Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3705776 | Prognosis of rheumatoid coxitis. | 1986 Jan | Geometrical analyses of the anteroposterior X-rays of 81 hips affected by rheumatoid arthritis for 1 to 17 years, have shown that the rate of progression of the inflammatory destructive lesions in the hip, expressed quantitatively in millimeters per year, depends on the local anatomical relations in the coxofemoral joint itself. This relationship is expressed by the angle of penetration of the plane of the acetabular opening (PEC) (angle PEC = angle CCD + angle n - angle PE). The PEC angle was found to be within the range of 85 to 128 degrees, and its mean value for the whole group was 104.6 degrees. In hips affected by rheumatoid arthritis for the same period of time, the average rate of progression of coxitis was twice as high when the PEC angle was up to 104 degrees than when it was 105 or more degrees. This difference is statistically significant. Irrespective of the magnitude of the angle of penetration through the plane of the acetabular opening (PEC), coxitis was found to progress the most rapidly during the first years of hip affection, and to diminish thereafter along a parabolic curve. The knowledge gained in this study makes it possible to predict the rate of progression of coxitis and is a contribution to a better clinical and radiological understanding of rheumatoid arthritis of the hip joint. | |
| 2069085 | An anti-CD4 antibody for treatment of chronic inflammatory arthritis. | 1991 | Monoclonal antibodies (mAb) to the CD4 surface molecule inhibit the function of CD4+ T cells in vitro and have been used for treatment of autoimmune diseases in several animal models. Recently, an anti-CD4 mAb has been described that improved the clinical situation of rheumatoid arthritis (RA) patients although no change in laboratory parameters could be observed. Here, we report on a different high-affinity anti-CD4 mAb (MAX.16H5) and its use for treatment of RA. Reduction of the Ritchie index, morning stiffness and the number of swollen joints demonstrated the clinical benefits of the therapy. In addition, laboratory parameters like ESR, CRP, and rheumatoid factor were reduced in 6/12 treatments. A rapid depletion of CD4+ T cells was observed in all patients which reached a minimum 1 hour after administration. However, efficacy of treatment did not correlate with T cell depletion. The antibody accumulates at the site of inflamed joints as detected by 99m-Tc-labelling. Affected digital joints were detected earlier by virtue of helper T cell imaging than by conventional bone scans. | |
| 2026371 | [Percutaneous therapy with non-steroidal anti-inflammatory drugs. Pharmacokinetic criteria | 1991 Jan 20 | As in the case of systemically administered drugs, there is also a requirement for reliable kinetic evidence for the clinical effectiveness of local therapeutic NSAIDs. The conditions required for this are discussed, and compared with provisions already existing in EC countries. On the basis of a comprehensive review of the literature, it is shown that among all the locally employed NSAIDs, kinetically reliable and plausible evidence of therapeutic effectiveness is, at present, available only for indomethacin, diclofenac, salicylic acid salts and ibuprofen. | |
| 2565128 | Sulphasalazine in rheumatoid arthritis: haematological problems and changes in haematologi | 1989 Apr | This prospective study documents the haematological responses in 300 rheumatoid patients (RA) treated with sulphasalazine (SASP) for between 1 and 9 years. It also examines the effect of SASP on the total white cell and platelet counts over 2 years in relation to disease activity in 80 RA patients. Neutropenia occurred in six (2%) (three severe--neutrophil count less than 0.8 X 10(9)/l) after 3 and 12 weeks. The drug was withdrawn in six immediately and in one patient after 21 months when the neutrophil count fell to 0.7 X 10(9)/l. An additional 11 (3.7%) developed mild or transient leucopenia between 2 weeks and 24 months, and eight continued therapy. Thrombocytopenia occurred in one patient at 18 weeks associated with other reactions. Four with Felty's syndrome developed a further fall in the total WBC associated with thrombocytopenia in two. A rise in mean cell volume was common (72%), and macrocytosis (MCV greater than 98 fl) occurred in 27 (9%). Macrocytic anaemia was rare (less than 1%). All haematological problems were reversible. In 80 patients treated with SASP for 2 years there was a significant fall in the median white cell and platelet counts at 3 months associated with improvement in disease activity. | |
