Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1856809 | Antinuclear antibody profile in juvenile rheumatoid arthritis. | 1991 Mar | Immunoblot positive sera from children with juvenile rheumatoid arthritis detected from 1 to greater than or equal to 10 proteins in HeLa nuclear sonicates. Thirty percent of the sera reacted with histone H1. Antibodies to at least 1 of 6 most frequently detected nonhistone proteins were present in 85% of the sera. Using immunopurified antibodies to each of the 6 common antigens, we found that 4 of them were associated with mitotic chromosomes. Most sera detected at least 1 of these 4 nonhistone chromosomal proteins. Fifteen percent of the sera immunoprecipitated ribonucleoproteins; some exhibited a novel specificity, precipitating mature transcripts of RNA polymerase III. When present, antibodies to a 45 kDa protein occur only in sera from children without iritis and not in those with active iritis. Overall, the antibody profiles were highly individual and did not appear to correlate with disease subtype or activity. | |
| 3097140 | Human monoclonal anti-T cell antibody from a patient with juvenile rheumatoid arthritis. | 1987 Jan 1 | Antibody JRAI is a human monoclonal IgM antibody derived from a patient with juvenile rheumatoid arthritis that is cytotoxic to a subpopulation of normal T lymphocytes. JRAI recognizes approximately 80% of normal peripheral blood T cells, 90% of CD4+ cells, and 75% of CD8+ cells, as determined by complement-mediated cytotoxicity. Within the CD8+ population, JRAI preferentially spares OKM1+ and Leu-11+ cells. These CD8+ cells retain suppressor-effector potential and show enriched natural killer cell activity. Within the CD4+ population, JRAI preferentially kills cells within the Leu-8+ subset, which contains suppressor-inducer cells, and spares the Leu-8- subset, which contains the helpers for immunoglobulin synthesis. JRAI appears to recognize a previously undefined human lymphocyte surface molecule expressed differentially on phenotypically and functionally distinct subsets of human T cells. | |
| 25025876 | Continuous passive mobilisation following total knee replacement: A retrospective review. | 1990 | A retrospective study of 87 total knee replacement (TKR) operations at the Royal Brisbane Hospital was undertaken in order to assess the effect of continuous passive mobilisation (CPM) of the knee on the post-operative course of the patients undergoing arthroplasty. Two mixed groups of patients with rheumatoid arthritis and osteoarthritis were compared. Forty-eight cases in which patients received CPM during their post-operative course were compared with 39 cases in which CPM was not used. Choice of treatment protocol was at the discretion of the surgeon in each case. The two groups did not differ significantly with regard to pre-operative or post-operative range of knee flexion, length of inpatient stay, or delay before the commencement of knee flexion after surgery. The CPM group was significantly older and this may have masked any beneficial effect of CPM on the measured outcomes. These results suggest that the use of CPM as applied in this study does not significantly alter the post-operative course or the range of movement on discharge. This finding is consistent with those of other studies. The difficulties inherent in this review and the possibilities for further prospective studies are discussed. | |
| 2672130 | Therapeutic approaches for ophthalmic problems in juvenile rheumatoid arthritis. | 1989 Aug | Juvenile rheumatoid arthritis is a disease of children which is chronic and painful, with the potential to produce permanent disability and blindness in a significant portion of cases. The treatment we provide these children may also disable them. Managing this disease process and caring for these patients is a challenging task in which therapeutic efficacy must be continually balanced against treatment morbidity. With respect to ocular disease, we must particularly recognize the difficulties parents have in treating a characteristically asymptomatic process with interventions that can produce unpleasant symptomatology. The importance of discussion of therapeutic decisions with parent and child cannot be overemphasized. Children with JRA should be carefully classified and those at greatest risk for development of ocular disease should receive frequent ophthalmologic screening exams. Early intervention and aggressive medical management of intraocular inflammation will minimize morbidity and permanent visual compromise. Patients should also be closely monitored for ocular side effects of therapies directed against articular disease. Procedures employed for treatment of cataract, glaucoma, corneal, and vitreal opacities must take into account the risk and complications of surgical intervention in the JRA patient prone to perioperative inflammation. | |
