Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
ID | PMID | Title | PublicationDate | abstract |
---|---|---|---|---|
3190781 | Formal education level as a significant marker of clinical status in rheumatoid arthritis. | 1988 Nov | Clinical status was assessed in 385 patients with rheumatoid arthritis, according to erythrocyte sedimentation rate, joint count, grip strength, walking time, and other quantitative measures. All measures indicated substantially poorer clinical status in patients who did not complete high school, compared with those who had completed high school. In general, the poorest results were seen in patients with only a grade school education. Progressively better results were seen in patients with some high school education, high school graduates, and patients with some college education. No differences in clinical status were seen among patients who had attended college, graduated from college, or had postgraduate education. Although patients seen at the Veterans Administration Medical Center had lower levels of formal education than those seen at a university clinic and private practices, trends in clinical status according to formal education level were similar in all three clinical settings. Differences in clinical status according to formal education level are not explained by age, sex, duration of disease, clinical setting, or multiple comparisons. Formal education level may identify an important marker of clinical status in rheumatoid arthritis. | |
1979513 | Methylsulphasalazine in rheumatoid arthritis. | 1990 Dec | Methylsulphasalazine, which differs from sulphasalazine by the addition of one methyl group, may provide the benefits of the parent drug with fewer side-effects in rheumatoid arthritis (RA). We describe the outcome of its use in RA. Of 21 patients entered into the study, 10 successfully completed 6 months of therapy; five developed adverse effects, four withdrew for reasons unrelated to drug treatment and two stopped because of inefficacy. No serious adverse effects were reported. A statistically significant improvement in most clinical assessments was observed from weeks 8-12 onwards. Significant improvement in plasma viscosity was observed and there was a trend towards improvement in serum CRP, histidine and IgM concentrations. There was a good correlation between mean serial changes in clinical and biochemical assessments indicating that the drug may exhibit the properties of a second-line agent. Median steady-state serum concentrations of methylsulphasalazine and methylsulphapyridine were 26.6 micrograms/ml and 2.85 micrograms/ml respectively. | |
2956558 | Effects of therapeutically induced affect arousal on depressive symptoms, pain and beta-en | 1987 Jun | The relationship among therapeutically induced affective arousal, depressive symptoms, pain and beta-endorphin levels were explored on 6 patients with chronic, active rheumatoid arthritis. An ABA, n of 1 study methodology was utilized, replicated 5 times. This procedure allowed the analysis of individualized changes across time in response to the therapeutic regimen. The results indicated that the treatment regimen activated the beta-endorphin system, particularly during the early and late phases of treatment. However, beta-endorphin response had little effect on reports of subjective pain. Depressive symptoms were affected positively by the treatment but were not strongly correlated to the beta-endorphin response. The results suggest that pain and depression represent independent systems and that beta-endorphin levels serve more as stress markers than analgesics in chronic, organic pain. | |
2147867 | Limiting dilution analysis of autocytotoxic and autosuppressor T-cells in rheumatoid arthr | 1990 Dec | Limiting dilution analysis has shown that the autologous mixed lymphocyte reaction is regulated by at least two cell populations, the autocytotoxic and the autosuppressor. Limiting dilution analysis in nine patients with rheumatoid arthritis has shown that there is a significant decrease in both populations when compared to 10 control subjects. The mechanism and the consequences of this decrease are not known. | |
3791720 | No effect of acetylcystein on refractory rheumatoid arthritis. | 1986 Oct | Acetylcystein has some chemical similarities with Penicillamine and other thiol containing compounds with effect on rheumatoid arthritis. We report an open trial on seven patients with refractory rheumatoid arthritis in which no beneficial effect could be seen after up to twelve months treatment in doses 600-1200 mg acetylcystein daily. No definite laboratory changes were seen, apart from a tendency towards higher IgA levels at the end of the treatment period. | |
