Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2637464 | [The role of circulating immune complexes in children with rheumatoid arthritis]. | 1989 Oct | The content of circulating immune complexes (CIC) was determined in 120 children with rheumatoid arthritis (RA). Of this number 24 children were included into the group with rheumatoid uveitis. For comparison a group of 33 children with arthritis of various genesis was examined. Determination of CIC showed that in RA children exhibited a high level of IC in the blood and the synovial fluid depending on the activity of the process, the presence of visceral manifestations and spread of the articular affection. Rheumatoid uveitis was not accompanied by any marked deviations in immunological indices as compared to an articular form of rheumatoid arthritis. An increased content of CIC in children with arthritis of various genesis allows one to consider that in rheumatoid arthritis its determination is of no diagnostic value though a considerable rise in their content is a prognostically unfavourable sign in this disease. | |
| 2082016 | HLA susceptibility genes in rheumatoid factor positive juvenile rheumatoid arthritis. | 1990 Nov | Rheumatoid factor positive (seropositive) juvenile rheumatoid arthritis (JRA) is a relatively uncommon but severe form of JRA which shares clinical features with classical adult onset rheumatoid arthritis. Immunogenetic analysis of these patients supports the concept that this likely represents childhood onset of the same disease process. In this report, we review the clinical features as well as previous HLA studies of this disease. We report complete DNA based HLA typing of a small group of these patients, and discuss mechanistic implications of the results. | |
| 2948511 | Abnormal immunoglobulin and rheumatoid factor synthesis by blood lymphocytes in patients w | 1986 Dec | Peripheral blood B lymphocytes from patients with primary Sjögren's syndrome showed significantly higher spontaneous synthesis of IgG, IgM, and IgM rheumatoid factor in vitro, compared with B lymphocytes from healthy controls. Lymphocytes from patients also showed higher IgM rheumatoid factor production after mitogen stimulation. Patients had competent suppressor activity for IgG, but not for IgM synthesis. Pre-irradiation of T cells, but not depletion of OKT8+ cells, markedly enhanced IgG synthesis in cocultures with autologous B cells; therefore, the T lymphocyte responsible for this effect is radiosensitive and is not identified by OKT8. OKT8+ lymphocytes from patients did not suppress Ig synthesis by autologous B plus T cell cocultures. However, OKT8+ cells from normal controls down-regulated Ig synthesis by B plus T cells from patients. The abnormal proportion of helper and suppressor cells suggests that there is altered redistribution of regulatory subpopulations in peripheral blood from Sjögren's syndrome patients. | |
| 2818018 | Validity of reported pain as a measure of clinical state in juvenile rheumatoid arthritis. | 1989 Oct | Reported pain is one valid indicator of clinical state which should be used in the assessment and management of children with juvenile rheumatoid arthritis. Parents' reports of children's pain for 101 children with juvenile rheumatoid arthritis differed significantly by type of juvenile rheumatoid arthritis. When multiple regression was used separately for pauciarticular and polyarticular classifications of juvenile rheumatoid arthritis a measure of clinical state, which reflected joint activity, morning stiffness, and overall disease activity as rated by the doctor, had a significant and independent effect upon pain reported by parents. The child's age was not significantly related to the pain reported by parents. Children's pain reports did not differ significantly between older and younger children. | |
| 3394086 | [Seronegative rheumatoid arthritis in adolescents]. | 1988 | Of 116 persons who developed rheumatoid arthritis (RA) as teen-agers, 56 were seronegative for RF a long period of time. Clinicolaboratory and x-ray manifestations in this group of patients were analyzed. Adolescents with seronegative RA presented a heterogeneous group requiring further investigation. | |
| 1864006 | An abnormal T cell repertoire in hypergammaglobulinaemic primary Sjögren's syndrome. | 1991 Aug | T cell antigen specificity is determined by the products of the genes which encode the variable regions of their receptors. Of the T cell receptor (TCR) variable region gene products examined, only V beta 6.7a TCR-positive lymphocytes were reduced in primary Sjögren's syndrome patients with IgG1 hypergammaglobulinaemia compared with an age-, sex- and HLA-matched control population. The levels of V beta 6.7a T cells were also significantly reduced when these patients were compared with an age- and sex-matched but HLA-unmatched control group and non-tissue typed normal people of both sexes. Since published studies show no such abnormality in rheumatoid arthritis, systemic lupus erythematosus or other autoimmune diseases, this abnormality may reflect a pathogenic process specific to primary Sjögren's syndrome. | |
