Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3557207 | [Arthrodesis of the wrist joint in patients with polyarthritis]. | 1987 Jan | In rheumatoid arthritis, extreme damage to the wrist joint with rupture of the wrist extensor tendons can only be treated effectively by arthrodesis. The authors describe the technique of wrist fusion by an AO-plate. Twenty-two arthrodeses have been performed between July 1974 and June 1984, representing 7.4% of all surgical procedures on rheumatoid wrists (n = 294). Radial deviation and dorsiflexion of the hand must be avoided. Follow-up was possible in nine patients (eleven wrist-fusions). All these patients were satisfied with the result. | |
| 3536261 | A randomized, double-blind trial comparing a pulse of 1000 with 250 mg methylprednisolone | 1986 Sep | We compared, in a double blind, randomized, 3-center study, a pulse of 1000 mg methylprednisolone with a pulse of 250 mg methylprednisolone, in patients with active rheumatoid arthritis. Improvement of patients was similar in both groups and lasted up to 3 weeks. Side effects were minor. | |
| 2565412 | Immunomodulating therapy of rheumatoid arthritis by high-dose intravenous immunoglobulin. | 1989 Mar 1 | 11 patients with rheumatoid arthritis were treated with intravenous immunoglobulin (IVGG). In 6 patients clinical results were impressive, although lasting responses could be achieved in 3 patients only. This treatment was immunomodulating, since the immunoregulatory T-cell ratio (CD4/CD8) decreased following therapy by reducing CD4-positive cells in-vivo. By use of anti-mu-antibodies as a B-cell specific mitogen, IVGG-treatment was seen to suppress early processes of B cell activation. In parallel to these cellular effects, IVGG led to a reduction in the levels of polyethyleneglycol-precipitated circulating immune complexes as measured by lasernephelometry. | |
| 3378124 | High prevalence of unrecognized osteomalacia in hospital patients with rheumatoid arthriti | 1988 Jun | A consecutive series of 31 patients with rheumatoid arthritis (RA) admitted over a 6-month period to the rheumatology unit of a District General Hospital were screened for possible osteomalacia. Transiliac bone biopsies were performed in 14 patients where the above diagnosis was suspected, yielding four (12.9%) cases of osteomalacia. All affected patients were elderly women who had a poor diet and were virtually housebound. Additional risk factors in two cases were partial gastrectomy and occult coeliac disease. Biochemical screening was of limited value in differential diagnosis, since elevated serum alkaline phosphatase levels were noted in both osteomalacic and non-osteomalacic patients. This study indicates that, in the West of Scotland at least, osteomalacia is a common, easily overlooked and treatable cause of morbidity in elderly patients with RA. | |
| 1948774 | [Non-drug and non-surgical measures in chronic polyarthritis]. | 1991 Sep | Therapy of rheumatoid arthritis requires a treatment plan which coordinates the different therapeutic measures within the framework of a long-term strategy. By detailed information the patient is to be gained for cooperation in the fight against the disease. Physiotherapy and a daily home program represent an important part of the treatment. Other decisive measures are ergotherapy, counselling on resources, prescription of splints, counselling on shoes, matching of walking aids, and sociomedical counselling. The treatment of the patient in a well coordinated team offers optimal conditions for therapeutic success. | |
| 1862244 | Antirheumatic effects of fasting. | 1991 May | Total fasting induces within a few days a substantial reduction of joint pain, swelling, morning stiffness, and other arthritic symptoms in patients with rheumatoid arthritis. This remission subsides slowly after discontinuation of fasting. Its mechanisms are complex and involves diminished activation of neutrophils and lymphocytes and decreased generation of leukotrienes and of concentrations of serum complement factors, as well as of other proinflammatory systems. Moreover, ketosis and other metabolic and endocrine changes may be of significance for symptom expression and recognition. | |
| 2190753 | Basic therapy of rheumatoid arthritis: nonsteroidal anti-inflammatory drugs. | 1990 May | Aspirin is recommended for initial therapy of RA. If aspirin is not tolerated, an NSAID is recommended. The choice of NSAID should be based on cost, convenience, safety, and the personal experience of the physician. An adequate trial of at least 2 weeks should be completed before changing to another NSAID. Therapy should be closely monitored for adverse reactions, particularly renal and gastrointestinal effects. | |
| 3329968 | Comparison of diflunisal and piroxicam in the management of patients with rheumatoid arthr | 1987 | The efficacy and tolerability of diflunisal (500 mg orally, twice daily) and piroxicam (20 mg orally, once daily) were compared in a 12-week open-label study in 44 patients with active rheumatoid arthritis. Both medications were equally effective and generally well tolerated. No significant differences were found between drug groups. Both groups showed statistically significant improvement in the overall number of swollen and tender joints, painful joint count, and the patients' assessment of pain and disease severity. Two (9%) of 23 patients in the diflunisal group and one (5%) of 21 patients in the piroxicam group reported adverse effects. Only one patient withdrew from the study because of side effects (lightheadedness during use of diflunisal). It is concluded that both diflunisal and piroxicam are highly effective and generally well tolerated in the management of rheumatoid arthritis. | |
