Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1092517 | Lack of effect of rheumatoid arthritis on clonixin metabolism. | 1975 May | The effect of rheumatoid arthritis on the metabolism of the analgesic, 2-(3-chloro-o-toluidino) nicotinic acid (clonixin), was evaluated in 12 patients with rheumatoid arthritis and in 12 matched healthy control subjects. Males, age-matched by decades, had no renal, gastrointestinal, or hepatic disease, and took no drugs during the study. Lower (p less than 0.02) serum albumins and higher globulins in the patients (albumin: 3.87 plus or minus 0.18; globulin: 3.14 plus or minus 0.28 gm/100 ml) than in the control subjects (albumin: 4.42 plus or minus 0.10; globulin: 2.36 plus or minus 0.08 gm/100 ml) were considered to be manifestations of rheumatoid arthritis. Fasting subjects were given single oral doses of 750 mg of clonixin. A spectrophotometric method was used to determine drug blood levels. Serum half-life was 1.45 plus or minus 0.12 hr in patients and 1.50 plus or minus 0.13 hr in control subjects (p greater than 0.5). Mean peak concentration developed at 1.7 hr and was 40.0 plus or minus 2.6 mug/ml for patients and 46.1 plus or minus 3.1 mug/ml for control subjects. Thus a single oral dose of clonixin results in comparable blood levels in male patients suffering from rheumatoid arthritis and in healthy control subjects. | |
| 7280491 | Rheumatoid arthritis: returning patients to work. | 1981 Aug | Fifty-two patients with stable rheumatoid arthritis were followed-up for one year after being referred to the Disablement Resettlement Officer for work counselling. The proportion of patients employed following work counselling initially increased from 35% to 67%, falling to 57% after one year. In addition, 44% of patients "off sick" were re-established at work by job modification. Comparison of patients employed or unemployed one year later indicated that successful employment was related more to social and environmental factors than disability ro financial considerations. | |
| 515627 | Elbow joint forces in patients with rheumatoid arthritis. | 1979 Nov | Whilst developing an elbow endoprosthesis, the joint forces were estimated for patients with rheumatoid arthritis. Elbow flexion strength of rheumatoid patients was found to be 45% of normal. Muscle strengths and limb geometry data were found by a dissection technique, which allowed joint forces to be calculated during flexion, extension and abduction efforts. Forces up to 2.4 kN were predicted to act on the distal humerus, with similar forces acting in both radius and ulna. The skeletal structure is well adapted to carry the predicted forces, and onlay-type prostheses are recommended for elbow replacement. | |
| 6839832 | Bronchocentric granulomatosis associated with rheumatoid arthritis. | 1983 May | A 49-year-old woman with biopsy-proved bronchocentric granulomatosis (BCG) had repeated exacerbations of seronegative rheumatoid arthritis and vasculitis of the skin concurrent with BCG. To our knowledge, there have been no prior reports of this form of systemic involvement in BCG. While its pathogenesis remains obscure, this case, along with another recent report of eye involvement, suggests that BCG is part of a widespread immunologic response and is not a distinct entity. | |
| 6541252 | Coexistence of rheumatoid arthritis and sarcoidosis: difficulties encountered in the diffe | 1984 Aug | Two patients with rheumatoid arthritis (RA) and sarcoidosis illustrate the dilemmas posed by their coexistence in the same patient. The first patient with classical RA developed iridocyclitis, interstitial lung disease and cranial neuropathies, initially attributed to extraarticular rheumatoid disease. Subsequent lung and skin biopsy revealed many granulomas consistent with sarcoidosis whereas synovium revealed changes typical for RA. In the second patient with cutaneous and pulmonary sarcoidosis development of persistent erosive polyarthritis and a subcutaneous nodule with typical pathology permitted the diagnosis of coexistent RA. These cases emphasize that uveitis alone or multiple cranial neuropathies are not features of RA and symptomatic interstitial lung disease in patients with RA warrants further investigation. | |
