Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3713605 | Pleuropulmonary necrobiotic rheumatoid nodules. A review and clinicopathological study of | 1986 Jun 9 | Pleuropulmonary rheumatoid nodules were diagnosed histologically in six patients of whom five were known to have rheumatoid arthritis; the pulmonary lesion preceded the development of arthritis in the sixth patient. Pulmonary lesions are commonly found in patients with rheumatoid arthritis. These lesions are either non-specific (effusions, pleurisy, fibrosis, arteritis and obliterative bronchiolitis) or the specific necrobiotic nodules that constitute Caplan's syndrome in association with pneumoconiosis. The necrobiotic nodules are usually pleural or subpleural and rarely occur in the bronchial tree. Pulmonary necrobiotic nodules can appear before, coincident with, or after the onset of arthritis. It is essential to distinguish these lesions from infections or neoplasia. | |
| 3956115 | Influence of previous gold treatment and other patient variables on outcome of treatment w | 1986 Jan | Based on a 2-year controlled double-blind trial of levamisole, penicillamine, and azathioprine (L, P, and A), a computer aided search for predictive factors of outcome was instituted. Already at month 4 several indicators of synovitis activity were able to discriminate between patients staying in the trial for 24 months and patients whose treatment was discontinued before that time. Patients who had previously received gold therapy responded less favourably to L, P, and A than those who had not received gold. This reduction of response was more pronounced in gold resistant patients than in patients whose gold treatment had been discontinued for other reasons. The only phase protein (of several) with a predictive value was haptoglobin. If, after 4 months of treatment, haptoglobin did not normalize, this finding indicated a lack of response to treatment or a deterioration of synovitis activity during the following 4 months. The response to treatment was not influenced by HLA-types, sex, age, or clinical synovitis, disease duration, functional or anatomical aberrations at the start of treatment. The shape of the response curve as reflected by means of monthly measurements of serum-albumin and ESR was not related to disease duration, HLA-types, or previous gold treatment. | |
| 2758710 | Felty's syndrome without concomitant arthritis: a variant. | 1989 May | A young female patient who had documented seropositive rheumatoid arthritis and was treated consecutively with aspirin, diclofenac, and gold salts was admitted years later for severe neutropenia. On examination she had, in addition, fever, positive rheumatoid factor, reversible swan-neck deformity of the fingers but otherwise normal joint findings. The patient responded to prednisone therapy. This case would appear to be a most unusual variant of Felty's syndrome. | |
| 1793024 | IgM-rheumatoid factor and responses to second-line drugs in rheumatoid arthritis. | 1991 Sep | We have examined the relationship between IgM-rheumatoid factor (RF) and responses to second-line drugs in patients with rheumatoid arthritis (RA). Patients with active RA who were beginning treatment with gold, methotrexate or both were studied. Clinical responses were assessed with ESR, joint count, grip strength and activities of daily living questionnaire scores. Production of IgM-RF by peripheral blood mononuclear cells in vitro and plasma levels of IgM-RF were measured by ELISA. Overall, 31 of 44 patients completing more than 6 months treatment improved including 10 treated with gold, 12 with MTX and 9 with both. Production of IgM-RF by peripheral blood mononuclear cells was decreased by 59% in patients who improved on treatment, but increased 2-fold in the unimproved group. Plasma levels of IgM-RF were decreased from 121 to 66 micrograms/ml in the improved group after 6 months of treatment, with similar decreases seen for each of the three treatments. In contrast, plasma IgM-RF levels in the unimproved group did not decrease until 1 year of treatment was completed. Nine patients converted to seronegativity, and all but one of these were in the improved group. The results suggest that IgM-RF is correlated with responses to second-line drug in RA patients. | |
