Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1877636 | The contribution of motor skills and playfulness to the play performance of preschoolers. | 1991 Aug | Consideration of a child's motor proficiency, intrinsic motivation, internal locus of control, and freedom to suspend many of the constraints of objective reality were proposed to provide a more comprehensive assessment of play than would an assessment of play performance alone. For empirical validation of this conceptual model of play, 29 subjects (15 nondisabled children and 14 children with juvenile rheumatoid arthritis) between the ages of 4 years 6 months and 6 years 6 months were given four assessments: (a) the Preschool Play Scale (Bledsoe & Shepherd, 1982, Knox, 1974); (b) the Bruininks-Oseretsky Test of Motor Proficiency (Bruininks, 1978); (c) the Preschool and Primary Internal-External Locus of Control Scale (Nowicki & Duke, 1974); and (d) tests of associative fluency (Wallach & Koogan, 1965; Ward, 1968). Multiple regression procedures revealed that, when considered together, scores on the Bruininks-Oseretsky Test of Motor Proficiency, tests of associative fluency, and the Preschool and Primary Internal-External Locus of Control Scale predicted scores on the Preschool Play Scale, thereby supporting the usefulness of the proposed theoretical model. Further, there was no significant difference in the mean scores of the two groups on the Preschool Play Scale. Although this finding may be an artifact of the small sample size, it also may support the authors' belief that children with motor impairments are able to compensate for their limitations by developing areas of relative strength that allow them to play normally. When this belief was further tested with Pearson product-moment correlations and Fisher's Z transformations, it was found that correlations between the test scores of the nondisabled children were not significantly different from those of the children with juvenile rheumatoid arthritis. Clearly, further research is needed. | |
| 2381137 | Correlation of anti-cytoskeleton antibody activities in synovial fluid with interleukin-6 | 1990 Jul 5 | Synovial fluids and sera from patients with rheumatoid arthritis, psoriatic arthritis, yersinia arthritis, Behçet's syndrome, Crohn's disease, and osteoarthritis were tested for antinuclear antibodies and antibodies to five cytoskeletal components in sensitive enzyme-linked immunosorbent assay (ELISA) systems and for IL-6 concentrations in a proliferation assay (IL-6 dependent hybridoma cell line B13.29, subclone B9). Statistically significant correlations between antibody activities and IL-6 levels were found for vimentin antibodies (r = 0.56; p less than 0.05) and actin antibodies (r = 0.44; p less than 0.05). In patients with chronic and active disease like rheumatoid arthritis and psoriatic arthritis, optical densities measured by vimentin- and actin-ELISA were significantly different from those measured in patients with osteoarthritis. To date only a few reports exist concerning the incidence of antibodies in synovial fluids. We have shown to our knowledge for the first time that IL-6 seems to induce synovial fluid antibody activities restricted to cytoskeletal components of synoviocytes (i.e., vimentin and actin). Synovial fluid antibody activities against vimentin and actin appear to be markers of activity in patients with inflammatory joint disease. | |
| 2343452 | HLA extended haplotypes in childhood and adult onset HLA-DR4-associated arthropathies. | 1990 Feb | Alpha HLA-DR4 extended haplotypes have been established by family studies in children and adults with chronic arthritis, the children having polyarticular juvenile rheumatoid arthritis and the adults rheumatoid arthritis. These diseases are probably the same disorder presenting at different ages. The results demonstrate age-related differences in the frequency of HLA-DR4 extended haplotypes between the two groups of patients. The childhood onset was associated with the presence of the HLA-B44, SC30, DR4 extended haplotype, whereas the adult form was more strongly associated with the HLA-Bw62, SC33, DR4 haplotype. These results suggest that differences in the age at onset are influenced by the MHC in addition to the presence of the HLA DR4 gene itself. | |
| 12290550 | [Causes of joint pain in children]. | 1991 Jan | ||
