Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2819351 | Non-contraceptive hormones and rheumatoid arthritis: possibilities of using a Swedish popu | 1989 | We report the possibility of, and the methodological problems associated with, using a large population-based cohort of 23,000 Swedish women, ascertained from a drug prescription database to have received non-contraceptive oestrogens; to further investigate the relationship between such therapy and the postulated protection against development of rheumatoid arthritis (RA). Although this study was primarily designed to look at cancer risk, it should be possible to study the relationship with RA. | |
| 3050082 | IgG subclass distribution of antinative type II collagen and antidenatured type II collage | 1988 | In 81 patients with rheumatoid arthritis (RA) with antibodies to native type II collagen, the frequencies of each IgG subclass to native type II collagen were IgG1 (70%), IgG2 (12%), IgG3 (84%) and IgG4 (6%) and to denatured type II collagen were IgG1 (86%), IgG2 (23%), IgG3 (86%) and IgG4 (6%). Thus serum antibodies to type II collagen in patients with RA were predominantly of the complement fixing subclasses IgG1 and IgG3. | |
| 3670132 | Autoantibodies--a mechanism of microdebridement. | 1987 Sep | Antibodies to foreign debris are generally beneficial because they speed inflammation and debridement of tissue. Intracellular components are debris if they reach extracellular space. If not rapidly debrided from extracellular space, intracellular components stimulate autoantibody production. If not debrided, cellular constituents like other foreign material can initiate a chronic tissue response. Antibodies will speed removal of debris if an effective microdebridement mechanism is present. This is their general biologic significance. If the patient has a defective microdebridement system as in lupus erythematosus or rheumatoid arthritis, the autoantibodies occur to large numbers of intracellular substances and accumulate and contribute to tissue damage. Tissue damage occurs and autoantibodies accumulate in lupus erythematosus and rheumatoid arthritis because of inadequate microdebridement. This should not detract from the fact that autoantibodies are a common secondary phenomenon which plays an important part in maintaining tissue microdebridement. | |
| 3321213 | Clues provided by animal models of arthritis. | 1987 Aug | All the findings discussed support the premise that animal experimentation is a pertinent endeavor for understanding chronic inflammatory synovitis in humans. Whether any of these data actually identify processes operative in RA or can be used to predict outcomes in the human disease is currently unclear. The review closes with an illustration of an area of controversy existing, in part, because of an absence of animal model research. The rationale for the use of gamma-interferon (IFN) in RA has been aptly described by S. H. Pincus as "curious". Evidence of deficient gamma-IFN production within the rheumatoid synovium has been acquired by several laboratories, suggesting that administration of this lymphokine might be helpful. This conclusion has been supported by news of short-term success in uncontrolled pilot trials. However, gamma-IFN is perhaps the most vigorous of the interleukins in terms of diversely activating the immune system. Thus, it would seem logical to envision that gamma-IFN would accelerate any process attributable to autoimmunity. The use of animal models to probe this dilemma, and others arising in the future, could provide a more convincing scientific cornerstone for clinical trials in RA. One caveat, however--animal models provide only clues or potential insights, not final answers, for human disease. | |
| 2787942 | [Functiono-morphologic characteristics of tissue basophils of the human skin based on elec | 1989 Apr | A study is presented of the ultrastructure of tissue basophils evaluated by electron microscopy in patients with rheumatism and rheumatoid arthritis. Four types of cells were distinguished according to their functional activity and morphological manifestations. Qualitative analysis of the population of tissue basophils allows to establish a relationship with such characteristics of the clinical picture as activity of the inflammatory process primarily and to analyze in detail the role and significance of these cell forms in the process of formation of inflammatory changes in the connective tissue. | |
