Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1745087 | [Rheumatoid arthritis and multiple neoplasms]. | 1991 Sep 28 | In patients with rheumatoid arthritis the appearance of neoplastic disease has been fundamentally described of lymphoproliferative origin. The case of a 59 year old woman with rheumatoid arthritis of a 4 year evolution is reported. The patient was treated with gold salts and methotrexate and presented successively a bronchogenic carcinoma and a non-Hodgkin lymphoma. The epidemiologic studies in the relation of rheumatoid arthritis-neoplasia are discussed and the pathogenic hypotheses to the immune alterations as well as the treatments employed are described. | |
| 3238353 | Rheumatoid factor isotypes in patients with rheumatoid arthritis and in subjects with "fal | 1988 | The appearance of RFs, as detected by standard serological techniques, often precedes the onset of clinical RA by years. This pre-rheumatoid immunological reactivity is not associated with C-reactive protein response or occurrence of antibodies against native type II collagen. The profile of RF isotypes appeared to be similar between pre-rheumatoid and rheumatoid sera. RA sera contained somewhat more frequently IgG and IgA class RFs than "false-positive" sera from a community-based population sample. 7S IgM could be detected at about the same frequency in rheumatoid sera, in RF-positive pre-rheumatoid sera and in sera with "false-positive" RF reactions. The significance of the findings in terms of the pathogenesis of RA will be discussed. | |
| 2612082 | Elevated level of IgA gliadin antibodies in patients with rheumatoid arthritis. | 1989 Nov | The possibility that dietary antigens contribute to the pathogenesis of rheumatoid arthritis (RA) has been proposed. Moreover, occasional patients have been described in whom coeliac disease and RA coincide. Furthermore, most RA patients are treated with non-steroidal anti-inflammatory drugs (NSAIDs), which are known to increase gut permeability. For these reasons antibodies against gliadin were measured in a group of 43 patients with rheumatoid arthritis (RA) and a group of 43 age- and sex-matched controls. The median IgA antigliadin ELISA index was 7.1 (range 2.1-22.4) for the RA group and 3.1 (range 0.3-34.9) for the controls (p = 0.0001). The median IgG and IgM antigliadin indexes for the RA group didn't differ significantly from those of the controls. In the RA group, the level of antigliadin antibodies did not correlate with the daily dose of NSAIDs. The elevated IgA antigliadin titre in the RA group might be ascribed to the use of NSAIDs, which are harmful to the gut, but the immunological trigger effect of gluten cannot be ruled out. | |
| 1669738 | Cellular and humoral reactivity pattern to the mycobacterial heat shock protein hsp65 in p | 1991 | We have analysed the cellular and humoral immunity to the mycobacterial 65 kD heat shock protein (hsp65) in groups of DBA/1 mice with arthritis induced by intraperitoneal injection of the mineral oil pristane. Here we confirm that DBA/1 mice are highly susceptible to pristane induced arthritis (PIA) and demonstrate that the incidence of arthritis can be modulated by either pretreatment with low dose irradiation or by preimmunisation with recombinant hsp65. Global cellular responses to antigens such as BSA or type II collagen were not enhanced or impaired within groups of arthritic (A) or non-arthritic (NA) mice. However, the cellular response to hsp65 in arthritic animals preimmunised with the 65 kD antigen was significantly elevated in comparison to hsp65 preimmunised mice that were resistant to the induction of disease. On the contrary, the level of hsp65 specific antibodies was much high in NA animals than in PIA mice. CBA/Igb mice are partially susceptible to the induction of PIA. We have previously reported that arthritic CBA/Igb mice have both elevated cellular and humoral reactivity to hsp65. Although a central pivotal role for hsp65 has been postulated in autoimmune diseases these results indicate that there is no simple relationship between the pathogenesis of PIA and immune responses to hsp65. | |
| 3423749 | Work capacity of patients with inflammatory joint diseases. An eight-year follow-up study. | 1987 | In a prospective study of recent arthritis, 103 patients had rheumatoid arthritis (RA), 63 seronegative oligoarthritis (SO), 67 reactive arthritis (REA), 20 ankylosing spondylitis (AS), and 13 psoriatic arthritis (PA). At the 8-year check-up, 36% of patients with RA were at work, compared with 69% in PA (p less than 0.002), and 85-90% in AS, SO, and REA (p less than 0.001). Correspondingly 43% of the RA patients were disabled by arthritis, compared with 23% in PA (NS), 15% in AS (p less than 0.005), none in SO, and 4% in REA (p less than 0.001). No significant differences in work capacity were noted between patients with PA, AS, SO or REA. In RA, the educational backgrounds of patients unable to work (44 patients) and able to work (37 patients) did not differ from each other or from the overall population of Finland, but a significantly (p less than 0.01) smaller number of patients with arduous work were able to continue at work. The mean age of 49 years for RA patients unable to work differed highly significantly (p less than 0.001) from the 35 years of RA patients at work. However, the weightiest cause of limited work capacity was severity of disease. | |
