Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3521858 | Controlled clinical trial of imidazole.2-hydroxybenzoate (ITF 182) versus sulindac in pati | 1986 | The efficacy and safety of the nonsteroidal anti-inflammatory drugs imidazole.2-hydroxybenzoate and sulindac were compared in 30 patients with classical or definite rheumatoid arthritis. The trial was designed as a randomized parallel-group study comprising 15 patients given imidazole.2-hydroxybenzoate and 15 given sulindac orally for 28 days. Patients in both groups improved significantly in almost all of the variables evaluated. Imidazole.2-hydroxybenzoate was more effective than sulindac on Ritchie's articular index, left hand proximal interphalangeal joint circumference, erythrocyte sedimentation rate, and C-reactive protein. The incidence of side effects was significantly higher in patients treated with sulindac. | |
| 1365473 | Variations between rheumatologists in using sulphasalazine. | 1991 | The increased use of audit and resource management within the health service will focus attention on variations in clinical practice. We have looked at one rheumatological example; the extent rheumatologists vary in their clinical use of a slow-acting anti-inflammatory drug. We studied a single drug - sulphasalazine. In a prospective study sulphasalazine was given to 298 rheumatoid patients at 24 rheumatology centres in South East England. They were followed for 6 months. There were large differences between centres in: the types of patient started on therapy; the numbers of patients remaining on treatment; the responses after 6 months. The difference between some centres was more marked than the expected improvement in clinical and laboratory variables given by sulphasalazine. The use of a slow acting anti-rheumatic drug like sulphasalazine in rheumatoid arthritis is agreed by most rheumatologists in the UK and yet there are wide variations in its use. Our results question the validity of comparing clinical practice and associated costs between centres for even a simple clinical procedure. | |
| 3522899 | Pectoralis pyomyositis: an unusual cause of chest wall pain in a patient with diabetes mel | 1986 Apr | We describe a case of isolated pectoralis swelling and tenderness, without systemic signs of infection, in a North American adult with diabetes mellitus and rheumatoid arthritis. The etiology was discovered to be pyomyositis, usually thought to be a disease of tropical climates. It is the first such case with group B Streptococcus as the causative organism. | |
| 3030173 | Fish-oil fatty acid supplementation in active rheumatoid arthritis. A double-blinded, cont | 1987 Apr | STUDY OBJECTIVE: to determine the efficacy of fish-oil dietary supplements in active rheumatoid arthritis and their effect on neutrophil leukotriene levels. DESIGN: nonrandomized, double-blinded, placebo-controlled, crossover trial with 14-week treatment periods and 4-week washout periods. SETTING: academic medical center, referral-based rheumatology clinic. PATIENTS: forty volunteers with active, definite, or classical rheumatoid arthritis. Five patients dropped out, and two were removed for noncompliance. INTERVENTIONS: treatment with nonsteroidal anti-inflammatory drugs, slow-acting antirheumatic drugs, and prednisone was continued. Twenty-one patients began with a daily dosage of 2.7 g of eicosapaentanic acid and 1.8 g of docosahexenoic acid given in 15 MAX-EPA capsules (R.P. Scherer, Clearwater, Florida), and 19 began with identical-appearing placebos. The background diet was unchanged. MEASUREMENTS AND MAIN RESULTS: the following results favored fish oil placebo after 14 weeks: mean time to onset of fatigue improved by 156 minutes (95% confidence interval, 1.2 to 311.0 minutes), and number of tender joints decreased by 3.5 (95% Cl, -6.0 to -1.0). Other clinical measures favored fish oil as well but did reach statistical significance. Neutrophil leukotriene B4 production was correlated with the decrease in number of tender joints (Spearman rank correlation r=0.53; p less than 0.05). There were no statistically significant differences in hemoglobin level, sedimentation rate, or presence of rheumatoid factor or in patient-reported adverse effects. An effect from the fish oil persisted beyond the 4-week washout period. CONCLUSIONS: fish-oil ingestion results in subjective alleviation of active rheumatoid arthritis and reduction in neutrophil leukotriene B4 production. Further studies are needed to elucidate mechanisms of action and optimal dose and duration of fish-oil supplementation. | |
| 2204221 | [Patient education in rheumatology]. | 1990 Jun 30 | Most of the patients with rheumatic diseases do not know enough about their disease and its treatment. This may influence patient's satisfaction and compliance. Patient education is a useful approach to reduce the negative consequences of the lack of knowledge and non-compliance. Rheumatologists have recognized patient education as an important part of the long-term management of rheumatic diseases. | |
