Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3554157 | Carprofen: a new nonsteroidal antiinflammatory drug. Pharmacology, clinical efficacy and a | 1987 Jan | Because a patient with arthritis (especially rheumatoid arthritis) may respond to one NSAID but not another, any addition to the ranks of these agents may be of clinical benefit to at least some of the millions of patients afflicted with rheumatoid arthritis, osteoarthritis and related conditions. In terms of potency both as an antiinflammatory and as an analgesic, carprofen appears to be in the middle of the NSAID range--roughly one-fourth as potent as indomethacin, and five times as potent as ibuprofen, milligram for milligram. The two most obvious potential advantages of carprofen are that it seems to have a low profile of major gastrointestinal adverse reactions (it may cause minor complaints similar to those seen with indomethacin, but thus far has caused no documented gastric or duodenal ulcers at 300 mg/d); and that, like naproxen, it offers the convenience of twice-a-day dosing. In clinical experience thus far, the two most bothersome adverse effects seen with carprofen have been a rare but serious photosensitivity reaction and minor, temporary elevations of liver function tests in approximately 14-20% of patients treated (although as yet there have been no reported cases of jaundice or hepatitis). For some patients with rheumatoid arthritis, osteoarthritis or related conditions, particularly for those who cannot tolerate aspirin or indomethacin or who want or need the convenience of twice-a-day dosing, carprofen may represent a useful therapeutic option to the NSAIDs previously available in this country. | |
| 3490573 | Circulating immune complexes in rheumatoid arthritis: a prospective study using five immun | 1986 Aug | We evaluated 257 patients with rheumatoid arthritis (RA) to determine the frequency of circulating immune complexes (CIC) in the serum, relationships between the presence of CIC, clinical indices of disease activity and other laboratory features, and relationships between changes in CIC levels and changes in disease activity. CIC were detected by fluid phase Clq binding activity, conglutinin binding activity, anti-C3 assay, staphylococci protein A binding assay and the precipitation of cryoglobulins. CIC in the serum were found to correlate with indices of disease activity, extraarticular features and the presence of rheumatoid factor. A change in Clq binding activity correlated with a parallel change in the joint count. | |
| 2617082 | von Willebrand factor in the plasma of patients with rheumatic diseases. | 1989 Oct | von Willebrand factor (vWf), an endothelial cell product, was evaluated in 39 patients with rheumatoid arthritis, 19 patients with connective tissue diseases and vasculitis, 21 patients with nonrheumatoid inflammatory arthritides, 14 patients with osteoarthritis and 19 controls. High plasma vWf levels were found in rheumatoid arthritis patients: 196.35 +/- 85.8 (p less than 0.001 versus control) connective tissue diseases and vasculitides: 306.50 +/- 43.4 (p less than 0.001 versus control) and inflammatory nonrheumatoid arthritides: 193.35 +/- 90.6 (p less than 0.01 versus control). Highly increased vWf concentrations of more than 300%, were found in one patient presenting Wegener granulomatosis, 6 patients with vasculitis associated to connective tissue diseases, 7 patients with rheumatoid arthritis and 2 patients with active forms of inflammatory arthritides. vWf was correlated with fibrinogen in the subgroup of systemic lupus erythematosus patients. Elevated vWf levels may reflect vascular damage as well as the acute phase reaction. Highly elevated levels of vWf appear to indicate a poor prognosis. | |
| 2290153 | Seronegative rheumatoid arthritis: a clinical study with HLA typing. | 1990 Sep | We examined both clinically and by determining HLA-A, -B, -C and -DR antigens 50 patients thought to have seronegative erosive polyarticular rheumatoid arthritis (RA) in Finland and the USSR. All the patients fulfilled at least 4 of the 1987 ARA criteria for RA. According to HLA typing and clinical findings, of which a part was collected by followup, the patients fell into 5 groups: HLA-B27 related diseases, putative psoriatic arthritis, putative juvenile chronic polyarthritis, and seropositive and seronegative RA. Our results indicate that most of the patients with seronegative RA had some other disease. In the remaining cases the presence of rheumatoid factors had not been examined adequately, especially at the early phase of disease. The classification of erosive seronegative polyarticular patients is discussed. | |
