Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 160999 | [Circulating immunocomplexes in patients with various morbid conditions]. | 1979 Dec 22 | The polyethylenglycol (PEG) precipitation technique has been employed for the measurement of immune complexes in the circulation of 100 normal subjects and in 14 patients suffering from a variety of diseases (systemic lupus erythematodes, nephrosic syndrome, cryoglobulinaemia, Buckley's syndrome). Values higher than 0.80 UA on the absorption scale were considered pathological, namely 2 standard deviations above the mean (0.32 UA) in the subjects examined; in the patients, values between a minimum of 0.98 UA and a maximum of 2.38 UA were observed. Longitudinal study of these cases also pointed to the disappearance of immune complexes during therapy. The results suggest that the PEG precipitation technique can play an important part as a screening test in situations in which circulating IC pathology is suspected; it is also a sensitive means of monitoring treatment. | |
| 111679 | Immunoblastic sarcoma with features of Sjögren's syndrome and systemic lupus erythematosu | 1979 Aug | A patient with immunoblastic lymphadenopathy and features of Sjögren's syndrome and systemic lupus erythematosus is presented. Clinical features included generalized lymphadenopathy, rash, alopecia, and synovitis, with associated laboratory abnormalities of a positive antinuclear factor and double-stranded DNA antibodies, positive lupus band test, and hemolytic anemia. Symptoms of Sjögren's syndrome included dry eyes and mouth and swollen parotid gland; biopsy results of the accessory salivary glands were positive. At autopsy immunoblastic sarcoma was found that involved the myocardium, which stained for both kappa and lambda light chains by immunoperoxidase techniques. | |
| 707068 | Sialochemical examinations in non-tumorous parotid enlargements. | 1978 Sep | Secretion rates and the composition of isolated parotid saliva samples were samples were examined in 51 patients suffering from chronic recurrent parotitis, sialosis, or Sjögren's syndrome, and in 17 healthy controls. Evaluation of the results indicated that sialochemical examination may provide a valuable help in the differential diagnosis of parotid diseases characterized by swelling of the gland. Chronic parotitis is characterized by a significantly decreased flow rate, extremely high sodium and protein concentration and lack of secretory response to stimulation. In Sjögren's syndrome the low flow rate was found to be associated with a decreased potassium secretion rate as well as decreased flow rate and decreased sodium concentration after stimulation. In sialosis, where flow rates display a considerable individual variation, a significant increase in potassium secretion rate could be revealed. | |
| 348164 | [Endocrine function of the salivary glands]. | 1978 | The concept of the incretory activity of the parotid and submandibular salivary glands stems from numerous clinical and experimental data indicating a close association between them, sex and pancreatic glands and the pituitary. The paper presents the data on the mechanism of action of the salivary glands hormone, parotine. The participation of the salivary glands, especially at early stages of body formation, in the processes of mineralization of bones and teeth, and in proliferation of the elastic carcass of mesenchimal tissues, has been proved. The compensatory role of the salivary glands has been established in damages of the insular apparatus of the pancreas with formation of an insulin-like substance. By the example of Sjögren syndrome, the possibility of the development of the salivary glands diseases associated with disorders in the neuroendocrine and immune systems has been demonstrated. | |
| 268012 | [Experimental study of Gougerot-Sjögren disease in mice. Initial results]. | 1977 | The mouse was selected to provide an experimental model for Sjögren's disease. A comparative study was made between the normal mouse (C 57 Bl 6) and the spontaneously auto-immune mouse (NZB) from an immunological and scintigraphic standpoint. The first immunological results involve study of the effects of sub-mandibulectomy on the thymus of the C 57 Bl 6 mouse. The are of little significance. First scintigraphic results show marked differences from the point of view of the uptake and excretion of Technetium 99 between normal old mice (17 months) (C 57 Bl 6) and those with spontaneous auto-immune behavior. Dynamic graphs of the uptake and excretion of Technetium 99 in the latter are closely similar to those found in mice after sub-mandibulectomy. | |