| 2564708 | [Results of a clinical trial of sulfasalazine in rheumatoid arthritis]. | 1989 Jan | The authors tested the therapeutic effectiveness and tolerance of the sulphonamide chemotherapeutic preparation sulfasalazine in 69 patients with active rheumatoid arthritis. A one-year open clinical investigation was completed by 41 patients (59%) where in the course of treatment significant improvement of the majority of clinical and laboratory indicators of the activity of the rheumatic process was recorded. Treatment was terminated prematurely by 28 patients (41%) incl. 16 (23%) where treatment was discontinued because of undesirable side-effects which developed most frequently during the first months of treatment and were not very serious. X-ray evaluation of the joints of the hands after a one-year interval did not reveal deterioration of the X-ray findings in patients who completed the course of treatment. | |
| 2722313 | Arthroscopic versus open synovectomy in the rheumatoid knee. | 1989 | We report the clinical and radiological results after arthroscopic synovectomy (41 knees) and open capsulosynovectomy (26 knees) in patients with rheumatoid arthritis, with an average follow-up of more than ten years. The clinical outcome was much the same in both groups, but there was gradual deterioration, especially after eight years. Radiological changes of osteoarthritis were worse in the knees treated by open capsulosynovectomy compared with the arthroscopic group. Arthroscopic synovectomy has many advantages and we believe that it is better than open capsulosynovectomy for patients with rheumatoid arthritis of the knee. | |
| 3962679 | Rheumatoid pleurisy. Specificity of cytological findings. | 1986 Jan | The cytological findings in pleural exudates from patients with rheumatoid arthritis are epithelioid cells, giant cells, cholesterol crystals and an amorphous granulated material. An important additional feature, we find, is lack of mesothelial cells. Based on 23 pleural fluids from 7 patients with rheumatoid arthritis and 44 pleural fluids from patients with various other diseases, a blind study showed, that these typical cytological findings in combination with lack of mesothelial cells were specific in pointing towards the determined diagnosis rheumatoid pleurisy. | |
| 1775908 | [Ulnar nerve compression at the elbow caused by synovial cyst of rheumatoid origin]. | 1991 Oct | The authors report on a case of a fifty year old white woman affected by a rheumatoïd arthritis of 3 year duration who develops a progressive ulnar nerve compression by a synovial cyst of the right elbow joint. Surgical procedure confirms the articular and rheumatoïd origin of the synovial cyst and obtains complete healing of the motor and sensory deficit without recurrence of the synovial cyst. Synovial cysts are rare at the elbow joint where they cause as an exception a compression of the ulnar nerve, the authors having found only five cases in the literature. | |
| 1675016 | [Renal microscopic hematuria in rheumatoid polyarthritis]. | 1991 Jan | In a retrospective study of 162 cases of rheumatoid arthritis we found that 24 patients (14.8%) had presented with microscopic haematuria with or without proteinuria. Renal biopsy had been performed in 15 of these 24 patients. Apart from the classical lesions of extramembranous glomerulonephritis, amyloidosis and interstitial nephritis, 60% of histological results showed lesions of mesangial glomerulonephritis. These lesions seemed to be independent of maintenance treatments, but they might have been facilitated by the chronic inflammation kept going by the rheumatoid disease itself. | |
| 2123816 | Severe rheumatoid arthritis: current options in drug therapy. | 1990 Dec | Therapeutic advances have been made in rheumatoid arthritis (RA), but patients (and sometimes physicians) may become frustrated at the apparent lack of breakthrough treatments. The latest advances in the treatment of severe RA are discussed, along with what investigators are using experimentally both in combination with other drugs and alone to treat RA now and, possibly, in the future. These agents include methotrexate, cyclosporine, gamma-interferon, and omega-3 fatty acids. | |
| 3088273 | Peripheral blood T lymphocyte subsets in active rheumatoid arthritis--effects of different | 1986 Apr | Peripheral blood T lymphocyte subset levels were prospectively analyzed in previously untreated patients with active rheumatoid arthritis (RA) with different drug regimens. Before treatment the patient group had reduced numbers of Leu 2a+ lymphocytes compared with controls (p less than 0.001). During penicillamine and chloroquine treatment a marked reduction in absolute numbers of Leu 3a+ lymphocytes was seen (p less than 0.01), whereas treatment with nonsteroidal antiinflammatory drugs was characterized by increased absolute numbers of Leu 2a+ lymphocytes (p less than 0.02). Thus, there seems to be a predictable variation of T lymphocyte subsets in RA with certain drug regimens. | |
