow production of neutrophils and neutrophil distribution were studied. Despite accelerated marrow release and disappearance of mature blood neutrophils, there was little or no increase in the marrow mitotic pool or in vitro progenitor cells. Only two patients had an increase in marrow neutrophils and precursors. Antineutrophil antibody was detected in seven of nine patients studied. Neither abnormal margination of blood neutrophils nor impaired marrow release of cells was detected. Skin exudate cellularity tended to correspond to prior history of infections, asymptomatic patients having more cellular exudates. Sustained neutrophil increments were observed in six of 10 patients following splenectomy, but in no patient did neutrophil kinetics return completely to normal. Three of four patients who failed to respond to splenectomy with sustained increments in blood neutrophils had a reduced mass of marrow neutrophils and neutrophil precursors when studied prior to splenectomy. No diminution in neutropenia was observed in any of five patients treated with lithium carbonate. This study indicates that multiple factors are involved in the pathogenesis of neutropenia in Felty's syndrome. In particular, neutropenia was associated with inadequate marrow granulocytopoiesis. The severity of the impairment, as determined by the mass of marrow neutrophils and precursor cells, may be useful in predicting response to splenectomy. | |
| 3872150 | Mixed connective tissue disease, Sjögren's syndrome, and abdominal pseudolymphoma. | 1985 Feb | A young female with mixed connective tissue disease (MCTD) presented with the unusual occurrence of abdominal pseudolymphoma. Although the pseudolymphoma could be related to concomitant sicca complex, some data suggest that MCTD, as such, could carry a high incidence of malignancy. | |
| 6543205 | Distribution of intermediate filaments and actin microfilaments in parotid autoimmune sial | 1984 Nov | In order to study the importance of myoepithelial cells in the formation of parotid epi-myoepithelial islands of the autoimmune sialoadenitis in Sjögren's syndrome, the distribution of cytoskeletal elements has been investigated by electron and immunofluorescence microscopy. Antibodies to intermediate filament proteins--prekeratins, desmin and vimentin--were used as well as a 'DNase I/anti-DNase I' immunohistochemical procedure to detect actin microfilaments for characterization of myoepithelial cells compared to the other types of parotid epithelial cells. Two types of prekeratin antibodies were raised. One of these reacted preferentially with myoepithelial cells. The same type of antiserum also showed a bright fluorescence in cells located peripherally in the epi-myoepithelial islands. These island cells, however, exhibited only a very low actin microfilament content and were thus not ordinary myoepithelial cells. The other type of prekeratin antibodies reacted with all types of parotid epithelia, except acinar secretory epithelium. They also stained all island epithelial cells, but the reactivity was less in cell regions with pronounced lymphocyte infiltration. The heterogeneity between the island epithelial cells, immunohistochemically as well as ultrastructurally, indicates different stages of island formation. Interepithelial lymphocytes showed less vimentin and actin filament content in comparison with lymphoid cells outside the islands. Conclusively, typical epi-myoepithelial islands are composed of metaplastic epithelial cells of intercalated duct origin and invaded lymphoid cells, and ordinary myoepithelial cells are lacking. | |
| 910106 | [Muscular lesions in Gougerot-Sjögren syndrome]. | 1977 Jul | The authors review the literautre and then proceed to analyse a series of 16 cases of Gougerot Sjögren Syndrome. The electromyogram (EMG) was abnormal on only 2 occasions. Histologically inflammatory aspects could be seen on 4 occasions with perifascicular atrophy in one case. Atrophy of II fibres was present in 7 cases together with signs of disorganization of the mitochondrial reticulum and images of mitochondrial aggregates. Under the electron microscope minor anomalies were particularly visiole and the internal structure was normal as often as not. Overall it is possible to distinguish forms of a subacute polymyositis type (4 cases), and a pauci-inflammatory myalgic type proximal to the scappular predominance (4 cases), in which the mitochondrial anomalies are commonest. Another "infraclinical" group shows no other frankly pathological changes. Finally in 3 cases the "dry" syndrome is strictly free of any muscular attack. | |
| 6488716 | A case of scleroderma with Sjögren's syndrome developed after mammoplasty. | 1984 Sep | A case of scleroderma and Sjögren's syndrome, which occurred 9 years after mammoplasty, was reported. The association between mammoplasty and connective tissue disorders was considered to be more than coincidental. The prolonged hypersensitization by injected material may be responsible for the development of connective tissue disorders, that is, a human adjuvant disease. | |