| 1212498 | Studies of granulocyte kinetics in normal and granulocytopenic subjects. | 1975 Mar | Granulopoiesis was studied simultaneously by three methods in normal subjects and in subjects with neutropenia of various aetiologies: in vitro labelling of autologous and homologous granulocytes for the study of peripheral kinetics, in vivo labelling with DF32P (di-isopropyl-flourophosphate 32P) or 75Se-selenomethionine, and bone marrow autoradiography after in vitro labelling with 3H-thymidine for the study of bone marrow granulopoiesis. Three main mechanisms of neutropenia can be distinguished: a) peripheral hyperdestruction, corpuscular or extra-corpuscular, and false leukopenias (change in the distribution of peripheral granulocytes from the circulating to the marginal granulocyte pool; b) quantitative bone marrow insufficiency without qualitative abnormality; c) qualitative abnormality in bone marrow granulopoiesis with cell death in either the maturation stage or the proliferative stage. There is no exact correlation between clinical and kinetic classifications, but most cases of post-infection chronic neutropenias and idiopathic neutropenias fall into the first two categories, and most cases of benzol intoxication and bone marrow insufficiency due to X-irradiation fall into the last category. Some of these last patients developed an acute myeloblastic leukaemia in the two following years and can be considered as preleukaemic states. | |
| 1116394 | Bronchial brushing through the flexible fiberoptic bronchoscope in the diagnosis of periph | 1975 Feb | Bronchial brushing was performed concomitantly with transnasal flexible fiberoptic bronchoscopy in 44 patients with localized peripheral pulmonary lesions and absence of visible bronchial abnormality down to subsegmental level. Fluoroscopic confirmation of brush placement was obtained. A diagnosis of malignancy was made by bronchial brushing in 12 of 23 patients (52 percent) proved to have neoplasm, although diagnostic accuracy rose to six of seven patients (86 percent) in the final quarter of the study. There was no relationship between diagnostic accuracy and tumor location. Diagnostic accuracy was highest for squamous cell carcinoma, intermediate for adenocarcinoma, and lowest for undifferentiated carcinoma. A diagnosis of tuberculosis was made in two of 21 patients found not to have malignancy, and bronchial brushing was the only procedure to yield diagnostic material in these two patients. There were no false-positive cytologic examinations and no complications. Fluoroscopic control of placement of the bronchial brush passed through the fiberoptic bronchoscope allows a single, highyield, diagnostic procedure to be performed with minimal risk to the patient. In selected cases, thoracotomy may be avoided by this procedure. | |
| 3882844 | Monoclonal antibodies to the Sjögren's syndrome associated antigen SS-B (La). | 1985 Feb 28 | The nuclear autoantigen SS-B (Sjögren's syndrome B antigen) was purified from rabbit thymus extract by immunoaffinity chromatography with human autoantibodies, and used to immunise BALB/c mice for production of monoclonal antibodies. Fusion of spleen cells from an immunised mouse with NS-1 myeloma cells resulted in the isolation of 3 clones secreting anti-SS-B antibody. Subclasses were shown to be IgG2b by immunodiffusion. Specificity of the monoclonal antibodies (MCA) was determined by ELISA and indirect immunofluorescence. By immunoblotting all 3 MCA identified a single 45 K immunoreactive polypeptide in rabbit thymus, identical with the major polypeptide recognised by human sera containing anti-SS-B. Affinity columns prepared from the 3 MCA all bound SS-B from rabbit thymus extract, without binding other nuclear antigens. Immunofluorescence studies on standard substrates showed that SS-B was located predominantly in the nucleoplasm but in cells transformed by EBV or phytohaemagglutinin more prominent nucleolar and cytoplasmic staining was seen. | |
| 6975496 | [Stimulation of T-lymphocytes by autologous monocytes. Decrease in the proliferative respo | 1981 Oct | A mixed autologous culture enables the measurement of the proliferative response of T lymphocytes which have been stimulated by preparations of autologous mononucleated cells. The role of the monocytes present in the preparation was examined in this study which sought to determine if the autologous response induced by these monocytes was modified during Sjögren's syndrome. Purified monocytes are a powerful stimulant of autologous response in normal subjects. However, high concentrations of monocytes were found to have an inhibiting effect. In patients with Sjögren syndrome, the autologous response induced by monocytes in significantly decreased. This decrease parallels a reduction on "non-T" lymphocytes observed in these same patients. The anomaly provoking these two modifications does not appear to be caused by a seric factor or by a deficit of the proliferation of responding T lymphocytes. It is more likely due to a blockage of lymphocyte T/monocyte interactions where the markers of the HLA-D system intervene. | |
