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Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes

PMID	Title	PublicationDate	abstract
3459890	HLA and disease manifestations in rheumatoid arthritis--a Canadian experience.	1986 Apr	Forty-eight Canadian patients with rheumatoid arthritis (RA) were tissue typed for class 1 (HLA-A, B, and C) and class 2 (HLA-DR and DQ) antigens in an attempt to identify HLA associations and to relate them to disease manifestations and drug toxicity. HLA-DR4 was found with a significantly higher frequency among patients with RA than in the control population. DR4 correlated with presence of rheumatoid nodules and pulmonary manifestations, and was more frequent among patients who had vasculitis. All 4 patients who died were DR4 positive. DR2 and DR7 were less frequent in our patients. There was no association between the presence of DR3 or DR4 and drug toxicity.
2678391	[Significance of osteoporosis and the functional state of the joints in elderly patients w	1989 Apr	The author distinguished significant factors characterizing the state of aged patients on the basis of the complete mathematical analysis of clinical and clinico-laboratory symptoms in 376 patients with rheumatoid arthritis. A diagram of interrelationship between these factors has been drawn up; the author also determined the role of osteoporosis in the assessment of a number of clinical symptoms, in particular, intensity of pain, and constraint in the morning and outlined the ways of improving medical aid to patients of old age.
1975462	[Comparative clinical characteristics of rheumatic and reactive arthritis].	1990	The difficulties encountered in differential diagnosis of rheumatic and reactive arthritides are caused by the similarity of the articular syndrome not infrequently seen in both diseases, especially in their acute phases, a high frequency of little manifest forms of rheumocarditis and the rarity of other main manifestations of rheumatic fever as well as by a possibility of myocardial derangement in reactive arthritides. At the same time of paramount diagnostic importance are a detailed study of the disease history, estimation of the epidemic situation, careful clinical assessment of the character and evolution of the articular syndrome, the signs of lesions of the heart, other organs and symptoms, recognition of the symptoms characteristic for diseases of the group of seronegative spondylarthropathies, particularly Reiter's syndrome.
2930604	Microheterogeneity of alpha 1-acid glycoprotein in the detection of intercurrent infection	1989 Mar	We evaluated the clinical usefulness of determinations of alpha 1-acid glycoprotein (AGP) microheterogeneity in distinguishing patients who have active rheumatoid arthritis (RA) from those who have RA and an intercurrent infection. AGP microheterogeneity was studied by affinity electrophoresis with concanavalin A as the ligand, and the results were expressed as reactivity coefficients (RC). Significant differences were found between the mean RC (+/- SD) in healthy individuals (1.27 +/- 0.16) and the mean RC in RA patients with intercurrent infection (1.74 +/- 0.90), as well as with the mean RC in RA patients with grades III and IV disease activity (0.92 +/- 0.18 and 0.81 +/- 0.25, respectively). Moreover, an additional microheterogeneous form of AGP, similar to that observed in non-RA patients with infections, was noted in RA patients with infections (sensitivity 100%, specificity 100%). The results show that an increase in AGP reactivity with concanavalin A is a sensitive indicator of intercurrent infection in patients with RA.
2603650	Synovectomy of the rheumatoid knee does not prevent deterioration. 7-year follow-up of 83	1989 Oct	Eighty-three knees in 65 patients were studied retrospectively 7 (3-11) years after synovectomy for rheumatoid arthritis. Half of all the knees had an osteotomy or prosthesis operation after a median interval of 4 years. Early synovectomy had been performed in 67 knees; half of these had a satisfactory result. Most of the late synovectomies were unsatisfactory. Our results support the opinion that deterioration of the rheumatoid knee cannot be prevented by early synovectomy. Late synovectomy is discouraged.