| 7091172 | Liver disease in Felty's syndrome. | 1982 Jul | Eighteen patients with Felty's syndrome were examined prospectively for the presence of hepatic abnormalities. Twelve patients had abnormal liver histologic features: five with nodular regenerative hyperplasia and seven with portal fibrosis or abnormal lobular architecture. Only seven of the 12 had abnormal liver chemistry results. Four of the 12 had portal hypertension, and three bled from esophageal varices compared with one of six with normal histologic features. When patients with normal and abnormal liver histologic findings were compared, there was no difference in clinical, serologic, or extra-articular manifestations between the two groups, although there was a tendency for the patients with abnormal findings to have a higher incidence of vasculopathy. All patients with Felty's syndrome should be screened for hepatic abnormalities and portal hypertension as they have an increased likelihood of bleeding from esophageal varices. | |
| 7346960 | Polymorphonuclear granulocytes in rheumatic tissue destruction. II. Demonstration of PMNs | 1981 | Necrotic areas of rheumatoid nodules were investigated electron microscopically. PMNs in different stages of disintegration were present in all cases. Granular material, sometimes in a fiberlike orientation, and small fibrils without periodicity were detected between the collagenous fibers. It is assumed that granular material and fibrillar remnants represent degraded collagen. Often these degradation products were present in the neighborhood of disintegrating PMNs. From this morphological relationship it is concluded that enzymes of PMNs may in part be responsible for the fibrinoid necrosis in rheumatoid nodules. | |
| 273851 | Sjögren's syndrome (sicca complex). | 1978 Apr | A case of sicca complex Sjögren's syndrome in a 41-year-old woman is presented. Symptoms related to xerophthalmia and xerostomia were severe but, ironically, served to confuse the clinical impressions of medical personnel managing this patient, resulting in a diagnostic dilemma. Biopsy of a labial minor salivary gland followed by histopathologic examination of the tissue provided invaluable information which, together with the clinical picture, aided in the establishment of the delayed diagnosis. | |
| 622471 | The relationship between HLA-B27 positive peripheral arthritis and sacroiliitis. | 1978 Feb | HLA typing for B27 antigen is a helpful diagnostic aid in the classification of peripheral arthritis patients (especially young patients) who are rheumatoid factor negative. We studied 109 patients with seronegative peripheral arthritis belonging to various clinical categories; 23% proved to be B27 positive in comparison to 7% of normal controls. In spite of a paucity of spinal manifestations there was a high prevalence of sacroiliitis (83%) in the B27 positive peripheral arthritis patients as opposed to only 21% in those without B27 antigen. HLA-B27 typing and radiographs of the sacroiliac joints are important differential tests. | |
| 911356 | Polyclonal hyperviscosity syndrome. | 1977 Sep | The clinical course of two patients who presented with polyclonal hyperviscosity syndrome is described. Polymerizing IgG rheumatoid factors were isolated from the serum of both patients. The presence of these polymers with their extraordinary rheologic properties was the principal determinant of the abnormal rheological properties of the plasma. Neither patient had a discrete rheumatic disease. In both, a lymphoproliferative syndrome was present with features suggestive of the "pseudolymphoma" of Sjögren's syndrome. | |
| 6828846 | [Still's disease in adults. 2 case reports]. | 1983 Jan 29 | Two patients with adult Still's disease are presented. Both had high "septic" fever, weight loss, mild pharyngitis, evanescent maculo-papular rash, myalgias, arthralgias, splenomegaly and pericarditis, while one of the two patients also had lymphadenopathy and pleurisy. Arthritis, which is a sine qua non for the diagnosis, developed only 5 months after disease onset in one patient. Both ultimately developed severe destructive joint disease requiring hip arthroplasty. Laboratory findings were neutrophilic leukocytosis, normochromic normocytic anemia, elevated ESR, slightly elevated liver enzyme values, negative IgM-rheumatoid factor and antinuclear antibodies, and normal or slightly elevated complement factors. Several biopsies failed to reveal pathognomonic findings. It is of the utmost importance that the exclusion diagnosis of adult Still's disease be posed in order to avoid repeated hospitalizations with undue investigations and unnecessary therapeutic trials with antibiotics. | |
