Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3314205 | [Clinical diagnostic strategy in rheumatology]. | 1987 Aug 1 | The diagnosis of rheumatic diseases should follow a pattern of stages, the first comprising family case history, the case history of the patient and basic physical examinations. The second stage should include X-ray examination and basic or, if necessary, more extensive laboratory tests and simple synovia analysis. The third stage would then incorporate articular biopsy, arthroscopy, different biopsies outside the joint, isotope examination, electromyography, thermography, arthrosonography, computed tomography etc. Allowance should be made in this connection for the diagnostic criteria established by different specialist bodies and the different degrees of diagnostic safety involved. While computerized diagnostic systems for rheumatic diseases can be of great help to the GP, they will never be as successful as the experienced rheumatologist. | |
| 3487947 | 1.5-T surface-coil MRI of the knee. | 1986 Aug | Five normal knees and 20 knees with suspected abnormalities involving the menisci or articular surfaces were examined with high-resolution surface-coil MRI. Surgical correlation was available in 15 cases. Signal-to-noise ratios were optimized using a field strength of 1.5 T and a round 7.6-cm surface coil. Spatial resolution was maximized by using fields of view reduced to as small as 8 cm. Separate examinations of the medial and lateral joint compartments were performed with the surface coil positioned vertically adjacent to the meniscus of interest. Ten meniscal tears were identified using sagittal and coronal images. T1-weighted images were adequate to detect most meniscal tears, and T2-weighted images were useful for providing an "arthrogram effect" in the presence of a joint effusion. Extrameniscal lesions that were examined included osteonecrosis of the femoral condyle, subchondral cysts, rheumatoid arthritis, degenerative arthritis, and anterior cruciate ligament tears. MRI was useful in determining the integrity of articular cartilage overlying defects in the subchondral bone and in detecting gross cartilage lesions in arthritis, but was less sensitive than arthroscopy in evaluating moderate changes in the hyaline cartilage. | |
| 1689601 | Rheumatoid discitis with cord compression at the thoracic level. | 1990 Feb | A 63-year-old man presented with spinal cord compression caused by rheumatoid discitis at a high thoracic level. Nuclear magnetic resonance imaging proved to be very useful in evaluating the extent of the inflammatory process. Early decompression and internal fixation resulted in cure with only some residual functional impairment. | |
| 3055117 | Respiratory manifestations of connective tissue disease. | 1988 Sep | Pleuropulmonary disease is a common feature of the following connective tissue diseases: systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), mixed connective tissue disease (MCTD), polymyositis/dermatomyositis (PM/DM), and Sjogren's syndrome (SS). Features common to most of these disorders include pleurisy with effusion and interstitial lung disease. Pleural effusions caused by SLE and RA have certain characteristics on pleural fluid analysis that aid in diagnosis, but infection and other causes of effusion must be excluded. Interstitial lung involvement is usually indolent in onset, but a more rapidly progressive course over weeks to a few months may mimic infection. Several drugs used to treat connective tissue diseases may cause interstitial disease, increase susceptibility to infection, or both. This complicates differential diagnosis. Acute lupus pneumonitis and SLE-related alveolar hemorrhage are usually fulminant processes, often associated with fever. Diagnosis of these conditions always requires exclusion of infection. Rheumatoid nodules may mimic infectious and neoplastic lung diseases. Needle biopsy helps reduce the likelihood of infection or malignancy, but open lung biopsy is needed if a firm diagnosis of rheumatoid nodules is required. | |
| 3084775 | Rheumatoid rigor: gold induced myokymia. A report and review of the literature. | 1986 Feb | Myokymia is a spontaneous movement disorder characterized by slow, undulating, persistent movement of the involved muscles. It is an unusual manifestation of gold neurotoxicity, rarely reported in the rheumatologic literature. We report a case of gold induced myokymia associated with gold-induced dermatitis and nephropathy. | |
| 3258776 | Rheumatic diseases in pregnancy. | 1988 Jan | The effects of pregnancy on the clinical course of the rheumatic diseases is not only variable but often unpredictable. Disease activity at the onset of pregnancy will have great bearing on fetal outcome. Thus the use of potentially harmful drug combinations in pregnancy has to be weighed against theoretical teratogenic effects. This review outlines some of these dilemmas. | |