| 3180629 | Juvenile rheumatoid arthritis. Monocyte dysfunction in selected patients. | 1988 Nov | The in vitro parameters of cell-mediated immunity were studied in 20 children with an established diagnosis of Juvenile rheumatoid arthritis (JRA) (age range 4-15 years) and 23 age- and sex-matched healthy children. (No attempt was made to correlate the observed changes with clinical course or treatment). We are not certain, at this time, of clinical relevancy or the generalizability of the findings. The normal level of T-lymphocytes (CD3+) and normal proportions of CD4+ and CD8+ lymphocytes were seen in children with JRA. The in vitro response of lymphocytes to T-cell mitogen phytohemagglutinin (PHA) also was normal. The suppressor activity of JRA monocytes was essentially the same as controls. In contrast, monocytes from patients with JRA showed the following: decreased expression of receptors for Fc part of IgG immunoglobulin (FcR), diminished nitro blue tetrazolium (NBT) reduction activity, and depressed expression of Ia.7 major histocompatibility complex (MHC) class II determinants. This indicates that certain monocyte functions in selected patients with a variety of manifestations of JRA are depressed. | |
| 2228045 | DNA typing for HLA-DPB1*02 and -DPB1*04 in multiple sclerosis and juvenile rheumatoid arth | 1990 | DP gene typing using in vitro DNA amplification combined with sequence-specific oligonucleotide probes (SSOP) has recently been reported. The amplification step may be specific for the HLA-DPB locus, or it may be specific for one or a group of HLA-DPB alleles, thus increasing the discriminatory power of the system. We report the combined use of group-specific DNA in vitro amplification followed by SSOP in typing for DPB1*02 and DPB1*04 variants. The method was used to type for these variants in 96 randomly selected, healthy Danes, in 37 patients with pauciarticular juvenile rheumatoid arthritis (PJRA), and in 38 patients with multiple sclerosis (MS). Increased frequencies of the cellularly defined HLA-DPw2 in PJRA and of HLA-DPw4 in MS have previously been reported. In the patient groups, the frequencies of the DPB1*02 and DPB1*04 variants did not differ significantly from those expected based on the cellularly defined HLA-DP types of the patients and the frequencies of the DPB1*02 and DPB1*04 variants among healthy Danes. | |
| 2350617 | Bone metabolism in juvenile rheumatoid arthritis. | 1990 May | Plasma and urinary indexes of bone metabolism were studied in 36 children affected by juvenile rheumatoid arthritis (JRA) during 1 year, in order to evaluate the calciotropic hormone levels and bone mass. Children were divided in three groups according to the subtype of JRA: pauciarticular, polyarticular, systemic. Patients of the latter two groups were on corticosteroid treatment. A control group of healthy children (matched for age and sex) was compared. Children affected by pauciarticular disease did not show any difference with respect to controls. In the polyarticular and systemic groups, basal observation revealed decreased levels of 25(OH)D, significantly lower (P less than 0.01) with respect to the control and pauciarticular groups. After one year, 25(OH)D showed a further decrease in the systemic group, while PTH levels were increased. Moreover, bone mineral density values in systemic JRA were significantly lower than values of a matched control group and did not increase as expected during the year. It seems thus possible that severe JRA has an influence on bone mass, perhaps mediated by a decrease in active vitamin D metabolites. | |
| 20144115 | Relationship Between IgG Complexes and ANTMgG Antibodies in Rheumatoid Arthritis. | 1987 | A selective concentration of antibodies to IgG, both IgM and IgG rheumatoid factors and antibodies to the pepsin site of IgG, was demonstrated in eluates of rheumatoid tissues, but not in control tissues. Many eluates with high amounts of IgG complexes lacked free antibodies to IgG, even when these antibodies were present in the serum. This indicated blocking by IgG complexes. Thus IgM rheumatoid factor could evade detection in some "seronegative" patients by fixation to tissue IgG complexes. | |
| 2518660 | Assessment of protein-energy malnutrition in children and adolescents with juvenile rheuma | 1989 Dec | The incidence of protein-energy malnutrition (PEM) in juvenile rheumatoid arthritis (JRA) patients referred to a dietitian was compared with PEM in a nonreferred JRA population. One pediatric dietitian evaluated all 28 patients using a standardized, 11-parameter comprehensive nutritional assessment profile. Thirty-six percent (10) were found to have PEM (greater than or equal to 6 of 11 parameters abnormal as defined for this study), 36% (10) had no abnormal parameters, and 28% (8) had one-five abnormal parameters. Seventy percent (7 of 10) of the patients referred to a dietitian had PEM: 17% (3 of 18) of the nonreferred JRA patients had PEM. PEM was found in all onset types of JRA. In the ten patients with PEM, 80% had weight less than 5th percentile, 30% had heights less than 5th percentile, 50% had subnormal visceral proteins, 90% had subnormal somatic proteins, and none showed depletion of subcutaneous fat reserves. The high prevalence of PEM supports the need for greater involvement of pediatric dietitians in the evaluation and treatment of JRA patients. | |