| 6971100 | Flow cytometry and cytoadherence studies of sera from children with juvenile rheumatoid ar | 1981 Mar | Recently, antibodies reactive with T cell subpopulations have been reported to exist in children with active juvenile arthritis (JRA). In an attempt to verify and extend these observations, we have studied children with JRA for the presence of anti-T cell antibodies by flow cytometry and cytoadherence rosette techniques. T cells were isolated from peripheral blood mononuclear cells (PBL) by two methods: 1) Differential sedimentation of PBL rosetted with neuraminidase-treated sheep erythrocytes, and 2) removal of immunoglobulin positive PBL by rosetting with rabbit anti-human F(ab')2 coated bovine erythrocytes and differential sedimentation. Utilizing these methods to detect lymphoreactivity of JRA sera to either population of T cell isolates, we observed the binding of ultracentrifuged normal human sera (NHS) to be comparable to JRA sera (active and quiescent). NHS reacted with 15-25% of T cells. Further studies demonstrate that monomeric IgG was chiefly responsible for lymphoreactivity. The results of these studies are discussed in the context of previous observations. | |
| 6091522 | [Caprine arthritis-encephalitis virus (CAEV). Short review]. | 1984 | After a short history, this work shows frequency of the articular form of the disease in France, and isolation of the virus. Although related to retrovirus, CAEV and maedi-visna have some differences: tropism of CAEV only for goats, low replication and expression in vitro, characteristic differences in protein composition. The virus seems to be transmitted during neonatal life; aerial transmission is still unclear. Separation of affected and non-affected goats is the only eradication technique when flocks are highly infected. An intervention a non-specific parameters is necessary to limit the spreading of the disease. Medical prophylaxis is non-existent. It is important to obtain a specific antigen in ELISA test for earlier detection of affected animals. Moreover, this research work could be a good model for further investigation into the rheumatoid-like syndrome in man. | |
| 7069178 | Hand involvement in psoriatic arthritis. | 1982 Mar | From a population of 105 patients with confirmed psoriatic arthritis, 25 patients required hand surgery. These 25 surgical patients were evaluated retrospectively both clinically and radiographically. The patterns of hand and wrist involvement as well as the results of surgery differed from those typically seen in rheumatoid disease. Spontaneous fusion of the wrist in a functional position, severe proximal interphalangeal involvement often with marked flexion contractures, severe erosion of the distal interphalangeal joint with spontaneous fusions, and generalized stiffness characterize these hands. Minimal improvement in motion and a significantly increased incidence of infection following arthroplasty were noted. | |
| 437821 | [Cell kinetics in experimental rheumatoid lesions and application in antirheumatic drug re | 1979 Feb | The kinetics of chronic inflammatory cellular infiltrates in antiglobulin-induced arthritis, peritonitis and subcutaneous fibrin granuloma were investigated. Only small numbers of the mononuclear cells were labeled after 3H-thymidine impulse labeling, whereas a high labeling index results after 3H-thymidine labeling of the bone marrow. It is concluded that in experimental arthritis the inflammatory so-called cellular hyperplasia consists in bone marrow derived mononuclear cells. In experimental peritonitis glucocorticoid treatment decreases the 3H-thymidine labeling indices. By means of such labeling studies the antiproliferative and antiexsudative properties of steroids were demonstrated quantitatively. Therefore we suggest to make use of experimental cell kinetics for the recognition of anti-rheumatic drugs. | |
| 340129 | Comparison of intra-articular methotrexate with intra-articular triamcinolone hexacetonide | 1977 | A comparison of intra-articular methotrexate and intra-articular triamcinolone hexacetonide was made in 42 arthritic patients with persistent bilateral knee effusions. One knee was injected with either 5 mg methotrexate (two injections of 2.5 mg a week apart) or a single injection of 20 mg triamcinolone. An objective assessment of both knees was made by quantitative thermography at 0,3,7,14 and 21 days. Joints injected with triamcinolone showed a greater fall in thermographic index (T.I) than the joints injected with methotrexate, which showed similar change to the non-injected knee joints in both groups. Four patients received larger doses of methotrexate, up to 20 mg, though the fall in T.I. was still less than the mean fall for triamcinolone injected joints. Peak venous blood levels of methotrexate were reached 1 hour after intra-articular injection, and a sphygmomanometer cuff inflated around the leg above the injected knee for periods of up to 1 hour did not appreciably delay this. Methotrexate had no immediate anti-inflammatory effect, even in psoriatic arthropathy, and did not give the relief of intra-articular steroid. |