| 3516495 | Antianemic and potential anti-inflammatory activity of desferrioxamine: possible usefulnes | 1986 Jan | In order to study the role of excessive synovial iron sequestration in the production of anemia in rheumatoid arthritis (RA), the antianemic efficacy and anti-inflammatory effect of desferrioxamine administered in a short-term treatment (14 days), were evaluated in 10 patients suffering from classic or definite RA and hyposideremic anemia. Treatment with desferrioxamine showed an elevated urinary iron excretion, a significant increase of serum iron, UIBC and hemoglobin, and a marked progressive decrease of serum ferritin. A moderate improvement of the pain intensity, morning stiffness and Ritchie's index was also observed. The results obtained suggest that excessive reticuloendothelial iron deposits occur in RA and that the iron uptake can be an important factor in the production of anemia. Desferrioxamine seems to be useful in the treatment of patients suffering from RA and anemia, in order to release iron from synovial tissue, reduce the inflammatory process and improve anemia, changing an anemia which is typically resistant to the martial therapy into an iron-sensitive anemia. | |
| 1673723 | Astemizole, an H1 antagonist, has no additional therapeutic effect in rheumatoid arthritis | 1991 Feb | Mast cells are found in increased numbers in the synovium of patients with rheumatoid arthritis (RA) and may play a role in synovitis. They produce proinflammatory substances including histamine. A double blind placebo controlled study was undertaken in 60 patients with active RA using the H1 receptor blocker, astemizole, as an adjuvant to usual therapies. After 3 months of treatment there were no significant differences in clinical and laboratory variables between the groups. We conclude that H1 antagonist treatment with astemizole has no additional therapeutic effect in RA. | |
| 3050786 | [Surgical therapeutic possibilities of the elbow in chronic polyarthritis]. | 1988 Aug | The natural history of rheumatoid arthritis of the elbow often includes impairment of the function of the upper extremity in advanced stages of the disease. Synovectomy performed by a large radial incision is considered a worthwhile procedure for stages 1-3 according to the classification of Larsen et al. Radiosynoviorthesis is possible in stages 0 and 1. In the authors' opinion, resection- and interposition arthroplasty remains the procedure of choice for advanced stages 4 and 5. For elbows with severe instability alloarthroplasty may be considered. The radial head should generally not be resected. Entrapment neuropathy of the ulnar and the posterior interosseus nerves is possible in rheumatoid arthritis patients. The surgical treatment consists in decompression, if necessary with transposition and synovectomy of the elbow joint. | |
| 2456388 | Elbow synovectomy and excision of the radial head in rheumatoid arthritis: a short term pa | 1988 Apr | We present the results of synovectomy and excision of the radial head in 65 elbows affected by rheumatoid arthritis. Eighty-four percent of elbows had good pain relief 6 months after operation but after an average of 5 years only 54% remained relatively pain-free. Range of motion remained the same or improved in the majority of patients. Synovitis occurred in 39% of elbows during the followup period and intraarticular steroid injections were frequently given. This undoubtedly modified results of pain relief that might have been attributed to the operation. Destructive changes in the humeroulnar joint were considered the main cause of elbow pain at the time of review. | |
| 3547750 | [The new basic agent prospidin in the therapy of rheumatoid arthritis. An evaluation of th | 1986 | A therapeutic effect of prospidine, a Soviet antitumor drug, was studied on the basis of clinicoimmunological correlations in 74 patients with proved rheumatoid arthritis (RA) who were resistant to well known basic drugs. It was administered parenterally and intraarticularly according to the methods developed by the authors, and its effect on the indices of T- and B-immune response was studied. Prospidine was shown to possess a true and high (91.8%) antirheumatic activity producing an analgesic, antiexudative and antiproliferative effect; it was capable of lessening hormone dependence and causing remission bringing about no serious side-effects which could require discontinuation of therapy. At the same time the use of the drug resulted in an elevation of the level of T-suppressors, a decrease in the amount of B-cells, T-helpers, titers of the rheumatoid factor, antisynovial antibodies, cytopathic and lymphokine synthesizing activity. Its mechanism of action and indications for use were discussed. Prospidine was considered as a drug of choice in drug therapy of rheumatoid arthritis. | |
