Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2975542 | Analysis of the responding and stimulating cells in the AMLR of patients with rheumatoid a | 1988 Oct | Plastic adherent and non-adherent mononuclear cells derived from synovial fluid were found to stimulate peripheral blood mononuclear cells of patients with rheumatoid arthritis (RA) in an autologous mixed lymphocyte reaction (AMLR). Stimulation produced by adherent cells was consistently greater than that produced by non-adherent mononuclear cells. CD11 enriched cells were not significant stimulators in the AMLR, however their presence was required for a significant reaction to occur. Limiting dilution studies revealed that the most plausible model involved two or more cells of the same type in each of the stimulator and responder populations for the AMLR to occur. | |
| 2320370 | [Gold salts in the treatment of psoriatic arthritis]. | 1990 Jan 28 | 270 psoriatic arthritis patients were studied retrospectively. 65 patients of them were treated with aurothiomalate. The drug was effective in 62% of aurothiomalate treated patients, in 35% were registrated side effects. These data correspond to the experiences with gold salt treatment in rheumatoid arthritis. Exacerbation of skin manifestation, as a special side effect occurring in psoriatic arthritis patients treated with gold salts isn't a contraindication. | |
| 2451482 | A search for retrovirus infection in systemic lupus erythematosus and rheumatoid arthritis | 1988 Mar | Evidence for retroviral infection in general and human immunodeficiency virus (HIV) infection in particular was sought in freshly isolated peripheral blood T cells, B cells, and monocyte-macrophages from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and also in T cell and B cell lines established from the same source. Similar cells isolated from rheumatoid synovial membrane were also examined. The strategy used for the detection of virus was cocultivation with susceptible cell lines looking for syncytia formation, reverse transcriptase production, and nucleic acid hybridisation with HIV cDNA probes. No evidence for infection was obtained. | |
| 3081289 | Absence of interferons-alpha and -gamma in renal lesions of systemic lupus erythematosus a | 1986 Apr | Frozen kidney biopsy sections from nine patients with systemic lupus erythematosus (SLE) as well as many other renal diseases, including IgA nephropathy, membranous nephritis, and minimal change nephrotic syndrome, were negative for interferons -alpha and -gamma by immunofluorescence. Lupus patients studied included several subjects with marked serum elevations of interferon activity as well as others with low or negative serum interferon levels. Isolated glomerular eluates prepared from normal and SLE kidneys showed no functional interferon activity by virus plaque inhibition assay. Components of normal as well as SLE serum showed no direct binding to interferon -alpha or -gamma by ELISA assays. | |
| 3559605 | Bilateral hip and knee arthroplasty. | 1986 | Twenty-six severely deformed patients with prosthetic arthroplasty of both hips and both knees because of rheumatoid arthritis (16), juvenile rheumatoid arthritis (6), ankylosing spondylitis (2), osteoarthritis (1), and inflammatory arthritis, cause unknown (1), were followed for a mean of 6.8 years. Severe pain was the primary indication for surgery, and consistent and substantial pain relief was achieved. Most patients also had limited ambulatory and functional improvement. Computer analysis showed that this improvement was related only to preoperative walking and function and a combined hip and knee flexion of at least 190 degrees. All other parameters had no correlation with walking and function improvement. Of the 104 arthroplasties (52 hips and 52 knees), six implants (4 hips and 2 knees) in two patients failed and another seven implants (2 hips and 5 knees) in five patients were revised. Of the remaining 91 implants, 89 were clinically stable, and only two hip implants in two patients appeared destined for revision. However, when radiographic review was included, nine acetabular components, three THA femoral components, and five tibial components in 12 patients had some evidence of impending aseptic loosening, despite low patient activity levels. | |