2911675	Axial bone density in rheumatoid arthritis: comparison of dual-energy projection radiograp	1989 Feb	The usefulness of dual-energy projection radiography (DEPR) in the evaluation of rheumatoid arthritis was compared with that of dual-photon absorptiometry (DPA). Bone density measurements of the lumbar spine and the proximal femur were obtained with DPA in 75 patients (45 women and 30 men). For comparison, the bone density of the lumbar spine was measured with DEPR in a subset of 52 patients (33 women and 19 men). High correlation was documented between DEPR and DPA measurements of the lumbar spine. No significant relationship between bone density and age was observed, in contrast to the known relationship in healthy subjects regardless of sex, site of measurement, or measurement technique. Bone density values in the spine and the proximal femur were significantly reduced for both sexes as compared with matched normative data. Interlevel variation in lumbar vertebral density as measured with DEPR was not significantly different in patients with rheumatoid arthritis as compared with control subjects. Significant correlation between bone density determination and body weight, as well as duration of menopause, was noted, whereas duration of disease, functional status, and cumulative corticosteroid dose were not predictive. Rheumatoid arthritis did not appear to influence the relationship between DEPR and DPA measurements of the spine, and neither method nor site of measurement exhibited a consistent advantage in discriminating patients with rheumatoid arthritis from healthy control subjects.
2261733	Can treatment with methotrexate influence the radiological progression of rheumatoid arthr	1990 Sep	We have recently reported that methotrexate (MTX) is an effective treatment of patients with refractory rheumatoid arthritis (RA) to second line medication. We showed that 54% of our patients continued having clinical benefit after 24 months therapy with MTX. In this study we evaluated pairs of hand radiographs from 35 patients taken before and after 24 months treatment. We used a scale scoring similar to Larsen's standard radiographs with minor modifications. No significant changes were observed in the overall scoring of the radiographs before (14.84 +/- 13.05) and after treatment (18.77 +/- 15.60) (p greater than 0.5). Of these 35 patients, 23 had a clinical remission and 12 had a good response. Twenty patients have shown a stabilization of erosions in radiographs while 15 showed a deterioration. No correlation was found between clinical response and radiological changes. We conclude that MTX does not appear to be a disease modifying agent, but may inhibit joint damage progression.
3486288	Interleukin 2 production and responsiveness in active and inactive rheumatoid arthritis.	1986 Feb	The interleukin 2 (IL-2) production and responsiveness of peripheral blood lymphocytes from patients with rheumatoid arthritis (RA) with active or inactive disease was compared with that of normal control donors. IL-2 production was assessed using a cellular interleukin assay in which an IL-2 dependent cell line was cocultured with varying numbers of irradiated IL-2 producing lymphocytes from the different donor sources. Cells from patients with active disease showed a significantly different pattern of IL-2 production from that of control or inactive RA patients in that a lower number of cells supported growth of the IL-2 dependent cell line. In one patient this shift in pattern was shown to correlate with change in disease activity. Lymphocyte responsiveness to IL-2 as determined by limiting dilution analysis did not differ significantly between the different groups. The results are consistent with a hyperproduction of IL-2 in RA during active disease.
3573827	Rheumatoid pseudocyst (geode) of the femoral neck without apparent joint involvement.	1987 May	Typically, rheumatoid cysts are associated with obvious joint involvement and are located in the subchondral portion of the adjacent joint. Giant pseudocysts (geodes) are uncommon and are characteristically associated with extensive joint destruction. The patient described in this report had a giant pseudocyst of the femoral neck but no joint involvement. To the best of my knowledge, this is the first report of such a manifestation of a giant pseudocyst. As such, it posed a somewhat difficult diagnostic problem.
2706419	Prospective long term follow-up of methotrexate therapy in rheumatoid arthritis: toxicity,	1989 Apr	We followed all 128 patients started on methotrexate (MTX) for rheumatoid arthritis (RA) over a 4-year period. Forty-nine were followed for over 3 years. Forty-three patients discontinued treatment, 23 because of toxicity, 15 for inefficacy and five for other reasons. Forty-seven of the 75 followed on treatment for over 2 years had hand radiographs available before and after this treatment period. None showed improvement and 15 showed marked deterioration. Patients' acceptance of this therapy was good although most were noted objectively to have persistent disease activity. We would recommend that if MTX is to be used, a more aggressive approach be adopted to reduce not only the symptoms but the signs of active disease.