| 3594981 | Elbow synovectomy in rheumatoid arthritis. Long-term results. | 1987 Jul | Fifty-seven elbows in 46 rheumatoid arthritis patients were followed from one to 20 years, with an average follow-up period of 86 months, and were treated with synovectomy and radial head resection. A silicone radial head prosthesis was inserted in 13 elbows. Surgery was performed through a lateral incision. Long-term follow-up study showed 77% of the elbows to fall in the excellent and improved categories. A trend toward better results was seen if the surgery was done at an earlier stage of the disease. The radial head prosthesis did not influence the results of synovectomy. | |
| 11188596 | Coping strategies and affect in rheumatoid and psoriatic arthritis. Relationship to pain a | 1991 Sep | Affective state and utilization of coping strategies are factors that may be related to pain and disability in chronic disease, but may also be interrelated. The relationship of coping strategies and affect to both concurrent and 18-month follow-up pain and disability was studied in 60 women with rheumatoid or psoriatic arthritis of < 8 years' duration. The type of coping strategy used was not associated with concurrent mood level. After accounting for physical variables, mood and strategy use were significantly, and largely independently, related to concurrent pain and disability measures. Future disability was not predicted by either mood or coping strategy use. These results show that mood and use of coping strategies are significantly related to concurrent function but, perhaps due to the variable nature of the disease process, are not predictive of future function. The clinical implications of this study are that interventions to promote better adjustment for people with rheumatoid or psoriatic arthritis should target both mood and coping strategies, as both may contribute independently to adjustment. | |
| 1981626 | [The cytochemical characteristics of neutrophilic leukocytes in the peripheral blood and s | 1990 Oct | The authors studied the activity of alkaline and acid phosphatase (AP), myeloperoxidase (MP), the level of cationic protein (CP), spontaneous and pyrogenal-induced tests of restoration of nitroblue of tetrazolium (HCT-test) in the blood and synovial fluid (SF) neutrophils in 116 patients with rheumatoid arthritis (RA) in the dynamics of a 3-4-week and subsequent 6-month therapy with chrysanol, salazopyridazine and delagil. In the active phase all the patients exhibited an abrupt increase in the activity of alkaline and acid phosphatase in blood neutrophils, a drop in the level of CP (in 69%), a rise in the activity of MP (in 32%); pyrogenal did not induce any capacity for restoring HCT (in 44%). Indices of alkaline and acid phosphatase in blood and SF neutrophils and also of the induced TCT-test in blood neutrophils correlated with the degree of RA activity. Statistically significant positive cytochemical shifts were noted only after 6 months of treatment: a decrease in alkaline and acid phosphatase activity, a rise in the level of CP, MP and capacity for restoration pf HCT with pyrogenal in blood neutrophils. Increase in the correlation of CP or MP levels by 0.2 or more in blood and SF neutrophils, and also of the normal level of CP in blood neutrophils or its increase not less than by 15% 3-4 weeks after the beginning of therapy evidence good prognostic informativeness with respect to the effectiveness of basic therapy. | |
| 3673141 | [Microbiologic aspects of inflammatory joint diseases]. | 1987 Aug 1 | Regarding of microbiological aspects of arthritis three forms of joint diseases are under investigation: the septic arthritis, the reactive arthritis and the Rheumatoid Arthritis. In 95% of patients with septic arthritis microorganisms as causative agents responsible for the disease are described: Staphylococci, Streptococci, some gram-negative bacteria. By an haematogenic route of infection predominantly patients with immunosuppressive therapy are altered. In newborns and children septic arthritis is to observe more rarely. A reactive arthritis is a postinfectious sterile process in dependence on an infection occurred at an earlier time. As etiologic agents Yersinia, Enterobacteriaceae and Campylobacter have been discovered. 80% of the patients suffering such a reactive arthritis are carrier of the HLA-B27 system. The etiology of the Rheumatoid Arthritis is an open, unanswered problem. Of importance are: immunogenetic conditions, autoimmune phenomena, endocrinologic, dietetic and psychologic factors as well as bacteria and viruses as causative agents: cocci, bacilli, Diphteroids, endoparasitic bacteria (Listeria, L-forms, Mycoplasma, Chlamydiae), viruses (Adeno-, Mumps-, Measles-, ECHO-, Coxsackie-A- and B-, Hepatitis-, Cytomegalo-, Para-influenza-, Retro-, Parvo- and Rubella viruses). In the last years the EBV is of interest covering the question of a distinct virus persistence in tissues and the adequate limiting factors. Perhaps a defect of the hu-IFN-gamma-system might be of immunopathological and clinical significance. | |
