Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7107333 | [Clinical picture, diagnosis and therapy of xerostomia--attempt of a survey under pathophy | 1982 Jun | Xerostomia is a symptom rooted in many causes. Considering the physiology of salivary secretion and its various mechanisms, a systematical classification of these causes can be given. Disorders in reflex evocation and transmission, disorders in the innervation of the salivary glands, in the production and transport of saliva as well as excessive depletion of saliva may lead to xerostomia. Chronic dryness of the mouth can in most instances be attributed today to disturbed innervation of the salivary glands (antidepressive and antihypertensive drugs) and to diseases of the salivary glands (Sjögren syndrome, irradiation). Depending on duration and extent of salivary deficiency, severe changes of the oral mucosa and teeth will develop. Treatment of xerostomia may be performed causally (withdrawal or exchange of drugs inhibiting salivary secretion) but will often only be possible as a symptomatic therapy. For this purpose there are available today saliva surrogate solutions ('artificial saliva') and substances that stimulate the secretion of the still intact salivary gland parenchyma. | |
| 7455119 | Parotid CT sialography. | 1981 Feb | Computed tomographic (CT) scanning of the parotid gland during the injection of water-soluble contrast medium allows precise mapping of the gland's parenchyma and of any filling defects or extrinsic masses. Thirty-six patients were examined in this way. The most valuable information that was gained was the differentiation of extrinsic and intrinsic tumors and an accurate appraisal of the location of the facial nerve with respect to intrinsic parotid lesions. In the majority of patients the diagnosis of benign or malignant tumor is suggested by the patterns of tumor growth. Inflammatory disease shows diminution in the amount of parotid parenchyma in relationship to interstitial tissues, but the appearance is not sufficiently characteristic for definitive diagnosis. | |
| 7295180 | Benign lymphoepithelial lesion and malignancy. | 1981 | Whereas most patients with benign lymphoepithelial lesion suffer from the involvement of a major salivary gland a number evolve into a clinical form of Sjögren's syndrome or Mikulicz's disease. In a small number development of malignant lymphomas, especially non-Hodgkin's lymphomas, have been described. Therefore, regular follow-up and appropriate histological evaluation of suspected areas in all patients with a benign lymphoepithelial lesion is indicated. Histologically, diagnosis of a non-Hodgkin's lymphoma may be difficult. Demonstration of a cell pattern, monoclonal for cytoplasmic Ig by means of the immunoperoxidase technique may facilitate the diagnosis. In this report we present the history of two cases out of our series with benign lymphoepithelial lesion who developed a non-Hodgkin's lymphoma. | |
| 491786 | [Sjögren's syndrome, mixed cryoglobulinemia and Waldenström's purpura (author's transl)] | 1979 Sep 15 | A 66-year-old patient was hospitalized after the appearance of a deep ulcer in the posterior face of the right calf. She had purpuric spots on the lower limbs only, as well as parotiditis, especially on the left side, and was affected with dryness of the mouth but not of the eyes. The patient also presented, in contact with the cold, Raynaud's phenomenon. Physical examination revealed as pathologic signs: purpura of the lower limbs, a deep ulceration on the right calf, parotiditis, and a reduction in the pallaesthesia of the lower limbs. Biologically an increased sedimentation rate, elevation of the total proteins (particularly the gammaglobulins), positive antinuclear factor, reduction of the total complement and of the C3 fraction, circulating immunocomplexes, positive latex test, positive Sia test, and the presence of mixed cryoglobulin IgG-IgM type kappa, stood out. The patient was diagnosed as having Sjögren's syndrome, mixed cryoglobulinemia and Waldenström's purpura. Probably the two latter conditions characterized by the presence or circulating immunocomplexes are part of the same process. According to recently studies described in the literature the relationships between these three entities are discussed, as well as the possibility of developing lymphoproliferative syndromes under certain immune stimuli. | |