| 3538345 | Enzyme immunoassay of complement-binding rheumatoid factors. | 1986 | We describe an enzyme immunoassay for the determination of complement-binding rheumatoid factors. Polystyrene tubes are coated with heat aggregated human IgG. The rheumatoid factors (RFs) of patients heat inactivated sera are allowed to bind to aggregated IgG and thereafter saturated with fresh human complement. The amount of C3 complement bound is measured by indirect enzyme immunoassay. The levels of complement binding RFs were measured in 30 patients with seropositive rheumatoid arthritis (RA), in 19 patients with systemic lupus erythematosus (SLE), and in 30 healthy control subjects. Compared to the controls high levels of complement-binding RFs were found both in RA and in SLE (P less than 0.0005). The mean level of the complement binding RFs was higher (P less than 0.05) in active than in inactive SLE. Even though the 19 S IgM RF bound complement, in RA no correlation was found between the level of complement binding RFs and Waaler-Rose titre, but the level of complement binding RF correlated with the levels of nonagglutinating IgM RF (r = 0.56, P less than 0.01) and IgG RF (r = 0.70, P less than 0.001) that were obtained by enzyme immunoassay. | |
| 2974833 | An immunohistological study of CD4+ lymphocyte subsets within inflammatory lesions with sp | 1988 Nov | The monoclonal antibodies (mAbs) WR16, UCHL1 and WR19 identify subsets of CD4+ lymphocytes that have been functionally characterized as suppressor inducer cells or helper inducer cells. These were applied as components of a panel of lymphocyte-specific mAbs for the phenotypic analysis of lymphocyte populations within biopsies taken from rheumatoid synovial membrane and normal and inflamed gut. The phenotype of peripheral blood lymphocytes from patients with rheumatoid arthritis were also compared to normal controls. The rheumatoid synovium was characterized immunohistologically by a lymphocytic infiltrate composed predominantly of CD4+ lymphocytes and a CD4:CD8 ratio of 2.4. The CD4+ population was composed of UCHL1+ cells to the exclusion of WR16+ cells. This finding was confirmed by double immunofluorescence staining using directly conjugated Leu-3a and WR16. The UCHL1+/WR16-/CD4+ phenotype was maintained in the synovial biopsies regardless of whether the patient had commenced treatment with disease modifying drugs. The absence of WR16+ cells within the rheumatoid synovium was shown to be a localized phenomenon as there was a slight elevation of circulating WR16+ lymphocytes in the peripheral blood of rheumatoids whilst the levels of UCHL1+ and WR19+ lymphocytes remained unchanged. As no appropriate normal control tissue is available for comparison to the rheumatoid synovium we also examined the lymphocytes present within Crohn's disease-involved bowel biopsies and compared them to normal gut tissue lymphocytes using WR16 and UCHL1 mAbs. The CD3+ lymphocytes present within normal tissue comprised a mixture of WR16+ and UCHL1+ cells. In contrast the CD3+ lymphocytes within Crohn's involved tissue were exclusively UCHL1+ as previously observed in the rheumatoid synovium. These data indicate that the CD4+ lymphocyte infiltrate present within inflammatory lesions of presumed distinct aetiology exhibit a localized selective loss of cells with the CD45R+/CD4+ suppressor inducer phenotype. This may be a consequence of the selective extravasation of CD4+ helper induced cells or more likely, in view of the previously documented loss of the p220 molecule identified by CD45R mAbs upon T-cell activation, the result of CD4+ T-cell activation at sites of inflammation. | |
| 3750012 | Myasthenia gravis caused by penicillamine and chloroquine therapy for rheumatoid arthritis | 1986 Sep | We have described a unique patient who had reversible and dose-related myasthenia gravis after penicillamine and chloroquine therapy for rheumatoid arthritis. Although acetylcholine receptor antibodies were not detectable, the time course was consistent with an autoimmune process. | |
| 2766649 | Are certain HLA haplotypes responsible for low testosterone levels in males? | 1989 Jul | The level of testosterone on 138 HLA typed healthy males and 71 male rheumatoid arthritis patients were analysed. HLA-B15 was associated with a lower mean serum testosterone level in males than any other tissue type. This was observed in both the normal and RA groups. | |