| 2399137 | Responses to chronic illness: analysis of psychological and physiological adaptation. | 1990 Sep | The Adaptation Nursing Model provided the theoretical framework for the comparative analysis of psychological and physiologic adaptation of 211 adults representing three diagnostic groups (rheumatoid arthritis, hypertension, and multiple sclerosis). Data were collected through interviews and completion of the Mental Health Index, Health-Related Hardiness Scale, and Margin in Life. Psychological adaptation was found to be independent of diagnosis. Four predictor variables (health promotion activities, psychological distress, physiologic adaptation, and dependence on medications) significantly discriminated among the three groups and correctly classified 73.08% of the total sample. Presence of the hardiness characteristic was significantly related to psychological and physiologic adaptation, involvement in health promotion activities, and participation in patient education programs. It can be concluded that a diagnosis-specific view of psychological status is not tenable or clinically meaningful. | |
| 1982566 | Application of a new electrophoresis technique (2D cryostat section electrophoresis) to sy | 1990 | We describe a new two dimensional electrophoresis technique which is based on the combination of cryostat section technology and IEF- and SDS-gel electrophoresis. The optimal conditions for two dimensional cryostat section electrophoresis are investigated. The application of this technique to synovial membranes of patients suffering from rheumatoid arthritis and osteoarthritis is described. | |
| 2943237 | Functional capacities of T lymphocyte subsets from synovial fluid and blood in rheumatoid | 1986 Jul | A reverse haemolytic plaque forming cell (PFC) assay was employed to analyse the impact of T suppressor/cytotoxic and T helper cells on B cell function in 10 patients with rheumatoid arthritis (RA). In all cases T8-enriched cells from synovial fluid and blood suppressed the pokeweed mitogen (PWM) induced IgM, IgG, and IgA secretion by autologous lymphocytes to the same degree. The suppression was partly abolished by irradiation of T8-enriched cells. T4-enriched cells from blood increased the PWM induced Ig secretion by autologous blood B cells. In six of 10 patients responses 1.2 to four times higher were obtained with T4-enriched cells from synovial fluid, but in four of 10 patients synovial fluid T4-enriched cells did not increase the PWM responses of blood B cells. T4- and T8-enriched T cells from synovial fluid comprised more Ia+ cells than did T cells from blood (36% v 3% and 43% v 6%). Ia+ T helper and suppressor/cytotoxic cells may modulate in vivo activation of synovial B cells in RA. | |
| 1795698 | [Detection of autoantibodies against phenylalanyl-, tyrosyl-, and tryptophanyl-tRNA-synthe | 1991 Jul | Sera of patients bearing autoimmune diseases (rheumatoid arthritis and systemic lupus erythematosus) and sera of clinically healthy donors were examined by ELISA for the presence of autoantibodies against tryptophanyl-, tyrosyl- and phenylalanyl-tRNA synthetases. Pure bovine synthetases served as antigens. It was shown that in patients with both autoimmune diseases all three enzyme autoantibodies were revealed at serum dilution 1/1600-1/3200. Moreover, by means of monoclonal antibodies against the same enzymes used for immunoaffinity sorption, antiidiotypic antibodies of IgG type against autoantibodies were detected. A conclusion has been made that autoimmune diseases are characterized by autoimmune response for many aminoacyl-tRNA synthetases irrespectively of their quaternary structure, intracellular location etc both at the level of primary and secondary antibodies. | |
| 3063517 | A cognitive-behavioral treatment for rheumatoid arthritis. | 1988 | This experiment tested a cognitive-behavioral rheumatoid arthritis treatment designed to confer skills in managing stress, pain, and other symptoms of the disease. We hypothesized that a mediator of the magnitude of treatment effects might be enhancement of perceived self-efficacy to manage the disease. It was predicted that the treatment would reduce arthritis symptoms and possibly would improve both immunologic competence and psychological functioning. The treatment provided instruction in self-relaxation, cognitive pain management, and goal setting. A control group received a widely available arthritis helpbook containing useful information about arthritis self-management. We obtained suggestive evidence of an enhancement of perceived self-efficacy, reduced pain and joint inflammation, and improved psychosocial functioning in the treated group. No change was demonstrated in numbers or function of T-cell subsets. The magnitude of the improvements was correlated with degree of self-efficacy enhancement. | |
| 1948776 | [Foot problems in chronic polyarthritis: shoe advice and foot care]. | 1991 Sep | Inflammatory alterations of the feet due to rheumatoid arthritis very often reduce the patient's quality of life. We present the pathogenetic mechanisms and discuss practicable and efficient prophylactic and therapeutic methods. A method recently developed by our occupational therapist for placing foot pads correctly in shoes is described. | |
| 2320762 | Perceived health status, self-esteem and body image in women with rheumatoid arthritis or | 1990 Apr | A cross-sectional, descriptive, comparative design was used with a sample of 26 women with rheumatoid arthritis (RA), 23 women with systemic lupus erythematosus (SLE), and 28 healthy (HLT) women to examine: (a) the relationship of illness to perceived health status, self-esteem and body image, (b) the relationships between perceived health status and both self-esteem and body image, (c) the relationship between these three variables and age and time since diagnosis, and (d) the problems, needs and fears of women with RA and SLE. Perceived health status differences were found between the ill and healthy subjects, but self-esteem differences were nonsignificant; mean scores on body image of RA and HLT groups approximated each other, while SLE subjects had lower scores. Perceived health status was directly related to self-esteem, but not to body image. Age and time since diagnosis were weakly positively related to perceived health status. Both similarities and differences were identified in the problems, needs and fears of RA and SLE subjects. | |