| 1973765 | [Special indications for Helal's serial metatarsal osteotomy]. | 1990 | Authors discuss, presenting case reports, the operative indications of Helal's metatarsal serial osteotomy. In their first case this kind of operation was performed because of metatarsalgia, following traumatic amputation of the hallux. In their second case, in a young female with rheumatoid arthritis, considering the age of the patient and the destruction in the metatarsophalangeal joints too, Helal's metatarsus osteotomies were completed with the resection of the basis of the ground phalanx. In both cases good correction was reached and without any complaints. | |
| 2689071 | Pulmonary manifestations of the collagen vascular diseases. | 1989 Dec | The collagen vascular diseases are a heterogeneous group of immunologically mediated inflammatory disorders. The organs and tissues that compose the respiratory system are frequently affected by these diseases. Potential targets of the inflammation and injury include the lung parenchyma, tracheobronchial tree, pulmonary vasculature, pleura, larynx, and respiratory muscles. In this article, the spectrum of respiratory disease caused by systemic lupus erythematosus, rheumatoid arthritis, scleroderma, polymyositis/dermatomyositis, mixed connective tissue disease, ankylosing spondylitis, relapsing polychondritis, and Sjögren's syndrome is reviewed. Where appropriate, therapeutic options are discussed. | |
| 2192058 | Longterm experience with low dose weekly methotrexate in rheumatoid arthritis. | 1990 May | Longterm prospective studies (several of greater than 5 years' duration) report sustained efficacy with low dose weekly methotrexate. A "steroid-sparing" effect has been noted with methotrexate in 2 of the studies. Of 230 patients enrolled in prospective studies, only 8% stopped therapy due to toxicity and 3% due to lack of efficacy. Life table analysis projected that 63% of these patients would receive therapy for 6 years. Even though adverse experiences were frequent, serious reactions have been rare in the published studies. | |
| 3184079 | Penicillamine induced mammary hyperplasia: report of a case and review of the literature. | 1988 Aug | A 41-year-old woman with rheumatoid arthritis developed massive breast enlargement while taking penicillamine. Her endocrine evaluation was unremarkable, and the breast enlargement resolved with danazol therapy. Penicillamine may increase breast tissue sensitivity to steroid hormones in some patients, resulting in breast growth. This rare complication resolves spontaneously in men, but in women reversal of breast enlargement requires androgen therapy. | |
| 3492755 | Immunoregulatory lymphokines in rheumatoid joints. I. Search for interleukin 2 in synovial | 1987 Jan | Since there have been conflicting findings about the presence of interleukin 2 (IL-2) in synovial fluid (SF) of patients with rheumatoid arthritis (RA), we decided to study this subject ourselves. In a sensitive assay utilizing CTLL-2 as indicator cells, no IL-2-like activity was found in SF from any of the 15 RA patients studied. Treatment of SF with hyaluronidase, dialysation, heating to 56 degrees C for 1 h, preincubation of CTLL-2 with SF prior to washing and incubation all resulted in no detection of any IL-2. SF itself did not inhibit the CTLL-2 assay. Failure to detect IL-2 may to some extent be explained by in vivo absorption of any IL-2 by IL-2 receptor-positive T cells in SF. The failure is discussed along with new evidence from various reports suggesting that impaired IL-2 production by activated T cells may be a feature of several autoimmune diseases. | |
| 3473706 | Subjective symptoms from the stomatognathic system in individuals with rheumatoid arthriti | 1987 | A group of 123 individuals with rheumatoid arthritis (RA-group) and 28 individuals with osteoarthrosis (OA-group) with previous or current symptoms from the stomatognathic system were compared with 52 individuals without general joint symptoms (C-group). The individuals in the RA- and OA-group attended the Rheumatism Hospital in Strängnäs, Sweden. They constituted 35 and 14%, respectively, of all individuals with RA and OA at the Hospital during the period of investigation. The individuals in the C-group attended the Public Dental Clinic in Strängnäs for regular dental care. All individuals were given a questionnaire concerning subjective symptoms from the stomatognathic system, general joint symptoms, dental condition and need of dental care. It was found that the individuals in the RA and OA-group generally had more frequent and more severe subjective symptoms of longer duration from the stomatognathic system than the individuals in the C-group. The subjective symptoms, especially in the RA-group, were correlated to the extension of the general joint symptoms. Reports of swelling of the TMJ and a sudden debut of symptoms were more frequent in the RA-group than in the OA- and C-group. Loss of contact between anterior teeth was reported in both diseases and was correlated to extension and duration of RA and extension of OA. The TMJ symptoms started frequently in the early phase of RA and chewing ability deteriorated with extension and duration. | |