| 1669957 | [Pulmonary toxicity of gold salts]. | 1991 | Pulmonary toxicity associated with gold salt treatment of rheumatoid arthritis is unusual. Only 60 cases had been reported before 1986. This disorder consists primarily of pulmonary interstitial involvement, characterized by hypersensitivity pneumonitis which can lead to variable degrees of pulmonary fibrosis. However, this disease has a good prognosis if treated properly with the simple interruption of gold salts or with corticosteroids, with complete cure in the majority of cases. A case with good response to corticosteroid therapy is reported and the differential diagnosis with pulmonary fibrosis associated with rheumatoid arthritis is analyzed. | |
| 3620270 | The effect of isoxicam on neutrophil and monocyte function. | 1986 | 1 Isoxicam was found to inhibit monocyte and neutrophil cell chemotaxis at therapeutic concentrations. 2 The effect was observed after in vitro incubation of normal cells and in vivo in patients with rheumatoid arthritis. 3 Compared to other NSAIDs studied in our laboratory, isoxicam was shown to have a broader spectrum of inhibitory action on the cells involved in the chronic inflammation associated with rheumatoid arthritis. | |
| 3630416 | Anatomical interposition arthroplasty with dermal graft. A study of 51 elbow arthroplastie | 1987 May | Seventy anatomical interposition arthroplasties of the elbow joint without ulnar nerve transposition were performed on 67 rheumatoid patients by one surgeon during the years 1978-1984. Between 1 and 6 years after arthroplasty, 51 arthroplasties were re-examined, the average follow-up being 3 years. There were 48 patients, 44 female (aged 25 to 66 years, mean 51) and four male, (aged 59 to 69 years, mean 63). The duration of the rheumatoid disease (46 cases of rheumatoid arthritis, 2 of juvenile chronic arthritis) was 4 to 33 years, mean 17 years. The disease was clinically active in 47 cases. ESR ranged from 12 to 82, mean 50. 51 elbow joints, 32 right (31 dominant), 19 left (2 dominant), had been affected for six months to 29 years, mean 8 years. 21 joints had been operated on one to four times before arthroplasty. Preoperative radiological joint destruction was of Larsen grade IV in 45 cases and of grade V in six cases. Flexion contracture was diminished from preoperative 0 degrees to 70 degrees, mean 38 degrees, to postoperative 0 degrees to 70 degrees, mean 25 degrees. Range of flexion was improved from preoperative 20 degrees to 150 degrees, mean 90 degrees, to postoperative 40 degrees to 145 degrees, mean 109 degrees. Before arthroplasty there were ulnar nerve symptoms in 13 cases, two of which had temporary ulnar symptoms postoperatively, too. After arthroplasty, eight patients had ulnar nerve symptoms, five of which had had previous operations of the joint. | |
| 3820200 | Arthroscopic synovectomy: a prospective study. | 1986 Oct | Seven patients undergoing arthroscopic synovectomy for painful knee joint synovitis with marked synovial swelling were assessed preoperatively and up to 24 months postoperatively. Six patients had rheumatoid arthritis and one psoriatic arthritis. Patients were assessed for overall disease activity and indices of synovitis and function of the knees. There was minimal or no loss of function in the operated knee at one month. Subsequent improvement was reflected in reduction of pain on walking, pain on using steps, and swelling of the knee, with improvement occurring up to 6 months and maintained at 24 months. No sustained loss of movement was observed in the operated knee and all patients had improvement in knee flexion at 24 months. Patients universally regarded the procedure as worthwhile. These results highlight the lesser morbidity of arthroscopic synovectomy compared to that known to be associated with open synovectomy. Further study is required to evaluate the longterm value of this procedure. | |
| 3594964 | Epidermal IgG deposits in patients with chronic inflammatory connective tissue diseases: d | 1987 Jan | Thirty-seven patients with primary Sjögren's syndrome (Primary SS), 12 patients with incipient primary SS, 100 patients with other chronic inflammatory connective tissue diseases (CTD) and 20 healthy controls had a punch biopsy taken from clinically unaffected skin from the buttock. Direct immunofluorescence examinations revealed intraepidermal IgG deposits in 68% of patients with primary SS, in 42% of patients with incipient primary SS, in 13% of patients with rheumatoid arthritis (RA, n = 31), in 15% of patients with systemic lupus erythematosus (SLE, n = 13), in 24% of patients with other well-defined CTD (n = 41), in 40% of patients with ill-defined CTD (n = 15) and in 10% of healthy controls. Immunoglobulin deposits along the dermoepidermal junction zone (DEJ) were not found in any of the patients with primary SS, but were present in 16% of the patients with RA and in 23% of the patients with SLE. In the patients with primary SS, no correlation was found between intraepidermal IgG deposits and age, disease duration, extraglandular manifestations, P-IgG concentration, ANA, rheumatoid factors or circulating immune complexes. Examination for intraepidermal IgG deposits seems valuable in the differential diagnosis between primary SS and RA or SLE, and it could supplement the lupus band test. | |
