Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2629219 | [The correction of disorders in transcapillary metabolism in children with rheumatoid arth | 1989 Nov | Children with rheumatoid arthritis in remission or minimal activity of the disease were examined after sanatorium treatment. It was established that health resort factors had produced a positive capillarotropic effect in rheumatoid arthritis, i.e. capillarotropic insufficiency, tissue hypoxia, inflammation and proteolysis reduced; microcirculation returned to normal. | |
| 1802495 | Diet and disease symptoms in rheumatic diseases--results of a questionnaire based survey. | 1991 Dec | Experiences with food intake, diet manipulations and fast were registered in rheumatic patients. The study was a questionnaire-based survey in which 742 patients participated. It comprised 290 patients with rheumatoid arthritis, 51 patients with juvenile rheumatoid arthritis, 87 patients with ankylosing spondylitis, 51 patients with psoriatic arthropathy, 65 patients with primary fibromyalgia and 34 patients with osteoarthritis. One third of the patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthropathy reported aggravation of disease symptoms after intake of certain foods while 43% of the patients with juvenile rheumatoid arthritis and 42% of the patients with primary fibromyalgia stated the same. Twenty-six percent of the patients with juvenile rheumatoid arthritis and 23% of the patients with rheumatoid arthritis, ankylosing spondylitis and primary fibromyalgia had previously tried certain diets in the attempt to alleviate disease symptoms, whereas 13% of the patients with psoriatic arthropathy and 10% with osteoarthritis had tried diet therapy. Less pain and stiffness were reported by 46% of the patients and 36% reported reduced joint swelling. Similar beneficial effects of diet were also reported in other rheumatic disease groups. Fifteen percent of the patients with rheumatoid arthritis and ankylosing spondylitis had been through a fasting period. Less pain and stiffness were reported by 2/3 of the patients in both groups and half of the patients in both groups reported a reduced number of swollen joints. | |
| 2084858 | [A case of progressive systemic sclerosis with Sjögren's syndrome complicated by nephroti | 1990 Oct | A 53-year-old woman was admitted with complaints of edema in the lower legs. The patient had developed polyarthralgia in 1982 and had been treated with D-penicillamine and prednisolone under the diagnosis of rheumatoid arthritis. She then had developed sclerosis of skin as well as dry eyes and dry mouth. In November 1987, bucillamine treatment had started and proteinuria had appeared in February 1988. Her blood showed hypoproteinemia and was positive for anti-Scl-70 antibody test and for anti-SS-A antibody test. The skin biopsy and labial salivary gland biopsy revealed the increased collagen fibers in the subcutaneous tissue and the round cell infiltration around the salivary ducts. We diagnosed her as progressive systemic sclerosis (PSS) with Sjögren's syndrome (SjS) complicated by nephrotic syndrome. Subsequently a renal biopsy was performed. There were the granular deposition of IgG and complements in the glomerular capillary wall and electron dense deposits in the subepithelial region. These findings suggested that she had membranous nephropathy. Since such a renal lesion was rarely observed in PSS and SjS, it was highly probable that bucillamine induced the nephropathy. The bucillamine treatment was discontinued about 2 months after the nephrotic syndrome had developed. However, the nephrotic syndrome has continued for additional 8 months. Thus it is concluded that the renal damage is one of the important side effect caused by bucillamine. | |
| 1944004 | [Cardiac involvement in juvenile rheumatoid arthritis]. | 1991 Jul | Four cases with cardiac involvement in patients suffering from systemic outset of juvenile rheumatoid arthritis are reported. The cases were chosen out of 83 juvenile rheumatoid arthritis patients studied from 1975 to 1988. They developed respectively myopericarditis (case 1), myocarditis (case 2), endopericarditis (case 3), myopericarditis (case 4). The drug employed in the acute disease phase was exclusively prednisone; in all subjects the acute inflammatory stage resolved. | |
