Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6851327 | Musculoskeletal infection with nongonococcal neisseria species not associated with meningi | 1983 Jun | Five patients with type III musculoskeletal infection from nongonococcal Neisseria species were examined during a 13-month period. The initial clinical diagnosis was incorrect in all cases. Synovial fluid analysis and Gram's stain were not helpful, and the correct diagnosis was made only after culture reports were available. The patients responded well to antibiotic treatment, but two patients with underlying rheumatoid arthritis required surgical debridement. All patients were asymptomatic, with resolution of their infection at follow-up evaluation. An early correct diagnosis is mandatory and Neisseria infection should be considered in patients with pre-existing joint disease. | |
| 6804399 | Collagen-anti-collagen complexes in rheumatoid arthritis sera. | 1982 | Immune complexes (IC) were detected in rheumatoid sera by means of anti-antibody (AA) neutralization tests. The sera with rheumatoid factor (RF) that did not agglutinate human Rh+ erythrocytes sensitized by incomplete Rh antibodies, Ripley, could be tested in an AA neutralization test without any further treatment. On the other hand, 'Ripley-positive' sera had to be treated with 2-mercaptoethanol or dithiothreitol in order to destroy RF. IC-containing sera were further studied for dispersion of IC by collagen. Surprisingly, roughly 50% of IC-containing sera were affected by collagen in that they lost AA-neutralizing activity completely or partially. Significantly, very similar results were obtained with collagen type I, collagen type II and denatured collagen type II. It was concluded that these sera contained IC formed by denatured collagen and its antibodies. Further experiments were devoted to the study of the effect of collagen on reactions of RF with Ripley-sensitized erythrocytes. In several sera, the addition of collagen eliminated the prozone. This was interpreted as deblocking of RF due to the dispersion of the blocking IC by an excess of collagen. In other sera, the addition of collagen seemed to remove or block RF. This blocking effect was interpreted as a neutralization of multispecific RF by collagen. An alternative explanation proposed that collagen formed IC with free anti-collagen antibodies and that these IC blocked the RF. | |
| 7288233 | [[HLA in rheumatoid arthritis (author's transl)]. | 1981 May | Despite many reports on the association between ankylosing spondylitis and HLA-B27, most studies have failed to find a significant relationship between HLA-A or B antigen and rheumatoid arthritis. Stastny, however, showed a significantly high frequency of HLA-Dw4 in rheumatoid arthritis in 1976. The study of HLA antigens in Japanese patients with rheumatoid arthritis are thought to be significant in view of the pathogenesis of disease. Eighty-eight Japanese patients with "definite" or " classical" rheumatoid arthritis according to the ARA criteria and 104 normal individuals were typed for serologically detectable HLA-A, B, C, and D antigens. Though small discrepancies were observed in several of the HLA-A, B, and C, antigens, they were not definitely significant. The frequency of HLA-DR4 increased to 70.5% in patients compared to 46.1% in the control (i.e. normal) group (p less than 0.001). However, the frequency increased to 80.6% in male patients (p less than 0.0005). Of interest was the significantly high frequency of HLA-DR4 in males, compared to the low frequency of HLA-DR2 (p less than 0.02). Rheumatoid patients were subdivided into different groups according to the year of onset, the presence of the the rheumatoid factor or rheumatoid nodules, the functional grade and treatment. There were no significant differences in the frequency of HLA-DR4 among subgroups. The results indicate that rheumatoid arthritis, especially in males, is associated with genes of the HLA-D region and that immunogenetic factors linked to HLA have an important role in its pathogenesis. | |
| 3864965 | Temporomandibular joint abnormalities and bite force in a group of adults with rheumatoid | 1985 Nov | Maximal mouth opening, translatory condylar motion (radiographically assessed) and bite force in sixteen adults with rheumatoid arthritis and radiographic temporomandibular joint abnormalities were compared with data from sixteen individuals without joint disease. Mean mouth opening in the arthritis group was reduced, but not statistically significant. Condylar translation and bite force showed significantly lower values than in the healthy individuals. Maximal mouth opening seemed to be the most uncertain parameter for the estimation of jaw function. In seven patients with a normal mouth opening (40-46 mm), both the condylar translation and the bite force were significantly impaired. | |
| 6669869 | Asialylated immunoglobulins and rheumatoid factors. | 1983 | A covalently coupled IgG-latex reagent was instrumental in isolating rheumatoid factors (RF) from normal immunoglobulins in the sera of patients with rheumatoid arthritis. It was found that RF contained hyposialylated immunoglobulins of both IgG and IgM classes. This biochemical alteration might be relevant to understanding the etiopathogenesis of the disease. | |
| 914086 | Arthritis of the trapezial articulations treated by prosthetic replacement. | 1977 Jun | This paper reviews experience with thirty-six trapezial replacements over a period of six years. The indications for replacement are given, the group of patients analysed and the technique outlined, with particular attention given to tendinous reinforcement of the capsular repair. The results with regard to pain, dislocation and other complications are recorded. The causes of dislocation and its prevention are discussed. | |