| 386495 | [Systemic lupus erythematosus--clinical aspects and laboratory findings]. | 1979 Sep 8 | In a retrospective multicenter study 106 patients with systemic lupus erythematosis were analyzed who had had the disease for an average of 8.6 years, and from whom an average of 8 sera were tested within 3 years for current immunologic parameters. Cumulative clinical data showed arthropathies in 86% of the patients, exanthema (67%), cytopenia (58%), and involvement of the kidney (45%), lung (43%) and heart (24%). In at least 1 serum per patient the following immune abnormalities were found: antinuclear antibodies (98%), anti-native DNA (92%), low C3 (71%), low C4 (82%), circulated immunocomplexes (70%) and cold lymphocytotoxins (46%). A clinical score and an immunological score was introduced and the two items were compared: the immune data from a single serum do not provide long-range prognostic information. The present disease state is best reflected by the total immune score, C3 and C4 with, however, many exceptions. Within the disease course of some SLE patients, periods were observed during which no pathological immune serologic data are measureable. This phenomenon may pose diagnostic problems. | |
| 585363 | [Neurologic and psychiatric syndromes of rare para-rheumatic diseases (author's transl)]. | 1977 Mar | In Wegener's granulomatosis peripheral nerves are more often involved than central nervous structures; functional psychoses are secondary e.g. to renal complications. Neurologic-psychiatric symptoms are varied and result from local spread from the upper respiratory tract with separate granulomata and vasculitis. Striped muscle is involved in about 10% of cases. Specific vegetative disturbances of function do not appear to occur. This is also true for Granuloma gangrenescens. Its multicentric inflammatory, ulcerating and necrotic foci involve midline structures and often start at the anterior neuroporus. Becet's disease, however, shows clear characteristic localisation, symmetry of various dermatologic phenomena in the extremities and the almost obligatory involvement of mouth, stomach and the genitals and their surroundings. This one may assume to be due to a mesencephalic parasympathicotonic reaction as the basis for the occurrence of perioral and acro-syndroms after Fischer-Brügge and Sunder-plassmann. Some similarity with the localization of other collagenous diseases is evident. The anterior basal ganglia represent a favored focus where e.g. initial, imcomplete and readily recurrent processes, possibly of an exsudative nature, may start off neurovascular changes of limited areas without necessarily producing clinically detectable signs of the usual neurologic-psychiatric type. In Behcet's disease, rather as in scleroderma, the nervous system appears to be decisively involved. About one third of the cases show changes in the nervous system ("Neuro-Behcet" in the usual sense) with little peripheral signs and rare myositis. But Behcet's disease may also-like erythematodes or progressive sclerodermia-simulate a disseminated encephalomyelitis. The pathogenetic factors of Reiter's syndrome appear to be closely related. The relatively constant main symptoms are also localized and permit the conclusion that they depend on vasomotorically linked innervation of the first bulbar segment. The preference for distal localization of bilateral skin involvement hints - as in Behcet's disease at hypothalamic distribution; main localization in midface and the oral mucosa, in eyes and the ends of the midline and, often, also involvement of certain midline and, often, also involvement of certain favored joints permit the assumption of mutural relations between the cranial and sacral fields of incidence of the trophotrop-endophylactic system which is linked via the parasympathic with periphery. According to present knowledge the bundles of Schütz and, further, Krüke may be the pathways. Where pelvic processes predominate viscero-cutaneous or cuto-visceral reflexes may - as in dermatomyositis - be involved. E.g visceroreflectory changes explain coincidences of signs in similar or adjacent segments of the urogenital system, the rectum and certain joints. Psychose on a physical basis are rare. As in other collagen diseases the spinal cord is rarely involved, but "multiple sclerosis" may be simulated... | |