| 3551966 | IgM rheumatoid factor plaque-forming cells in juvenile rheumatoid arthritis. | 1987 Mar | Using a direct, plaque-forming cell (PFC) assay with sensitized sheep erythrocytes, lymphocytes that secrete IgM rheumatoid factors (RF) have been detected in the peripheral blood of patients with juvenile rheumatoid arthritis. Of 15 juvenile rheumatoid arthritis patients tested, 8 were seropositive and 7 were seronegative, but 6 of the seronegative patients had hidden 19S IgM-RF. Ten patients (5 seropositive and 5 with hidden 19S IgM-RF) demonstrated RF-PFC in their peripheral blood (range 15 to greater than 200 RF-PFC/10(6) mononuclear cells). Of 11 patients who had active disease, 10 had RF-PFC, and the 4 patients who had inactive disease had no PFC in their peripheral blood. HLA typing of all 15 patients revealed no correlation between the presence of RF-PFC and HLA type. | |
| 1920311 | The major rheumatoid factor crossreactive idiotype and IgA rheumatoid factor in juvenile r | 1991 Jul | One third of patients with juvenile rheumatoid arthritis (JRA) are seronegative for classic or hidden IgM rheumatoid factor (RF) yet express the major RF crossreactive idiotype (RCRI). We studied 60 children with JRA and 57 pediatric controls for IgA RF and RCRI expression to determine whether RCRI is associated with IgA RF in JRA. Twenty-one patients had IgA RF using rabbit or human IgG as substrate. Twenty-seven patients with JRA expressed high concentrations of RCRI in their sera. Only 9 of these had IgA RF. Eleven of the RCRI+ sera contained neither IgA RF nor classic or hidden IgM RF, and IgA RF was found in patients with all JRA onset subtypes. In JRA, RCRI may be expressed on either IgG RF or on parallel set antibodies without RF activity. | |
| 2155428 | Defective cAMP-dependent phosphorylation of intact T lymphocytes in active systemic lupus | 1990 Mar | The present study was undertaken to establish whether cAMP-dependent phosphorylation of endogenous substrates is impaired in T lymphocytes from subjects with active systemic lupus erythematosus (SLE). In normal human T lymphocytes, the cell-permeable cAMP analog, N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate, induced phosphorylation of substrates with molecular masses of 17.5, 23/25, 33.5 kDa on one-dimensional SDS/PAGE. Maximal phosphorylation occurred at 60 min. In contrast to healthy T cells, the extent of substrate phosphorylation achieved in active SLE T cells (n = 8) was only 15% at 60 min in the 17.5-kDa substrate, 21% in the 23/25-kDa substrate, and 9% in the 33.5-kDa substrate. The rheumatic disease controls (rheumatoid arthritis; primary Sjögren syndrome; n = 8) exhibited a mean 72%, 124%, and 85%, respectively, of phosphorylation observed in healthy T cells. Because the only known mechanism by which cAMP acts is via cAMP-dependent protein kinase (protein kinase A), these data raise the possibility of a defect at the level of this kinase in SLE T lymphocytes. | |
| 3774195 | [Clinico-developmental aspects of juvenile rheumatoid arthritis]. | 1986 Oct 6 | The first part of the report confirms the nosographic autonomy of juvenile rheumatoid arthritis (JRA) in the light of recent international discoveries. The second part identifies the particular clinical and evolutive aspects of the disease that are now universally accepted but still the subject of further research. | |
| 1907395 | Nutritional aspects of juvenile rheumatoid arthritis. | 1991 May | This article focuses on the factors contributing to increased risk for malnutrition in juvenile rheumatoid arthritis patients, the methods of identifying and treating nutritional problems (including protein-energy malnutrition and obesity), and outlines national statistics demonstrating that the pediatric rheumatic patient population is nutritionally underserved. The dietitian, in conjunction with the interdisciplinary treatment team, should be involved in the initial evaluation of all juvenile rheumatoid arthritis patients to facilitate early detection of nutritional problems and initiate nutritional intervention strategies. | |