| 3567110 | Self-esteem and perception of attractiveness: an investigation of early rheumatoid arthrit | 1987 Mar | During an investigation into the self-esteem of early rheumatoid patients and controls matched individually by age and sex, it was found that at their first visit to out-patients, patients had lower self-esteem. The items of low self-esteem showed a similarity with features of the rheumatoid personality. An observation that the word attractive in the Carlson Adjective Checklist was rarely used by both groups, and that items at the beginning and end of the checklist were less often ticked, led to a second study of 67 undergraduates where the position of the word attractive was experimentally varied in three forms of the scale. The results show that position only marginally affects response to this item. Probability analyses confirm that the word attractive is used very rarely by patients, rarely by healthy adults and less often than expected by healthy students, possibly demonstrating the respective effects of pain and illness, and age. Attractive tends to be included in the self-concept only after self-esteem reaches a relatively high level. | |
| 1944747 | Mesangial glomerulopathy in rheumatoid arthritis patients. Clinical follow-up and relation | 1991 | 23 patients (16 women, 7 men) with rheumatoid arthritis (RA) and renal biopsy-proven mesangial glomerulopathy (MGP) were followed for 4-117 months (median 42) in order to evaluate the clinical course of their renal disease. Urinalysis was made, and 24-hour urine protein excretion and serum creatinine were determined. At the time of renal biopsy, the clinical renal findings of the patients were isolated hematuria (n = 10), isolated proteinuria (n = 6) and hematuria combined with proteinuria (n = 7). Hematuria persisted and renal function remained normal in all patients with isolated hematuria. A possible association between the presence of hematuria and the use of antirheumatic drugs was not established in this study. Proteinuria was clinically closely associated with the use of antirheumatic drugs in 9 out of 13 cases (6 with gold sodium thiomalate, 2 with D-penicillamine and 1 with auranofin) suggesting that antirheumatic drugs are important contributors to proteinuria in these patients. Renal function, although initially reduced in some patients, remained stable in all but 1 patient with IgA glomerulonephritis who developed the nephrotic syndrome and died of uremia. In conclusion, the clinical course of MGP in RA patients is benign in most patients. Moreover, this nephropathy may not represent a clinical entity. Proteinuria was related to antirheumatic drugs in most patients whereas microhematuria was constant even after stopping the antirheumatic drugs. | |
| 2335051 | Effect of oral gold salt therapy on bile acid absorption in rheumatoid arthritis patients. | 1990 Mar | Several studies pointed out an altered stool pattern as the most common side effect of auranofin therapy. The major mechanism in the aetiology of auranofin-induced impairment in bowel habit seems to be the inhibition of Na+/K+ ATPase in the gut. In vitro experiments proved that auranofin can affect active bile acid (BA) reabsorption in rat terminal ileum; this action, due to the ability of the drug to reduce Na+ pump activity by inhibiting Na+/K+ ATPase, may make a significant contribution to the auranofin-induced diarrhoea. The ability of auranofin to reduce the Na+ gradient necessary for active BA reabsorption, however, could cause a decrease of serum BA levels in patients taking auranofin before or without the development of an overt diarrhoea. We measured fasting and postprandial serum conjugated BA levels in 10 female rheumatoid arthritis patients before and after one month and two months' auranofin treatment. No patient developed diarrhoea during the chrysotherapy. When oral gold salt therapy was started, we observed a slight decrease in serum BA levels, but difference was not statistically significant. We can conclude that auranofin therapy does not cause BA malabsorption in patients who do not develop diarrhoea during the treatment. | |
| 3365529 | Campylobacter pylori associated gastritis in patients with rheumatoid arthritis taking non | 1988 Apr | Fifty-two patients with rheumatoid arthritis taking nonsteroidal anti-inflammatory drugs were studied in order to assess the carriage rate of Campylobacter pylori (C. pylori) with reference to dyspeptic symptoms, endoscopic appearance and antral histology. All patients were interviewed using a standard gastrointestinal symptom scoring questionnaire and underwent endoscopy at which two antral biopsies were obtained. Sections were examined for the presence and severity of gastritis and of C. pylori. Forty-four of 52 patients (85%) had histological evidence of gastritis. Twenty-six of 44 (59%) patients with gastritis were positive for C. pylori. Twenty-six of 28 patients with 'active' (polymorph infiltration) chronic gastritis were positive for C. pylori (p less than 0.002). Sixteen of 26 bacteria-positive patients had gastrointestinal symptoms compared with eight of 26 bacteria-negative patients (p less than 0.05) and this may have therapeutic implications. There was no correlation between the presence of organisms and the appearances at endoscopy. | |