| 1369850 | [Total knee arthroplasty with GSB endoprosthesis (introductory information)]. | 1990 | The construction of GSB prosthesis and surgical technique was presented. The prosthesis having no fixed axis enables flexion and extension as well as shifting and rolling. Unlike the other systems GSB implantation does not require vast resection of femoral and tibial condyles. This is very important in case of failure and necessity of removal of the prosthesis--the revision arthroplasty or arthrodesis does not result in great shortening of the extremity. GSB prosthesis was implanted by the authors in 25 knees of 23 patients. The average follow up was 9 months. In all cases results were good, complications were not observed. The authors conclude that GSB prosthesis deserves wider propagation in surgical treatment of advanced destructive changes in the knee, especially in rheumatoid patients. | |
| 2630557 | The relationship between impairment and disability in arthritis: an application of the the | 1989 Apr | We investigated the relationship between impairment, as represented by limitation in range of movement and pain in the knee joint, and disability as measured by a series of activities of daily living in 123 patients with either rheumatoid arthritis or osteoarthrosis. A log-linear modelling technique found there was a positive association between functional limitation, as measured by reduction in angle of flexion, and disability. However, there was only a marginal relationship between pain in the knee joint and disability, and no association between pain and range of movement, which suggests that conventional beliefs that pain is a key factor in assessing health outcomes may need to be reassessed. | |
| 3178317 | Adult onset Still's disease and viral infections. | 1988 Sep | Several micro-organisms, especially viruses, have been associated with juvenile and adult onset Still's disease. In the present study a search for probable triggering viral infections in five consecutive patients with early, active adult onset Still's disease has been made. In one patient echovirus 7 was identified as a probable triggering agent. Evidence of infection with this virus was acquired by virus cultures and serological tests. In two patients the illness was probably initiated by a rubella reinfection. Both had initially high stable monospecific IgG antibody titres but no IgM antibodies to this virus. In the remaining two cases no particular triggering viral infection could be designated. Evidence of a viral infection was thus found in three of these five patients. Adult onset Still's disease may represent a reaction pattern to certain infections. | |
| 2232713 | localization of type VI collagen in the lining cell layer of normal and rheumatoid synoviu | 1990 Nov | Types I to VI collagens were immunolocalized in normal and rheumatoid synovium using monospecific antibodies. Immunofluorescence studies showed type VI in the extracellular matrix of the lining cell layer, whereas positive staining for type III collagen was observed in both the lining and sublining cell layers. All other collagens could not be detected in the lining cell layer. Immunogold staining of the rheumatoid synovium localized type VI collagen to filamentous material, which was the major extracellular structure of the lining cell layer. Type III collagen was associated with thin cross-striated collagen fibrils. A brief treatment of rheumatoid synovial tissue with bacterial collagenase produced in the lining cell layer numerous broad-banded fibrils with 100-nm periodicity; these fibrils could be labeled with the antibody against type VI collagen. This suggests that type VI collagen filaments have the potential to form periodic structures under certain conditions. We further studied the susceptibility of type I to VI collagens to matrix metalloproteinase 1, 2 and 3 (collagenase, gelatinase of molecular weight 72,000, stromelysin), which are secreted by synovial lining cells in rheumatoid synovium, and found only type VI collagen to be completely resistant to all these metalloproteinases. These data indicate that type VI collagen, which has the ability to bind to cells and to interstitial collagens, plays an important role in supporting the synovial lining cells in the normal and rheumatoid synovium. | |
| 2378178 | [Urinary calculus protective side effects of anti-rheumatic therapy]. | 1990 Apr | In a retrospective study two patient groups suffering from recurrent calcium oxalate lithiasis are compared before and after antirheumatic therapy using Diclofenac-Natrium alone or in combination with xanthine oxidase inhibitors and/or hydrochlorothiazides. The examination of concentration and excretion of lithogenic important parameters show a partly significant reduction of the concentration mean values of calcium, oxalic acid and uric acid. The influence of non-steroidal antiphlogistics (NSAP) on calculus recurrence rate in calcium oxalate lithiasis is recognized. | |