| 1970208 | [Therapy study of chronic polyarthritis with sulfasalazine with special emphasis on the pr | 1990 Jan | 138 patients, suffering from rheumatoid arthritis, were treated with sulfasalazine for up to 43 months. In 58.7% of the patients a good or moderate effect was ascertained. Side-effects occurred in 40.5% of the treated patients, mostly in the first 4 months after starting treatment, but some of the more serious adverse reactions occurred some months later. Presumably, drug-induced antinuclear antibodies were found in 29%, using Hep II cells and crithidia-luciliae flagellates. A lupus-like syndrome was not seen. Close controls of laboratory parameters are necessary including determination of liver enzyme levels a renal test, and blood counts according to the investigations in gold treatment. Detection of abnormal immunological reactions should be carefully scrutinized. | |
| 3496724 | [Cryoglobulins in arthritis]. | 1987 Mar | During the years 1984-1986 we saw 22 patients with cryoglobulinemia, 8 of whom had rheumatoid arthritis, 1 psoriasis arthritis, 2 Sjögren syndrome, 1 progressive systemic sclerosis, 5 different arthralgias, 1 soft tissue rheumatism, 2 vasculitis and arthralgias and 2 purpura-arthralgia-nephritis syndrome. The measurement of cryoglobulins is done only in special cases of diagnostic importance. The prognostic outlook in patients with nephritis is bad. A monoclonal cryoglobulinemia is always suspicious for a lymphoproliferative syndrome. | |
| 2791347 | Determinants of genetic susceptibility in HLA-associated autoimmune disease. | 1989 Nov | The predominant genetic elements contributing to HLA-associated disease susceptibility have been localized within the HLA-D, or class II, region of the major histocompatibility complex for a large number of autoimmune diseases. Two likely candidate susceptibility genes in this region have been identified: the DQ beta 3.2 gene is the single allele most highly associated with type I diabetes (IDDM) and accounts for the HLA-DR4 association with that disease. DNA sequence analysis and mutagenesis studies implicate a small set of key residues within the DQ3.2 molecule as critical polymorphic residues likely contributing to disease-associated immune mechanisms. Different class II genes, Dw4 and Dw14, specific alleles at the DR beta locus, account for the HLA-DR4 association with rheumatoid arthritis (RA). A single cluster of polymorphic residues within the DR beta molecule may be sufficient to account for nearly all of the structural and genetic contributions of the HLA complex to the pathogenesis of RA. | |
| 1867155 | Fine-tuning theory to the needs of the world: responding to Heller et al. | 1991 Feb | Comments on the Heller et al. telephone intervention with isolated elderly women are presented. The importance of addressing contextual factors involved in assessments of social support in community samples is discussed. Comparisons are drawn between the assessment of social support among an elderly sample and an assessment of social support among a sample of chronic illness patients. Three key issues are discussed: (a) Is a little support better than no support and is a little all we really need? (b) Is family support more important than friend support, at least to this population? (c) Can long-term relationships be replaced? | |
| 3094108 | [Occupational factors in rheumatic diseases as a principle of rehabilitation--analysis of | 1986 Aug | The study evaluates unselected "blue-collar" patients (n = 642) included under the social insurance law guidelines of rehabilitation. Rehabilitation measures had become necessary in these patients because of existing or impending invalidity in diseases of rheumatic origin. In 421 patients (= 66%), a connection with the place of work appeared possible. This entailed adaptation or change of the place of work in 297 patients (= 71%), the result of these measures after a period of two to three years being described. General aspects of occupational rehabilitation measures are discussed. | |
| 3501469 | Synovial fluids from patients with rheumatoid arthritis possessed B cell differentiation a | 1987 Oct | B cell differentiation activity assayed on B cells preactivated by Staphylococcus aureus Cowan I was found in synovial fluids (SF) of patients with rheumatoid arthritis (RA) (n = 14), while little, if any, activity was found in SF of patients without RA (n = 13) including patients with osteoarthritis and traumatic arthritis. There was a positive correlation between the RA hemagglutination assay titer and B cell differentiation activity (r = 0.7438). This molecule with molecular weight ranges 15-20 kDa as well as supernatant from phytohemaglutinin stimulated normal T cells could promote not only polyvalent immunoglobulin synthesis but also rheumatoid factor synthesis by lymphocytes from patients with RA in vitro, and was considered to be distinct from interleukin-1, interleukin-2, interferon r, or proteolytic lysosomal enzymes which have been shown to modulate B cell activation. | |