| 3872595 | Systemic lupus erythematosus: delineation of subpopulations by clinical, serologic, and T | 1985 Apr | Patients with systemic lupus erythematosus (SLE) (n = 194) were analyzed for correlation of clinical features. In addition, the proportions of the two major T cell subsets were determined in 87 subjects. Two patient subgroups were discerned: one in which severe renal disease, leukopenia, and thrombocytopenia predominated, and a second in which sicca syndrome and involvement of the central nervous system, lungs and muscle occurred. The ratio of T helper/inducer to T suppressor/cytotoxic cells was reduced in the first group and increased in the second. We conclude that SLE does not comprise a single disease entity, but rather represents a number of syndromes with overlapping clinical features. The correlation of clinical symptoms with the proportions of circulating T cell subsets suggests that several immunologic mechanisms may underlie the various types of SLE. | |
| 7004446 | Immunization of patients with Sjögren's syndrome with pneumococcal polysaccharide vaccine | 1980 Nov | Thirty-two patients with Sjögren's syndrome were randomly selected to receive either multivalent pneumococcal polysaccharide vaccine or saline placebo in a double-blind study. Among placebo treated patients, levels of antipneumococcal antibodies remained constant. Immunized patients developed significant elevations of antibody concentrations against all 12 capsular serotypes measured. Levels fell, but persisted above baseline, for 8 of the serotypes 6 months after immunization. During the 6-month study no clinical or serologic evidence of disease exacerbation occurred in either group. We conclude that pneumococcal vaccine can be safely and successfully administered to patients with Sjögren's syndrome. | |
| 102969 | [Burning tongue (author's transl)]. | 1978 Dec 8 | Burning tongue mostly does not occur as a disease per se, but as a symptom primarily of internal but also of neurological, dermatological, psychiatric and dental diseases. To facilitate differential diagnostic considerations, a short description is given of the individual clinical pictures as well as of the pertinent findings. The knowledge of these diseases is a prerequisite to the causal and lasting treatment of patients affected by the obstinate and occasionally even painful symptom of the burning tongue. | |
| 960384 | Keratoconjunctivitis sicca. | 1976 Jul | KCS in man is often associated with a systemic disease whose pathogenesis is still obscure. A spontaneous animal model resembling Sjögren's syndrome has been developed in the NZB and NZB-NZW mouse. Other spontaneous animal models analagous to lupus erythematosis and polyarteritis have been found in dogs and Aleutian mink, respectively. Studies of the eyes and lacrimal glands in such animals, and in dogs with distemper, should be pursued. A viral etiology is implicated in each of the models. The roles of both the main and accessory lacrimal glands in normal and KCS eyes have been discussed, as well as drug-induced KCS and opportunities for its further investigation and treatment. | |
| 6723160 | Prediction of outcome of total hip arthroplasty based on initial postoperative radiographi | 1984 Jun | All patients treated by total hip arthroplasty (THA) from 1971 to 1980 were analyzed to assess cause and rate of revision. Multiparameter radiographic analysis of failed femoral components ( FFC ) and matched control THAs was performed to determine predictability of failure, based on initial postarthroplasty and subsequent follow-up radiographic examinations. Rate of revision for all causes was 10.4% (35 THAs ) for 335 THAs in 270 patients with a follow-up period averaging 5.0 (range, 2-10) years. Cause of revision was component loosening in 7.2% (24 THAs ) [23 (6.9%) with femoral component loosening, 3 (0.9%) progressing to stem fracture, 3 (0.9%) with associated acetabular loosening, and 1 (0.3%) with isolated acetabular loosening]; infection in 1.5% (5 THAs ); and 1.8% (6 THAs ) comprised other causes. Older, inactive women, light in body weight (not including 42 THAs for rheumatoid arthritis), had fewer clinical failures. Second revision rate after revision for component loosening was 29% after an average follow-up period of 3.1 years. Paired comparison of initial postoperative and time-of-failure radiographs of 15 patients with THAs requiring revision for femoral component loosening versus initial postoperative and equivalent follow-up radiographs of 15 age-, sex-, weight-, activity-, diagnosis-, prosthesis-, and follow-up-matched patients with clinically successful THAs revealed the FFC group to be worse with regard to the following parameters: on initial postoperative radiographs, (a) femoral and acetabular bone-cement radiolucency (p less than 0.006 and p less than 0.02, respectively) and (b) when analyzed together, femoral bone-cement radiolucency, calcar-collar contact, femoral metal-cement radiolucency, femoral cement mantle adequacy, cement adequacy distal to the femoral component stem tip, and femoral component stem position (p less than 0.006); and on failure/equivalent radiographs, (a) femoral metal-cement radiolucency (p less than 0.01) and (b) when analyzed together, femoral metal-cement and bone-cement radiolucency, subsidence, cortical hypertrophy, calcar resorption, and sclerosis (p less than 0.006). | |