| 2210315 | [Study of isoenzymes of lymphocyte populations during controlled immunization and in autoi | 1990 Jul | It has been shown that during immune system activation pronounced alterations are observed in the metabolic process course in lymphoid cells that, probably, reflect the changes in T- and B-lymphocyte functional activity, and the kinetics of intercellular relationships. The ratio of LDH1 and LDH5 fractions most differing in electrophoretic mobility has been recommended as a sign of B-system immunity activation. | |
| 3015467 | The generation of superoxide anions by polymorphonuclear leucocytes from patients with ank | 1986 Apr | Superoxide anion (O2-) generation in response to the chemoattractant f-met-leu-phe was measured in PMNL from 30 patients with ankylosing spondylitis and in PMNL from 27 controls. At a concentration of stimulant above that necessary to achieve maximal response, no differences in O2- production between the groups were noted. With a lower concentration of stimulant, cells from patients with AS or RA taking non-steroidal anti-inflammatory drugs had lower levels of O2- generation, compared both to controls and to AS patients, off medication. Results suggest any decrease in O2- generation seen in patients with AS is likely to be related to therapy and not to the disease or to possession of HLA B27. | |
| 3813673 | Predictive value of mean platelet volume in gold induced thrombocytopenia. | 1987 Jan | In rheumatoid arthritis the mean platelet volume does not alter with the institution of parenteral gold therapy and with long term gold therapy. It appears to have no value in predicting the onset of thrombocytopenia. It may, however, predict a haemorrhagic diathesis once gold induced thrombocytopenia is established. | |
| 3818968 | Clinical value of ELISA assays for IgM and IgG rheumatoid factors. | 1987 Jan | The clinical value of enzyme linked immunosorbent assays (ELISA) assays for IgM and IgG rheumatoid factors was assessed in a series of studies using rabbit IgG as antigen. The tests were reproducible with intra-assay coefficients of variation of 6% and could be simply and rapidly performed. Normal ranges were established using 106 sera from healthy controls. In a cross sectional study of 208 rheumatoid patients these assays were compared with the Rose-Waaler and laser nephelometric assessments of rheumatoid factor. In some patients there were discrepancies between rheumatoid factor positivity determined by one method or another. IgM ELISA and Rose-Waaler titres showed a significant correlation (r = +0.58; p less than 0.001), but there was a low correlation between IgM and IgG ELISA (r = +0.27; p less than 0.001). There was no evidence to show that the measurement of IgM or IgG rheumatoid factor gave significantly more clinical information than traditional tests such as the Rose-Waaler or latex agglutination tests. | |
| 3196128 | The influence of general and case-related experience on primary care treatment decision ma | 1988 Dec | In an effort to examine how general vs case-related clinical experience influenced physicians' treatment decisions, four clinical case vignettes (rheumatoid arthritis, fever of undetermined origin, exercise-induced asthma, and cor pulmonale) were presented to 387 primary care physicians. For each case, physicians indicated (1) their willingness to proceed with treatment without seeking additional information, (2) their preferences for sources of supplementary information, and (3) their preferences for continued care responsibility. The results indicated that the nature of the particular vignette had a major impact on how physicians made treatment decisions. Also, having greater case-related experience and being younger led to greater willingness to proceed with treatment and preferences for continued care responsibility. Preferences for information sources were largely independent of either form of experience. Treatment decision making appears to be quite dependent on experience with similar problems and being up-to-date on current treatment procedures. | |
| 2149102 | Imaging rheumatoid arthritis specifically with technetium 99m CD4-specific (T-helper lymph | 1990 | CD4 expressing T-lymphocytes are involved in the pathogenesis of rheumatoid arthritis, so the possibility of using radiolabelled CD4-specific antibodies to localise diseased joints was studied. Prospectively six patients with rheumatoid arthritis were investigated. Five of them received 200-300 micrograms of a 555 MBq technetium 99m CD4-specific antibody (MAX.16H5) and were examined with three phase bone scans. Max.16H5 (IgG1) was labelled according to the mercaptoethanol (Schwarz) method. Lymphocytes of one patient were isolated on a Ficoll-Hypaque gradient and labelled with the antibody in vitro. Scans were performed 1.5 h, 4 and 24 h post injection in anterior and posterior views. In all patients, diseased joints could be clearly imaged at as early as 1.5 h. The localisation of the diseased joints correlated (P less than 0.01) with the clinical signs, with the early methylene diphosphonate (MDP) scan (P less than 0.01) and only weakly with the late bone scan (P greater than 0.05). According to these data we conclude that 99mTc-labelled CD4-specific antibodies specifically image actively diseased joints in rheumatoid arthritis. | |
