Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3251352 | Mapping of synovial fibroblast proteins by high resolution two-dimensional polyacrylamide | 1988 | The highly sensitive protein separation technique two-dimensional polyacrylamide gel electrophoresis was used to study the cellular protein synthesis in 1) cultured human rheumatoid and 2) normal synovial fibroblasts and 3) normal skin fibroblasts. No reproducible differences were found that could be ascribed to cellular origin, the disease or in vitro cellular aging. The reasons for that probably were related to the cell cultures and not to failure of protein detection. | |
| 2241290 | Arthritis in a human T lymphotropic virus type I (HTLV-I) carrier. | 1990 Sep | The case is described of a 57 year old woman with polyarthritis fulfilling the 1987 revised criteria of the American Rheumatism Association for rheumatoid arthritis, accompanied by clinical carrier state infection of HTLV-I. Anti-HTLV-I IgM antibodies were detected by western blot analysis in her synovial fluid and serum. Atypical lymphocytes with nuclear convolutions were found in synovial fluid and synovial tissue obtained from the affected knee joint, suggesting in situ activation of HTLV-I infected lymphocytes in the affected synovial compartment. The HTLV-I antigens were detected (1.2%) in short term cultured synovial fluid lymphocytes, by indirect immunofluorescence. These findings supported the possibility that HTLV-I has a role in triggering or modifying inflammation in the synovial compartment. | |
| 2923507 | Factors predicting a poor life prognosis in rheumatoid arthritis: an eight year prospectiv | 1989 Jan | This prospective study evaluates the usefulness of clinical features and measurements of circulating immune complexes and autoantibodies for identification of patients with rheumatoid arthritis with a poor life prognosis. One hundred and seven hospital clinic patients, 64 with extra-articular manifestations, were followed up for a mean period of eight years, during which 50 deaths occurred. Comparison with an age and sex matched control population showed an increased incidence of deaths from myocardial infarction, pneumonia, and complications of rheumatoid arthritis. Patients with cutaneous ulcers, vasculitic rash, neuropathy, and scleritis had a higher mortality than patients whose disease was confined to the joints. Positive serological tests for precipitating antibodies to soluble cellular antigens and cryoglobulinaemia also predicted a poor prognosis. Eleven out of 12 patients (92%) with antibodies to soluble cellular antigens died compared with 21 out of 64 patients (33%) without antibodies. The presence of cryoglobulinaemia was associated with almost a twofold higher mortality. The laboratory measurements may reflect immunopathogenic mechanisms which lead to the occurrence of extra-articular disease features and reduce life expectancy. | |
| 3259984 | Further analysis of learned helplessness in rheumatoid arthritis using a "Rheumatology Att | 1988 Mar | A Rheumatology Attitudes Index (RAI) has been modified from the Arthritis Helplessness Index to assess the psychological construct of learned helplessness. The validity of the RAI was established in comparisons to the Arthritis Helplessness Index. The external criterion validity of the RAI was established by identification of statistically significant correlations between RAI scores and physical measures of disease status, including joint count, grip strength, walking time, and button test, as well as with questionnaire self-report scores for difficulty, dissatisfaction and pain in activities of daily living (ADL). Any variation in RAI scores which could be explained by available disease status measures was explained entirely by ADL self-report scores, with no additional explanation by traditional physical measures. Responses to individual RAI statements were significantly correlated with either questionnaire or physical measures of disease status for only 6 of the 15 RAI statements. | |
| 2324853 | Effects of isolated rheumatoid synovial cells on cartilage degradation in vitro. | 1990 May | Rheumatoid synovium in coculture with cartilage has been shown to release a factor(s) that stimulates the depletion of glycosaminoglycans (GAG) from cartilage matrix. Human rheumatoid synovium was enzymatically disaggregated and the isolated cells were subjected to a variety of mechanical and immunological treatments. Synovial cell conditioned media (SCCM) were prepared and analyzed for their ability to stimulate GAG depletion. SCCM prepared from increasing concentrations of isolated synovial cells demonstrated cartilage degradative activity in a dose-dependent manner. This activity was characterized as interleukin-1 like and was found mostly within the adherent cell population where the synovial macrophages retained significant degradative ability. T cells alone were found to have no direct degradative effect on cartilage, but their presence appeared to augment the response of the adherent cells. The techniques described here provide a quantitative model for examining the degradative factors from synovium as well as the cellular interactions that promote their release. | |
