Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2667829 | Familial occurrence of systemic sclerosis, rheumatoid arthritis and other immunological di | 1989 May | We report two Caucasian families with systemic sclerosis and other connective tissue and immunological disorders, including rheumatoid arthritis, discoid lupus erythematosus, psoriasis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, asthma, Sjögren's syndrome, Raynaud's phenomenon and thyroid disease. In one of these families, two sisters are affected with systemic sclerosis. Clinical, serological, and HLA haplotype results are reported, along with a review of the medical literature on familial occurrence of systemic sclerosis. | |
| 3365542 | A prognostic index for erosive changes in the hands, feet, and cervical spines in early rh | 1988 Apr | Clinical and laboratory measurements taken at the onset of rheumatoid arthritis in 149 patients were compared with the severity of radiological changes seen at 3 years in the hands and feet, and cervical spine. The strongest association with the severity of peripheral radiological damage was rheumatoid factor (p less than 0.0001 for both the latex titre and RAHA titre). Subluxation of the cervical spine was associated only with the presence of HLA-Dw2 (p less than 0.02) and HLA-B7 cross-reacting group (p less than 0.02). Discriminant function analysis utilizing latex titre, RAHA titre, haemoglobin level, and platelet count predicted the development of erosive or nonerosive disease in 79%. This method was less successful in predicting the actual severity of erosive damage and was not improved by the addition of HLA data. Radiological outcome in the cervical spine was successfully predicted in 82% using HLA-Dw2, HLA-B27 and age of onset of disease. It is concluded that the best predictors of erosive disease were standard laboratory features measured at onset, but that more powerful discriminant factors are needed if these are to influence clinical practice. Further prospective studies will establish whether rheumatoid involvement of the cervical spine is an expression of the influence of HLA determinants in this disease. | |
| 2084861 | [Knee synovitis in a rheumatoid patient with separated joint cavity]. | 1990 Oct | A 40-year-old female patient with seropositive rheumatoid arthritis of 10 years duration. She had performed a total knee replacement of her left knee. At surgery the suprapatellar pouch was found to be separate from the rest of the knee joint, where direct access to the articular collagenous tissue remained. The suprapatellar pouch, presumable separate from the knee cavity since birth, was free of disease. The rest of the knee joint had gross and histopathological evidence of severe rheumatoid synovitis. The sparing of this suprapatellar pouch by rheumatoid disease is not easily explained, but the finding of this case suggests that synovium and articular collagenous tissues are requisites of chronic rheumatoid arthritis. | |
| 2281756 | Holding power impaired in rheumatoid femoral heads. Cadaveric study of fracture fixation d | 1990 Dec | A measurement was made of the holding strength and the energy needed to extract a NoLok hip screw, a von Bahr screw, and a Hansson hookpin from cadaveric femoral heads. The specimens were obtained from female subjects aged 65 years or more, with 36 specimens each from rheumatoid (RA) and nonrheumatoid (non-RA) donors. Retraction of the implants was made by a continuous uniaxial pullout at 10 mm/min. For each type of device, the holding strength in rheumatoid femoral heads was less than in non-RA specimens. In rheumatoid specimens the maximum holding strength for the NoLok screw (1,622 N) was higher than that of the other two devices, whereas the von Bahr screw (1,177 N) had a higher maximum holding strength than the Hansson hook-pin (603 N). In non-RA, there was no difference in maximum holding power between the NoLok screw (2,549 N) and the von Bahr screw (2,282 N); however, both had a higher holding strength than the Hansson hook-pin (851 N). A rapid fall off was experienced in the force required to continue extraction of both types of screws, whereas for the Hansson hook-pin the strength decreased slowly. For each type of device, the energy needed for extraction of the implant was less in the RA group femoral heads, while there were no differences in total extraction energy between devices. | |