| 2102034 | [Classification of rheumatic diseases. Knowledge and problems]. | 1990 Dec 15 | A classification of diseases serves following purposes: --Collection and processing of data on morbidity and mortality (administrative objective) --Tool for diagnostic evaluation (clinical decision making) --Indicator of the scientific state of the art of the disease (theoretic taxonomy). In the efforts to unify the classification of rheumatic disease, following two goals are realistic: 1) Improvement in the effective communication 2) Agreement with the targets set. The International Classification of Diseases for Rheumatology and Orthopedics (ICD-R and O), which has been jointly elaborated by the International League Against Rheumatism (ILAR) and the Societé Internationale de Chirurgie Orthopédique et de Traumatologie (SICOT), is a practicable international standard for the next years. | |
| 2657889 | Rheumatoid arthritis and pregnancy. | 1989 May | The activity of RA is significantly altered by pregnancy with approximately 70 per cent of patients experiencing substantial improvement in symptoms, signs and sometimes extra-articular manifestations. This lessening of disease activity occurs in association with an almost complete cessation of medications. However, whether partial or complete this remission is short-lived with more than 90 per cent of women who improved relapsing by 6 to 8 months postpartum. Further, in approximately 30 per cent of RA patients the course remains unchanged or worsens during gestation and indeed the first symptoms of RA may develop during pregnancy or shortly thereafter. Conversely active rheumatoid arthritis seems to little influence the maternal course or fetal outcome of pregnancy. The multiple and complex immunologic alterations of the pregnant state are designed to ensure survival of the fetal allograft in a foreign host. A number of these alterations particularly involving modulation of cell-mediated immunity, immunoglobulin composition, immune complex generation, or the inflammatory response have the potential to interfere with the pathophysiology of RA. In short, although the specific mechanism remains an enigma, the reason for the amelioration of RA during pregnancy is probably an incidental and fortuitous reaction to one or more of these immunomodulatory factors. | |
| 1948098 | Total elbow joint arthroplasty in patients with rheumatoid arthritis. | 1991 Aug | As a result of better patient selection, implant design, and surgical technique, the long-term results of total elbow arthroplasty in patients with rheumatoid arthritis has improved significantly over the past 10 years. The semiconstrained hinge implant is used in the presence of severe bone and ligament destruction. The non-constrained surface replacement requires intact bone and ligamentous supports. Best results are obtained if surgery is undertaken before severe soft tissue contractures, muscle atrophy, and neurologic disability of the involved extremity develop. | |
| 2328035 | The relationship of sulfoxidation status to efficacy and toxicity of penicillamine in the | 1990 Apr | Penicillamine shows some structural similarities to carbocysteine. The ability to oxidize carbocysteine, i.e., the sulfoxidation status, shows a bimodal distribution in the general population. In this study, sulfoxidation status was determined in 50 of 60 rheumatoid arthritis patients receiving penicillamine. We found that poor sulfoxidation status, compared with good sulfoxidation status, was associated with a 3.9 times higher incidence of toxicity. | |
| 2290088 | Gradual low riding of the patella during postoperative course after total knee arthroplast | 1990 Dec | Patellar height in the lateral view of radiograms was measured on 94 knees of 61 women before and after total knee arthroplasty in order to study postoperative changes of position. The mean age of patients at surgery was 58.4 years (range, 30-77 years). Eighty-one knees were rheumatoid and 13 osteoarthritic. Inserted prostheses were Kinematic anteriorly joined type in 49 knees, Kinematic posterior cruciate retention type in 19, and UCI type in 26. The observation period ranged from 6 months to 9 years, with an average of 2.6 years after surgery. The ratio of length of the patellar ligament to that of the patella (Insall-Salvati's ratio) decreased by more than 10% of preoperative value in 61 knees, remained unchanged in 31, and increased in only 2. The average ratio was 0.93 +/- 0.16 before surgery and 0.75 +/- 0.20 at the final follow-up examination (P less than .01). | |