| 2756652 | [Effect of mud therapy on the links in the pathogenesis of rheumatoid arthritis in childre | 1989 Mar | One hundred and ninety-nine children aged 7-14 and 177 adolescents in remission and minimal manifestations of rheumatoid arthritis (RA) were examined before and after fangotherapy with allowance for activity of the process, age-related reactivity. The comparison involved sympathetic-adrenal function (by urine excretion of epinephrine and norepinephrine), specific and nonspecific immune reactivity (by the level of IgA, IgM, IgG, circulating immune complexes, T and B lymphocytes; RF titers, leukocyte migration inhibition test), platelet components of hemostasis (number of platelets, adhesion induced by ADP and epinephrine). | |
| 3059798 | Juvenile rheumatoid arthritis, human leukocyte antigen, and other immunoglobulin supergene | 1988 Dec 23 | The following four points are discussed in this study: (1) Human leukocyte antigen (HLA) genes are associated with all groups of juvenile rheumatoid arthritis patients to varying degrees. (2) These HLA associations are similar to those of some adult inflammatory arthropathies (rheumatoid arthritis and ankylosing spondylitis), but distinct in others. (3) Predisposition commonly involves a contribution from both of a subject's HLA haplotypes. (4) Unusual immunogenetic aspects include a HLA-DP association, independent of linkage disequilibrium with other class II genes, and a HLA-associated mechanism increasing the relative proportion of girls in the involved sibships. | |
| 2526220 | Variation in the CD4/non-T cell autologous mixed lymphocyte reaction with disease activity | 1989 Feb | Variation in the CD4/non-T autologous mixed lymphocyte reaction (AMLR) with disease activity in juvenile rheumatoid arthritis (JRA) was evaluated by repeated study of 5 patients with rheumatoid factor (RF) negative and 8 patients with seropositive polyarticular onset. Results of repeated studies of adult controls fell within the limits of 1 SD from the previously established normal mean. In contrast, greater variation occurred in results of patients with JRA. Patients with RF negative JRA showed no correlation with disease activity but in seropositive patients stimulation indices in the AMLR improved with a reduction in disease activity and RF titer. | |
| 3738392 | [Relation between the cellularity and lactic acid level in 55 synovial fluids and research | 1986 May | The authors investigated 55 determinations of synovial lactic acid in 7 groups of patients: septic arthritis, seropositive rheumatoid arthritis, seronegative rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitic arthritis, reactive arthritis, mechanical fluids of osteoarthritis. Statistical analysis confirmed the diagnostic contribution of this determination in septic arthritis and demonstrated a correlation between the lactic-acid and cell levels within a cell-level range of 5,000-20,000. A significant difference was detected between seronegative and seropositive forms of arthritis. The physiopathologic interpretation of the findings in cases of rheumatoid polyarthritis and in non-rheumatoid inflammatory rheumatism is discussed. | |
| 2080614 | [The treatment of gonarthritis with yttrium-90]. | 1990 | 200 patients with gonarthritis--142 patients with rheumatoid arthritis, 38 patients with psoriatic arthritis, 7 patients with ankylosing spondylarthritis, 2 patients with collagenosis, 2 patients with antero-arthritis, 2 patients with hemophilia and 7 patients with gonarthrosis were treated with yttrium-90--4-5 mCi intra-articularly. All patients were with high activity of the process and were in the I up to the III roentgenologic stage. The results in 81.25% of the 80 patients with rheumatoid arthritis I and II stage and in 62.57% of the 62 patients in the III stage were considered "very good" and "good". Since the results in these groups are very close and the differences are insignificant it could assumed that synoviorthesis is a useful method also in the III stage of rheumatoid arthritis. The results in the other types of arthritis were favourable in 79.8% of the patients treated, i. e. they are similar to those in rheumatoid arthritis. This allows the assumption that synoviorthesis is a universal method for local treatment of all types of arthritis. The follow up of the patients for one year established a reliable reduction of the articular edema and improvement of the joint movements. | |