| 2943396 | Rheumatic dermatoarthropathies. | 1986 Jul | Drs. Black and Fenske have presented a topic that fits in very well with the discussions provided by Dr. Graff concerning overall patient evaluation and the understanding that skin diseases may be external expressions of internal disease. As podiatrists, we are frequently exposed to patients who present with skin conditions secondary to rheumatic diseases or other forms of connective tissue disease. This review, with illustrations, will help us to improve our diagnostic abilities. | |
| 1818543 | A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid a | 1991 Dec | Fifty-two patients with severe rheumatoid arthritis (RA) from four Australian centres were randomised to receive cyclosporin A (CSA) (n = 25) or azathioprine (AZA) (n = 27) for six months. Initial mean doses of CSA and AZA were 4.2 mg/kg and 1.7 mg/kg respectively. The mean doses of CSA and AZA at six months were 3.4 mg/kg and 1.9 mg/kg. Assessments of side-effects and outcomes of benefit were made monthly by independent, blinded observers. Both treatment groups exhibited statistically significant improvement in standard outcome parameters when compared with baseline values. However, there were no statistically significant differences in these parameters between the two groups. There was a mean increase in serum creatinine concentration associated with CSA; no persons were withdrawn from the study for this reason. Seven CSA recipients (three gastrointestinal symptoms, two neurological symptoms, two other) and 12 AZA recipients (six gastrointestinal symptoms, four inefficacy, two other) withdrew from treatment prematurely. Seven CSA recipients became hypertensive and four required anti-hypertensive therapy. Adverse events not requiring cessation of therapy were more commonly seen among CSA patients. In this group of severely affected patients with RA both cyclosporin and azathioprine were effective therapies. CSA toxicities were predictable and manageable but required close monitoring. | |
| 3196364 | Histopathologic findings in the liver of rheumatoid arthritis patients treated with long-t | 1988 Dec | Twenty-three patients with severe rheumatoid arthritis were treated with oral methotrexate (MTX) for more than 10 years. MTX was given as a bolus of 5-15 mg/week; the total cumulative dose ranged from 4,690 mg to 10,230 mg. Liver biopsies were performed on 21 of the patients to assess possible fibrosis and cirrhosis. Grade I histopathologic changes were found in 13 of the 21 biopsy samples, grade II changes were found in 3, and grade IIIA changes (mild fibrosis) were found in 5 specimens. None of the biopsy samples showed cirrhosis. Repeat biopsies were performed on the 5 patients with grade IIIA changes while they were still taking MTX. No progression of the fibrosis was noted. Two of the 5 samples, however, were graded IIIB because of portal and perilobular inflammation. Our findings support the premise that prolonged administration of oral MTX, when given as a weekly bolus at a low dose, does not cause cirrhosis or severe fibrosis in the rheumatoid arthritis patient who does not abuse alcohol. | |
| 3038132 | Persistent synovial lymphocyte responses to cytomegalovirus antigen in some patients with | 1987 Jun | Synovial lymphocytes from 6 of 40 patients with rheumatoid arthritis responded to cytomegalovirus antigen stimulation. 3H-thymidine uptakes were more than 3 times greater than were those of the responses to 13 other microbial antigens. Similar results were obtained in 1 patient on 7 occasions over 17 months, and in the 5 other patients on each of 2 occasions. In 3 of the 6 patients, synovial lymphocyte responses to cytomegalovirus antigen were markedly different from simultaneous peripheral blood lymphocyte responses. | |
