Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1709520 | Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by | 1991 | The synthesis and release of collagenase in the presence of the neuropeptide substance P (SP) and capsaicin, were investigated in vitro using identical synoviocyte cultures from patients with rheumatoid arthritis (RA). On average 10(-12) M SP augmented statistically significantly the collagenase production by approximately a factor of five. An increase in the concentrations up to 10(-6) M SP resulted in a decreased collagenase synthesis, which, however, was still above the level of that of the untreated synoviocytes. Capsaicin, a homovanillic acid derivative that acts as a releaser of SP from primary afferent neurons, caused a strong stimulation of collagenase production and release at 10(-8) and 10(-6) M (about 7 times the amount of the control). With increasing concentrations up to 10(-3) M capsaicin this effect diminished continuously. The experiments clearly show that in RA synoviocytes in vitro SP and capsaicin in low concentrations act as potent inducers of the synthesis and release of collagenase. | |
| 2781492 | [Radioisotope synovectomy in multi-modality treatment of rheumatoid arthritis]. | 1989 | The colloid solution of radioactive gold 198 was administered to 91 knee joints of 50 patients with rheumatoid arthritis in a dose of 5-7 mCu. The patients were examined before and 6-12 months after radionuclide synovectomy. The treatment turned out effective in 35% of the cases, while in 19% of the cases, the effect was assessed as beneficial, and in 16% as satisfactory. The treatment efficacy decreased with age and disease standing. Three groups of the joints were distinguished in relation to the absorbed dose of ionizing radiation. In group I, this parameter constituted less than 80 Gy, in group II, from 80 to 100 Gy, and in group III, over 100 Gy. The efficacy of the different absorbed doses was assessed by the double blind method. In group I, the increase of the absorbed dose to over 100 Gy maintained 25%, and in group III, in 72% of the cases. Therefore, the increase of the absorbed dose to over 100 Gy maintained a significant (p less than 0.01) rise of the treatment efficacy. | |
| 2810605 | Relationships between knowledge and experience in the use of disease-modifying antirheumat | 1989 Nov 17 | The timely dissemination of new medical information is a complex and often faulty process. We surveyed primary care physicians to determine their knowledge and use of disease-modifying antirheumatic agents for the treatment of rheumatoid arthritis. Only 26.2% of patients hospitalized for rheumatoid arthritis had been treated with disease-modifying antirheumatic agents in the past, and 13.9% were presently receiving them. When responding to a clinical vignette on rheumatoid arthritis, only 12% (10/84) of practitioners would implement therapy with disease-modifying antirheumatic agents, while the majority would refer the patient to a rheumatologist. Experience with similar patients was clearly the factor that led to initiation of therapy. While 73% of practitioners were aware of the value of disease-modifying antirheumatic agents, only 14% prescribed them in the last year. These findings suggest that dissemination of information concerning disease-modifying antirheumatic agents has been successful, but the problems inherent in their use result in referral rather than initiation of therapy. | |
| 2319940 | Rheumatoid pericarditis: clinical features and survival. | 1990 Mar | We describe the clinical characteristics and actuarial survival of a consecutive cohort of 41 patients with rheumatoid arthritis and clinical pericarditis who were seen at the Mayo Clinic between 1970 and 1987 and followed up until death or through 1987. The survivors were followed up for a median of 5.1 years. Approximately three-fourths of our patients had acute pericarditis, the remainder having recurrent acute pericarditis, chronic pericarditis with effusion, or chronic constrictive pericarditis. Most patients had symmetrical joint swelling, morning stiffness, subcutaneous nodules, rheumatoid factor, and classic radiographic changes of rheumatoid arthritis. Common extra-articular features included fatigue, loss of weight, and fever. Dyspnea or orthopnea, typical pericardial pain, peripheral edema, tachycardia, tachypnea, a diminished mean blood pressure, a pericardial friction rub, jugular venous distension, rales, radiographic evidence of cardiomegaly and pleural effusions, and abnormal echocardiograms were the most common cardiac manifestations. An elevated erythrocyte sedimentation rate and anemia were other common laboratory findings. Our cohort demonstrated decreased survival in comparison with an age- and sex-matched North Central white population (from the upper midwestern United States), especially during the first year after diagnosis. Increasing age, the presence of other heart disease, an increasing total number of other extra-articular manifestations of rheumatoid arthritis, jugular venous distention, and a lower mean blood pressure were associated with decreased survival. | |
