Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3489218 | A comparison of memory for induced ischaemic pain and chronic rheumatoid pain. | 1986 Jun | Ischaemic pain was induced in two groups of subjects. The pain was initially assessed using the McGill Pain Questionnaire and then by recall 7 days later. The pain experienced by a group of patients suffering from rheumatoid arthritis was similarly assessed before and after rehabilitatory surgery. Memory for the single episode of ischaemic pain was superior to that for the chronic rheumatoid pain. | |
| 2799302 | Chronic arthritis. Prevalence, severity and distribution between primary care and referral | 1989 | By a simple self-administered hand test, hand handicap was revealed in 689 out of a population of 5262 individuals aged 40-70 years. Subsequent medical examination showed inflammatory hand disease in 119, 67 of whom had previously been in contact with the public health service at some level because of hand dysfunction. These 67 patients formed the material for our study, whose purpose was to analyse the distribution, treatment and follow-up of patients with inflammatory joint disease on different health care levels. In primary health care, rheumatoid arthritis (RA) was found to be underreported. For half the cases the interval between onset of disease and assessment by a rheumatologist exceeded 5 years, and follow-ups were few and far between. In the referral centres, RA cases were dealt with more adequately. The prevalence of definite and probable RA was found to be 0.7 and 0.4%, respectively. | |
| 3257873 | Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoi | 1988 Jan | Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation. After radiotherapy, there was a marked decrease in the number and function of peripheral blood helper/inducer (Leu-3+) T lymphocytes, in the spontaneous secretion of interleukin-1 by synovial biopsy specimens, and in the activity of the joint disease. In contrast, levels of IgM, IgA, and IgG rheumatoid factors and C3 concentrations in blood and synovial fluid samples did not change significantly after therapy with total lymphoid irradiation. | |
| 2012935 | Magnetic resonance imaging in the assessment of rheumatoid arthritis--a comparison with pl | 1991 Apr | Conventional radiography lacks sensitivity in early rheumatoid disease. MRI with its advantages of soft tissue discrimination and multiplanar imaging facility might detect earlier disease. This study compares the MR images and conventional radiographs of 11 rheumatoid patients' wrists and carpi. In all cases, erosions were more extensive and numerous on the MR images compared to plain radiographs. MR is useful in detecting early aggressive disease and in monitoring the response to treatments. | |
| 3134898 | Peripheral lymphocyte depletion in gold sodium thiomalate-treated rheumatoid arthritis pat | 1988 Jul | It has been reported that gold sodium thiomalate treatment of rheumatoid arthritis reduces the number of peripheral blood lymphocytes. In a prospective, double-blind, randomized trial comparing gold sodium thiomalate, auranofin, and placebo in the treatment of rheumatoid arthritis, we investigated absolute lymphocyte counts. We found that peripheral lymphocyte counts decreased, but there was no correlation with clinical change in disease activity. | |
| 2374539 | [Dental occlusion and temporomandibular involvement in rheumatic pathology]. | 1990 Apr | A clinical trial was performed in order to highlight the signs and symptoms of mandibular dysfunction in a sample group of 51 adults affected by chronic rheumatoid arthritis. Results were quantified according to Helkimo's indices and compared to those in a control group of nonrheumatic adults. The prevalence was found to be statistically significant. Dental support, calculated according to Eichner, appears to play an important role. Results in the same subjects were also compared with systemic articular involvement and Ritchie's index, but did not reveal significant associations. This underlines the peculiarity of the masticatory dysfunction, its relative autonomy and multifactorial etiopathogenesis. | |
| 1936108 | Muscle protein synthesis in patients with rheumatoid arthritis: effect of chronic corticos | 1991 Aug | Using stable-isotope techniques, we measured rates of quadriceps muscle protein synthesis in twelve women with sero-positive rheumatoid arthritis. The results were compared to those from the normal limb of seven women with unilateral osteoarthritis of the knee. Six patients had never received corticosteroid immuno-suppression, but the other six had taken an average of 8 mg Prednisolone per day for 9 years. Quadriceps atrophy was present in both sets of patients with rheumatoid arthritis (normal legs 444 +/- 182, rheumatoid 190 +/- 40, rheumatoid + steroid 300 +/- 110 micrograms protein/micrograms DNA, means +/- SD, both P less than 0.001). Muscle protein synthesis, calculated by comparing the incorporation of 13C-leucine into biopsy samples taken after an 8 h L-[1-13C] leucine infusion with the time averaged enrichment of blood alpha-ketoisocaproate, was 0.056 +/- 0.005% h-1 in the patients not receiving steroids compared with 0.050 +/- 0.02% h-1 in normals (P greater than 0.05) indicating that muscular atrophy was primarily due to an increase in rate of muscle protein breakdown. Intra-muscular PGE2 concentration was increased in these patients (rheumatoid 0.12 +/- 0.06 ng mg-1 tissue, normals 0.06 +/- 0.03 ng mg-1 tissue, P less than 0.05). Patients taking corticosteroids had a markedly depressed rate of muscle protein synthesis (0.035 +/- 0.008% h-1, P less than 0.05) and reduced intra-muscular PGF 2 alpha concentration (P less than 0.01). We conclude that steroid therapy significantly influences the mechanism of skeletal muscle atrophy in patients with rheumatoid arthritis. | |