| 3549319 | Effect of cyclosporin on serum creatinine in patients with rheumatoid arthritis. | 1987 | Serum creatinine levels were measured before, during and after the administration of cyclosporin (Cy) in a double-blind placebo-controlled study in patients with rheumatoid arthritis (RA). The level rose significantly during and after Cy therapy, whereas the initial serum creatinine value did not change in the placebo group. The increase in the Cy group was not correlated with the mean Cy blood level. The rise in serum creatinine during Cy therapy was gradual and was not significantly correlated with the initial creatinine level; relative to the pretreatment value, the post-treatment increase was significantly correlated with the increase during Cy therapy. It is concluded that Cy administration for not more than 6 months, and at a maximum dosage of 10 mg/kg for 2 months, leads to an irreversible loss of more than 10% of renal function in RA patients. The damage may be ascribed to the combination of Cy with other factors compromising the kidneys, e.g., the use of non-steroidal anti-inflammatory drugs in the potentially systemic disorder of RA. | |
| 2242757 | Glycosylation of IgG, immune complexes and IgG subclasses in the MRL-lpr/lpr mouse model o | 1990 Oct | The MRL-lpr/lpr (MRL/lpr) mouse spontaneously develops a disease syndrome which, in many respects, is similar to human rheumatoid arthritis. These mice developed joint inflammation, circulating rheumatoid factors and immune complexes. We now show that the parallel with human disease extends to a glycosylation defect which is observed on IgG from rheumatoid arthritis patients. Using the lectins ricin and Bandeiraea simplicifolia II we have found that terminal N-acetylglucosamine is clearly raised in MRL/lpr IgG. Increased exposure of galactose was also detected, indicating that a second glycosylation site must be present on these molecules. Polyethylene glycol-precipitated IgG complexes bound significantly more of each lectin than did free IgG, indicating that the changes in glycosylation were associated with complex formation. The sugar abnormality was most marked in the IgG2a/IgG3 fraction from protein A IgG subclass chromatography. Our results suggest that the IgG glycosylation defect seen in rheumatoid arthritis is apparent in the MRL/lpr mouse and may contribute, through complex formation, to the pathological processes in the rheumatoid syndrome. | |
| 2259899 | Resection arthroplasty of the shoulder. | 1990 | Destruction of the gleno-humeral joint is a well-known and common feature of progressive rheumatoid arthritis. The most striking symptoms are pain and limited motion. Very occasionally spontaneous ankylosis occurs. The impact often relegates the patient to the second and third functional class according to the ARA classification system. The most commonly used surgical methods are endoprosthetic arthroplasty, double osteotomy and early and late synovectomy. Resection interpositioning arthroplasty (RIAP) of the rheumatic elbow joint using lyophilized dura mater has shown excellent results. This encouraged us to apply the same surgical principles to the shoulder joint in rheumatoid arthritis and this report presents the surgical procedure and the primary results of our first 13 patients. Very good results were achieved concerning immediate pain relief and mobility gain, while the muscle strength improved significantly after approximately one year. The surgical technique is fairly simple and postoperative exercises are preferably performed with the help of relatives. | |
| 2512042 | Intestinal calcium absorption in rheumatoid arthritis. A study using whole body counting. | 1989 Jul | Conflicting results are reported in the literature concerning the changes in intestinal calcium absorption in rheumatoid arthritis (RA). In the present work, intestinal calcium absorption was studied in 27 postmenopausal women with RA, using whole body counting as the study method and orally administered Ca-47 as the tracer. Nobody was on corticosteroid therapy, but all received non-steroidal anti-inflammatory drugs and hydroxy chloroquine or gold compounds. The mean calcium absorption was 22.3% of the dose administered, with a standard deviation of 8.0%. The results obtained were not significantly different from those of 40 age- and sex-matched controls (mean +/- SD: 22.0% +/- 6.0%). Our findings seem to exclude the hypothesis of calcium malabsorption as one of the causes leading to osteoporosis in RA. | |