| 3052971 | The effect of physical training on patients with rheumatoid arthritis: changes in disease | 1988 Jul | For decades, physical training of rheumatoid arthritis (RA)-patients has been controversial, especially for patients with active disease. The aim of this study was to investigate whether RA-patients could receive graduated training without increasing the activity of the disease. In a controlled cross-over study the effect of graduated progressive training has been evaluated in 18 RA-patients with moderately active disease. The training was performed twice weekly with aerobic conditioning and strength exercises progressing to strenuous exercises over an 8-week period. The design was a crossover project with two groups obtained by minimisation. After training the patients had significantly fewer swollen joints than before. Training of the muscles acting over the swollen joints resulted in more than a 35% decrease in the number of swollen joints. The hemoglobin level increased significantly after the training period. The erythrocyte sedimentation rate, the complement factor C3d, and the number of sore joints remained unchanged. A decrease in the need for medicine was non-significant. From this study it appears that RA-patients with some activity are trainable without aggravating the disease, even in the chronically swollen joints. The rheumatoid arthritis activity decreased with fewer swollen joints and higher hemoglobin level after training. | |
| 2634524 | [Evaluation of the results of synovectomy of the knee joint performed in the early period | 1989 | The authors analyzed the results of 77 early knee synovectomies in 65 patients with rheumatoid arthritis, performed in 1976-1987. Special attention was paid to pain, exudate, range of motion, flexion contracture, instability, ability to walk, and radiological changes in the Larsen's scale. The patient's subjective evaluation and the surgeon's intraoperative evaluation were also taken into account. The results were excellent --32.5 per cent, good 46.8 per cent, fair 6.5 per cent, and poor 14.2 per cent. | |
| 3962637 | Radical synovectomy with muscle release for the rheumatoid elbow. | 1986 Feb | Twenty-three synovectomies of the elbow with concomitant muscle release at the humeral epicondyles were performed in 21 patients with rheumatoid arthritis. Ten elbows were classified as anatomical Stage 2, 12 as Stage 3, and one as Stage 4. The patients were followed from 1 to 8 years. Postoperative clinical results showed improved relief of pain, and range of motion, and activities of daily living. Increased range of motion with improvement of flexion contracture was obtained in most cases by releasing the muscle insertions around the humeral epicondyles and by resecting the radial head and bony spurs of the coronoid and the olecranon. The operation was beneficial even at advanced stages. | |
| 3958532 | Elbow arthrography in the evaluation of posterior interosseous nerve compression in rheuma | 1986 Feb | This is a case report of a fifty-nine-year-old rheumatoid arthritic woman who developed lack in finger extension bilaterally. These deficits had two completely different aetiologies, Posterior Interosseous Nerve (PIN) Syndrome and extensor tendon rupture. No previous report in the literature has used elbow arthrography as a diagnostic tool in a patient with PIN Syndrome. Elbow arthrography confirmed the abnormality at this joint and aided in appropriate management. | |
| 1887217 | Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic f | 1991 Aug 30 | Human T cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T cell leukemia and has also been suggested to be involved in other diseases such as chronic arthritis or myelopathy. To elucidate pathological roles of the virus in disease, transgenic mice were produced that carry the HTLV-I genome. At 2 to 3 months of age, many of the mice developed chronic arthritis resembling rheumatoid arthritis. Synovial and periarticular inflammation with articular erosion caused by invasion of granulation tissues were marked. These observations suggest a possibility that HTLV-I is one of the etiologic agents of chronic arthritis in humans. | |
| 3539037 | Prediction of progressive joint damage in patients with rheumatoid arthritis receiving gol | 1986 Nov | Seventy two patients with classical or definite rheumatoid arthritis (RA) were randomly allocated to receive gold or D-penicillamine therapy (DPA) in a prospective study designed to evaluate whether it is possible to predict which patients will show radiological progression despite therapy. Forty five patients completed 12 months' treatment. There were no significant demographic or clinical differences between them and the 27 drop outs. Twenty of the 45 patients showed no radiological progression between six and 12 months. These patients had less severe initial radiological damage, lower levels of serum aspartate transaminase (serum AST) and lactic dehydrogenase (LDH), but higher levels of serum cholesterol. Twenty five patients did show progression during the six to 12 month period. This group included all the men with nodules. Of the 43 pretreatment clinical and laboratory variables examined, however, the majority failed to predict whether or not progression would subsequently occur. This included the acute phase response and seropositivity. | |