| 1143088 | Cardiac tamponade, constrictive pericarditis and pericardial resection in rheumatoid arthr | 1975 May | Four patients with rheumatoid constrictive pericarditis and two patients with rheumatoid cardiac tamponade are presented, and 60 previously reported cases with these two complications are reviewed. Rheumatoid arthritis was moderate to severe in 84% of the patients with cardiac tamponade and in 74% of the patients with constrictive pericarditis. However, both these complications were also seen in patients who had only mild arthritis and in two previously reported cases constrictive pericarditis actually preceded the onset of rheumatoid arthritis. The duration of rheumatoid arthritis had no bearing on the development of these complications. In 75% of patients with cardiac tamponade, and in 66% of cases with constrictive pericarditis, subcutaneous nodules were present. In those cases where the rheumatoid factor was measured it was positive in 92% with cardiac tamponade and in 84% with constrictive pericarditis. In 63% of patients with cardiac tamponade and in 70% of cases with constrictive pericarditis a history of pericardial type of pain was obtained and/or a pericardial rub heard. The diagnosis of cardiac tamponade and constrictive pericarditis was made clinically and in doubtful cases confirmed by cardiac screening and intracardiac pressure recordings. The low sugar content in the pericardial fluid in the absence of infection or malignancy was an important clue to the rheumatoid etiology of the effusion. In the majority of the cases histological appearances of the pericardial tissue showed non-specific fibrous reaction and infiltration with plasma cells and lymphocytes. Only in five of the cases, including one from the present series, were typical rheumatoid granulomatous lesions demonstrated. Treatment with corticosteroids neither prevented the occurrence nor led to amelioration of either cardiac constriction or tamponade. Pericardial resection was life saving, producing both symptomatic and objective involvement of the cardiac function. In the present series of six cases two patients developed aortic incompetence. In one of these it was due to rheumatoid granulomatous valve disease and in the other due to non-specific aortic valvulitis. The combination of constrictive pericarditis and granulomatous aortic valve disease has not been previously recorded. | |
| 6521628 | Degeneratio corneae nivalis. Snow-crystal degeneration. | 1984 | Report of an aged woman in whose corneal stroma point and snow crystal-like, ivory-white, opaque granules developed with calcium granules localized under the conjunctiva. The patient suffered further of general arthrosis and osteopoikilosis in the proximal epiphysis of the femur, demonstrable by X-ray examination. The authors compare the syndrome of their patient with the artificially induced calcification syndrome of rats, which was developed by H. Selye et al, after the administration of isoproterenol, 5-hydroxitriptamin, and dihydrotachysterol to the animals. All three compounds inducing the artificial calcification syndrome, or similar ones, are also normally present in the organism. Their application in the described order causes the abnormal calcification of the connective tissues, probably by the metabolic disturbance of the mucopolysaccharides. | |
| 7235901 | Rheumatoid arthritis: a two-axis goniometer to measure metacarpophalangeal laxity. | 1981 Mar | A 2-axis goniometer has been developed which accommodates the metacarpophalangeal (MCP) changes of rheumatoid arthritis and permits accurate measurement of laxity of the MCP joints. Measurements made with the instrument on 51 subjects with definite or classical rheumatoid arthritis showed high percentages of intrarater and interrater agreement for repeated trials. These results suggest that, following the methods outlined, the 2-axis goniometer can be used to obtain reliable objective measurements of MCP lateral mobility by 1 or more raters with a minimum of training. | |
| 7415584 | [Susceptibility for infections in patients with chronic polyarthritis]. | 1980 May | The case histories and autopsy findings of 79 patients with rheumatoid arthritis (RA)--15 patients with and 64 patients without a history of long term corticoid treatment--who had died in the years 1952-1977 and who had been autopsied in the University Institute of Pathology of Graz were evaluated with respect to organic lesions caused by infections and were compared with an exactly matched control group. Both in the rheumatoid group material and in the 64 RA patients without steroid. long term treatment there was a highly significant accumulation of putrid bronchitis and pneumonia and a significant accumulation of pyelonephritis in comparison to the control group. As far as bronchiectases and pulmonary tuberculosis are concerned, there was an increased prevalence in the RA group, but this was beyond the range of statistical significance. Possible reasons that might account for the elevated susceptibility to infections in patients with RA are discussed. | |
| 6370151 | D-penicillamine withdrawal in rheumatoid arthritis. | 1984 Apr | Thirty-eight patients with rheumatoid arthritis in remission on penicillamine were entered into a prospective, randomised, placebo controlled study to determine the effects of gradual penicillamine withdrawal, to find a serological marker capable of predicting relapse, and to assess the effects of reintroduction of penicillamine. 80% of patients attempting gradual penicillamine withdrawal flared. There was no single serological marker capable of predicting outcome consistently. Decreasing SH levels were highly specific for recurrence of active synovitis but were insensitive. Reintroduction of penicillamine was successful. The implications of these findings, particularly concerning duration of therapy with disease modifying drugs, are discussed. | |