3052682 | 50-foot walking time: a critical assessment of an outcome measure in clinical therapeutic | 1988 Oct | Fifty-foot walking time was used in 51 of 187 clinical therapeutic trials of antirheumatic drugs and in only 21 instances was statistical significance reached. Measurement of the 50-foot walking time showed no better performance in long-term trials of SAARDs than in short-term trials of NSAIDs. It is concluded that the 50-foot walking time is a poor outcome measure in rheumatic disease trials, despite a high intra- and interobserver reproducibility. | |
2213751 | The clinical significance of immune reactions with some streptococcal antigens in rheumato | 1990 Jul | The level of antibodies and delayed-type hypersensitivity to the group specific polysaccharides and cell wall proteins of groups A, B, C and G streptococci was determined in 247 patients with rheumatoid arthritis (RA) as well as in healthy persons and in patients with other articular disorders by means of an enzyme linked immunosorbent assay, passive hemaglutination and leukocyte migration inhibition tests. An increase of the immune response to antigens of group B streptococcus was found in patients with RA. The greatest sensitization against these antigens was typical for high disease activity of short duration, and a rapidly progressive course of RA. High titers of antibodies to polysaccharide of group B streptococcus appeared in the synovial fluid in the early stages of the clinical development of RA. Values of immune response to streptococcal antigens correlated well with the titer of rheumatoid factor and the concentration of immunoglobulins and immune complexes. The presence of group B streptococcus in the urogenital tract appeared more often in patients with RA than in healthy persons. The possibility of a triggering role for immune reactions with antigens of group B streptococcus in the immunopathological process of RA is discussed, as well as the diagnostic significance of our results. | |
3342590 | Treatment of hip fractures in rheumatoid arthritis. | 1988 Mar | Of 1100 femoral neck fractures observed through an eight-year period, 27 occurred in rheumatoid conditions. The complications and functional results were compared with unselected femoral neck fracture data of nonrheumatoid patients. At two-year follow-up examinations, five of 27 surviving rheumatoid patients had had undisplaced fractures; one of the five developed segmental femoral head collapse. Nineteen of 20 patients with displaced fractures lost position or developed non-union or segmental femoral head collapse; 14 required total hip arthroplasty. In the control non-rheumatoid group, six of 27 undisplaced fractures and 34 of 67 displaced fractures developed complications. In displaced fractures, complications occurred more often in rheumatoid patients (p less than 0.0004). Because in rheumatoid patients internal fixation in displaced fractures is associated with an unacceptably high failure rate, primary hip arthroplasty may prove to be the procedure of choice. | |
3789828 | Serum alkaline ribonuclease derived from vascular endothelial cells is raised in patients | 1986 Nov | We investigated the mechanisms of the marked increase of alkaline ribonuclease (RNase) in the sera of patients with rheumatoid arthritis associated with vasculitis. Among various tissues examined, blood vessels contained higher levels of alkaline RNase than acid RNase. Cultured human endothelial cells contained significantly higher amounts of alkaline RNase than acid RNase. In contrast, acid RNase was predominant in most other tissues and cells. Endothelial cells cultured with sera from patients with vasculitis released alkaline RNase into the extracellular medium. The phosphocellulose chromatographic profile of these sera differed from that of sera from healthy subjects. These results imply that the alkaline RNase in sera of patients with vasculitis is derived from blood vessels, probably from endothelial cells. | |
3499154 | 2,000-centiGray total lymphoid irradiation for refractory rheumatoid arthritis. | 1987 Sep | Because toxicity with the use of 3,000 centiGray (cGy) of total lymphoid irradiation (TLI) was observed in an earlier study, 2,000-cGy treatments were delivered in a 2-portal format to 7 patients and in a modified 3-portal fashion to 6 patients, as part of a randomized, investigator-blinded trial of TLI treatment for refractory rheumatoid arthritis. Analysis of combined data from the 13 patients revealed statistically significant improvement in 5 clinical indicators of disease activity at the end of TLI and 6 and 12 months later, accompanied by T4-specific immunosuppression. Management considerations resulted in the introduction of prednisone therapy in 5 patients, methotrexate in 4, and azathioprine in 1 during the interval of 8-12 months post-TLI. Herpes zoster occurred in 5 patients prior to the initiation of this additional therapy. These data indicate that, in patients with rheumatoid arthritis, a TLI dose of 2,000 cGy is sufficient to produce measurable benefit that lasts for 6 months, and that the improvement can be maintained at 12 months by the use of prednisone and methotrexate. | |