| 2487727 | Pharmacokinetics of aspirin and its application in canine veterinary medicine. | 1989 Dec | In preliminary investigation of the pharmacokinetics of aspirin in dogs it became apparent that the drug was well absorbed following oral ingestion with food. Multiple dosing appeared to lead to a substantial increase in half-life; a twice daily dosage regimen would, therefore, be adequate for maintenance of therapeutic levels in dogs. The marked variation in pharmacokinetic parameters observed suggested that therapeutic drug monitoring would be benefit in the control of canine inflammatory conditions using aspirin. Therapeutic monitoring of dogs (n = 20) showed that clinical improvement paralleled plasma salicylate concentrations and the therapeutic concentrations so determined were within the range considered therapeutic in humans. No overt gastric irritation was noted in this study over a period of a year which suggests that aspirin can be successfully used to treat canine inflammatory disorders, routine monitoring of plasma salicylate being recommended to ensure therapeutic success. | |
| 2974802 | Visualization of reversible macromolecular reactions in an analytical ultracentrifuge. | 1988 Dec 15 | It has been shown that the saw-like disturbances of sedimentation observed in an analytical ultracentrifuge are not caused by convective disturbances of the solution but result from a special type of intermolecular reaction of reversible association/dissociation. A qualitative theory of saw-like anomalies has been suggested and the sedimentation and kinetic conditions of their origin have been indicated. Such reactions are a frequent occurrence in the serum of patients affected with rheumatic diseases and acute myocardial infarction. Experimental data indicate the involvement of immunoglobulins (viz., low-affinity antibodies) which form reversible immune complexes. Saw-like sedimentation patterns, especially those of the schlieren type, are a direct testimony to reversible association/dissociation reactions in macromolecular solutions, whereas other experimental methods provide only oblique evidence. | |
| 2525274 | Inflammatory synovial T cells in different activity subgroups of patients with rheumatoid | 1989 | Mononuclear cells were eluted from synovial membranes of 39 patients with rheumatoid arthritis and 12 patients with juvenile rheumatoid arthritis. A considerable cell loss, about 50% or more, was seen during the various isolation steps. The CD4/CD8 ratio just after enzyme treatment (stage I) was significantly higher than at later stages, i.e. after removal of adherent cells (stage II, p less than 0.05) and after Isopaque Ficoll gradient centrifugation (stage III, p less than 0.01). This indicates a selective loss of CD4+ cells during isolation. In addition, stages I and II had higher CD4/CD8 ratios than peripheral blood of normal controls (p less than 0.01 and p less than 0.03), but not significantly higher than in peripheral blood of patients (p greater than 0.05). The CD4/CD8 ratio in eluted synovial membrane cells did not differ between patients with high and patients with low disease activity (p greater than 0.05). No correlation was found between any of the CD4/CD8 ratios and individual disease activity variables. Furthermore, a laboratory activity index and a disease outcome index were determined for each patient and no correlation was found between these indices and the CD4/CD8 ratios. | |
| 2530990 | Elevated plasma levels of alpha 2-plasmin inhibitor-plasmin complex in patients with rheum | 1989 Nov | Plasma levels of alpha 2-plasmin inhibitor (alpha 2PI) and alpha 2-plasmin inhibitor-plasmin complex (alpha 2 PIPC) were measured by sandwich enzyme-linked immunosorbent assay, using a recently developed monoclonal anti-alpha 2PI antibody, in patients with collagen diseases. Twenty patients had systemic lupus erythematosus (SLE), 4 of whom also had vasculitis, 11 patients had rheumatoid arthritis (RA), 4 of whom also had vasculitis, and 5 patients had other types of vasculitis. There was no significant difference in alpha 2PI levels between the 3 patient groups and the control groups. However, plasma levels of alpha 2PIPC in all 3 patient groups were significantly higher than those in the control group. Moreover, plasma concentrations of alpha 2PIPC in SLE patients with vasculitis were statistically significantly higher than those in SLE patients without vasculitis. These concentrations were also higher in RA patients with vasculitis than in RA patients without vasculitis, although the difference was not statistically significant. Our findings indicate that measurement of plasma alpha 2PIPC levels is useful for detecting and evaluating the severity and activity of vasculitis in patients with collagen diseases. |