| 2781874 | [Assessment of the functional origin of shoulder pain in chronic polyarthritis by diagnost | 1989 May | We examined 40 patients with rheumatoid arthritis suffering from painful shoulder. While the shoulder itself was not treated, Mepivacain was injected into an arthritic joint of wrist or elbow. In 36 out of 40 patients we achieved full or partial improvement of pain and movement of the shoulder. We conclude that pain in the shoulder of these patients was caused by a regulatory mechanism, triggered by nociceptors in an arthritic distal joint in order to protect this damaged structure. The therapeutic consequence implies treatment of the distal joint rather than treatment of the painful shoulder itself. | |
| 3476752 | Pain perception and personality measures as discriminators in the classification of fibros | 1987 Jun | Twenty patients with fibrositis were compared to age and sex matched groups of patients with rheumatoid arthritis (RA) and normal controls regarding personality variables measured by the Basic Personality Inventory (BPI) and responsiveness to experimentally induced pain. The group with fibrositis scored significantly higher than the normal group on 4 of the BPI scales and had lower pain threshold and tolerance than the normal group. The group with RA was found to be significantly different from the normal group on hypochondriasis and pain tolerance. Using only pain and personality measures, a statistical discriminant function that was developed resulted in a 72% classification accuracy for the 3 groups studied and 85% accuracy when only the 2 clinical groups were considered. | |
| 3958017 | The outcome of infected arthroplasty of the knee. | 1986 Mar | In order to define the predisposing factors and outcome of infected arthroplasty of the knee, a retrospective analysis of a consecutive series of 471 knee arthroplasties was performed. There were 23 cases of superficial wound infection and 25 of deep infection. Superficial wound infection alone resulted in a painfree gait, with little limitation of movement. Rheumatoid arthritis, the use of constrained prostheses and the presence of a superficial wound infection, all predisposed to deep infection. Deep infection was eradicated by long-term antibiotics in only two patients in whom skin cover was successfully provided by a gastrocnemius musculocutaneous flap. Excision of a sinus track, wound debridement and exchange arthroplasty were universally unsuccessful. Arthrodesis, however, in 11 out of 12 cases, provided the painfree gait these patients desire. | |
| 2085054 | [Rheumatic manifestations in HIV infection]. | 1990 Nov | The two main rheumatic manifestations of infection by human immunodeficiency virus (HIV) are arthropathies and autoimmune diseases. The pathogenesis of the rheumatic manifestations is currently undefined. Among the different mechanisms implicated, the severe immunosuppression and immunodysregulation, as well as recurrent infections are possible. A direct infection by HIV is another mechanism. The course of some rheumatic diseases may be altered by HIV-infection. Remission of rheumatoid arthritis during the course of HIV-infection is anecdotally reported in the literature, whereas patients with Reiter's syndrome seem to have a severe clinical course. | |
| 3314249 | [Genetic influences in chronic polyarthritis]. | 1987 Jul | Genetically determined diseases exhibit the following characteristics: 1. They appear with different frequencies in various populations. 2. They show tendencies to aggregate in certain families. 3. The disease risk is higher for monozygotic twins than for dizygotic twins. 4. They show an association with genetically determined markers in a population e.g. certain HLA-antigens. All of these characteristics are observed in rheumatoid arthritis. Despite an abundance of data suggesting a genetic influence in the etiopathogenesis of rheumatoid arthritis, it has not been possible, as yet, to uncover a definitive genetic mechanism. There is evidence to suggest that both histocompatibility-complex-associated genetic factors and genes outside the HLA region are of significance for predisposition to the disease and possible for the pathogenesis and course of rheumatoid arthritis. Using modern genetic technology it should be possible to investigate further the influence of genetic factors on the etiology and pathogenesis of rheumatoid arthritis. | |