| 6712287 | Cancer morbidity in rheumatoid arthritis. | 1984 Apr | A consecutive series of 489 patients with rheumatoid arthritis seen at the centre was studied to determine their cancer morbidity. Overall the 36 cancers diagnosed in the series between 1964 and 1981 were not significantly in excess of the expected number, but there was a highly significant excess of tumours of the reticuloendothelial system. The excess was mainly due to 6 observed cases of lymphoma. We conclude that there is a highly significant association between rheumatoid arthritis and the subsequent development of lymphoproliferative malignancy in this series. | |
| 196340 | [Intra-articular iron sequestration and rheumatic anemia. Histologic and isotopic study]. | 1977 May 9 | The authors explored 48 patients with various forms of inflammatory rheumatism and 8 controls. The exploration consisted of seeking in the synovial membrane ferric pigments by Perls stain, or studying the movements of Fe 59 bound to siderophyllin in the joints. Intra-articular iron deposits were thus demonstrated only in the inflammatory cases. Its mechanism is discussed. It seems sufficient to be the cause of rheumatic anemia which is thus different from other forms of inflammatory anemia owing to the importance of the iron uptake. | |
| 2998290 | A seroepidemiological study of cytomegalovirus and Epstein-Barr virus in rheumatoid arthri | 1985 Nov | Antibodies to cytomegalovirus (CMV) and Epstein-Barr virus capsid antigen (EBVCA) were examined in 41 patients with rheumatoid arthritis (RA), 26 patients with primary sicca syndrome, and 26 healthy subjects of similar age and sex. IgG antibody titres to EBVCA and CMV were similar in all three groups, apart from a trivial increase of antibodies to EBVCA in RA. False positive IgM anti-CMV antibodies detected in serum from one patient with sicca syndrome and 20 patients with RA were shown to be due to rheumatoid factors. These data did not support recent suggestions that patients with these diseases showed exaggerated immunological responses to either virus and emphasised the need to incorporate adequate laboratory and disease controls when seroepidemiological studies are performed on sera containing rheumatoid factors and autoantibodies. | |
| 7188498 | Lytic lesions of the femoral neck in rheumatoid arthritis simulating pigmented villonodula | 1982 Mar | Large lytic lesions, relatively asymptomatic, involving the femoral neck and the base of the head are described in two patients suffering from a classical seropositive rheumatoid arthritis. Histological examination failed to reveal signs of malignancy, infection or pigmented villonodular synovitis. There were no rheumatoid nodules but a chronic hypertrophic villous synovitis was found. Rheumatoid synovium may invade the superior extremity of the femur; this fact is important in the differential diagnosis of destructive lesions of the femoral neck in RA. | |
| 200018 | [Biochemical methods in the assessment of activity in rheumatoid arthritis (author's trans | 1977 Nov 11 | An investigation was carried out in 120 patients with classical rheumatoid arthritis (RA). Prolylhydroxylase activity was determined in the synovial membrane and serum and compared with the level of collagen-like protein in plasma and the hydroxyproline-creatinine quotient in urine. The data were related to the activity of RA as measured according to Voit and Gamp and also according to Lansbury. Activity was, furthermore, also assessed on the basis of newly defined criteria considering clinical, biochemical and histological findings. Prolylhydroxylase activity was significantly correlated to the activity of the RA assessed according to each of these systems. The significance of the known parameters, collagen-like protein in plasma and hydroxyproline-creatinine quotient in urine were confirmed in this larger series of patients. The positive correlation between prolylhydroxylase activities in the synovial membrane, as well as in serum, and the level of collagen metabolites in plasma and urine corroborated the value of biochemical methods in the assessment of activity of RA in order to undertake differentiated therapy. | |
| 7188435 | Recurrent transient ischemic attacks associated with thrombocytosis in rheumatoid arthriti | 1982 Dec | Thrombocytosis may appear in rheumatoid arthritis, nevertheless, thromboembolic phenomena have rarely been recorded. This case describes a 71-year old patient suffering from long-standing seropositive and nodular rheumatoid arthritis with severe pulmonary involvement. During an exacerbation of her disease and following the appearance of thrombocytosis, several episodes of transient ischemic attacks occurred. The neurological manifestations were right facial nerve paralysis, paraesthesia of the right cheek and dysarthria. The patient was treated successfully by antiaggregants, anticoagulants and busulfan. | |
| 184511 | [Mixed neuropathies in rheumatoid arthritis. Motor and sensory nerve conduction velocities | 1976 Jan | Nerve conduction studies and analysis of the sensory action potential (110 nerves investigated) demons treated abnormalities in 15 to 20 patients with rheumatoid arthritis. It is concluded that moderate, often subclinical peripheral neuropathy is a common complication in rheumatoid arthritis. | |