| 3820205 | Severe airway obstruction caused by laryngeal rheumatoid arthritis. | 1986 Oct | Ankylosis of the cricoarytenoid joints due to rheumatoid arthritis (RA) may cause upper airway obstruction by fixation of the vocal cords in the midline. In early stages, this condition usually results in minor symptoms which are easily overlooked. It may, however, very rapidly, e.g., in association with an upper respiratory tract infection, become life-threatening. It is essential to diagnose this condition early to avoid emergency situations. In 5 patients with classic RA and in one patient with juvenile RA severe laryngeal obstruction was operated on using a new simple technique consisting of a mobilization of the arytenoid cartilages and laterofixation of one of the vocal cords. | |
| 1753545 | [A case of broncho-bronchiolitis obliterans associated with rheumatoid arthritis and Sjög | 1991 Sep | A 45-year-old female patient with rheumatoid arthritis and Sjögren's syndrome was admitted because of progressive exertional dyspnea and palpitation. The chest X-ray film was normal except for slight overinflation. Pulmonary function tests indicated severe mixed-type impairment, and arterial blood gas analysis revealed hypoxemia. 99mTc-MAA lung perfusion scintigraphy and 81mKr lung ventilation scintigraphy showed multiple nonsegmental defects in both lungs. During six months of observation, the perfusion defect increased in size and intensity, although the chest radiography remained unchanged. The diagnosis of bronchobronchiolitis obliterans (BBO) was confirmed by open lung biopsy. Glucocorticoid therapy was ineffective, and she died of respiratory failure a month after discharge. It is noteworthy that perfusion scintigram demonstrated the progression of the disease much better than chest radiography, which showed no apparent change during the observation period. | |
| 3763223 | [Rheumatoid hip joint and its orthopedic surgical treatment]. | 1986 Aug | In the early stage of the disease, synovectomy of the hip seems to be a successful technique, but the timing of the operation is difficult because of interference with conservation treatment. Osteotomy in rheumatoid arthritis of the hip is not very successful; arthrodesis is not recommended. In the late stage of the disease the treatment of choice is joint replacement. Here osteoporosis and the protrusion of the acetabulum present more technical problems than in other hip diseases. Implants with various designs and various implantation techniques with or without bone cement are used. The use of bone grafts, especially for protrusion, represents real progress, and there is a trend toward using cementless implantation, especially for young patients. Failures are due to difficulties in morphology, but there are no more reoperations than in osteoarthritis, and mortality seems to be higher than in osteoarthritis. | |
| 1981199 | Control of oxidative damage in rheumatoid arthritis by gold(I)-thiolate drugs. | 1990 | The roles of anti-arthritic gold(I)-thiolate drugs such as disodium aurothiomalate ('Myocrisin') in the modulation or promotion of oxygen radical-mediated oxidative damage in vivo are reviewed. In particular, the precise molecular mechanisms by which these novel second-line agents exert their therapeutic effects are discussed in terms of (i) the direct and indirect control of enzymes involved in the generation or scavenging of reactive oxygen species (ROS) such as superoxide ion, hydrogen peroxide and hydroxyl radical, (ii) the protection of proteins and relevant enzyme systems against attack by ROS and (iii) their direct involvement in the production (at appropriate 'target' sites) or scavenging of ROS in vivo. In addition, the role of the orally-effective gold(I)-phosphine complex auranofin in the control of oxidative damage in rheumatoid arthritis is also discussed. | |
| 3164984 | Somatization and depression in fibromyalgia syndrome. | 1988 Aug | Psychiatric diagnoses, self-reports of symptoms, and illness behavior of 20 fibromyalgia patients and 23 rheumatoid arthritis patients were compared. The fibromyalgia patients were not significantly more likely than the arthritis patients to report depressive symptoms or to receive a lifetime psychiatric diagnosis of major depression. These results do not support the contention that fibromyalgia is a form of somatized depression. Fibromyalgia patients, however, reported significantly more somatic symptoms of obscure origin and exhibited a pattern of reporting more somatic symptoms, multiple surgical procedures, and help seeking that may reflect a process of somatization rather than a discrete psychiatric disorder. | |