| 3309293 | Advances in orthotics for the patient with rheumatoid arthritis. | 1987 Aug | Orthotics are externally applied devices which support a joint or enhance its function. In arthritis orthotics are prescribed to stabilize joints, provide better positioning, reduce pain, prevent deformity and improve function. Splints are used primarily for the upper extremity. Specially designed shoes can control foot and ankle pain and instability. Continuous passive motion devices are becoming widely used for early postoperative rehabilitation after arthroplasty. Unfortunately, few controlled studies have been performed to determine the utility of orthoses in patients with arthritis. Some of the most important questions on this subject are posed and available data discussed as well as the need for additional information. | |
| 3064524 | Immunosuppressive therapy in rheumatoid arthritis. | 1988 | Immunosuppressive drugs are used since 1951 for the treatment of rheumatoid arthritis. The most extensive used ones are azathioprine, cyclophosphamide, chlorambucil and methotrexate. The efficacy of these immunosuppressive drugs is clinical proven. Nevertheless it is necessary to use these drugs in severe disease only that has failed to respond to less toxic agents. The number of severe side effects is higher and the consequences of this therapy concerning cancerogenity is not clear yet. The efficacy and side effects of these drugs are discussed and guidelines for using immunosuppressive drugs in the treatment of rheumatoid arthritis are given. | |
| 2691162 | Regulation of rheumatoid factor synthesis. | 1989 Sep | Rheumatoid arthritis is associated with high titers of IgM and IgG autoantibodies against IgG (rheumatoid factors, RF) and is prevalent in individuals with the HLA haplotypes Dw4, Dw14 and DR1. Our investigations have aimed to determine the molecular genetic basis for RF autoantibody synthesis in people, in an effort to understand eventually how RF production may become improperly regulated in rheumatoid patients. The results have defined several cross-reactive idiotypes on the heavy and light chains of RFs that are serologic markers for specific immunoglobulin variable region genes. These autoantibody associated genes are highly conserved in human populations and are preferentially rearranged and expressed during early B cell development, and in certain lymphoproliferative diseases. They may be associated with a B cell subpopulation that is important for the processing and presentation to T cells of protein antigens trapped in immune complexes. These RF-associated idiotypes are eventually lost during the T cell dependent antibody diversification that accompanies rheumatoid arthritis. The stimuli for the diversification have not been clearly established. However, the rheumatoid arthritis disease susceptibility determinant on the beta-1 chain of individuals with the HLA Dw4, Dw14 or DR1 haplotypes is reproduced by the gp110 protein of the Epstein-Barr virus, and is a potent stimulus for T cell proliferation. Moreover, anti-gp110 antibodies are abundant in rheumatoid arthritis patients. Thus, it is possible that their continual binding and processing of gp110-IgG immune complexes by RF precursor B cells in the joints and other extravascular sites may lead to the emergence of self-reactive T cells that can trigger anti-IgG autoantibody synthesis in the absence of an external antigen. | |
| 3321214 | Autoimmunity in rheumatoid arthritis. An approach via a study of B lymphocytes. | 1987 Aug | In this article the relationship between the cellular elements of the immune response and inflammation are examined with reference to the B lymphocyte repertoire. Evidence is presented that, in addition to an environment in the joint that favors localization and activation of auto-reactive B lymphocytes, the circulating B lymphocyte pool in rheumatoid arthritis is abnormally enriched in cells that bear a receptor for mouse erythrocytes and possess CD5 antigen. B lymphocytes with these novel phenotypic markers secrete autoantibodies and are found in abundance in fetal lymphoid tissues and cord blood; analogous cells in the mouse belong to a distinct lineage and are implicated in allotype- and idiotype-restricted interactions. It is postulated that a subset of B lymphocytes is of primary importance in the etiopathogenesis of rheumatoid disease. | |