| 3579386 | Parvovirus associated antigen in the synovial membrane of patients with rheumatoid arthrit | 1987 Mar | Homogenates of synovium from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were centrifuged on caesium chloride density gradients to obtain isolates of a density similar to that of parvoviruses. Six of 11 RA isolates and none of six OA isolates reacted with an antiserum raised against a rheumatoid associated, parvovirus-like agent (RA-1 virus). An anti-B19 parvovirus antiserum did not react with any of the isolates tested. Electron microscopy of negatively stained preparations of the isolates showed that small particles of diameter 10 nm were abundant in most of the RA isolates (11/13) but absent from all OA isolates. Such particles, whose identification is unknown, were also present in RA-1 positive lysates prepared from cultured RA synovial cells. These results suggest that the RA-1 virus can be directly identified in RA synovial tissue and that the virus appears to be unrelated to the human B19 parvovirus. | |
| 2730982 | A comparison of glutathione reductase and glutathione peroxidase activities in patients wi | 1989 Jun | A 30% increase in erythrocyte glutathione peroxidase (GP) activity was found in patients with rheumatoid arthritis when compared with healthy controls (p = 0.001) whereas the increase in glutathione reductase (GR) was statistically insignificant. No correlation was found between the activities of the enzymes and the erythrocyte sedimentation rate (ESR). The enzyme activities were independent of age, sex, or type of drug treatment of the patients. A possible interpretation of the results is presented. | |
| 2722316 | The Neer II replacement for rheumatoid arthritis of the shoulder. | 1989 | Thirty-eight patients had a Neer II replacement for rheumatoid arthritis of the shoulder. The average age at operation varied from 23 to 68 years. The average follow-up was 20.9 months. Forty shoulders were free of pain and function was reasonable in 21. Overall evaluation showed an excellent or satisfactory result in 15, 16, were acceptable and 10 poor. The most frequent radiological finding was upward subluxation which was present in 20 shoulders. An incomplete radiolucent zone was found around the glenoid component in 32% and around the humeral in 5%; there was no gross loosening. | |
| 2369419 | Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheu | 1990 Jul | A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX). Her serum transaminase and albumin levels were normal. A liver biopsy revealed chronic hepatitis with bridging fibrosis and piecemeal necrosis. Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active. This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis. | |
| 1795315 | Effect of spa therapy in Tiberias on patients with rheumatoid arthritis and osteoarthritis | 1991 Dec | Forty-one patients with rheumatoid arthritis were treated for 2 weeks at a Tiberias spa hotel. Randomized into 2 groups, Group 1 received a combination of mineral baths and mud packs, and Group 2 had tap water baths only. Both groups had a significant but temporary improvement in Ritchie index. Group 1 showed a significant improvement in grip strength. No improvement was noticed in morning stiffness, 15 meter walk time and laboratory variables of disease activity in either group. Twelve patients with osteoarthritis (OA) received 2 weeks of treatment with mineral baths and mud packs. Statistically significant improvement for a period of 6 months was noticed in night pain, pain on passive motion, tenderness on palpation and in the index of severity of OA of the knee. | |
| 2068455 | [Clinical characteristics of disorders of sexual functions in patients with rheumatoid art | 1991 Jan | The method of structural analysis was used to study the presence of sexual disorders in 26 male patients with rheumatoid arthritis (RA). The incidence of sexual disorders was 42.3 per cent (11 patients). In this case the ejaculatory and neurohumoral components of the copulative cycle were mostly disturbed. Sexual dysfunction developed during the disease and was often associated with exacerbation of RA. Disorders in pubertal development were revealed in none of the patients. But patients with a disturbed sexual function exhibited a significant decrease in the total cumulative index in the male sexual formula, in the level of total and free testosterone, a rise in the content of prolactin. Possible causes and mechanisms of sexual disorders in male patients with RA are discussed. | |