| 3598993 | Analysis of combined rheumatoid factor determinations by the rheumatoid arthritis latex an | 1987 Apr | The clinical records of randomly selected patients receiving both the sheep cell agglutination test (SCAT) and the latex agglutination test (RA latex) for rheumatoid factor (RF) were analyzed for the presence of American Rheumatism Association (ARA) criteria for rheumatoid arthritis (RA). When both tests were positive there was a 3-fold increase compared to only one test positive in the relative risk that a patient met ARA criteria for RA, and there was a 2-fold increase in the probability that a patient with 2 positive tests had classical RA compared to only a positive RA latex. The occurrence of RF reactive with both human and rabbit IgG identifies a population of patients likely to have more ARA criteria for RA and classical disease. | |
| 2380232 | The importance of the valgus hindfoot in forefoot surgery in rheumatoid arthritis. | 1990 Jul | The relationship between hindfoot deformity and forefoot pressure was assessed in 28 rheumatoid patients who had undergone forefoot reconstruction four years previously. Patients with valgus hindfoot deformities tended to have high forefoot pressures whereas those with a normal hindfoot recorded normal pressures on the dynamic pedobarograph. All patients with residual forefoot pain recorded abnormal forefoot pressures. We believe that orthotic control of hindfoot deformities should be considered for those patients who require forefoot surgery as a combination of surgical and orthotic management may offer the best chance of success. | |
| 2802794 | Isolation and propagation of endothelial cells derived from rheumatoid synovial microvascu | 1989 Sep | Synovial angiogenesis may play an important part in the destruction of articular cartilage in patients with rheumatoid arthritis (RA). As an important first step towards developing in vitro models of synovial angiogenesis, microvascular endothelial cells have been isolated, purified, and cultured from operative synovial specimens obtained from adult patients with RA. | |
| 2116042 | [Well controlled comparative study in early rheumatoid arthritis with gold sodium thiomala | 1990 Feb | RA Center Liaison Council conducted a comparative study of Auranofin and GST by envelope method on the patients with early RA who experienced the onset of the disease not more than two years ago. In final assessment of overall improvement, 57.9% of Auranofin-administered cases (22/38) showed moderate improvement or above. The comparable figure for GST group was 71.8% (28/39), but there was no statistically significant difference. Adverse reaction ADR incidence for Auranofin group was 12.2% (5/41), while 22.0% for GST (9/41), but the difference was not statistically significant. Drop out due to ADR was observed in 9.8% of Auranofin-administered cases and in 19.5% of GST-administered cases. The results of the study indicate that Auranofin is a most suitable DMARD than GST to be used for early RA, and GST is suitable for more active RA in view of its efficacy. But GST should be administered carefully because of its high ADR incidence. | |
| 1975737 | Comparison of the single dose pharmacokinetics of sulphasalazine in rheumatoid arthritis a | 1990 Aug | The pharmacokinetics of sulphasalazine and its principal metabolites in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) were compared. Patients with RA had a significantly greater concentration of plasma sulphapyridine than patients with IBD (medians 14.0 micrograms/ml and 7.4 micrograms/ml respectively). Patients with RA also tended to maintain a higher plasma sulphapyridine concentration with time, as determined by the area under the curve (AUC), but a lower plasma sulphasalazine AUC than patients with IBD. It is suggested that more sulphasalazine may be presented to the lower bowel for cleavage to sulphapyridine and 5-aminosalicylic acid in patients with RA than in IBD. Patients with RA may also have impaired metabolism of sulphapyridine as a consequence of their disease. Together these factors may contribute to higher peak circulating sulphapyridine concentrations and may be responsible for the higher incidence of side effects of sulphasalazine treatment in patients with RA than in patients with IBD. | |