| 3323254 | Screening test for rheumatic diseases: a combined enzyme immunoassay of rheumatoid factors | 1987 Dec | Three hundred and one sera from patients with rheumatic and other diseases were investigated using a simple enzyme immunoassay for screening of rheumatoid factors and antinuclear antibodies. The assay had a sensitivity of 77% for systemic lupus erythematosus, 90% for the primary sicca syndrome, and 89% for rheumatoid arthritis. Only 13% of sera from patients with chronic non-rheumatic diseases were positive. The test was further evaluated in a group of patients with suspected rheumatic disease who were followed up for six to 12 months. The test was positive in 16 of 17 sera from patients with connective tissue diseases but in only seven of 36 sera (19%) from patients with non-inflammatory joint diseases. None of the four patients with reactive arthritis was positive by this test. The sensitivity of the assay was comparable with that of the agglutination and immunofluorescence tests for rheumatoid factors and antinuclear factors. For the screening of rheumatoid factor and antinuclear antibodies this kind of test panel offers a simple alternative to the conventional tests for small clinical laboratories and for those in which the autoantibody tests could be automated, as the assay can be performed in one working day and only one dilution of serum is needed to obtain a quantitative result. | |
| 2766336 | [Response of peripheral blood lymphocytes to antigenically nonspecific mitogens in systemi | 1989 Jun 16 | In 24 patients with systemic lupus erythematosus the proliferating response of lymphocytes of the peripheral blood stream to mitogens PHA, ConA and PWM was examined. The spontaneous incorporation of 3H-thymidine was increased in two patients. The mean response to PHA and PWM was reduced, while the response to ConA was within the normal range. In the active stage of the disease the lymphocyte response was in general lower in the stage of low activity. There was no correlation between the number of CD4 and CD8 lymphocytes nor the CD4/CD8 index and the lymphocyte response to mitogens. In systemic lupus erythematosus the response to PWM was lower than in rheumatoid arthritis, while in rheumatoid arthritis the response to PHA and ConA was lower than in systemic lupus erythematosus. | |
| 21234065 | [Not Available]. | 1990 Mar | Rheumatoid arthritis is the most common chronic inflammatory joint disease. To overcome joint inflammation and eventually induce disease remission, the physician must often use drugs that are more and more toxic. Indications, method of administration, and common adverse effects of non-steroidal anti-inflammatory drugs, local steroid injections, second-line agents, and steroids are reviewed. The author briefly discusses a new therapeutic concept and emphasizes the importance of patient education and early referral to an interdisciplinary rehabilitation team. | |
| 2307887 | The hand in psoriasis. | 1990 Feb | Fifty-six patients with psoriatic arthropathy have been reviewed to asses the extent and severity of their hand involvement. The hand was affected in 84% of cases. Although the distal interphalangeal joints are said to be classically affected, we found the proximal interphalangeal and metacarpophalangeal to be more frequently involved. Many other findings often associated with rheumatoid arthritis (e.g. boutonniere and swan-neck deformities, or tenosynovitis) can be seen in psoriatic arthropathy. | |
| 3050922 | Rheumatic disease in childhood. | 1988 | The autoimmune diseases, juvenile rheumatoid arthritis and systemic lupus erythematosus, are two of the more common acquired chronic diseases of childhood. In this article we will describe features of the diagnosis and treatment of these disorders. Particular emphasis is placed on the complications and how to anticipate them. The management of these diseases must include an appreciation of how chronic illness can affect family function and school relationships. With early attention to these nonmedicinal details, the majority of children can progress through childhood and adolescence with few physical or emotional handicaps. | |
| 1917408 | Carpo-metacarpal growth disturbance and the assessment of carpal narrowing in children wit | 1991 Aug | Second metacarpal length (M2), radio-metacarpal length (RM), and intermetacarpal width (W) were measured on 96 radiographs in 52 children with polyarticular juvenile rheumatoid arthritis (JRA), and compared with body height and skeletal maturation in order to: (1) differentiate between processes resulting in retardation of bone growth and those producing delay in skeletal maturation; (2) assess the severity and progression over time of such retardation; and (3) assess the impact of retardation of the second metacarpal on the assessment of carpal narrowing in children with JRA. All measurements were converted into z scores (the units of standard deviation above or below the normal mean for each measurement) based on published norms. Retardation of M2 (mean z scores -0.91) began earlier and was more severe compared with retardation of height (mean z score -0.25). This disproportion widened with increasing duration of disease. That this primarily represents a disturbance in M2 growth rather than a secondary effect due to altered maturation is suggested by the bone ages being normal (mean z score 0.14) and the absence of premature closure of the metacarpal physes. Z scores for RM/W (mean -3.53) were at least 1 Z more negative than for corresponding measurements of RM/M2 (mean -2.41) in 47 (90.4%) children and the mean difference between the z scores for RM/W was -1.12. This discrepancy between RM/W and RM/M2 was eliminated by correcting for the reduction in M2. | |