| 7009443 | The deposition of immunoglobulins and complement in osteoarthritic cartilage. | 1980 | In a prospective study of 117 patients having reconstructive surgery for osteoarthritis, biopsies of hyaline articular cartilage and meniscal fibrocartilage were taken which exhibited immunofluorescence in their articular surfaces, for at least two immuno-globins (Ig) and beta 1c. These could represent immune complexes. The cases were classified into three Groups according to clinical, radiological and laboratory features, (1) non-arthritic -- 27 (3% positive); (2) secondary degenerative -- 32 (16% positive); (3) idiopathic osteoarthritic -- 89 (51% positive). The incidence of positive findings in Group III was significant at p less than 0.001 and less than 0.005 levels respectively as compared to those of Groups I and II. Our study of the disease features and their associated laboratory parameters indicated the following: positive findings correlated with an older mean age and longer disease duration. The gradings for mononuclear cell infiltration in synovial biopsies of Group III were more than two times higher than those of secondary arthritics. Group III also had an increased incidence of circulating auto-antibodies. A careful review of clinical features has not suggested a mixed population with rheumatoid disease but rather that Group III represents part of the spectrum of primary generalised osteoarthritis. These data suggest involvement of local immune mechanisms in cartilage degradation in the joints of those patients with longer term involvement. | |
| 6590041 | Chloroquine inhibits the production of a mononuclear cell factor by inhibition of lectin b | 1984 Aug | The effect of chloroquine (CQ) on the ability of normal human peripheral blood monocytes to produce a soluble mononuclear cell factor (MCF) capable of stimulating prostaglandins from adherent rheumatoid synovial cells was studied. CQ inhibited concanavalin A (Con A)- and bacterial peptidoglycan-induced MCF activity, but not colchicine-induced activity, in a dose-dependent manner. After incubation with CQ for 20 minutes, 3H Con A binding was reduced by 50%, and metabolism of pre-bound 3H Con A was inhibited. These data suggest that CQ can inhibit MCF production by inhibition of lectin binding, perhaps by inhibition of receptor recycling. | |
| 7156323 | Systemic inflammatory complications following jejuno-ileal bypass. | 1982 | The clinical and laboratory features of three patients with systemic inflammatory complications following jejuno-ileal bypass surgery for morbid obesity are described. The constellation of an asymmetrical polyarthritis, tenosynovitis, sterile skin pustules, mucous membrane ulceration and retinal vasculitis resembled Behçet's syndrome. Serum complement levels were normal and circulating immune complexes not regularly detected, although hypocomplementaemia, elevations in Clq and rheumatoid factor binding materials were noted prior to clinical relapse in one patient. Antibiotic therapy proved disappointing, whereas dapsone produced a sustained remission. Bacterial overgrowth was not invariably found which together with recurrence of symptoms following bypass reversal, suggest that bacteria may only be required to initiate, not perpetuate inflammatory complications. | |
| 547366 | Rupture of a non-rheumatoid popliteal cyst: a syndrome mimicking thrombophlebitis. | 1979 Apr | Rupture of a popliteal cyst and dissection of its contents into the calf may produce pain, swelling, a positive Homan's sign and other findings closely resembling thrombophlebitis of the calf. The correct diagnosis is not often made, and the patient is subjected to needless long term anticoagulant therapy with its potential complications. To avoid this, it is essential that this possibility be kept in mind in all patients in whom the diagnosis of thrombophlebitis is considered. The history of preexisting arthritis of the knee, joint effusion and popliteal cyst are strongly suggestive of a ruptured popliteal cyst. This diagnosis can be verified by arthrography, ultrasonography, computed tomography and radionuclide scanning. Arthrography is preferred because it reveals superior anatomic detail thereby making differentiation between an encapsulated calf cyst, with smooth walls, and rupture, with irregular feathery margins, possible. Three illustrative cases are presented and the literature is reviewed. | |