| 2287944 | Methotrexate: mechanism of action in rheumatoid arthritis. | 1990 Dec | Most studies of immune function in rheumatoid arthritis (RA) patients treated with methotrexate (MTX) show only marginal effects on humoral or cellular immune responses. These include measurements of lymphocyte subsets, proliferative responses to mitogens, immunoglobulin production, rheumatoid factor and immune complexes. The mechanism of action of MTX in RA might be more antiinflammatory than immunosuppressive. This is supported by the rapid clinical response to drug treatment and by data from in vitro and animal studies. The inhibition of interleukin-1 (IL-1) activity or other inflammatory cytokines by MTX may play an important role in the antiinflammatory effect of MTX. MTX effects in RA are not fully understood and further studies are needed to clarify its mechanism of action. MTX has crucial effects on the cascade of events initiated by some cytokines (IL-1, IL-6, tumor necrosis factor), which plays a major role in RA and other inflammatory diseases. | |
| 2128462 | Kinetic study of a galactosyltransferase in the B cells of patients with rheumatoid arthri | 1990 | The sugar chains of IgG samples purified from sera of patients with rheumatoid arthritis (RA) contain many fewer galactose residues than those from sera of healthy individuals. Enzymatic studies revealed that the low galactose content in the IgGs of RA patients results from the reduced activity in the B cells of a galactosyltransferase (EC 2.4.1.90), which preferentially transfers galactose to asialo-agalacto-IgG. Asialo-agalacto-transferrin and asialo-ovine submaxillary mucin were also galactosylated by detergent-activated human B cell homogenates. However, no difference in the enzymatic activities toward these two acceptors was detected between the B cells from RA patients and from non-RA patients and healthy individuals. Enzyme kinetic studies revealed that an affinity of the galactosyltransferase in the B cells from RA patients was lowered for UDP-Gal but not for asialo-agalacto-IgG, while the affinities for UDP-Gal and asialo-agalacto-transferrin of the galactosyltransferase were not changed between the B cells from RA patients and from non-RA patients and healthy individuals in accordance with their enzyme activities. The results indicated that the reduced galactosyltransferase activity toward asialo-agalacto-IgG in the B cells from RA patients can be ascribed to the lowered affinity for UDP-Gal. | |
| 2058151 | [Myocardial rupture in primary chronic polyarthritis. Sequela of a rare combination of acu | 1991 | Severe chronic rheumatoid arthritis is sometimes associated with several internal organic lesions. This is the report of a patient with malignant chronic rheumatoid arthritis complicated by an acute myocardial infarction, left ventricular wall rupture and pseudoaneurysm besides reactive amyloidosis and perimyocarditis. | |
| 3392077 | Use of a total condylar knee prosthesis for treatment of osteoarthritis and rheumatoid art | 1988 Jul | Between May 1975 and December 1979, 113 patients had 153 arthroplasties using a total condylar knee prosthesis. Thirty patients (forty-two knees) died, and one (two knees) was lost to follow-up. Thirty-eight of these forty-four knees had been followed for more than two years, and none had had a revision. The remaining eighty-two patients (109 knees) were followed for an average of nine years (range, seven to 11.5 years). At the time of the latest examination, ten had had a revision for various reasons. For the ninety-nine knees that had the original prosthesis, the findings were compared with those of an evaluation that had been done four years postoperatively. The average over-all knee score was found to have decreased between the four-year and the latest follow-up evaluation, primarily because of a 7-point decrease in the score for function. The rate of infection was 0.6 per cent. The knees that had had patellar resurfacing had better over-all scores and better scores for pain than those that had not. This was particularly true in the patients who had osteoarthritis. The results of arthroplasty using a total condylar prosthesis appeared to be consistent and durable. Although there was a decrease in the quality of the functional result with increasing age, the patients reported consistent relief of pain. |