| 2497750 | Therapy for systemic juvenile rheumatoid arthritis with gamma-interferon: a pilot study of | 1989 May | Nine severely ill patients with a confirmed diagnosis of systemic juvenile rheumatoid arthritis were treated with recombinant gamma-interferon (gamma-IFN) in addition to the therapy they were previously receiving for their disease. Improvements in clinical symptoms were noted in 7 of the patients, and median laboratory values also showed a marked improvement after gamma-IFN treatment. A relapse occurred in 1 patient. The results of this study should stimulate further research on the use of gamma-IFN in systemic juvenile rheumatoid arthritis, particularly in determining the appropriate effective dosage. | |
| 3395384 | Synovial lymphocyte response to chlamydial stimulation associated with intrasynovial chlam | 1988 Jul | A 48-year-old man with "rheumatoid arthritis" of 3 years duration was found to have synovial fluid lymphocytes that were maximally stimulated in vitro by chlamydial antigen, on 5 of 6 tests over 18 months. Immunocytochemical staining of a synovectomy specimen, using the peroxidase-antiperoxidase technique, subsequently revealed chlamydial antigen in the synovium. The possibility that Chlamydia in the synovium may produce features of rheumatoid arthritis is discussed. | |
| 2734057 | [Clinical and morphologic parallels in children with rheumatoid mono- and oligoarthritis]. | 1989 | Altogether 88 children with rheumatoid arthritis were examined. Of these, 36 patients were with an injury to one articulation and 52 with an injury to one to three articulations. The clinical features of the articulation syndrome, the data obtained as a result of studying synovial fluid and of the morphological picture of synovial biopsy specimens made it possible to denote rheumatoid mono- and oligoarthritis in children as benign varieties of the disease with primarily local (in articulations) inflammatory process. The difference found was only qualitative as regards the intensity of the clinico-laboratory signs (more pronounced in patients suffering from oligoarthritis). This fact provides basis for making the diagnosis of monoarticular or oligoarticular rheumatoid arthritis. | |
| 20144096 | Thermography in juvenile rheumatoid arthritis. | 1987 | In the present investigation, thermography turned out to be a very useful tool for examination and follow-up study of child patients with rheumatoid arthritis. The series comprised 46 patients with juvenile rheumatoid arthritis (JRA) and 50 non-rheumatic children of the same age groups. | |
| 2098890 | [HLA antigens in juvenile rheumatoid arthritis]. | 1990 Jul | Antigens of I class HLA system (locus A and B) were investigated in 67 patients of Latvian nationality suffering from juvenile rheumatoid arthritis (JRA). Associations of HLA antigens with juvenile rheumatoid arthritis partially coincided with the ones revealed earlier. Typing established an increased incidence of antigen B27 (p less than 0.01) and gaplotype A2, B40 (p less than 0.01). Antigen B15 possessed a protective action with respect to JRA. Interlocus combinations demonstrated a closer association with the disease than a single antigen. The authors also revealed markers of various clinico-anatomical variants of JRA. | |
| 3789007 | Cherubism, gingival fibromatosis, epilepsy, and mental deficiency (Ramon syndrome) with ju | 1986 Nov | This is a report on four persons in one family with a condition similar to that described by Ramon et al [Oral Surg 24:436-48, 1967] in two sibs born to a consanguineous couple. Our patients also had mental deficiency, epilepsy, cherubism due to fibrous dysplasia of the maxillae, gingival fibromatosis, hypertrichosis, and stunted growth. This appears to be an autosomal recessive trait in both families. Our patients are the second set reported with this syndrome; they also have juvenile rheumatoid arthritis, which was not described in the family reported by Ramon et al [Oral Surg 24:436-48, 1967]. We conclude that the Ramon syndrome should also include juvenile rheumatoid arthritis. |