| 3499722 | Adult septic arthritis with Hemophilus influenzae. | 1987 Jul | Two cases of Hemophilus influenzae septic arthritis are reported, one in a rheumatoid patient and the other in a healthy young woman after meningitis. The evolution of this rare infectious arthritis was not as good as usual in spite of early therapy. The first patient later presented a Staphylococcus albus bacteriemia and the other a post-infectious persisting arthritis. | |
| 2275166 | [The levels of circulating immune complexes and immunoglobulins in patients with systemic | 1990 Apr | The authors studied the levels of large- and medium molecular circulating immune complexes (CIC) and immunoglobulins of main classes (Ig) in 17 patients with systemic lupus erythematosus (SLE) and 47 patients with rheumatoid arthritis (RA). RESULTS: low molecular CIC increased in 35.2% of patients with SLE and in 42.5% with RA; patients with SLE showed a significant reduction of IgA in 80.4%. The IgA/IgM ratio was significantly reduced in SLE due to the above finding. The IgA level remained unchanged in RA. | |
| 2700237 | [An evaluation of the efficacy of treating rheumatoid arthritis with preparations for loca | 1989 Oct | Assessment was made of the efficacy of local therapy of rheumatoid arthritis patients with dimexide during a double blind method of investigation. The articular index, duration of constraint in the morning and the strength of the hand were taken as the leading criteria for objective assessment of the drug efficacy. Applications of a 50% solution of dimethylsulforoxide give a statistically significant favourable effect as compared to the conventional physiotherapeutic methods of treatment: ultrasound and phonophoresis with analgin. Addition of analgin to a 50% solution of dimethylsulforoxide intensifies its antiphlogistic and analgesic properties. | |
| 3355256 | Alterations in carbohydrate composition of serum IgG from patients with rheumatoid arthrit | 1988 Feb | The carbohydrate composition of IgG purified from serum of patients with rheumatoid arthritis (RA), pregnant women, and blood donors has been determined by gas-liquid chromatography. Comparison of the results indicates that IgG from patients with RA contains significantly less galactose but more N-acetylglucosamine than normal IgG, whereas the fucose and sialic acid contents are not changed. The carbohydrate content of IgG in RA is reduced. IgG in pregnancy contains more galactose and more sialic acid than normal IgG, whereas fucose, N-acetylglucosamine, and the total carbohydrate content are not changed. These data suggest a temporal compensation of the RA associated undergalactosylation of IgG in female patients with RA during pregnancy, a period during which remission of the disease is often observed. | |
| 2830060 | Collagenase-like (CL) peptidase activity in synovial fluid from patients with rheumatoid a | 1987 Dec | We found the presence of collagenase-like (CL) peptidase in synovial fluid by a highly sensitive fluorescence assay using (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methyl-coumaryl-7-amide (Suc-GPLGP-MCA) as a substrate. Suc-GPLGP-MCA is hydrolyzed at the Leu-Gly bond by CL-peptidase. The CL-peptidase activity in synovial fluid was significantly higher in patients with rheumatoid arthritis (RA) than in patients with osteoarthritis (OA) and in arthropathy-free controls. No significant difference in CL-peptidase activity in synovial fluid was found between patients with OA and arthropathy-free controls. | |
| 2803204 | [Arthrodesis as an alternative in infected knee arthroplasty]. | 1989 Aug | There is reported on ten arthrodeses after infected knee arthroplasty, nine of these were completely built through after 4.4 months on the average. The fixation and stabilization of the arthrodeses were carried out by means of fixateur externe. |