| 3245349 | [Lung changes in chronic polyarthritis]. | 1988 | Pulmonary alterations in cases of chronic polyarthritis are covered in this paper. The investigations reported were based on literature data and on the author's own postmortem examinations. Rheumatoid pneumonia is defined as an independent disease in its own right. | |
| 2681759 | Lymphedema associated with juvenile rheumatoid arthritis. | 1989 Oct | We describe 3 children with lymphedema associated with polyarticular juvenile rheumatoid arthritis (JRA). We review the occurrence of lymphedema in adult rheumatoid arthritis (RA) as well as other associations. | |
| 3944157 | Changes in the cervical spine in juvenile rheumatoid arthritis. | 1986 Feb | One hundred and twenty-one patients with juvenile rheumatoid arthritis were studied clinically and roentgenographically for evidence of disease of the cervical spine. None of the fifty-seven patients with pauciarticular-onset juvenile rheumatoid arthritis had cervical symptoms or signs, and only one had minor roentgenographic changes of disease in the cervical spine. In contrast, clinical stiffness and roentgenographic changes in the cervical spine occurred commonly in the fifty-one patients with polyarticular-onset disease and in the thirteen patients with systemic-onset disease. Despite extensive roentgenographic involvement of the cervical spine, however, pain in the neck was not a common complaint. Neither severe pain in the neck nor torticollis, occurring either separately or concomitantly, is frequently found in patients with juvenile rheumatoid arthritis, and its presence may suggest an intercurrent problem such as a fracture or infection. As patients with juvenile rheumatoid arthritis rarely have disease in the cervical spine alone, the patient should be carefully examined for involvement of multiple joints. | |
| 1754469 | [Juvenile rheumatoid arthritis with pauciarticular onset and HLA-A, B, DR in Italian child | 1991 Jul | Juvenile Rheumatoid Arthritis is a heterogeneous disease currently divided into different subtypes based on clinical characteristics. Significant alterations in frequencies of HLA-A, B and DR antigens have been described previously in children with pauciarticular onset Juvenile Rheumatoid Arthritis. We report the results of a study on 42 italian children with pauciarticular onset Juvenile Rheumatoid arthritis that partially confirm the literature data. | |
| 3301123 | In vitro binding of IgG from patients with primary and secondary Sjögren's syndrome to di | 1987 Apr | The ability of serum IgG from patients with Sjögren's syndrome (SS) to bind to keratinized stratified squamous epithelium of human skin or rat oesophagus was examined, using an indirect immunofluorescence technique. No in vitro binding of serum IgG to the cell membranes of normal human epidermis was demonstrated in 7 patients with primary SS and two normal controls. Thus, the intraepidermal in vivo IgG deposits previously found in 5 of the 7 patients could not be imitated in vitro. Examination for in vitro binding to rat oesophageal epithelium of serum IgG from 21 consecutive patients with primary SS, 19 consecutive patients with rheumatoid arthritis and secondary SS and 22 normal controls showed that antikeratin antibodies occur more frequently (p less than 0.001) in the patients with secondary SS compared to patients with primary SS and to normal controls. | |
| 2435236 | Amyloidosis secondary to juvenile rheumatoid arthritis: a case report from Saudi Arabia. | 1986 Dec | A case of histologically documented renal amyloidosis occurring in a boy who had juvenile rheumatoid arthritis is presented. The presenting problem was massive proteinuria resulting in nephrotic syndrome. Secondary amyloidosis is a serious complication of juvenile rheumatoid arthritis and it indicates very poor prognosis. | |
| 3343058 | Endomyocardial fibrosis in a white girl with sero-positive juvenile rheumatoid arthritis. | 1988 Jan | A white girl with sero-positive juvenile rheumatoid arthritis was subsequently found to have endomyocardial fibrosis. We believe that these two rare conditions were not causally related. | |
| 2015009 | Relation between antinuclear antibodies and the autoimmune rheumatic diseases and disease | 1991 Mar | Antinuclear activity was assessed in serum samples from a series of 40 patients with differing clinical subsets (including renal and neurological disease) of systemic lupus erythematosus (SLE) against a transformed keratinocyte line (SvK14)* and normal human keratinocytes. Paired serum samples were studied during disease activity and inactivity, and the effects of ultraviolet radiation on the availability of nuclear antigens in the cell substrates were assessed. Serum samples from 20 healthy controls and 40 disease controls, comprising 10 patients each with rheumatoid arthritis, Sjögren's syndrome, scleroderma, and myositis, were also studied. The keratinocytes all provided sensitive substrates for the detection of antinuclear antibodies (ANAs), and in normal keratinocytes treated with ultraviolet radiation nuclear antigens were exposed on the cell surface. There was no correlation between ANAs and disease activity or patterns so, apart from assisting diagnosis, the detection of ANAs is of little relevance to predicting disease activity. | |