| 3474778 | Auranofin therapy in juvenile rheumatoid arthritis: a 48-week phase II study. | 1986 | A 48-week phase II open, uncontrolled study of auranofin (AF) in patients juvenile rheumatoid arthritis (JRA) was conducted to assess efficacy, tolerance and serum gold levels, and to consider the feasibility of further controlled studies (phase III) in such patients. The study group included 25 patients (20 F, 5 M) with active pauciarticular (n = 4) or polyarticular (n = 21) JRA. Median age was 100 months (range 62-176); median disease duration was 55 months (range 13-155). AF was given at 0.1 mg/kg/day divided into 2 doses, and increases to maximum of 6 mg/day were permitted if clinical improvement was insufficient. Nonsteroidal anti-inflammatory drugs and physiotherapy also were allowed. Significant improvement (p less than or equal to 0.05) was observed in the various joint counts and articular indices, as well as in the physician's global assessment of health. Some subjective functional measurements also were improved, but the differences were not statistically significant. There were no clinically important trends in the laboratory measurements. No patient was withdrawn because of adverse reactions; 1 was withdrawn because of disease exacerbation and 3 for lack of response. Mild adverse reactions were seen in 9 patients: 6 had abdominal pain, 6 diarrhea/loose stools, 1 nausea, 3 rash, 2 pruritus. Two patients had dosage reduced because of loose stools. Serum gold levels varied greatly; increased dosage usually resulted in increased serum levels. Occurrence of adverse reactions or response to therapy was not related to increases in dose or to serum gold levels.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1784287 | [Electromyographic and electrognathographic analysis of patients with juvenile rheumatoid | 1991 Sep | Seven patients, affected by JRA, underwent an examination by electromyography and electrognathography, to judge variations in the activity of some masticatory muscles and in the movements of the jaw. The muscular activity and masticatory mechanics show a reduction in the freedom of movement. The system cannot work in all the positions allowed by the physiological mobility of the TMJ. | |
| 3417702 | The Dana total shoulder arthroplasty. | 1988 Sep | Fifty-six Dana unconstrained total shoulder arthroplasties in forty-seven patients were followed for a minimum of two years. The preoperative diagnoses included osteoarthritis, rheumatoid arthritis, traumatic arthritis, avascular necrosis, failed hemiarthroplasty, and failed total shoulder arthroplasty of another design. For all of the patients, the average rating for pain improved from 3 points preoperatively to 8 points postoperatively, and the average rating for function improved from 3 to 7 points. The ranges of abduction and of external rotation improved substantially in the shoulders that were affected by osteoarthritis, rheumatoid arthritis, or osteonecrosis. Ten patients were treated with a hooded glenoid component, designed to improve stability in shoulders in which the rotator cuff is deficient. In these shoulders, both the rating for pain and the rating for function improved, although the range of motion did not. Complications that required revision of the arthroplasty developed in five shoulders in which a regular component had been implanted and in two that had a hooded glenoid component. A radiolucent line developed at the bone-cement interface of the glenoid component in fifty-three shoulders, but only two revisions were done for loosening of the glenoid component. | |
| 2010592 | Misdiagnosis of rheumatoid arthritis in an elderly woman with gout. | 1991 Apr | Polyarticular gout may be misdiagnosed in the elderly. This reflects the confusing clinical presentation of "diuretic gout" in the elderly, characterized by polyarticular onset, subacute symptoms, hand involvement, and early development of tophi. A misdiagnosis of rheumatoid arthritis can lead to poor treatment of gout, failure to recognize underlying renal insufficiency, and associated cardiac risks. Hyperuricemia may reflect systemic ATP depletion in acutely ill patients and thus represents a predictor for mortality. Medical treatment of polyarticular gout in elderly patients with compromised cardiac and renal function requires recognition of the clinical profile and consideration of the increased toxicity from standard therapies. | |
| 3532285 | Separation and characterization of complement-fixing immune complexes in juvenile rheumato | 1986 | Immune complexes (IC) in sera from patients with juvenile rheumatoid arthritis (JRA) were isolated by the use of immunoabsorbent columns. Sera from 14 JRA patients (four seropositive for 19S IgM RF and 10 seronegative, but nine having hidden 19S IgM RF) were analyzed by the anti-human Clq (alpha HClq) and anti-human C3 (alpha HC3) columns. The columns were sequentially eluted with veronal buffer, 0.02 M EDTA, 0.5 M NaCl, and 1 M propionic acid. By the alpha HClq column, IgM RF were detected in at least one of the separated IC fractions of 13 of 14 patients and IgG RF in three patients. By the alpha HC3 column, only five patients demonstrated IgM RF and only one IgG RF in the eluted fractions. On sucrose density gradient analysis (SDGA), all IC were demonstrated in the peaks greater than or equal to 19S.19S IgM RF were demonstrated by ELISA in all 14 patients, but IgG RF in only three. These studies demonstrate that complement-fixing 19S IgM RF, IgG, and IgG RF containing IC can be detected in the serum of JRA patients. |