2582690 | [A case of malignant rheumatoid arthritis with severe peripheral neuropathy]. | 1989 Jun | A 72-year-old woman of definite type of malignant rheumatoid arthritis (MRA) with severe peripheral neuropathy. She has often noted pain of both shoulders or knee joints since some years ago. At the age of 71, she noticed numbness of the feet with pain and swelling of knee joints. She was diagnosed as definite type of rheumatoid arthritis by one podiatrist. Although she took some medications, she subsequently developed general fatigue, appetite loss, exacerbation of arthritis, drop feet and hands with prominent coldness. She was admitted to our hospital on March 22, 1985. On examination, she revealed purpura, decubitis, heart murmur, arthritis of knee joints, and fingers necrosis with skin ulcer. She had severe muscle weakness, and wasting of four limbs. Moderate impairment of all-modality sensations were noted in all extremities. Distal involvement was greater than proximal. Laboratory data during administration of prednisolone (60 mg/day) were as follows: glucose in urine, 2+; occult blood in urine, 1+; white blood cells count, 18600 with 92% polymorphonuclear leukocytes; erythrocyte sedimentation rate, 60 mm in an hour; CRP, 14.62 mg/dl (normal 0.5 greater than); RA test, 2+; RAHA, 10240; CH50, 10 U/ml (normal 32-42); C3, 37 mg/dl (normal 55-75); C4, 9 mg/dl (normal 15-28); immune complex, 4.4 micrograms/ml (normal 3.0): Chest X-ray film showed cardiomegaly (CTR, 57%). ECG disclosed atrial premature contraction, and echo cardiography suggested epicarditis with aortic valve insufficiency. 99mTc RI angiogram revealed impairment of peripheral circulation. SCV on sural nerve was not elicited. Sural nerve biopsy showed obliterans type of endoarteritis and axonal degeneration with loss of myelinated fiber. | |
2402987 | Hand function and total locomotion status in rheumatoid arthritis. An epidemiologic study. | 1990 Aug | The effects of destructive rheumatoid arthritis (RA) on hand function, as well as total locomotion status, were assessed in a Swedish population sample. In a community of 12,707 inhabitants, 82 were found with RA fulfilling ARA criteria 5-8, i.e., a prevalence of 0.7 percent. Seventy-seven of the 82 cases were evaluated with Sollerman's hand function test and our total locomotion score. The mean hand score (max. 80) was 61 (0-78), with no difference between the right and the left hand or between men and women. Hand function worsened with increasing age of the patient, as well as with increasing disease duration. It was highly correlated with the total locomotion status of the patient. A high correlation was found between hand function and hospital care. However, total medical or social costs for these patients were not related to hand function, but merely to the status of the lower extremities. | |
2213773 | A double blind placebo controlled trial of low dose clotrimazole in rheumatoid arthritis. | 1990 Aug | Seventy-three patients with rheumatoid arthritis were randomized in a double blind study to receive either clotrimazole (20 mg/kg/day) 2 days a week for 12 weeks or matching placebo. Patients receiving clotrimazole had significant improvements (p less than 0.05) from baseline in measurements of grip strength, joint count, and patient assessment of pain, but did not show significant improvement over patients treated with placebo. More adverse experiences, predominantly gastrointestinal complaints, occurred in patients taking clotrimazole resulting in 9 patients discontinuing therapy. | |
1770373 | Results of cementless total knee arthroplasty in an older rheumatoid arthritis population. | 1991 Dec | Fifty-five total knee arthroplasties (TKAs) in thirty-nine adult (mean age, 62 years) patients with rheumatoid arthritis were studied prospectively for a period of 1-7 years. All of the procedures were performed using cementless fixation of the tibial and femoral components. The Knee Society clinical rating system mean knee scores increased 56 points after operation (mean, 88 points), and the mean functional scores increased 28 points (mean, 64 points). Two revisions (4%) have been required, one for secondary late infection and one for failure of a cementless metal-backed patellar component. Good bone stock was retained in both, allowing for uneventful cementless revision. Forty-two arthroplasties (76%) were completely pain-free, twelve (22%) had mild, occasional discomfort with weight-bearing, and one (2%) had moderate pain at last examination. In this older rheumatoid population, cementless TKA offers good or excellent early clinical results and excellent preservation of bone stock should revision become necessary. | |