| 6813478 | Oral gold therapy with auranofin (SK&F 39162). A multicenter open study in patients with r | 1982 Jul | One hundred and fifty patients with rheumatoid arthritis received 6 mg of auranofin daily for 2-24 months. Thirty patients were withdrawn from the study, and 82 patients were observed for 12 months. Statistical evaluation was available for 74 patients at weeks 24, 38, and 48, respectively. The major side effects observed were diarrhea, rash, and alopecia. Significant improvement was noted in the articular index, ESR, pain, and morning stiffness. | |
| 7013056 | Effectiveness of levamisole in rheumatoid arthritis: Immune changes and long-term results. | 1981 | After a double-blind trial of 4 months, 40 patients with RA were treated with 100 mg Levamisole. Clinical results were good or excellent in 50%. The immunological status is not a valuable criterion for the selection of patients apt to respond to Levamisole. A good correlation was found between clinical improvement, reduction of ESR, percentage of immunoblasts, rheumatoid factor titre and the enhancement of lymphoblastic response to polyclonal mitogens. The treatment maintenance rate for efficacy was much lower for Levamisole than for D-penicillamine. | |
| 1233314 | Experimental allergic serous rabbit endocarditis and cardiav valvular lesions in rheumatoi | 1975 | Fibrosis of the chordae tendinae pathogenetically comparable to the rheumatoid arthritis (RA) conditioned alterations in the chordae tendineae was to be induced experimentally using the model of allergic-hyperergic rabbit endocarditis. 2. Furthermore, 45 hearts of RA autopsy cases were compared with 200 control heart. All heart valves and chordae tendineae were examined for occurence of diffuse fibroses, adhesions and rufflings as well as for ulcerations and thrombi. The degree of the pathological changes was classified in ""slight'', ""mean'', and ""severe'' (see table 1). 3. The tissue lesion can either lead to endothelial injury resulting in verruciform endocarditis or it can change over from recurrent edema with subsequent edematous sclerosis to etiologically ambiguous nonspecific fibrosis. 4. The persistent allergic-hypergic irritation in rabbit endocarditis likewise caused fibrosis of the chordae tendineae. During the progress of the disease the lesions are ranging from acute edema over edematous sclerosis to fibrosis. In the relatively short experimental period adhesions of the chordae tendineae and sheat-like depositon of newly formed connective tissue as common in allergic processes in RA were not observed. The pathogenetic reactions due to experimental endocarditis were comparable with those in RA. | |
| 7224686 | Posterior subtalar joint synoviography and corticosteroid injection in rheumatoid arthriti | 1981 Apr | Ten posterior subtalar joints of 8 patients with rheumatoid arthritis and 12 posterior subtalar joints of 6 cadavers were studied by contrast synoviography. In the rheumatoid group the abnormalities included posterior capsule distension, filling defects caused by hypertrophic synovitis, limited or irregular filling of the anterior recess of the joint in 5 out of 10, and communication with the ankle joint in 3 out of 10. None of the cadaveric joints showed posterior capsule distension or limited or irregular filling of the anterior recess of the joint, but communication with the ankle was present in 2 joints. The joints of the patients were injected with a 1:1 mixture of sodium iothalamate 70% (Conray 420) and triamcinolone hexacetonide (Lederspan) 20 mg/ml. All patients noticed a decrease in and an improvement in walking beginning 24-48 hours after the examination. Quantitative thermography was done immediately before and 1 after injection in 2 patients who showed an improvement in thermographic index. We conclude that hindfoot inflammatory pain arising from the posterior subtalar joint is caused by distension with hypertrophic synovitis which can be difficult to detect clinically. | |
| 4599671 | Comparison of ibuprofen and acetylsalicylic acid in the treatment of rheumatoid arthritis. | 1974 Jun 22 | A double-blind crossover study of ibuprofen and acetylsalicylic acid was carried out in 27 patients with rheumatoid arthritis. Patients were evaluated by joint counts, grip-strength determination, erythrocyte sedimentation rate, and number of acetaminophen tablets required in addition to the test drug, as well as by various biochemical measurements. In the doses used ibuprofen and acetylsalicylic acid appeared comparable in anti-inflammatory effect, but statistically fewer side effects were observed during administration of ibuprofen. | |