| 3901873 | Hip replacement arthroplasty in rheumatoid arthritis. | 1985 | Numerous factors conspire to make hip replacement arthroplasty for rheumatoid arthritis different from the same operation in osteo-arthritis. Patients are frequently younger, arousing fears that the patient will outlive the prosthesis. However this factor is more than counterbalanced by the constraints imposed by the disease in other joints: polyarticular involvement usually protects the hip arthroplasty from weight-bearing stress thus prolonging its life. Protrusio acetabuli, uncommon in osteo-arthritis is the commonest presentation in rheumatoid arthritis because of the concentric cartilage degradation which erodes the acetabulum medially and proximally. In arthroplasty for protrusio, a plea is made for grafting of the floor of the acetabulum with solid bone derived usually from the femoral head. This offers a stronger and more physiological support for the acetabular component than synthetic devices. The hip is often only one of the many joints requiring arthroplasty to maintain locomotor function in severe cases of rheumatoid and the results of multiple operations are usually very gratifying. However, any form of surgery may be contra-indicated in a patient enfeebled by prolonged immobilisation from involvement of multiple joints. Late infection of cemented prosthesis is commoner in rheumatoid than in osteo-arthritis: such patients need antibiotic cover during transient bacteraemia from any cause such as dental extraction, trivial infections etc. | |
| 1161266 | Reconstructive surgery in the rheumatoid hand. | 1975 Jul | Reconstructive hand surgery is an established, proved, and effective method to correct deformities and increase function in rheumatoid patients. As more experience has been gathered, the indications for both arthrodesis and arthroplasty have been better established, and a better approach to reconstructive hand surgery has developed. In this discussion we have evaluated in detail the surgical treatment indicated for wrist, metacarpophalangeal joint, and thumb deformities. The treatment of swan-neck deformities and boutonniere deformities is discussed in other sections in this volume. | |
| 6824824 | Use of aids during the first three months after total hip replacement. | 1983 Feb | The supply and use of aids following total hip replacement was monitored to see why therapists supplied aids and how quickly and why patients stopped using them. Postal questionnaires were sent to 163 patients with unilateral or bilateral osteoarthrosis of the hip or rheumatoid arthritis 2, 6 and 10 weeks after discharge from hospital. Patients had 2.2 aids per person on admission and 5.8 aids per person 2 weeks after discharge. They used 2.3 aids per person 10 weeks after discharge. Improvement in the pattern of walking was the main reason for supplying walking aids, safety for providing bath aids, and pain/insufficient range of movement for supplying dressing and toilet aids. The main reason for discarding aids was that patients could manage without them. Disease group, sex and the presence of other orthopaedic or medical problems influenced the use of aids but these differences were not apparent until 6 weeks after discharge. | |
| 4070923 | Rheumatoid factors in rheumatoid arthritis and vasculitis. | 1985 | To study the occurrence of rheumatoid factors (RF) in relation to the activity of rheumatoid arthritis and the occurrence of vasculitis, RF of IgM, IgA, and IgG classes were measured in sera from 35 patients with definite or classic rheumatoid arthritis (RA) using ELISA. For 26 patients, the RF levels were studied longitudinally and compared with changes in the articular index. Although IgM RF was occasionally found in patients without RA, IgA and/or IgG RF were almost exclusively associated with RA. The titers of IgM, IgA, and IgG RF were significantly higher in sera from patients with clinically diagnosed rheumatoid vasculitis than in sera from patients without vasculitis. No significant correlation between changes in the articular index and changes in titer of any class-specific RF could be found for the group of RA patients as a whole. However, in individual patients, increases or decreases in IgM and IgG RF titer were significantly correlated with an increase or decrease in the articular index. | |
| 439116 | Psycho-social adjustment of rheumatoid arthritis patients from two alternative treatment s | 1979 Jan | Fifty rheumatoid arthritis (RA) patients are compared with a control sample of 72 non-patients on five attitude scales which measure psychol-social adjustment. Patients generally indicate more negative attitudes toward self, which are significantly related to variables such as severity of condition and socio-economic status. The adjustment of patients who are being treated by registered nurses (physician extenders) is not significantly different from that of patients who are being treated by physicians. | |
| 7358952 | Arthroplasty of the rheumatoid wrist with silicone rubber: an early evaluation. | 1980 Mar | A review of the results of 37 arthroplasties of the wrist with flexible silicone, done at least 6 months before, in patients with rheumatoid arthritis showed six (16%) to have residual discomfort and two (5%) to have recurrent deformity. Pain was the primary indication for treatment in 31 and deformity in six. Three of 37 wrists had prosthetic fractures (8%). Ten patients who had the opposite wrist fused before the arthroplasty felt the movable wrist was more functional. Contraindications are marked deformity, significant instability, excessive bone loss, and multiple tendon ruptures. | |
| 7121067 | In vivo platelet survival in rheumatoid arthritis. | 1982 Oct | We studied the in vivo consumption of chromate-labeled platelets in 14 patients with active rheumatoid disease and demonstrated shortened platelet survival in 8. We were unable to find significant relationships between diminished platelet survival and clinical features (including vasculitis), the presence of circulating immune complexes (as measured by both a monoclonal rheumatoid factor and the Raji cell assays), the presence of intravascular coagulopathy with fibrinolysis (as measured by the protamine gel test), other laboratory variables commonly obtained in rheumatoid patients, or various drug regimens. |