| 2165629 | [The collagenolytic and general proteolytic activity in synovial fluid cells in rheumatoid | 1990 Jan | The authors made a comparative study of collagenolytic (CA) and neutral caseinolytic activity (NCA) in the cells of the synovial fluid (CSF) depending on the peculiarities of the course of rheumatoid process and also on the duration of the disease prior to and after treatment of rheumatoid arthritis (RA). It has been shown that proteinase is one of the factors of RA pathogenesis. The level of enzymes directly depended on the activity of synovitis. The data obtained show that with a rapidly progressing RA and also with the III degree of the disease activity, CA in CSF were twice as high as those observed with a slowly progressing RA and also with the I-II degree of RA activity. The treatment conducted promoted a rise in CA, NCA in CSF. The possible mechanism of these processes is being discussed. | |
| 2607509 | Diurnal hormone variation in fibromyalgia syndrome: a comparison with rheumatoid arthritis | 1989 Nov | Twenty patients with fibromyalgia syndrome and 20 patients with rheumatoid arthritis (RA) were assessed as outpatients over a 3 day period with respect to peak and trough levels of plasma cortisol, growth hormone, prolactin, ACTH and thyroid stimulating hormone. Patients with fibromyalgia syndrome had loss of diurnal variation in plasma cortisol (trough levels 347.3 +/- 254.7 vs 232.8 +/- 70.0 nmol/l, p less than 0.001) compared with RA patients. Thirty-five percent (7/20) of patients with fibromyalgia syndrome and only 5 percent (1/20) of those with RA exhibited abnormal dexamethasone suppression tests (p less than 0.001). No differences were noted in the diurnal variation of other hormones tested. Beck Depression Inventory scores were similar in both groups and no patient exhibited clinical evidence of depression. These data suggest alteration in the pituitary hypothalamic axis with respect to cortisol secretion in fibromyalgia syndrome, perhaps as a consequence of chronic pain. | |
| 1983331 | Association of DR4 related RFLP bands and RA in Greeks. | 1990 | Using the Taq1 restriction enzyme and DR beta, DQ alpha probes, the DNAs of Greek RA patients and controls were characterised for RFLP's associated with DR4. Three DR beta bands, 14.8kb, 6.1kb and 5.4kb were observed at significantly higher frequency in the patients compared with controls. By using a DQ alpha probe, the 2.6kb band (associated with DR1, DRw10, DRBR and DRw14 (Dw9)) was at a significantly raised frequency in the patients. The DQ alpha 5.3kb band associated with DR4, DR7 and DR9 was also raised in the RA patients although this increase did not reach statistical significance. In view of the previously documented lack of association between DR4 (and other DR antigens) and RA in Greeks, the results suggest that some degree of HLA class II association exists with RA in this population at the DNA level which may not be overtly reflected serologically. | |
| 2444303 | Paired serum and synovial fluid values of alpha 2-macroglobulin and TIMP in rheumatoid art | 1987 Oct | The levels of alpha 2-macroglobulin and tissue inhibitor of metalloproteinases (TIMP) were determined in paired serum and synovial fluid samples from rheumatoid arthritis patients. Serum levels of alpha 2-macroglobulin (mean 1580 +/- 340 mg/l) were always higher than the corresponding synovial fluid although the spread of synovial fluid levels was broad (mean 520 +/- 340 mg/l). Tissue inhibitor of metalloproteinases was always higher in synovial fluid (mean 4.59 +/- 1.8 mg/l) than serum (mean 1.3 +/- 0.39 mg/l) indicating that local synthesis occurred within the joint. | |
| 3672013 | The alterations of the synovial membrane in rheumatoid arthritis treated with corticostero | 1987 Jul | Sections of synovial tissue removed from patients with rheumatoid arthritis treated, for a long period of time or a brief period of time or not at all, with corticosteroids were examined for the incidence of histopathologic changes. Comparison of the quantification of these changes in the differently treated groups revealed that prolonged administration of corticosteroids had an inhibiting effect on the occurrence of lymphocytes and histiocytes in inflammatory infiltrates as well as on the hypertrophy of synoviocytes, on the proliferation both of fibroblasts and fibrocytes, and on the formation of villi and collagen fibers. | |
| 3076394 | The pathophysiology of rheumatoid arthritis. | 1988 Nov | Recent knowledge of the pathophysiology of rheumatoid arthritis offers new approaches to treatment of the disease. The topic is herein summarised and discussed. | |