| 3389200 | Pannus tissue at the cartilage-synovium junction in rheumatoid arthritis. | 1988 Apr | The cartilage-synovium junction of knees afflicted with rheumatoid arthritis was observed light microscopically using formalin-fixed, decalcified and immunohistochemically stained tissues. Decalcification had little or no influence on immunoreactivity for lysozyme and S-100 protein. All the specimens had pannus formation, which was classified into four types: A) cellular pannus with homogeneous cell pattern, B) cellular pannus of inflammatory cells, C) fibrous pannus with many fibrous bundles, D) fibrous pannus including round cells with scattered fibrous bundles. Type A pannus may be responsible for extensive cartilage degradation, and may occur at the first stage of pannus formation. Type B pannus may occur afterwards, and may be followed by type C pannus at a later stage. Type D pannus was found in two out of 19 specimens. Round cells in type D were positive for S-100 protein and lysozyme, and were probably chondrocytes. The findings indicated that chondrocytes were responsible for cartilage degradation and pannus formation. | |
| 3175723 | Social relationships and psychological well-being in rheumatoid arthritis. | 1988 | This study examines the social relationships of a sample of 158 patients attending a hospital rheumatology clinic with rheumatoid arthritis (RA). Scores of the sample were compared with those of other samples on the Interview Schedule for Social Interaction (ISSI). In addition the effects of severity of disease activity and of disability upon social relationships were examined. Diffuse social relationships such as with friends and acquaintances, rather than more intimate ones appear to be more affected in individuals with RA. Psychological well-being was assessed by means of two measures. The more favourably patients scored for social relationships, the more favourable were their scores for psychological well-being using both scores. More diffuse social relationships were more strongly correlated with psychological well-being than were the scores for more intimate relationships. Despite the strong effects of social relationships upon well-being, no buffering action on the effects of disability upon well-being were found. | |
| 2151575 | Effectiveness and safety of etodolac in treatment of rheumatoid arthritis: a multicentre t | 1990 | One hundred and seventeen outpatients (87 females and 30 males; mean age 53.5 +/- 13.2 years) encompassing the 1987 American Rheumatism Association criteria for rheumatoid arthritis were admitted into a multicentre open study. All patients were evaluated at baseline and after two months of therapy with etodolac (400 or 600 mg/die per os). Clinical evaluation was performed by using the following indicators: viso-analogic scale of global pain; index of pain on active movements; index for sleep disturbances, and duration of morning stiffness. The erythrocyte sedimentation rate was chosen for the laboratory evaluation of the activity of the disease. One hundred patients received 400 mg/die, while only 17 patients received 600 mg/die; 115 patients undertook the evaluation after treatment, whereas two patients were considered "lost to follow-up". One hundred and five patients completed the study while ten patients withdrew (seven because of inefficacy and three because of intolerance of the gastrointestinal tract). Only nine patients presented side-effects, among these: five were judged etodolac-related, whereas four were not. A complete resolution of all these side-effects was achieved in all cases. Significant improvements were registered for all the four clinical variables. At the end of the study 56.5% of patients expressed a preference for etodolac, 16.5% for one of the non-steroidal anti-inflammatory drugs previously taken and 27% did not answer or were not able to express any definite preference. Strict concordance was found between the degree of clinical improvement achieved and the preferences expressed. The laboratory parameters did not reveal any variation at the end of the study in comparison with baseline values.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2138449 | Effects of fish oil supplementation in rheumatoid arthritis. | 1990 Feb | Sixteen patients with rheumatoid arthritis entered a trial to determine the clinical and biochemical effects of dietary supplementation with fractionated fish oil fatty acids. A randomised, double blind, placebo controlled crossover design with 12 week treatment periods was used. Treatment with non-steroidal anti-inflammatory drugs and with disease modifying drugs was continued throughout the study. Placebo consisted of fractionated coconut oil. The following results favoured fish oil rather than placebo: joint swelling index and duration of early morning stiffness. Other clinical indices improved but did not reach statistical significance. During fish oil supplementation relative amounts of eicosapentaenoic acid and docosahexaenoic acid in the plasma cholesterol ester and neutrophil membrane phospholipid fractions increased, mainly at the expense of the omega-6 fatty acids. The mean neutrophil leucotriene B4 production in vitro showed a reduction after 12 weeks of fish oil supplementation. Leucotriene B5 production, which could not be detected either in the control or in the placebo period, rose to substantial quantities during fish oil treatment. This study shows that dietary fish oil supplementation is effective in suppressing clinical symptoms of rheumatoid arthritis. |