1810045	[The clinico-morphological assessment of the efficacy of local radiation therapy in rheuma	1991	Ten patients with rheumatoid arthritis underwent arthroscopy of knee joints and spot biopsy of the synovial membrane before and 6-12 months after intraarticular injection of radioactive gold-198. In 8 joints there was a decrease of inflammatory infiltration of the synovial membrane. Still, the clinical signs of arthritis persisted in 5 of them. In 3 cases, the clinical and morphological manifestations of arthritis remained practically unchanged. The decrease of inflammatory infiltration of the synovial membrane may favour a reduction of destructive potential of chronic synovitis even if the exudative component of inflammation is preserved. The clinicomorphological estimation of the results of local radiotherapy is more informative than the purely clinical one, for it allows the positive dynamics to be recorded even in the absence of evident clinical improvement.
2376830	Vitamin C influence on localized adjuvant arthritis.	1990 Aug	This work attempts to determine the influence of vitamin C on locally induced inflammation and arthritis in rat paws, as measured by rat paw swelling, polymorphonuclear leukocyte infiltration, pain, and surface skin temperature. Daily subcutaneous administration of 150 mg/kg of vitamin C over 20 days reduced arthritic swelling, increased pain tolerance, and decreased polymorphonuclear leukocyte infiltration, with no significant change in surface temperature. Vitamin C may provide podiatrists with a supplemental or alternative treatment for patients with rheumatoid arthritis.
3178906	Self-evaluation processes and adjustment to rheumatoid arthritis.	1988 Oct	In this study we examined whether the impact of rheumatoid arthritis (RA) on psychological well-being is mediated by the way patients evaluate their physical abilities. The primary focus was on patients' satisfaction with their physical abilities and the types of comparisons that patients make between themselves and other people (i.e., social comparisons) when evaluating their abilities. Seventy-five women with RA were interviewed. Findings indicate that satisfaction with one's physical abilities appears to mediate the relationship between physical and psychological impairment. Furthermore, satisfaction was associated not only with one's abilities per se, but also with the types of comparisons patients made when evaluating their abilities. These findings help explain differences in the levels of psychological well-being noted among individuals with the same degree of physical impairment.
2273520	The systematic study of drug therapy in rheumatoid arthritis.	1990 Nov	Important advances in therapeutics for rheumatoid arthritis (RA) will probably require coordination of the experience with new developing agents with an ongoing program of systematically collected open data, and formal controlled clinical trials to address key problematic issues. Controlled trials, despite formidable obstacles, not the least of which is the lack of satisfactory end points, are necessary because randomized treatment assignment is the only valid way to obtain results with a defined degree of certainty. A formal test of whether early aggressive intervention can arrest disease appears feasible. On the other hand, it does not now seem desirable to pursue a controlled, blinded study of RA over the longterm.
3820196	Hearing and middle ear function in rheumatoid arthritis.	1986 Oct	The hearing and middle ear function in 68 patients with rheumatoid arthritis were tested. Reduced middle ear compliance, presumably due to stiffening of the tympanossicular chain, was noted in 48 patients (70.50%). Conductive hearing loss and absence of the stapedius reflex, were recorded in only one patient (1.40%). In 20 patients (29.40%) a moderate (20-30 dB) high frequency sensorineural hearing loss was found. The results of loudness balance and tone decay tests and the speech discrimination scores suggested cochlear pathology in some cases. However the multiplicity of factors that might be involved in sensorineural hearing loss, and the absence of a significant relation between such a loss and the activity of the disease or drugs used in its treatment makes the postulation of a plausible explanation a difficult, still unfinished task.