| 4094837 | Effect of thymectomy in immune diseases other than myasthenia. | 1985 | In the course of thymectomy of patients with myasthenia gravis, surprising data concerning the recovery or considerable improvement of other immune disorders have been observed. Among these disorders rheumatoid arthritis figured in six instances, immune thrombocytopenia in two cases, polymyositis and psoriasis in one case each. Thymectomy as a powerful immunosuppressive procedure may have a role in the therapeutic management of some immune disorders other than myasthenia gravis. | |
| 3927858 | Association of MHC antigens with susceptibility to and severity of rheumatoid arthritis in | 1985 Aug | A study of HLA association with rheumatoid arthritis (RA) in multicase families has been performed in north east England. Two hundred and nineteen individuals from 13 families were assessed for the presence of RA, and all were HLA typed. Thirty-nine were found to have classical or definite RA by American Rheumatism Association (ARA) criteria. Thirty-five (90%) of these possess HLA-DR4, confirming the previously reported association of RA with DR4. A further 19 individuals were found to have probable RA or gave a convincing history of previous inflammatory polyarthritis. Thirteen (68%) of these possess HLA-DR4, and this is not significantly different from non-affected family members of whom 63% possess DR4. These results suggest that HLA-DR4 is associated only with the more severe forms of RA. Homozygosity for HLA-DR4 was not associated with either earlier onset or more severe disease when compared with heterozygous DR4. Possession of the haplotype most commonly inherited with the RA in individual families was not associated with earlier onset but may be associated with more severe disease. The severity of RA appears to be influenced by the major histocompatibility complex (MHC) in these families. | |
| 842144 | [Lung function disorders in Sjögren's syndrome]. | 1977 Jan | Pulmonary function tests were performed in 15 patients with Sjögren's Syndrome (SS). All patients presented with rheumatoid arthritis (RA) as well as with sicca syndrome. The mean values of residual volume, compliance and diffusion capacity were found to be abnormal. Vital capacity was abnormal in 40 percent of patients with SS, residual volume in 46 percent, compliance in 60 percent, and diffusion capacity in 66 percent respectively. The lung function was apparently affected more severely in SS than in rheumatoid arthritis. Thus in addition to the well known changes of lung function occuring in rheumatoid arthritis, progressing fibrosis might also contribute to a more extensive impairment of the lung function in SS. Although symptoms of chronic bronchitis and coughs were prevalent in our patients, obstruction was only observed in a comparatively small number. | |
| 6802082 | Compliance and long-term effect of azathioprine in 65 rheumatoid arthritis cases. | 1982 | Azathioprine has been used in our unit as a third line disease modifying drug (DMD) since 1969. In 65 patients with severe rheumatoid arthritis (RA), [45 females and 20 males, mean age 55.2 years (32 to 76), mean duration of disease 14 years (1 to 41)], azathioprine was given in an average dose of 1.5 mg/kg body weight/day for a mean duration of 33.4 months (range 1 to 108). The mean follow-up was five years. One hundred and eighty-four patient years of treatment with azathioprine were observed. After three months' treatment, significant subjective and objective improvement was observed in 65% of the cases. This improvement remained in 29 cases who received continuous treatment for two years. In 12 of the 20 seropositive RA cases, a reduction of at least three dilutions in the rheumatoid factor titre was noted. In the 24 patients who were corticosteroid dependent, the dosage of steroids could be reduced by 35% and in four steroids could be stopped completely. Compliance after two years (n = 54) was still 67%. Azathioprine treatment had to be stopped in 23 patients because of ineffectiveness in nine and adverse effects in 14. In three cases (4.6%) a malignant tumour occurred: one lymphoma and two adenocarcinomata. Low dose azathioprine therapy was shown to be useful as a third line disease modifying drug in RA without an increase in oncogenic risk. Compliance for azathioprine was found to be very satisfactory compared to other drugs. | |
| 6360291 | Yersinia reactive arthritis. | 1983 Nov | A review of Yersinia reactive arthritis is presented with a description of clinical manifestations and immunological features. The pathogenesis of the reactive lesion has so far not been resolved since no conclusive data on the existence or nonexistence of Yersinia antigens in the inflamed joints have been reported. It does not appear that Yersinia is involved in rheumatoid arthritis. |