| 20144110 | Involvement of the lateral atlanto-axial joints as first and late symptom of rheumatoid ar | 1987 | Thirty cases of unilateral or bilateral atlanto-axial arthritis are described. They were found among 606 RA patients. According to the degree of involvement, the 30 cases were divided into four groups: A. 16 cases. B. 5 cases. C. 7 cases. D. 2 cases. In two patients the atlanto-axial arthritis was the primary lesion. The clinical and the radiological course of the disease is described. The systematic search for this type of arthritis is emphasized as it is often asymptomatic. The author gives details of a clinical test, specific for the function of the atlanto-axial joints. | |
| 3560094 | Routine analysis of synovial fluid cells is of value in the differential diagnosis of arth | 1986 Dec | Results of synovianalysis are reported in 129 children, 91 with juvenile rheumatoid arthritis (JRA), 13 with septic arthritis, 12 with enteroarthritis, 12 with acute transient arthritis and 1 with bacillus Calmette-Guerin arthritis. Mononuclear cells were dominant in the patients with oligoarticular JRA (mean 64%, median 74%), and among these, significantly lower proportions of polymorphonuclear (PMN) cells were found in patients with early onset disease with antinuclear antibodies or chronic uveitis than in those with late onset with HLA-B27. PMN cells were dominant in polyarticular and systemic onset JRA, septic arthritis and enteroarthritis. The sensitivity and specificity of a white cell count above 40,000/mm3 exceeded 90% in differentiating septic arthritis from the other kinds of arthritis. Measurement of total protein, glucose and lactate in synovial fluid was of limited diagnostic value. | |
| 27237911 | Cautionary tale. | 1990 Jan 30 | I read with interest Saraswathi Vaidyanathan's article Rheumatoid arthritis: educating the patient in India' (Nursing Standard December 13-19), when she illustrated some very sound principles in establishing health education and teaching programme for sufferers of this disease. | |
| 2077155 | [A case of psoriatic arthropathy complicated with clinical feature of ankylosing spondylit | 1990 Nov | A 25 years old man with psoriatic arthropathy complicated with clinical feature of ankylosing spondylitis was reported. 230 Japanese cases of psoriatic arthropathy were discussed. RESULT: 1) commoner in male 2) the cases that skin lesions were prior to arthritis and the cases that arthritis was prior to skin lesions were almost the same number 3) rheumatoid factor was seropositive in 17% of the cases 4) HLA-B27 was present in 9 of 50 cases and 7 of these 9 cases had central type arthritis 5) the cases had accompanied nail dystrophies in a high rate 6) concerning on skin lesion, many cases had atypical psoriatic lesion 7) 21.1% of the cases had central type arthritis 8) there were no certain effective therapy 9) prognosis of central type cases were relatively worse. | |
| 2057725 | [Rheumatic diseases in hospital outpatients in Lome (Togo)]. | 1991 May | The aim of this study was to point out the different kinds of diseases in patients attending the rheumatology unit of Lomé Hospital from October 1989 to October 1990. Eight hundred and forty three patients (456 females, 387 males) were examined. The main results of this study are as follows: degenerative spinal involvement: 39.6%; tendinitis: 13.8%; knee osteoarthritis: 12.7%; hip osteoarthritis: 0.7%; hip involvement associated with hemoglobinopathies: 1.3%; gout: 5%; spondylarthropathies/0.8%; asymmetrical oligoarthritis: 0.6%; rheumatoid arthritis/0.2%; chronic polyarthritis without joint destruction: 1.2%; osteoporosis: 0.1%; connective tissue diseases: 0.7%. The scarcity of hip osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus and osteoporosis is in accordance with previous studies. The same is true of the high frequency of degenerative spinal involvement and knee osteoarthritis. However, the high frequency of gout and the non exceptional character of spondylarthropathies are in contrast with previous studies effected in Black Africa. | |
| 2478136 | Lack of association of a restriction fragment length polymorphism for serum amyloid P gene | 1989 Oct | The prevalence of a recently described restriction fragment length polymorphism using Msp I for the serum amyloid P gene was determined in 5 groups of patients. Patients with reactive (secondary) amyloidosis, juvenile rheumatoid arthritis, related inflammatory conditions, or juvenile rheumatoid arthritis with reactive amyloidosis, and healthy control subjects were found to be polymorphic for 8.8-kb and 5.6-kb gene fragments; they either had one or the other or both fragments. No significant differences were seen between these groups with relation to this polymorphism, and no correlation with the presence of reactive amyloidosis was observed. | |