| 2242059 | Aspirin, hydroxychloroquine, and hepatic enzyme abnormalities with methotrexate in rheumat | 1990 Nov | Levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) in patients with rheumatoid arthritis from 5 centers involved in the Arthritis, Rheumatism, and Aging Medical Information System were correlated with the use of specific antirheumatic medications. Elevated levels of SGOT and SGPT were most frequent in patients taking salicylates and methotrexate (MTX) and least frequent in patients taking hydroxychloroquine. The combination of MTX and salicylates greatly increased the frequency of abnormal liver enzyme values. In contrast, the addition of hydroxychloroquine to a regimen of either MTX or aspirin essentially eliminated the SGOT and SGPT abnormalities. Results from all 5 centers were consistent and remained so after adjustment for age, sex, and disease duration. Knowledge of these important drug interactions may permit continuation of MTX therapy in patients in whom the drug might otherwise be discontinued. | |
| 3495876 | Anti-Ro/SSA and -La/SSB antibodies in patients with connective tissue diseases. | 1986 | The frequency of anti-Ro/SSA and anti-La/SSB antibodies in patients from Japan with Sjögren's syndrome, systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), polymyositis-dermatomyositis (PM-DM), rheumatoid arthritis (RA) and blood donors is reported. Anti-La/SSB ab was especially detected in patients with severe glandular and extraglandular manifestation and could be found in sera years prior to the confirmation of Sjögren's syndrome. The purified Ro/SSA antigen consisted of 60 k peptide and 16 k RNA while the La/SSB antigen consisted of 41 k and 29 k peptides. Some molecular association seems to exist between the peptides and corresponding IgG anti-Ro/SSA and anti-La/SSB antibodies. | |
| 3495942 | [Roentgenology in rheumatology]. | 1987 Jan | The paper takes a retrospective view back to the historical beginning of roentgenology. The development of radiology of bone and joints is high-lighted with special respect of rheumatology. Completeness was not intended regarding the size of this paper. It is shown, especially to our younger colleagues, how hard it was in the past 90 years to achieve our today-knowledge in x-ray-diagnostic. Three factors determined Roentgenology to become an indispensable method. The continuing development and improving of efficient x-ray-machines. The development and improving of investigation methods. The scientific workup of radiological signs leading to radiomorphologic features. Some milestones of technical development of conventional radiology are listed up. Also, innovations in microelectronics. Computed tomography and Magnetic Resonance are listed up. Remarks are made about costs of "big machines" and about declining knowledge in conventional radiology in young american radiologists. Recommendations are made for efficient collaboration of rheumatologists and radiologists. | |
| 2589249 | Amyloid goiter and arthritides after kidney transplantation in a patient with systemic amy | 1989 Dec | A case of hereditary AA amyloidosis with Muckle-Wells syndrome is described. After a successful kidney transplantation for chronic renal failure due to renal amyloid deposits at age 21, the patient, a white female now 26 years of age, developed a large amyloid goiter as a manifestation of the systemic amyloidosis and recurrent monarthritides. Both observations are novel for this disease. Subtotal thyroidectomy and oral colchicine administration, known to be effective in preventing complications of familial Mediterranean fever, another hereditary type of AA amyloidosis, proved highly effective in the management of this unusual case. | |
| 3604487 | [Chronic cephalalgia as a sequela of rheumatic spondylarthritis of the cervical spine]. | 1987 | Deformity and instability of the cervical spine is quite frequently recordable from patients with chronic rheumatoid arthritis. More than 70 per cent of patients who had been suffering this rheumatoid disease for more than ten years with mutilating peripheral joint lesions exhibited radiologically visible and clinically recordable cervical spine disorders. Anterior atlanto-axial subluxation has proved to be the most common rheumatic deformity of the cervical spine and was found to cause severe, even intolerable occipito-cervical headache. The authors have obtained good results from posterior C1-C2 fusion operation on patients in whom headache had been invalidising and resistant to conservative treatment. | |