| 3632067 | Incidence and size of erosions in the wrist and hand of rheumatoid patients: a quantitativ | 1987 Jun | Quantitative macroradiographic examination of a group of early to moderately advanced rheumatoid patients showed the wrist and hand to have an average of 75 (SD 26) erosions out of 142 possible sites. Joint involvement was greatest in the wrist followed by the metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints respectively. In the wrist erosion distribution was concentrated in the radiocarpal and medial carpometacarpal complex, in the hand it tended to be located at the second and third MCP and third PIP joints. No difference was observed in erosion number and area between the right and left extremities. The distribution of the lesions is discussed in relation to the intra-articular pressures on normal hand function. The similarity of erosion development, across the joints at the different regions of the hand, suggests the presence of factors other than mechanical pressure. In general, erosions were widespread, and the largest erosions occurred in the larger bones of the wrist and hand. | |
| 2487718 | Coping with arthritis pain. A review of the literature. | 1989 Dec | Pain associated with arthritis is the primary reason patients with arthritis seek medical attention. The complex and multidimensional nature of pain among arthritis patients is examined. Self-reports of pain, the impact of pain, cognitive factors associated with pain, and the treatment of arthritis pain are reviewed. Psychosocial pain management programs emphasizing improved coping appear to be important as an adjunct to medical treatment. Implications for future research are discussed. | |
| 2813191 | Aneurysm in the sequestrated lung and aortitis associated with the malignant rheumatoid ar | 1989 Sep | A scar phase of rheumatoid aortitis and aneurysms in the sequestrated lung with a lesion continuous to an aortic lesion was found in autopsy specimens from a 50 year-old-woman, who had suffered from generally disseminated carcinoma of the breast. The aorta revealed a scar phase of granulomatous panaortitis continuously from the ascending to the descending thoracic aorta. The media and adventitia of the aorta were largely replaced by scar tissue, although the aortic valve was spared. The systemic arteries in the sequestrated lung were destroyed completely by the necrotizing angiitis and showed saccular aneurysm filled with organizing fibrin thrombus. The pulmonary artery was intact. These findings suggest that the saccular aneurysm in the sequestrated lung was produced by necrotizing angiitis, in association with rheumatoid aortitis. | |
| 1816209 | Mitral stenosis and aortic regurgitation in rheumatoid arthritis. | 1991 Oct | A patient of rheumatoid arthritis having mitral stenosis and aortic regurgitation is reported. Our findings are based on clinical and echocardiographic study. | |
| 3701741 | Complement activation by 19S IgM rheumatoid factor: relationship to disease activity in rh | 1986 Feb | 19S IgM rheumatoid factor (RF) in rheumatoid arthritis (RA) are polyclonal autoantibodies directed against the Fc piece of IgG. Rheumatoid patients with RF tend to have aggressive synovitis, nodules, and extraarticular manifestations. Although RF titer does not correlate with disease activity, RF activates complement (C) by the classical pathway. Thus, we postulated that selective stimulation of cell clones producing efficient C activating RF molecules might be associated with disease flares, independent of changes in serum RF concentration. To address the question, 42 patients with RA were evaluated prospectively. Serum RF concentration was measured by radioimmunoassay (RIA) and C activating activity by hemolytic assay. We then calculated the mean hemolysis (MH) of sensitized sheep erythrocytes (SRC) produced/ml of RF serum (MH/ml) and MH/microgram of RF as an expression of RF C activating properties (CAP). The following observations were made: RF CAP varied among the patients studied; RF CAP varied over time in individual patients; RF CAP differences varied in both groups independently from RF concentration; RF CAP correlated with both systemic and articular disease activity; and total RF concentration correlated with articular findings and nodules but less well with systemic disease activity. | |
| 2363742 | Biliary elimination of low-dose methotrexate in humans. | 1990 Jun | We studied the pharmacokinetics of methotrexate (MTX) in a 64-year-old man with rheumatoid arthritis. After 6 months of treatment, acute clinical complications arose, requiring emergency laparotomy and cholecystotomy. A biliary tube was inserted, and this allowed for direct analysis of the bile. The pharmacokinetics of 2 separate doses of MTX (orally and intravenously) were assessed (dosage 10 mg/m2). No substantive differences in the pharmacokinetics were found between pre- and post-cholecystotomy MTX treatment, including clearance rates, volumes of distribution, and terminal half-lives. The results, however, demonstrated a change in the bioavailability of the drug (decreasing from 84.7% to 38.9%). Based on extrapolations of the data, with assumed rates of bile flow, the findings also suggest that there is substantial biliary elimination of MTX (8.7-26.0%) and its principal 7-hydroxy metabolite (1.5-4.6%). |