| 4073179 | Retinal vasculitis associated with autoantibodies to Sjögren's syndrome A antigen. | 1985 Dec 15 | Severe retinal vasculitis caused by a systemic lupus-like illness developed in two patients with distinctive clinical and immunologic characteristics. Both patients were young women with mild systemic disease and autoantibodies directed against a protein-ribonucleic acid complex termed the Sjögren's syndrome A antigen (SSA). One patient had no antibodies to nuclear antigens on conventional testing, and the other had a low-titer antinuclear antibody test. At the time of onset of retinal arteriolitis, neither patient had an exacerbation of multisystem disease or serologic activity. Despite oral and parenteral corticosteroids, cytotoxic agents, and panretinal photocoagulation, both patients suffered progressive irreversible retinal ischemia, optic disk and retinal neovascularization, vitreous hemorrhage traction retinal detachment, and anterior segment neovascularization. | |
| 4052126 | Two histopathologic types of inflammatory vascular disease in MRL/Mp autoimmune mice. Mode | 1985 Oct | We have recently described 2 histopathologic types of inflammatory vascular disease (IVD) in patients with Sjögren's syndrome (SS): neutrophilic IVD (NIVD) and mononuclear IVD (MIVD). Autoimmune MRL/Mp mice, which have many features of SS, spontaneously develop IVD which is histopathologically indistinguishable from that observed in human SS patients. Both MRL/Mp-+/+ and MRL/Mp-lpr/lpr mice develop MIVD which evolves into NIVD and results in decreased survival; the transition to NIVD is accelerated by the lpr gene. The presence of the lpr gene on other genetic backgrounds does not result in a similar acceleration of IVD and associated decreased survival. Thus, the spontaneous autosomal recessive mutation lpr appears to modulate the development of IVD in a strain of mice with an underlying propensity for vasculitis. Based on our observations on IVD in SS patients and MRL/Mp mice, we propose a new model which may enhance our understanding of the immunopathogenesis of IVD in connective tissue disease. | |
| 6703198 | Palisading prostate granulomas following surgery. | 1984 Mar | Fifteen cases of palisading granulomas of the prostate occurring in patients with a history of previous prostate surgery are described and illustrated. This distinctive histologic lesion strongly resembles a rheumatoid nodule, but is not associated with connective tissue disease or infection and is probably related to prior transurethral prostatectomy or needle biopsy. | |
| 6873616 | Intrahepatic cholestasis and sicca complex after thiabendazole. Report of a case and revie | 1983 Sep | Thiabendazole is a relatively safe and effective agent with a wide range of activity against nematodes infesting the gastrointestinal tract. A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy. Endoscopic retrograde cholangiopancreatography demonstrated normal biliary tree and pancreatic ducts. Liver biopsy was consistent with a drug-induced intrahepatic cholestatic reaction. The patient recovered completely from his liver injury, but the sicca complex persisted 1 yr after the drug was given. The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed. | |
| 6408145 | Antinuclear antibody determinations in Ro(SSA)-positive, antinuclear antibody--negative lu | 1983 May | Antinuclear antibody determinations were performed on the sera of twenty-eight Ro(SSA)-positive patients, who failed to demonstrate significant antinuclear antibody titers on mouse liver, with the use of various heterologous and homologous substrates. These studies demonstrated the following: (1) The existence of substrate specificity among various tissues and cells employed in the detection of antinuclear antibodies in Ro(SSA)-positive patients. (2) The existence of a significant group of Ro(SSA)-positive lupus patients with prominent cutaneous findings and systemic disease who, despite the employment of a variety of antinuclear substrates, failed to demonstrate significant antinuclear antibody titer. | |