| 2083305 | Reproductive factors, smoking, and the risk for rheumatoid arthritis. | 1990 Jul | Risk factors for rheumatoid arthritis were examined in a cohort of 121,700 female nurses aged 30-55, followed in the Nurses' Health Study. Baseline information on reproductive variables, cigarette smoking, obesity, and other variables was obtained in 1976 and updated every 2 years. Cases of rheumatoid arthritis were defined by standardized questionnaire and review of medical records. During 883,187 person-years of follow-up, 217 new cases of rheumatoid arthritis were identified (115 had definite rheumatoid arthritis and 102 had "undifferentiated polyarthritis"). When compared with women who experienced menarche at age 13 years, the age-adjusted relative risk of rheumatoid arthritis among women with early menarche was 1.9 (95% confidence interval, 0.9-2.4). There were, however, no significant associations between parity, age at birth of the first child, menopause, or obesity and the incidence of rheumatoid arthritis. Cigarette smokers had a slight apparent increase in the risk of rheumatoid arthritis. Among current smokers, the age-adjusted relative risk for RA rheumatoid arthritis was 1.3 (0.9-2.1); among former smokers, the relative risk was 1.5 (0.9-2.3). | |
| 2910592 | Position of shoulder arthrodesis measured with Moiré photography. | 1989 Jan | A new method for measuring the position of a shoulder arthrodesis is presented. With Moiré photography and two mirrors, it is possible to find the neutral position of the scapula and to record the position of the humerus with great accuracy. | |
| 2587055 | [Clinical, x-ray and arthroscopic parallels in initial stages of deforming arthrosis of th | 1989 Aug | The study is based on the results of a clinical, roentgenologic and arthroscopic examination of 166 patients at the early stages of development of deforming arthrosis of the knee joint. The peculiarities of the early clinical, roentgenologic and arthroscopic symptoms and their relationship with the causative factors of the development of the disease have been investigated. The parallels between clinical and roentgenologic manifestations have been determined with regard to the degree of the degree of the degenerative and dystrophic changes in the articular cartilage, which is of major importance for the early diagnosis and the development of rational treatment of this pathologic condition. | |
| 2396217 | [The characteristics of the course of rheumatoid arthritis combined with thyroid pathology | 1990 | As many as 28 patients with associated rheumatoid arthritis (RA) and thyroid pathology were examined. Comparison with the control group of RA patients (n = 100) revealed a number of the clinical characteristics: the lack of severe destructive lesions of the joints, bone ankyloses, aseptic necroses of the head of the femur, a higher percentage of the development of secondary amyloidosis of the kidneys, attesting to the presence of a definite pathogenetic interrelation between these diseases. | |
| 2066943 | Intramuscular gold therapy is associated with long survival in patients with rheumatoid ar | 1991 Apr | To investigate whether the premature death of patients with rheumatoid arthritis (RA) was associated with intramuscular (im) gold treatment or side effects due to gold, a sample of 573 adult patients with RA treated at hospital for the first time during 1961-66 was retrospectively studied for the duration and side effects of im gold treatment as well as death and causes of death. By 1989 a total of 251 patients had died. Gold treatment was not associated with premature death. On the contrary, longterm gold treatment was associated with a high survival rate. Secondary amyloidosis was diagnosed in 28 out of 63 patients, who had gold associated renal disease and who died. | |
| 3705054 | Genetics of rheumatoid arthritis. | 1986 Feb | The haplotype sharing distribution in affected sib pairs are used to demonstrate the linkage of a susceptibility gene for rheumatoid arthritis (RA) to the HLA region. Family and population studies suggest heterogeneity in the etiology of RA. | |
| 2682774 | Soft-tissue changes in the hand in rheumatoid arthritis: evaluation with US. | 1989 Dec | High-frequency (5.0 and 7.5 MHz) ultrasonography (US) was performed in 16 patients with rheumatoid involvement of soft tissues in the hand or wrist; surgery was performed in 11. In 15 (94%) patients, a hypoechoic thickening of one or several tendon sheaths was noted. The thickening ranged from 2 to 13 mm (mean, 5.2 mm +/- 3.0). Complete or partial flexor tendon ruptures were correctly suspected preoperatively at real-time dynamic US examination in three patients. A discrete, elongated, hypoechoic soft-tissue nodule was demonstrated in five patients; one nodule was intra-tendinous. In 10 of 11 patients, US findings correlated well with those of surgery. Real-time US proved highly accurate in demonstrating rheumatoid soft-tissue changes in the hand. A hypoechoic rim around a tendon in the hand or wrist in a patient with rheumatoid arthritis is highly suggestive of rheumatoid tenosynovitis. US also provides surgeons with an accurate preoperative map of the lesions. |