| 3941651 | Cardiac rheumatoid nodules. | 1986 Jan 20 | Rheumatoid nodules in the heart are unusual specific manifestations of rheumatoid arthritis. This paper describes three cases in which these nodules were found at necropsy. The patients were women with long histories of rheumatoid arthritis, two of whom had significant but unexplained congestive cardiac failure. The rheumatoid nodules were present in the patients' myocardium and in one patient's pericardium. We suggest that in patients with rheumatoid arthritis with severe but unexplained cardiac failure, the possibility of rheumatoid nodules in the heart should be considered. | |
| 3328905 | [Auriculo-electropuncture in rheumatoid arthritis (a double-blind study)]. | 1987 | A study of the efficacy of auriculo-electropuncture (AEP) by a double blind method was conducted in 16 patients with rheumatoid arthritis (RA). Points on the auricle were looked for by means of an device of individual use. After that during true AEP (the study group of 10 patients) the device was switched on to the stimulation mode, during false AEP (the control group of 6 patients) it was switched off. Each patient was given 10 procedures except one patient of the study group in whom treatment had to be discontinued after the 3rd procedure because of the development of phlebitis of the left crural veins. Subjective assessment showed improvement in all the patients of the study group (considerable improvement in 2 patients), in the control group improvement was noted in one patient only, no effect--in 3 patients, deterioration--in 2 patients; objective assessment showed improvement in 6 (considerable improvement in one patient) and in one patient, no effect--in 2 and 2, deterioration in one and 3, respectively. In the study group a positive time course of all 8 indices characterizing a degree of pain and inflammatory activity was noted (it was statistically significant for 7 of them), in the control group a positive time course of 3 indices was noted, 5 indices grew worse. A statistically significant decrease in the initially elevated level of blood alpha (2)-globulin was noted against a background of true AEP.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2357503 | Raynaud's phenomenon in primary Sjögren's syndrome. | 1990 Jun | Forty-five consecutive primary Sjögren's syndrome (SS) patients were divided into two subgroups according to the presence (n = 30) of Raynaud's phenomenon (RP). Non-erosive arthritis was significantly more frequent in the patients with RP than in those without. RP was not associated with HLA-DR4 in primary SS patients. | |
| 1718359 | The rheumatoid elbow: patterns of joint involvement and the outcome of synoviorthesis. | 1991 | Rheumatoid arthritis of the elbow is a common condition. A group of 86 patients has been reviewed. Patterns of joint involvement are described. These patients have been subjected to 137 radioisotopic synoviortheses. 72% achieved a result classed as "good" and this review underlines the efficacy of the procedure of synoviorthesis. Radiological staging has been shown to have prognostic significance; 89% of good results were obtained in management of Steinbrocker grade I. No complications were recorded. | |
| 3030335 | Assessment of kininases in rheumatic diseases and the effect of therapeutic agents. | 1987 Feb | Bradykinin is degraded in human plasma by a carboxypeptidase to yield desArg9-bradykinin (DBK) which is then digested by angiotensin-converting enzyme (ACE) to the pentapeptide Arg-Pro-Pro-Gly-Phe and the tripeptide Ser-Pro-Phe. We have studied the rate of kinin degradation by each of these enzymes in patients with rheumatoid arthritis (RA) and with systemic lupus erythematosus (SLE), compared with the degradation rate in degenerative joint disease and normal subjects. Carboxypeptidase activity was the same in all individuals, but ACE activity was increased in the RA and SLE patients. We examined the effects of aspirin, sodium salicylate, auranofin, penicillamine, and corticosteroids on kinin metabolism, and all of these were marked inhibitors of ACE; however, only penicillamine had any demonstrable inhibition of carboxypeptidase. These observations suggest rapid degradation of DBK in patients with untreated RA and SLE, whereas drugs utilized in therapy have the opposite effects. Studies to examine the role of DBK in disease manifestations are in progress. | |
| 1880168 | Stabilization of the distal ulna. | 1991 May | Stabilization of the remaining distal ulna following its resection for various disorders resulting in pain and instability of this joint is necessary for long-term satisfactory results. The method described uses a distally based flap of the extensor carpi ulnaris to provide stability of the distal ulna and support to the carpus along its ulnar border. |