| 6342581 | Idoxuridine-induced conjunctival cicatrization. | 1983 May | Four patients had idoxuridine-induced conjunctival cicatrization similar to ocular cicatricial pemphigoid develop, but in the treated eye only. Three of the four patients had chronic, recurrent herpes simplex epithelial and stromal keratitis. The fourth patient had Sjögren's syndrome. All received idoxuridine (0.1% drops and/or 0.5% ointment) and topical corticosteroids from one to 3 1/2 years. Substantial morbidity resulted that included visual loss, stromal ulceration, corneal scarring, and keratinization. Conjunctival biopsy specimens showed cicatrization with a mixed inflammatory cell reaction and absence of goblet cells. Results of direct immunofluorescent microscopy of the conjunctiva were either negative or nonspecific for autoantibody. No circulating autoantibody was detected in any of the four patients. | |
| 7299770 | Chronic neutropenia: possible association with Sjögren's syndrome. | 1981 Jul | Three white males, ages 42-59, with chronic neutropenia are described. All 3 patients had splenomegaly, positive tests for rheumatoid factor, elevated erythrocyte sedimentation rates, hypergammaglobulinemia and bone marrow examinations which showed normal to increased cellularity. Two of the 3 patients had recurring arthralgias and positive tests for antinuclear antibodies. All 3 patients had evidence for decreased tearing suggestive of Sjogren's syndrome, but in only 1 patient was a positive lip biopsy obtained. One patient had repeated cutaneous infections which ceased after splenectomy resulted in an increased neutrophil count. Serum IgG neutrophil-binding and in vivo neutrophil kinetic studies on 1 patient were consistent with a humoral immune mechanism for his neutropenia. | |
| 7013016 | [Anti-Candida salivary immunoglobulins. Evidence of a specific local immune reaction (auth | 1981 | Parotid saliva was studied in 119 subjects, some of whom were demonstrated as carrying Candida albicans in the oral cavity. No significant differences were found in the levels of total salivary IgA between the two groups, but specific IgA levels in the saliva differed significantly between the groups with or without the presence of Candida albicans. This confirms the existence of a specific local immunological response in the parotid saliva. | |
| 6483164 | Psychiatric assessment of children. II. Comparison with mothers. | 1984 | An attempt is made to demonstrate the relevance of a diagnostic method described in a preceding paper by comparing observations in 95 children aged 7-8 with independent findings in their mothers. The mothers had been chosen at random and exhaustively studied by another team at the time of the pregnancies which resulted in the birth of the children of our study. | |
| 6896080 | Lymphoma and the parotid gland. | 1982 Apr | The rich parotid lymphatic network makes necessary the inclusion of benign and malignant lymphoid disease in the differential diagnosis of parotid swelling. This area is affected directly by lymphoma in many clinical situations and has an indirect relationship with lymphoma through Sjögren's syndrome. These associations can produce uncertainty about the etiology and significance of parotid masses. Patients with Sjögren's have a spectrum of lymphoproliferative disorders from benign lymphoepithelial disease (BLD) to lymphoma and a significantly greater incidence of the latter than the general population. Nine patients with lymphoma and also benign and malignant lymphoid disease in the parotid illustrate various diagnostic considerations. These include that both benign and malignant parotid lymphoid pathology are seen with systemic lymphoma, that lymphoma can co-exist with BLD, may be misdiagnosed as BLD, and can develop in the same gland after appearance of BLD. | |
| 277498 | Alterations in lactoferrin in salivary gland disease. | 1978 Jan | During the active phase of chronic recurrent parotitis there is a marked elevation in the parotid concentration of lactoferrin (Lf), and iron-binding glycoprotein with antibacterial properties. The Lf concentration decreases during the recovery period, but still remains above normal levels. The changes of Lf in parotitis parallel recent findings in mastitis and pancreatitis. Elevations in Lf were also noted in five of six subjects with Sjögren's disease, but not in subjects with sarcoidosis, diabetes or "dry mouth" without sialographic changes. The source of the Lf has not been determined; it could arise in part from disrupting polymorphonuclear leucocytes and in part from epithelial cells that synthesize Lf in the salivary glands. Inflammatory stimulation of Lf synthesis would suggest a basic protective mechanism in exocrine glands and should be fully explored. |