| 7041057 | [Results of leukocyte migration inhibition test against elastin in joint diseases (author' | 1981 Dec | The purpose of this work was to report the results of the test TML inhibition of leukocytes' migration, using elastin, by Soborg and Bendixen method, modified with elastin rates of 100 micrograms and 200 micrograms/ml, in joints disease. We verified that the test is generally negative in healthy controls (1 TML positive out of 26 cases); we studied 72 patients, and 38 out of them had a positive test. TML is frequently positive in Horton disease, spondylarthritis, rheumatoid polyarthritis without corticoids, collagen disease; in this cases there is a significant difference of migration between patients and controls group. We also noted a positive TML in infections arthritis and other inflammatory but not in joint's diseases with alteration of elastic tissue (scabs and lung's injury). IN CONCLUSION: TML positive test with elastin, is not a specific test of articular injury neither a proof of its immunologic nature but it contributes in diagnostic for joints diseases. | |
| 212086 | Collagen production by cultures containing multinucleated cells derived from synovial fibr | 1978 Sep | Multinucleate cells are found frequently in rheumatoid synovium. In this study, polyethylene glycol was used to fuse rabbit synovial fibroblasts. Approximately 40% of the cells developed more than one nucleus in a 24 hour period, during which time cell membranes had increased permeability. In cultures containing multinucleate cells, 3H-thymidine incorporation was depressed for 24 hours although 3H-leucine incorporation into TCA precipitable material was unaffected; autoradiography showed that depression of 3H-thymidine continued for at least 4 days. Collagenase production by cultures containing fused cells was increased more than 10-fold over control cultures during a 28 day period. | |
| 6182503 | Rud syndrome: congenital ichthyosis, hypogonadism, mental retardation, retinitis pigmentos | 1982 May | Rud syndrome consists in the association of oligophrenia and hypogonadism with congenital ichthyosis; in the majority of cases, epilepsy, short stature or delayed in growth are also found. We described a child with such a syndrome. In addition to the classical findings, the patient had retinitis pigmentosa and hypertrophic polyneuropathy. Histological studies, including ultrastructural findings of a sural nerve biopsy, showed signs of a chronic demyelinative neuropathy with onion bulb formation. The world literature was reviewed and only nine other cases fulfilled our criteria for inclusion in Rud syndrome. This case represents the one with the most extensive neurological involvement ever reported. | |
| 7031242 | Relapsing polychondritis - pathogenic role of anti-native collagen type II antibodies. A c | 1981 Sep | A patient with relapsing polychondritis and Sjogren's syndrome is reported. Diagnosis was confirmed by ear cartilage biopsy. Antibodies against rat costal cartilage were present in the patient's serum. Antinative collagen type II antibodies were detected using a passive hemagglutination technique and the titer grossly correlated with the clinical course. Direct immunofluorescence using the patient's ear cartilage as a target suggested that anti-collagen antibodies might play a major pathogenic role in the course of relapsing polychondritis. | |
| 6257214 | cAMP and cGMP in the human parotid saliva. | 1980 | Human parotid saliva was revealed to contain considerable amounts of cAMP and cGMP. On sour lemon drop stimulation, the salivary cyclic nucleotides concentration decreased and the cyclic nucleotides secretory rate increased in close relationship with the salivary flow rate in control subjects. On feeding, both cAMP concentration and secretory rate increased significantly in control subjects. Parotid saliva from a patient of Sjögren's syndrom was revealed to have a significantly higher of cGMP concentration than those from control subjects. Saliva derived from the malignant tumor of the parotid gland was revealed to have a higher cGMP concentration and a lower cAMP concentration than the healthy site. From these findings, the possibilities of the clinical usefulness of studying salivary cyclic nucleotides were discussed. |