| 1724013 | Phenotypic abnormalities in CD8+ T lymphocyte subsets in patients with rheumatoid arthriti | 1991 Nov | We analyzed the cell surface phenotype of CD8+ cells in both peripheral blood and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Utilizing the monoclonal antibodies anti-CD45RA, anti-CD29 and anti-S6F1-, one can define both suppressor effector (CD45RA+CD29-S6F1-) and killer effector (CD45RA-CD29+S6F1+) cells within the CD8 population. In patients with OA, normal proportions of CD8+CD45RA+, CD8+CD29+ and CD8+S6F1+ cells were found in both peripheral blood and SF. The peripheral blood of patients with RA, in contrast, showed a decreased percentage of CD8+CD45RA+ cells (13.4 +/- 2.6) (p less than 0.05), but a normal percentage of CD8+CD29+ and CD8+S6F1+ cells. In the SF of patients with RA, we observed a more dramatic decrease in CD8+CD45RA+ suppressor effector cells (6.4 +/- 5.0) (p less than 0.001), a significant increase in killer effector cells as measured by both CD8 + CD29+ (35.5 +/- 9.9) (p less than 0.001) and CD8 + S6F1+ cells (28.2 +/- 11.4) (p less than 0.01). These changes may contribute to the immunologic abnormalities previously noted in this disease and may provide some insight into the pathophysiologic mechanisms of RA. | |
| 2053911 | Treatment of rheumatoid arthritis by extracorporeal photochemotherapy. A pilot study. | 1991 Jun | In a 6-month pilot study of 7 patients with rheumatoid arthritis, we tested a treatment involving the extracorporeal photoactivation of biologically inert methoxsalen (8-methoxypsoralen) by ultraviolet A energy to a form that covalently cross-links lymphocyte DNA; the injured cells are reinfused into the patient. Prior experimental studies had indicated that this regimen produces an immune reaction against antigens on treated T cells, and a clinical trial in patients with cutaneous T cell lymphoma had been successful. The current study patients were treated monthly, on 2 successive days (or biweekly, later on). Between 12 and 16 weeks of therapy, there appeared to be a breakpoint, after which the joint counts and joint scores of 4 of the patients began to improve. In 3 of the 4 patients, these measures eventually diminished by a mean of 71% and 80% of baseline values, respectively, and there was variable improvement in less direct indicators of clinical response. The joint counts and scores of the fourth patient improved modestly (by 33% and 59% of baselines, respectively) but he required alternative therapy, and those of the remaining 3 study patients did not improve. Mean slopes for the joint counts were significantly different from zero after the apparent breakpoint (but not before), whether one examined the 4 apparent responders (P = 0.01) or the entire group of 7 patients (P = 0.01). After completion of therapy, there was also a delay, of 2-3 months, in the clinical deterioration of those patients who had improved. There was only 1 mechanical adverse effect--a single episode of transient hypotension in 102 treatment sessions--and no toxic effects.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2298028 | Practical use of immunosuppressive drugs in autoimmune rheumatic diseases. | 1990 Feb | Immunosuppressive drugs are frequently used in the treatment of autoimmune rheumatic diseases when more conventional therapy, including corticosteroids, fail to control the manifestations of disease. The practical use of these drugs in rheumatoid arthritis, systemic lupus erythematosus, and vasculitis (including Wegener's granulomatosis and Sjögren's syndrome) are reviewed. The focus is on the indications for the administration of these agents and proper monitoring of their effect on disease activity. | |
| 3174137 | [Arthroplasty of the elbow]. | 1988 Aug | Elbow arthroplasty is still one of the less frequently performed joint replacement procedures. It is technically demanding, and numerous complications are possible. It is therefore indicated mainly in severely handicapped patients in whom all other alternatives have been attempted. A review of the literature relating to arthroplasties monitored over follow-up periods of more than 5 years shows that the results are now quite acceptable. They are far better than those seen following most resection arthroplasties. The results achieved with our GSB III prosthesis are compared with those obtained with other prosthetic devices in current use. It appears that in a large proportion of cases our prosthesis allows a good range of painfree motion, which we attribute in part to the operative approach used. The complication rate appears to be relatively low. | |