3454364	Myelopathy due to cervical spine rheumatoid arthritis. A case report.	1987 Oct	A 62-year-old woman with cervical myelopathy due to cervical spine rheumatoid arthritis is presented. Transoral decompression of the spinal cord, followed by posterior spine fusion in the same session was performed with good results. Unfortunately she died 3 months later due to cardiovascular disease. Clinical, radiological, surgical and autopsy data are presented.
3452479	Epidemiological aspects of family studies in rheumatoid arthritis.	1986 Jun	The study of multicase families is of value in the analysis of genetic association between rheumatoid arthritis and markers such as HLA. There are a number of ways that multicase families arise but it is likely that the affected individuals within these families are not genetically distinct from sporadic cases. More problematic, however, is the nature of the disease itself. Its variable presentation, at any age, and the existence of self-limiting forms renders classification of individuals within families complex. In the absence of continuous life-long observation the only reasonable alternative is to use all available data for analysis and not be constrained by rigid criteria developed for other purposes.
3075082	Sandimmun (cyclosporin A): mode of action and clinical results in rheumatoid arthritis.	1988	Cyclosporin A (Sandimmun) has gained wide acceptance by most transplant physicians as the immunosuppressant of choice for preventing rejection of solid organ grafts and graft-versus-host disease. The drug has a specific effect on T-lymphocytes in which it seems to prevent the transcription of genes for several lymphokines. The reduction in IL-2 prevents the clonal expansion of T-lymphocytes and their differentiation into effector T-cells. The reduction in IFN-tau interrupts the feedback mechanism between T-cells and macrophages and the aberrant expression of MHC class II molecules. Through these mechanisms Sandimmun exerts an immunosuppressive and anti-inflammatory effect. Considerable evidence has accumulated to suggest that rheumatoid arthritis (RA) is an auto-immune disease. Activated T-lymphocytes interrelate with macrophages, other inflammatory cells and effector cells in joint tissue, leading to symptoms of inflammation accompanied by joint destruction. Immunosuppressive treatment is already well established in this disease and several trials have already taken place using Sandimmun. A total of 224 patients with RA refractory to conventional disease-modifying drugs have participated in 11 published clinical studies. A review of these studies concludes that Sandimmun is efficacious in controlling inflammatory and functional symptoms, although this improvement is no generally accompanied by reductions in ESR and rheumatoid factor. The frequency of adverse events is comparable to that of other treatments but nephropathy remains the principal factor limiting the use of Sandimmun. Recent evidence suggests that with a strict dosage strategy and good monitoring this problem is controllable and reversible. Further studies are under way to confirm these claims.
2267848	[Significance of occupational, health and life satisfaction in coping with rheumatic compl	1990 Aug	In a pilot study with a prospective study design we analyzed the interaction between disease modifying drugs and coping styles. We examined 45 inpatients with definite or classical rheumatoid arthritis at the beginning of disease modifying drug treatment and eight months later. In this paper we evaluate the role of health satisfaction in relation to an effective therapy. The results of the discriminant analyses between sufficient and non-sufficient persons show that a differential discrimination can be achieved with psychosocial variables, for example diseasecompetency and self-mobility. Finally, our results show that a disease modifying drug treatment in rheumatic diseases must be completed with psychosocial treatments.
3698360	Hypergastrinemia in rheumatoid arthritis.	1986 Jan	Fasting hypergastrinemia was noted in 13-41% of 82 of outpatients with definite or classical rheumatoid arthritis. No differences were noted between the normogastrinemic and the hypergastrinemic subjects in their age, sex, duration of rheumatoid disease, serological status, or medications. The food-stimulated gastrin response was 117 mg/L, or 216% above the basal levels, and the integrated gastrin response was increased to the level previously reported in patients with duodenal or gastric ulcer disease. These results suggest that hypergastrinemia is a feature of patients with rheumatoid arthritis, the gastrin response to food may be abnormal in some rheumatoid patients.