| 2600941 | Discriminant and convergent validity of self-report measures of affective distress in pati | 1989 Nov | The discriminant and convergent validity of several self-report measures of affective distress commonly administered to patients with rheumatoid arthritis (RA) were examined. Fifty-two patients with RA completed the Arthritis Helplessness Index, the Beck Depression Inventory, Spielberger's State Anxiety and Trait Anxiety Inventories, and the Arthritis Impact Measurement Depression and Anxiety Scales. Correlational and factor analyses revealed that the measures of anxiety and depression demonstrated adequate convergent validity but poor discriminant validity. Our results suggest that these measures index a general feeling of distress rather than discrete affective difficulties. The ability of these measures to assess separate problems of anxiety and depression among RA patients is questioned. | |
| 2437556 | [Treatment of rheumatoid arthritis. Comparative study of the effect of immunoglobulins G e | 1987 Apr 25 | A double-blind multicenter study comparing the effect of placenta eluted IgG and venoglobulins in the treatment of rheumatoid arthritis was conducted in 113 hospitalized patients. Rheumatoid arthritis was severe, classical (92 cases) or definite (21 cases), seropositive in 87 cases, with nodules in 32 cases; the mean duration of the disease was 10 years. The majority of patients had previously received numerous slow-acting drugs without result or with side-effects. A statistically significant decrease of all the quantitative indices but one (grip strength) was obtained with both products on the 8th day of treatment; the effect of placenta eluted IgG was statistically superior for the number of swollen joints (P less than 0.025), Ritchie's index (P less than 0.0005) and some extra-articular manifestations. There was no significant decrease in associated treatments and biological parameters (erythrocyte sedimentation rate, rheumatoid factor). Tolerance was excellent; some cases of benign venulitis were observed; treatment was never discontinued on account of side-effects. Further placebo-controlled of each of these immunoglobulins of placental origin are needed for firm conclusions to be drawn. | |
| 2290093 | Polyethylene bearing component failure and dislocation in the triaxial elbow. A report of | 1990 Dec | Two cases of polyethylene bearing failure in the Triaxial elbow are presented. Although these were low-demand patients with the prostheses properly aligned, the severity of the wear suggests inadequate prosthesis design. | |
| 2382891 | Inspiratory muscle strength and respiratory drive in patients with rheumatoid arthritis. | 1990 Aug | In 15 patients with rheumatoid arthritis (RA) and in 12 age- and sex-matched normal subjects, we evaluated inspiratory muscle strength and respiratory control system. Inspiratory muscle strength was assessed by measuring maximal inspiratory pressure (MIP). Respiratory drive was assessed by evaluating surface electromyographic activity of the diaphragm (EMGd) during both room-air breathing and hypercapnic rebreathing. Compared to the predicted value (mean +/- 1.65 SD), MIP was significantly reduced in nine patients (60%). All told, we noticed a significant inverse relationship in the patients between MIP and duration of steroid therapy (p less than 0.01). During room-air breathing, both EMGd and mouth occlusion pressure (P0.1), expressed both in actual values and as percentage of MIP, were significantly greater in patients than in the normal control group (p less than 0.001 for both). Both EMGd and P0.1 (%MIP) response slopes to CO2 were significantly greater in patients than in the normal control group (p less than 0.01 and p less than 0.001, respectively) and significantly related to the functional stage of disease. During quiet breathing and for a PETCO2 of 60 mm Hg, both EMGd (p less than 0.01 and p less than 0.05, respectively) and P0.1 (%MIP) (p less than 0.01 and p = 0.001, respectively) were inversely related to MIP. These results indicate that RA patients may exhibit inspiratory muscle weakness and increased respiratory drive. Steroid myopathy and rheumatoid myositis could explain the reduction in MIP, whereas neural afferents arising from respiratory muscle, lung, or joint receptors could be involved in the observed increase in neural drive. | |
| 1716134 | [Osteoid osteoma of the trapezoid bone]. | 1991 | The present report describes a case of osteoid osteoma of the trapezoid. It'is an unusual localisation. Synovitis was the first clinical symptom. Tomograms allowed diagnosis and guided the treatment. Radical excision prevented recurrence. |