| 3281604 | Salicylate ototoxicity in patients with rheumatoid arthritis: a controlled study. | 1988 Feb | Tinnitus or subjective hearing loss, or both, were reported by 61 of 134 (45%) patients with rheumatoid arthritis (RA) taking regular salicylates and by 73 of 182 (40%) untreated healthy subjects. In the patients with RA mean salicylate levels were not higher in those with tinnitus than in those without tinnitus, but levels were significantly higher in those with subjective hearing loss than in those with no symptoms. Twenty five per cent of the patients with RA had tinnitus or subjective hearing loss with salicylate levels less than 1.42 mmol/l. Audiometric responses in 31 patients correlated poorly with symptoms. Tinnitus and subjective hearing loss may be too non-specific to be reliable as tools for adjusting the salicylate level into the therapeutic range. | |
| 1710727 | [A study of the initial suppressor function of lymphocytes]. | 1991 | The new method for analysis of initial suppressor lymphocyte function in newly isolated monocultures is based on quantitative cytofluorometric analysis of early mitogen-induced activation of B lymphocytes in the presence of prednisolone that switches off a T lymphocyte immunoregulatory effect. Suppressor lymphocytes monitor B lymphocyte exit into proliferative pool and early processes of nuclear chromatin activation. The levels of initial suppressor lymphocyte function and lymphocytic proliferative activity are in inverse correlation. Suppressor lymphocyte function has been essentially reduced in rheumatoid arthritis patients as against normal subjects. A reduction as low as 70 percent of the normal value (recorded in 1/3 of the patients) is compensated with unchanged regulatory control over B cells, and reduction as low as 40 percent of the normal value (in 2/3 of the patients) is characterized by loss of regulatory control and B cell hyperactivation. | |
| 3369244 | [Morphology of synovial cells of the human in organ and explant cultures]. | 1988 Jan | Biopsy material of synovial tissue was taken from 36 patients (with arthrosis, rheumatoid arthritis, traumatic and unaffected joints). Cell and tissue cultures, as well as cells dissociated by enzymes, were investigated by light microscopy (LM), immunohistochemistry, and electron microscopy. Synovial A-cells were endowed with all morphological characteristics of phagocytic capacity but lacking the peroxidase reaction. In contrast to the monocytes, they were not immunostained by OKM-1 antibodies. The A-cells could be observed in subsequent in vitro growth for up to 2 weeks. In addition to B-cells, a third cell type was identified. This cell type had the morphological characteristics of a dendritic cell and was glass and plastic adherent. It can be referred to also as a stellate cell. We assume that these stellate cells represent modified synovial fibroblasts. | |
| 1647426 | Analysis of antibody titers to Epstein-Barr virus nuclear antigens in sera of patients wit | 1991 Jul | To examine if Epstein-Barr virus (EBV) infection is associated with the two autoimmune diseases, Sjögren's syndrome and rheumatoid arthritis, IgG antibody titers of sera from patients with the disorders were evaluated for five constituents of EBV nuclear antigens (EBNA-1, -2, -3, -4, and -6). To circumvent interference by autoantibodies in the sera, fusion proteins synthesized in Escherichia coli were used as specific antigens. By ELISA the average IgG antibody titers to domains of the five EBNAs, especially the amino-terminal domain of EBNA-2, in sera of patients with Sjögren's syndrome were slightly higher than those in normal sera. The tendency of sera from Sjögren's syndrome patients to have higher reactivities to the EBNA domains was also observed by immunoblotting. By comparison, few heightened serologic responses to EBNAs were observed in sera from patients with rheumatoid arthritis. Further analyses are required to determine if EBV is associated with Sjögren's syndrome in any way. | |
| 2463633 | Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patie | 1989 Jan | Rheumatoid arthritis is an autoimmune disease characterized by T-cell infiltration of the synovium of joints. Analysis of the phenotype and antigen specificity of the infiltrating cells may thus provide insight into the pathogenesis of rheumatoid arthritis. T cells were cloned with interleukin 2, a procedure that selects for in vivo-activated cells. All clones had the CD4 CDW29 phenotype. Their antigen specificity was tested by using a panel of candidate joint autoantigens. Four of 17 reacted against autologous blood mononuclear cells. Two clones proliferated in response to collagen type II. After 21 months, another set of clones was derived from synovial tissue of the same joint. One of eight clones tested showed a strong proliferative response against collagen type II. The uncloned synovial T cells of a third operation from another joint also responded to collagen type II. The persistence of collagen type II-specific T cells in active rheumatoid joints over a period of 3 years suggests that collagen type II could be one of the autoantigens involved in perpetuating the inflammatory process in rheumatoid arthritis. |