| 2077456 | Retinal vasculitis as a complication of rheumatoid arthritis. | 1990 | Two middle-aged women developed retinal vasculitis in the moderately active phase of classical rheumatoid arthritis. Fluorescein angiography disclosed diffuse leakage from the retinal capillaries and cystoid macular edema, which subsided in response to oral steroid. They did not show any clinical signs of vasculitis in other parts of the body. Retinal vasculitis should be included in the list of complications observed in rheumatoid arthritis. | |
| 2757409 | Rheumatoid neutrophilic dermatitis. | 1989 Aug | We recently examined a patient with severe rheumatoid arthritis who presented clinically with fixed urticaria-like plaques. Histologic examination revealed a dense neutrophilic dermal infiltrate without associated vasculitis. On clinical and histologic grounds, this case differs from other noninfectious neutrophilic inflammatory disorders. We present a case of rheumatoid neutrophilic dermatitis and review the salient features of this unique disorder. | |
| 2792359 | [The pentosephosphate pathway of carbohydrate metabolism in evaluating the pharmacologic c | 1989 May | Treatment with roxicam, rengasil and flugalin tended significantly to normalize the activity of enzymes of carbohydrate metabolism pentosophosphate pathway in the blood of patients with systemic lupus erythematosus and rheumatoid arthritis. The dynamics of the change in the activity of enzymes of pentose phosphate pathway in the blood of patients with systemic connective tissue diseases against the background of treatment with roxicam, rengasil and flugalin is the enzymological criterion in assessing efficacy of pharmacological correction of the inflammatory process in the diseases. | |
| 2441920 | Acute phase proteins and clinical synovitis activity in patients with rheumatoid arthritis | 1987 Jun | A number of laboratory variables, including Hb., ESR and several phase proteins, fluctuated in concord with the clinical signs of synovitis activity in patients with rheumatoid arthritis during a controlled study of 3 disease-modifying anti-rheumatic drugs (DMARD). The correlation between laboratory variables and clinical synovitis was significant in a large patient population but the correlation coefficients were not of such magnitude that any of the laboratory variables reflected clinical synovitis activity in a reliable manner in the individual patients. In patients treated with azathioprine, the response of the Hb, (and consequently of the ESR), was reduced compared to patients given other DMARD. This phenomenon was caused by the bone marrow suppressing effect of azathioprine. However, the effect of azathioprine on the clinical synovitis activity did not differ from that of the 2 other drugs. Similar results were found by reviewing the literature about controlled trials of DMARD. In the present trial the clinical evaluation was performed under optimal conditions. In daily clinical practice the evaluations of the joints may be less than optimal since they may be performed by different rheumatologists with varying experience. Consequently, it may be difficult to do without the unreliable laboratory variables mentioned in the routine assessments of disease activity, unless the quality of routine evaluations of synovitis activity is improved considerably. | |
| 3589989 | [Chronopharmacological and pharmacokinetic evaluation of the therapeutic effect of naproxe | 1987 | Patients with exacerbation of rheumatoid arthritis without antiinflammatory therapy demonstrated no regular circadian variations in clinical-laboratory indices of disease activity. A study of the therapeutic effect of 3 schemes with naproxen has shown that one should consider the time of development of maximum arthralgia in each individual patient and administer the drug 1 hour before it at quite a large single dose. The drug concentration in the blood plasma of the rheumatoid arthritis patients corresponded, on an average, to an administered dose showing no parallelism with a clinical effect of the drug. |