| 2267381 | [Preliminary experience of the study of the hand using digital radiology with photo-excita | 1990 Nov | Photostimulable phosphor computed radiography (CR) is a new technique. The authors applied direct magnification CR to hand study (IP matrix: 1770 x 2370), and compared the results with conventional radiography ones (high MTF industrial type film, without screens, 5 x optic enlargement reading). In both cases, a mammographic unit was employed for acquiring the images. Thirty patients affected with renal osteodystrophy, psoriatic arthropathy or rheumatoid arthritis, and 20 normal subjects were examined. Digital images were processed by a particular sensitometry curve and spatial filtering with unlinear unsharp masking: we obtained good visualization of small lesions (subperiosteal resorption, cortical bone tunnelling, minute periosteal necrosis), not inferior to that obtained with conventional techniques. CR has further advantages, such as low economic and biological cost, wide exposure and recording range, image processing, easy archiving and networking. | |
| 3439372 | [Acemetacin in patients with rheumatic disease with concomitant liver diseases. Pharmacoki | 1987 | 10 male patients suffering from rheumatic diseases and from a liver disease (fat liver, cirrhosis) received acemetacin (Rantudil forte capsules) t.i.d. for 10 days. Blood levels were measured on days 2, 4, 7 and 9, 2 and 4 hours after the administration at noon, as well as after the last dose (day 10) during a 48 hours elimination period. The following kinetic parameters were determined: maximal blood level (cmax), elimination half life (during the 48 hours elimination period), area under the blood level time curve (AUC). Values are compared to corresponding data of rheumatic patients and healthy volunteers. Daily doses were 180 mg acemetacin each. Mean maximal blood levels (cmax) were 1.51 +/- 0.19 (rheumatic patients with liver diseases), 1.85 +/- 0.33 (rheumatic patients without liver diseases) and 1.24 +/- 0.05 mumol/l (healthy volunteers). Elimination half lives are 4.63 +/- 2.25, 4.52 +/- 2.81 and 4.03 hours. AUC-values were in the same range for rheumatic patients with liver diseases (11.62 +/- 5.56) and volunteers after Rantudil forte (14.30 +/- 8.79) or Rantudil retard (12.52 +/- 5.90 mumol.l-1.h). Toxic or infective liver damage therefore does not substantially change kinetics of acemetacin. The drug was efficient and well tolerated in all patients. There were no hints as for a special risk for patients with liver damage taking this drug. | |
| 3358799 | The importance of age, education, and comorbidity in the substantial earnings losses of in | 1988 Mar | A population-based survey designed to be representative of the entire US population of working age (18-64 years) includes data on pain and swelling of specific joints in each subject. We analyzed these data to estimate work status and disability status, as well as earnings losses, associated with Symmetric Polyarthritis. Subjects identified in the survey as having Symmetric Polyarthritis were similar in age, race, sex, and marital status to rheumatoid arthritis patients seen in clinical settings. Overall, 51% of women with Symmetric Polyarthritis and 47% of men with Symmetric Polyarthritis were severely disabled, compared with 4.5% of women and 3.7% of men with no arthritis. Earnings of women and men with Symmetric Polyarthritis were only 27% and 48%, respectively, of earnings of individuals without arthritis. The total earnings gap between the 2 groups was +17.6 billion (1986 dollars). Econometric regression analyses indicated that about one-third of this earnings gap was explained by the presence of Symmetric Polyarthritis. The remaining two-thirds was explained by differences in age, education, and comorbidity between individuals with Symmetric Polyarthritis and those without arthritis. The earnings of individuals with Symmetric Polyarthritis, therefore, would be expected to be considerably lower than those of the general population, even if these individuals were not affected by arthritis. Nonetheless, earnings losses of at least +6.5 billion annually are explained by Symmetric Polyarthritis. | |
| 3625641 | Chronic active hepatitis presenting with rheumatoid nodules and arthritis. | 1987 Jun | Chronic active hepatitis is often accompanied by extrahepatic rheumatic symptoms of mild or moderate severity. We report a 16-year-old girl with this disorder who presented with severe polyarthritis and rheumatoid nodules mimicking juvenile rheumatoid arthritis. Rheumatoid nodules have not previously been described in chronic active hepatitis, and the severity of the rheumatic symptoms in our patient led to a delay in the recognition of the underlying liver disease. Our report provides support for an autoimmune etiology in some patients with chronic active hepatitis, notes the occurrence of rheumatoid nodules in the disorder, and emphasizes that severe extrahepatic symptoms may obscure the diagnosis and institution of therapy in some individuals. | |