| 2118353 | [Oral lichenoid reaction secondary to gold salt therapy]. | 1990 Feb | Lichenoid Eruptions due to gold salts therapy appear in some patients affected of active Rheumatoid Arthritis. This reaction completely disappear after the drug suppression and must be differenciated of the idiophatic lichen planus. In the case presented in this paper, the more interesting features of this yatrogenic disease are discussed. | |
| 3147512 | Panhypogammaglobulinaemia caused by gold therapy. | 1988 Oct | Gold compounds have been successfully used for over 50 years in the treatment of rheumatoid arthritis, but their mechanism of action is unknown. The main disadvantage is the frequent occurrence of side effects which often necessitate discontinuation of therapy. Recently, there have been reports of reduction in immunoglobulin levels in patients on gold treatment; we report a further case of hypoglobulinaemia associated with gold therapy and recommend that immunoglobulins be monitored prior to and during treatment. | |
| 3763220 | [Elbow joint]. | 1986 Aug | The elbow joint is a key joint for positioning of the hand. Four operations have to be considered for the rheumatoid elbow: removal of rheumatoid nodules and bursectomy, resection of the radial head, synovectomy, and arthroplasty. Synovectomy and arthroplasty are carefully analyzed, both from the point of view of recent international literature as well as personal experience. Synovectomy of the elbow is highly effective even when performed relatively late (stage 3 according to Larsen-Dahle-Eek) insofar as pain relief and swelling are concerned. In long-term disease, deterioration as assessed by radiology can usually not be prevented, but clinical improvement may be the reason for the relatively rare indication for arthroplasty. According to recent literature, the results of elbow arthroplasty vary greatly. Fully constrained hinges should no longer be used, and no decision has been made so far on whether semiconstrained or nonconstrained surface replacement is preferred. We use the semiconstrained GSB Mark II prosthesis, which has provided results in nearly 50 cases that rank among the best reported from the point of view of pain relief, improvement of ROM, and low complication rate. Use of our so-called transtricipital approach to the elbow has proved particularly valuable, especially with regard to lack of extension and muscle strength. | |
| 3456291 | Studies of rheumatoid synovial fluid lymphocytes. III. Phenotypic and functional analysis | 1986 Apr | Synovial fluid and peripheral blood lymphocytes from patients with rheumatoid arthritis have been compared in terms of phenotypic and functional expression of natural killer (NK) activity. Following pretreatment with the monoclonal antibodies anti-HNK-1 (anti-Leu-7) or anti-Leu-11b and complement, NK activity against K562 cells was assessed in 4-hr chromium release assays. Rheumatoid peripheral blood lymphocytes resembled those of normal individuals, in that complement-mediated lysis of Leu-11b+ cells virtually eliminated all NK activity. Complement-mediated lysis of Leu-7+ cells resulted in only a modest reduction in NK activity. Rheumatoid synovial fluid lymphocytes differed from autologous peripheral blood lymphocytes: the overall cytotoxicity was generally less and only a fraction of the NK-like activity appeared to be mediated by Leu-11b+ cells. This apparent lack of Leu-11b expression by rheumatoid synovial fluid NK-like cells could not be accounted for by blockage or alteration of the Leu-11b antigen by factors present in synovial fluid. These observations support and extend previous data showing a discordance of phenotype and function of lymphocytes in rheumatoid synovial fluid possibly representing activation of such cells within the rheumatoid joint. | |
| 2941698 | [Side effects of d-penicillamine in the treatment of rheumatoid arthritis]. | 1986 May 31 | In the present study, the side effects of d-Penicillamine therapy in 54 patients with rheumatoid arthritis are analyzed. The therapeutic efficacy of the drug is emphasized; but in the meantime, the necessity is also stressed that the choice of this antirheumatic agent must imply the knowledge of the possible complications caused by its use and of the clinical features and laboratory data which would be useful for their early detection. |