| 1808416 | [Plasmapheresis in the treatment of anemia in patients with rheumatoid arthritis]. | 1991 Nov | The study included 136 rheumatoid arthritis (RA) patients with anemia. Adjuvant plasmapheresis (PA) was performed in 81 of them. The control group of 55 patients received chemotherapy alone. Hemoglobin levels measured in the end of the treatment course rose significantly only in the PA group. The trend to anemia normalization correlated with decline of inflammation. This favours introduction of PA in the treatment of RA patients. | |
| 3592788 | Synovial accumulation of technetium labelled liposomes in rheumatoid arthritis. | 1987 Apr | Technetium labelled, negatively charged, unilamellar liposomes were given by intravenous injection to patients with rheumatoid arthritis and the joints scanned 20-22 hours later. Positive scintigraphy was obtained in all six patients with active disease, and, with the exception of the small interphalangeal joints, all clinically involved joints could be visualised. | |
| 2896829 | Galactosylation of IgG associated oligosaccharides: reduction in patients with adult and j | 1988 Apr 30 | The prevalence of agalactosyl N-linked oligosaccharides on serum IgG was determined for patients with juvenile onset and with adult rheumatoid arthritis. A significant difference in the prevalence of these structures from age matched controls was found in both types of arthritis. In patients with adult onset rheumatoid arthritis, the results showed a strong correlation between the prevalence of IgG-associated agalactosyl oligosaccharides and disease activity. A correlation between disease activity and agalactosyl structures was also seen in a retrospective analysis of serial IgG samples from patients with juvenile onset disease. The finding that childhood onset arthritis and adult rheumatoid arthritis share a defect of glycosylation of serum IgG suggests that there may be a greater similarity between these two varieties of rheumatoid arthritis than has been hitherto considered. The observation that the incidence of agalactosyl oligosaccharides on IgG fluctuates with disease activity provides indirect evidence for a seminal role for this change of glycosylation in the inflammatory process which, in rheumatoid arthritis, is focused on the synovial tissues and results in bone erosions and joint destruction. | |
| 1710721 | [The Willebrand factor in the diagnosis of hemostatic disorders in patients with rheumatoi | 1991 | Studies of coagulation hemostasis in 108 patients with rheumatoid arthritis have revealed that high blood coagulation is characteristic of this disease, and a number of coagulation parameters (antithrombin III, fibrinogen, fibrinolytic activity, ethanol test) point to intravascular microthrombi formation (disseminated intravascular coagulation). Along with hemostasis investigations, Willebrand's factor levels were measured in the blood plasma of 44 patients. Enhancement of the inflammatory process activity was found to be associated with elevation of this factor level and augmentation of the blood coagulation activity. These results permit considering Willebrand's factor as one of the diagnostic criteria of thrombophilic conditions in patients with rheumatoid arthritis. | |
| 2899646 | In vitro immunomodulatory effects of sulfasalazine and its metabolites. | 1988 Apr | We assessed the in vitro effects of sulfasalazine and its 2 main metabolites, sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) on functional aspects of peripheral blood lymphocytes (PBM) of normal controls and patients with rheumatoid arthritis (RA). Sulfasalazine, but not its 2 main metabolites, inhibited mitogen induced proliferative responses of PMB at high drug concentrations (100 micrograms/ml). Similar results were obtained with purified B lymphocytes. Sulfasalazine depressed, in a dose dependent manner, pokeweed mitogen induced Ig synthesis by PBM of normals and patients with RA. Moreover, synthesis of IgM rheumatoid factor was depressed to a greater degree than total IgM at low sulfasalazine concentrations (10-25 micrograms/ml). Both SP and 5-ASA were not inhibitory at the concentrations tested. Experiments with purified lymphocyte subpopulations indicated that sulfasalazine exerted its major inhibitory activity on the B lymphocyte. These studies indicate that sulfasalazine, but not its 2 main metabolites, has immunomodulatory characteristics which may be related to its therapeutic activity in RA. | |