| 21234074 | Approach to the patient with polyarthritis. | 1990 Mar | When a patient has joint pain, the most important decision for the physician is to distinguish between an inflammatory or non-inflammatory process. The most common inflammatory polyarthritides include rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and less likely, chronic tophaceous gout. Investigations usually help only to confirm a diagnosis already suspected. Generally, few symptoms are pathognomonic of a particular diagnosis. Follow up over several months to a year and anti-inflammatory medications, when indicated, are the mainstay of early management. | |
| 2638886 | [Compromised function of the masticatory apparatus in juvenile rheumatoid arthritis]. | 1989 Jan | A clinical and epidemiological study was conducted on a sample of 30 J.R.A. patients in order to identify the signs and symptoms of masticatory dysfunction. Helkimo's indices were used to quantify the data obtained. The incidence of masticatory dysfunction was significantly high as was confirmed by comparison with a random sample of healthy adolescents. The most common signs were alterations in the quality of mandibular movement, pain on muscle palpation and joint crepitus. The symptoms included spontaneous pain during mastication and tension headache with obvious psychobehavioural implications. The importance of early orthognathodontic intervention to reduce the sequelae of the joint damage became evident as did the role of the dentist in the framework of a broader and more specific multidisciplinary approach. | |
| 2217093 | [Sicca syndrome in sarcoidosis--an overlap syndrome?]. | 1990 Aug | This is a case report on a 66-year old woman who suffered from chronic polyarthritis for 15 years and developed a sicca syndrome pattern for 2 years. 2 years later epithelioid cell granulomas were found from a submandibular lymph node as well as from a suspicious area at the epiglottis and the mucosa of the upper lip. Moreover, there was a chronic keratoconjunctivitis and discrete lung involvement. The sarcoidosis on the lip and at the epiglottis disappeared, and lung involvement and conjunctivitis improved under corticosteroid therapy. In spite of above therapy, the sicca syndrome pattern and the rheumatic complaints (osteoporosis) persisted. | |
| 1909467 | [A comparative assessment of the efficacy of thiophosphamide electrophoresis and ultrasoun | 1991 | The results of the treatment of patients suffering from rheumatoid arthritis with ultrasound (group I), thiophosphamide electrophoresis (group II), ultrasound and thiophosphamide (group III) and with medicamentous agents alone (group IV) are compared. The positive therapeutic effect was recorded in patients of all 4 groups, with that effect being most remarkable in group III. | |
| 2563402 | Advanced drug therapy for juvenile rheumatoid arthritis. | 1989 Feb | Childhood rheumatic diseases are frequently chronic, painful, and potentially debilitating. They may adversely affect growth and development, compromise future quality of life, and contribute added stress to the patient and family. Awareness of these consequences provides a stimulus to develop more effective therapeutic regimens. There is optimism that new therapeutic strategies will result in the more widespread and earlier use of drugs, including those discussed, that may substantially impede or arrest the underlying disease. | |
| 3430996 | [Juvenile uveitis]. | 1987 Nov | Chronic anterior uveitis in children suffering from juvenile rheumatoid arthritis may develop very early, when the patient is as young as two or three years old; it affects twice as many girls as boys. The arthritis is often localized in one joint (pauciarticular or oligoarticular form); Still's syndrome is very rare. Local treatment with cycloplegics and steroids has to be combined with systemic immunosuppressive medication with cyclophosphamide. Chronic intermediate uveitis (pars planitis) usually affects teenagers in good health. Peripheral fundus changes can be detected most easily by biomicroscopy with the three-mirror contact lens. Cystoid macular edema is frequent and, together with vitreous opacities, is responsible for a deterioration in central vision. In most cases local treatment with subconjunctival injection of depot steroids is sufficient. Immunosuppressive treatment or surgical intervention is only indicated in severe cases where there is a risk of complete loss of vision. | |