| 1654973 | Infection as a cause of arthritis. | 1991 Aug | The etiology of most rheumatic tissues is unknown; however, recent investigation into this area is rapidly providing new clues to the pathogenesis of many of these diseases. This article reviews several infectious agents (Epstein-Barr virus, parvoviruses, and mycobacteria) and the data supporting their roles in the etiology of rheumatoid arthritis. In addition, current data on the potential roles of Epstein-Barr virus and retroviruses in the etiologies of Sjögren's syndrome and Kawasaki disease are also reviewed. Finally, the reactive arthritides, for which there is stronger evidence of an infectious etiology, are reviewed. | |
| 2802839 | Arthroplasty of the rheumatoid wrist with Swanson implant. Long-term results and complicat | 1989 | Seventy-five patients with Steinbrocker stage III et IV rheumatoid wrists underwent arthroplasty with Swanson implant. Sixty-two implants were reviewed at 5 years postoperatively. Functional criteria, namely pain, mobility and grip proved satisfactory in 66% of cases. Radiological examination revealed 23% radial implant fractures, 50% dislocated or fractured ulnar implants and 29% foreign body synovitis. This high rate of complication is disappointing given the encouraging initial results, and leads us to reconsider the appropriateness of such surgery in severe cases of rheumatoid wrist. | |
| 1948101 | Nodular regenerative hyperplasia of the liver in rheumatic diseases: report of seven cases | 1991 Aug | Nodular regenerative hyperplasia (NRH) of the liver is an uncommon pathologic finding associated, in most cases, with rheumatic and hematologic diseases. Although its pathogenesis remains unclear, NRH probably results from liver regeneration to maintain its functional capacity after ischemia-induced injury. An intrahepatic microvascular occlusive mechanism has been considered most likely pathogenetically. NRH may lead to portal hypertension. Thus, the diagnosis of Felty's syndrome must be considered with caution in patients with rheumatoid arthritis (RA) and NRH of the liver. We report seven additional cases of NRH in patients with rheumatic disorders and review the literature to determine the patterns of clinical presentation and natural history of this condition. We also report four patients (three systemic lupus erythematosus [SLE] and one primary antiphospholipid syndrome [PAPS]) in whom antiphospholipid antibodies may have played a role in the genesis of NRH. | |
| 2730786 | Rheumatoid arthritis cells and biochemical changes in turpentine-induced pleuritis in rabb | 1989 May | When turpentine was instilled into the right pleural cavity in rabbits a pleural effusion developed in half of the animals, with a low pH, low glucose concentration, high lactic dehydrogenase activity and the constant presence of rheumatoid arthritis cells in the affected pleural cavity. The biochemical values in the pleural fluid were significantly different from the values for normal pleural fluid obtained by a special microtechnique. These changes resulting from the experimentally induced, simple, irritative turpentine pleuritis are similar to the findings in the pleural effusion in human rheumatoid pleuritis; this implies that such changes are probably non-specific and without evidence of an immunological background. | |
| 3440330 | ELISA determined IgM, IgG and IgA rheumatoid factors in rheumatoid arthritis and in other | 1987 Oct | We used an adaptation of an enzyme-linked immunoadsorbent assay (ELISA) to determine serum levels of IgM, IgG and IgA rheumatoid factors (RF) in 50 patients with classic or definite rheumatoid arthritis (RA) according to the ARA criteria, balanced for positive or negative-routine Latex-RF reaction. A control group of 50 young normal subjects and a reference group of 44 patients with other connective tissue diseases (OCTD) were also studied. We confirmed the high sensibility of the method, together with its good specificity and reproducibility. For the IgM RF a very significant correlation was found between ELISA results and Latex-RF titration (p less than 0.001). Many Latex-RF negative RA patients had high ELISA levels of IgM RF, suggesting that this assay reveals, at least in part, hidden or non-agglutinating IgM RF. Among the OCTD group only some SLE cases, mainly Latex-RF positive, had enhanced IgM RF on ELISA. Considered quantitatively, IgG RF did not play a significant diagnostic role for RA (p greater than 0.05), because they were also found, with widely dispersed values, in normal subjects, and because the mean increase in RA patients was relatively small. Interestingly, IgA RF were above the normal range in many RA patients, both Latex-RF positive or negative. The mean values differed significantly from those of controls (p less than 0.005), and a correlation was observed between IgA RF levels and IgA containing immune-complexes. Normal IgA RF values were observed in SLE patients, even if Latex-RF positive, suggesting that their increase in RA patients is not the mere expression of a polyclonal B cell activation. |