| 1767076 | The immunogenetics of juvenile rheumatoid arthritis. | 1991 Nov | Recent major advances in understanding the genetic structure of the human leukocyte antigen (HLA) region and how HLA molecules contribute to immune responses have been paralleled by more precise identification of specific HLA genes conferring susceptibility to the various forms of juvenile rheumatoid arthritis (JRA). This article presents current models for HLA-associated autoimmune disease susceptibility and summarizes the HLA Class II alleles currently known to be associated with JRA: primarily DR8, DR5, DR6, and DPw2.1 in pauciarticular onset JRA; and DR4 in rheumatoid factor-positive polyarticular onset JRA. Rheumatoid factor-negative polyarticular onset JRA and systemic onset JRA are variously associated with several of these same genes. Gene interactions and the clinical utility of HLA typing in this disease are also discussed. | |
| 21263856 | Update on treatment of rheumatoid arthritis. | 1987 Mar | Treatment of rheumatoid arthritis consists of use of drugs, physical measures, social work interventions, education and reconstructive surgery. The physician plays a co-ordinating role, since most patients with significant rheumatoid arthritis will require treatment by more than one member of the health-care team. Our drug armamentarium, including anti-inflammatory agents, disease suppressants, analgesics, rarely steroids, and even more rarely immunosuppressants, can be used to good effect in suppressing the synovitis of rheumatoid arthritis and in relieving pain. Physiotherapy, occupational therapy, nursing and social work interventions will help the patient to maintain function and to maintain their optimal level of fitness, including exercise tolerance, joint range, muscle strength and psycho-social function. Coping abilities can be greatly enhanced by a positive approach from the physician, and this, together with the very real benefits of the foregoing treatments, can produce a highly rewarding result for physician and patient alike, in terms of improved quality of life for the rheumatoid arthritis patient. | |
| 1937185 | [Premature maturation of the carpal bones as an early diagnostic sign of juvenile rheumato | 1991 Jul | A rare premature maturation of the carpal bones in combination with swelling and flexion contracture of the wrist is demonstrated in two cases of juvenile rheumatoid arthritis. The radiologically verified premature and asymmetrical maturation of the carpal bones was the earliest diagnostic sign in juvenile rheumatoid arthritis. | |
| 2757772 | [Autoantibodies in juvenile rheumatoid arthritis. Clinical and serologic study]. | 1989 May | Twenty five patients with juvenile rheumatoid arthritis were studied in order to define the frequency and kind of circulating autoantibodies in this entity, as well as, their relationship with the different disease subgroups and complications. Also the association of these autoantibodies with the activity stage of the illness was determined. There were 14 pauciarticular, 8 polyarticular and 3 systemic juvenile rheumatoid arthritis patients. Twelve have a flare of the disease and 13 were completely asymptomatic. Rheumatoid factor measured by the latex agglutination tests was positive in 6 children. These included 2 patients with pauciarticular disease, showing titers below 1:40 and 4 cases with polyarticular disease, showing titers above 1:320. One of these last patients developed and adult type rheumatoid arthritis during her evolution and was treated with D-penicillamine. The polyarticular but not the pauciarticular patients showed positive tests for rheumatoid factor by nephelometry. No definite association between these laboratory results and the activity of the disease was noted. Positive antinuclear antibodies by the indirect immunofluorescence test were found in 3 pauciarticular and one polyarticular patients. A predominant homogeneous staining was found with the mouse kidney substrate, whereas homogeneous and speckled patterns were noted with the homologous HEp-2 cells. One patient with persistent positive antinuclear antibodies revealed uveitis. Three of the 4 sera with positive antibodies by the indirect immunofluorescent test have also anti-nucleoprotein antibodies by the hemagglutination test with titers above 1:32.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 3197355 | Cerebral infarction in juvenile rheumatoid arthritis. | 1988 | Cerebral involvement associated with juvenile rheumatoid arthritis is rare. It is not influenced by treatment and the presentation can be varied. We describe a case of cerebral infarction secondary to vasculitis in a child with juvenile rheumatoid arthritis. | |
| 3316195 | Use of autologous pregnancy plasma to treat a flare of juvenile rheumatoid arthritis: case | 1987 | A patient with juvenile rheumatoid arthritis whose disease was in remission during pregnancy underwent third-trimester plasmaphereses. The stored plasma was returned to her 1 year postpartum, when the disease flared, without beneficial results. The literature on the use of blood products in rheumatoid arthritis and pregnancy is reviewed. |