| 3814201 | Evidence of the validity of the Arthritis Impact Measurement Scales. | 1987 Jan | The Arthritis Impact Measurement Scales (AIMS) were administered to 120 patients with rheumatoid arthritis. These patients also rated the importance of various aspects of their treatment. Our findings support the validity of the pain, anxiety, depression, dexterity, and physical activity subscales of the AIMS. The household activity subscale, however, may not be appropriate for use with men, and the activities of daily living subscale may be insensitive to mild impairment. | |
| 1979063 | A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis. | 1990 | We studied the first domain of the HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci of 67 HLA-DRw8-positive Caucasians including 43 with early-onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA, alternatively known as early-onset pauciarticular juvenile chronic arthritis). Serology, restriction fragment length polymorphism (RFLP), and polymerase chain reaction (PCR) oligotyping revealed that 62, including all the EOPA-JRA patients, carried the HLA-DRB1*0801, DQA1*0401, DQB1*0402 genotype. Approximately one-fifth of the controls carried atypical HLA-DRB1, HLA-DQA1, and/or HLA-DQB1 loci on their HLA-DRw8 haplotype confirmed by family studies. DNA sequences of HLA-DRB1, DQA1, and DQB1 alleles in patients and controls were identical to those previously reported. Disease association studies in 113 EOPA-JRA patients and 207 controls unselected for HLA-DRw8 revealed that the HLA-DRB1*0801, DQA1*0401, DQB1*0402 genotype was associated with a higher relative risk (RR) for disease (RR = 12.8, chi 2 = 48.8, P less than 10(-4)) than was the serologically defined presence of HLA-DRw8 (RR = 8, chi 2 = 39, P less than 10(-4)). Further analysis suggested that the DQ genes on HLA-DRw8 haplotypes are as likely as the DR genes to contribute to the pathogenesis of EOPA-JRA. This study increases to five the number of HLA-DR/DQ haplotypes identified in HLA-DRw8 Caucasians. | |
| 2735961 | Toxicity and serum levels of methotrexate in children with juvenile rheumatoid arthritis. | 1989 Jun | Twenty-three children with destructive polyarticular juvenile rheumatoid arthritis (JRA) were treated for 0.5-4.3 years (median 1.6 years) with weekly doses of methotrexate (MTX) (0.11-0.6 mg/kg/week). Serum levels of MTX at 1 hour and at 24 hours after drug administration were obtained at each dosage level and every 3 months after a stable dosage was achieved. No patient had serum levels of MTX that were in the toxic range nor evidence of hematologic, skin, mucous membrane, gastrointestinal, or pulmonary abnormalities. Ten patients had transiently elevated serum transaminase levels. Arthritis symptoms improved in 21 of these JRA patients, and the improvement was significantly associated with a mean 1-hour serum MTX level of greater than or equal to 5.8 x 10(-7)M (P = 0.008) and a dosage of greater than or equal to 0.3 mg/kg/week (P = 0.004). The 1-hour serum level of MTX was correlated with the MTX dosage (r = 0.28, P = 0.005). Our observations suggest that with close monitoring, MTX can be used safely at dosages as high as 0.6 mg/kg/week, and improvement in the symptoms of JRA will become evident when the serum levels of MTX 1 hour after administration approach 6.0 x 10(-7)M. | |
| 2023215 | Arthritis and nephritis in patients with systemic lupus erythematosus. | 1991 Feb | Previous publications suggest that in patients with systemic lupus erythematosus (SLE), rheumatoid factor (RF) may be "protective" against nephritis. In our study of 662 patients with SLE, we found that persistent, rheumatoid-like arthritis showed a much stronger inverse correlation with nephritis than RF. Of 186 such patients, 59 developed clinically evident nephritis (32%) compared to 263 of the other 476 patients (55%) (p less than 10(-7). RF showed only a weak inverse relationship to nephritis (p = 0.064). We conclude that the presence of persistent rheumatoid-like arthritis in patients with SLE identifies a clinical subset of patients who are less likely to develop nephritis than those with no arthralgia, no objective arthritis or only episodic arthritis. We hypothesize that such patients represent a genetically determined subset among patients with SLE and that perhaps they are more likely to bear the HLA-DR4 allele. |