| 2317114 | Partial purification and characterisation of a synovial fluid inhibitor of osteoblasts. | 1990 Feb | A polypeptide inhibitor of osteoblast proliferation is described which occurs in synovial effusions of patients with rheumatoid arthritis. Partial purification of the inhibitor showed a molecular weight of approximately 81,000 by gel electrophoresis. This polypeptide seems to be unique as no inhibitor of osteoblasts of similar molecular weight has been previously described in rheumatoid synovial effusions. | |
| 2281661 | [The effect of D-penicillamine on the immunological indices of rheumatoid arthritis patien | 1990 | In 25 patients with rheumatoid arthritis the action of D-penicilamine (Cuprenyl) on the following indices was studied: IgG, IgA, IgM, circulating immune complexes (CIC), rheumatoid factor titer (RF), T- and B-lymphocytes in the peripheral blood. The action on some clinico-laboratory indices was also studied--joint index, duration of morning stiffness, erythrocytes sedimentation rate. The results reveal that the D-penicilamine treatment leads to a lowering of the immunoglobulins, circulating immune complexes and rheumatoid factor titer which is most expressed between the 3 and 6 month from the beginning of the treatment. This drug does not influence significantly the percentage of T- and B-lymphocytes in the peripheral blood. | |
| 2341957 | The temporomandibular joint in rheumatoid arthritis--a comparative clinical and tomographi | 1990 Mar | Six partially or fully edentulous rheumatoid patients participated in the study. By comparing the clinical symptoms and tomograms of the temporomandibular joints (TMJS) pre-prosthesis with those post-prosthesis, this report assesses whether dental treatment could provide positive help for TMJS in patients with rheumatoid arthritis (RA). Among the clinical symptoms of TMJ dysfunction, pain from the TMJ region and limitations of movement were improved in all the patients post-prosthesis. Tomographic evidence of desirable remodelling of the condylar heads was observed in two cases. | |
| 2453561 | Activation of latent rheumatoid synovial collagenase by human mast cell tryptase. | 1988 Jun 1 | The functional role of mast cells in rheumatoid synovium was investigated by assessing the ability of mast cell tryptase to activate latent collagenase derived from rheumatoid synoviocytes. Tryptase, a mast cell neutral protease, was demonstrated in situ to reside in rheumatoid synovial mast cells, by an immunoperoxidase technique using a mouse mAb against tryptase, and in vitro to be released by dispersed synovial mast cells after both immunologic and nonimmunologic challenge. Each rheumatoid synovial mast cell contains an average of 6.2 pg of immunoreactive tryptase and the percent release values of this protease correlated with those of histamine (r = 0.58, p less than 0.01). The ability of purified tryptase to promote collagenolysis was demonstrated in a dose-dependent fashion using latent collagenase derived from rheumatoid synovium, synovial fluid, IL-1-stimulated cultured synoviocytes, and partially purified latent collagenase derived from conditioned media, with between 10 and 92% of the collagen substrate degraded. [3H] Collagen, treated with tryptase-activated latent collagenase, was subjected to electrophoresis on SDS polyacrylamide gels and autoradiography showed the collagen degradation pattern (A, B) characteristically produced by collagenase. Mast cell lysates also activated synovial latent collagenase yielding 24% digestion of collagen substrate. This activator in mast cell lysates could be inhibited by diisopropylflurophosphate or by immunoadsorption of tryptase. Thus, mast cells may activate metalloproteinases and play a role in the catabolism of collagen that occurs in rheumatoid synovium. | |
| 2109438 | Correlation of clinical and serological findings in patients with rheumatoid arthritis tre | 1990 Jan | Results of a large therapeutic trial of interferon-gamma in patients with rheumatoid arthritis (RA) are described. Of 110 RA-patients enrolled in this clinical trial, 46 were treated with interferon-gamma for 12 months. During the treatment period, dosage was reduced on an individual basis. There was a correlation between the improvement of clinical parameters, such as pain or morning stiffness, and the improvement of laboratory parameters such as erythrocyte sedimentation rate, anemia, leucocytosis or thrombocytosis. Interferon-gamma was well tolerated, and no organ toxicity was detected. |