2568110 | Leucopenia during sulphasalazine treatment for rheumatoid arthritis. | 1989 Jun | Leucopenia appears to be a more frequent complication of sulphasalazine treatment in rheumatoid arthritis than in inflammatory bowel disease and poses a management problem. In this study leucopenia was found in 20 patients, 14 of whom were participating in prospective studies (252 patients), giving an incidence of 5.6%. Treatment had to be discontinued in half of these patients. Most (14) episodes of leucopenia occurred early in treatment (less than 24 weeks) but some occurred late and sustained monitoring seems necessary. No predictive factors for leucopenia were elucidated. All patients recovered fully with dose adjustment or, in more severe cases, after withdrawal of sulphasalazine and appropriate supportive therapy. The incidence of leucopenia may be higher in Glasgow than in other units in Britain. | |
2781491 | [Importance of beta-glucuronidase activity and glycosaminoglycan concentration in synovial | 1989 | In 30 patients with rheumatoid arthritis, the activity of beta-glucuronidase and the content of sulfated and non-sulfated glycosaminoglycans (GAG) were measured in synovial fluid (SF) and in the cells of SF. It has been established that as the local inflammation increases, the activity of the enzyme and the content of sulfated GAG in SF also rise. This is accompanied by simultaneous reduction of beta-glucuronidase activity in the cells and by the drop of the hyaluronic acid content in SF. | |
3563364 | [Rheumatoid factors. Isotypes and severity of rheumatoid polyarthritis]. | 1987 Jan | The immuno-enzymatic method permits the separate study of rheumatoid factors (RF): IgM as well as IgG, IgA, IgE, IgD. In 43 patients with rheumatoid polyarthritis (RP), classic or definite, we have studied the correlations between the various parameters of articular and extraarticular activity of RP and the levels of each isotype of RF. A statistically significant correlation of the articular activity was found with RF IgG (p less than 0.01), RF IgA (p less than 0.01). As compared to RP without rheumatoid nodule, RPs with rheumatoid nodules presented a level of RF IgM (p less than 0.05), RF IgG, IgA, IgE (p less than 0.01) which was statistically higher; a statistically significant correlation was found between haptoglobin levels and those of RF IgG (p less than 0.01). A negative correlation, statistically significant, was found between CH 50 and the levels of RF IgM. This study confirms previous studies which were carried out with an immuno-enzymatic method of detection of RF isotypes. | |
2952139 | Pharyngeal function in patients with rheumatoid arthritis of the cervical spine and tempor | 1987 Jan | Pharyngeal function was studied in 31 patients with rheumatoid arthritis. Eighteen of these patients had dysphagia. Cervical spine abnormalities were present in 14. Destruction of the capitulum and/or ramus of the mandible was registered in 9. Pharyngeal dysfunction was revealed in 20. Patients with a vertical dislocation of the C1-C2 in relation to the occipital bone and patients with destruction of the capitulum and/or ramus of the mandible had an increased frequency of pharyngeal dysfunction. Pharyngeal dysfunction is thought to be due to mechanical factors and caused by derangements of muscular attachments and turning points. | |
2880997 | Cholestasis and fatal agranulocytosis complicating sulfasalazine therapy: case report and | 1986 Oct | A 55-year-old woman with rheumatoid arthritis in overlap with polymyositis received sulfasalazine for control of synovitis. Cholestatic jaundice, fever, urticaria and agranulocytosis developed after 20 days of treatment and culminated in fatal adult respiratory distress syndrome secondary to Legionella pneumophila. The increasing use of sulfasalazine in the therapy of rheumatoid arthritis mandates that the clinician be aware of this idiosyncratic drug reaction. | |
3589588 | Cutaneous sensory impairment in rheumatoid atlanto-axial subluxation assessed quantitative | 1987 | Thresholds for cutaneous perception and pain in 27 rheumatoid patients were investigated by electrical stimulation. Patients with atlanto-axial subluxation showed impaired sensibility over the ophthalmic division of the trigeminal nerve. Patients with vertical atlanto-axial subluxation showed in addition to a pronounced decrease in the sensibility over the ophthalmic and maxillary divisions of the trigeminal nerve, also sensory disturbances over cervical, thoracic and lumbar levels. The mandibular division was never affected. The trigeminal sensibility seems to be affected early in the rheumatoid atlanto-axial subluxation and progresses with the severity of the subluxation, possibly due to bony compression of the trigeminal spinal tract at C 1 level. |