Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1772291 | Absence of autoimmunity to type II collagen in generalised nodal osteoarthritis. | 1991 Nov | A cardinal feature of generalised nodal osteoarthritis is the loss of articular cartilage. To determine if autoimmunity to these cartilage collagens occurred, serum antibodies to native and denatured type II collagen were measured by enzyme linked immunosorbent assay (ELISA) in 96 patients (90 women, six men, aged 47-91 years) with generalised nodal osteoarthritis. Generalised nodal osteoarthritis was diagnosed by typical clinical and radiological features. Serum samples from 42 blood donors were assayed as controls. No significant difference was found between the patients with generalised nodal osteoarthritis and the controls. Furthermore, the 20 patients who were HLA-A1, B8 positive had similar antibody levels to the group as a whole. One woman patient with generalised nodal osteoarthritis (HLA-A1, B8 negative) had markedly increased antibody levels to native and denatured type II collagen in a pattern similar to that seen in patients with rheumatoid arthritis. This patient did not develop super added rheumatoid arthritis during a three year follow up period. Autoimmunity to type II collagen is therefore rare in generalised nodal osteoarthritis. A lack of collagen antibodies in a condition characterised by hyaline cartilage loss suggests that the presence of such antibodies in rheumatoid arthritis is more than a secondary event to joint damage. | |
| 2399579 | [Sociomedical aspects of primary Sjögren's syndrome]. | 1990 Jul 16 | Forty patients with primary Sjögren's syndrome were interviewed. Poor social conditions during adolescence were not predisposing factors. A significantly higher number of patients grew up in urban than in rural districts, but this difference may be because most of these patients were from Zealand. Patients over the age of 35 years had left school later than the normal population. The matrimonial status did not differ from the normal population, except that the patients had significantly fewer children. The first symptoms of disease were recorded at an age of 20-50 years by 73%. More than half of the patients employed at commencement of the disease had to give up, and received disability pensions or retired early. A number of patients found less demanding jobs. The reasons were extreme fatigue (54%), arthralgia (42%), ocular- (17%) or oral dryness (8%). Social isolation was a problem for many patients and about 50% reported psychological problems. Drug expenses were moderate, whereas dental treatment was often considered to be a major economic problem. | |
| 1851057 | Autoantibodies to DNA topoisomerase II in juvenile rheumatoid arthritis. | 1991 May | Sera from 58 children with juvenile rheumatoid arthritis were examined for the presence of antibodies to DNA topoisomerase II. Eight sera were reactive in immunoblotting with purified human topoisomerase II and a protein encoded by a cloned cDNA expressed in Escherichia coli which represents the carboxy-terminal domain of the human enzyme. In addition, the sera detect topoisomerase II in mitotic chromosomes and chromosome scaffolds. Five of the sera bind to the native enzyme in solution and deplete such solutions of the active enzyme. All eight sera also contain antibodies to nuclear antigens other than topoisomerase II. | |
| 2523911 | D-penicillamine-induced elastosis perforans serpiginosa in a child with juvenile rheumatoi | 1989 May | Elastosis perforans serpiginosa is a rare complication of D-penicillamine therapy. It has been reported to occur in Wilson's disease and cystinuria, usually after many years of high-dose therapy. We report a case of D-penicillamine-induced elastosis perforans serpiginosa with unique clinical features occurring in a 10-year-old child with juvenile rheumatoid arthritis who received only 71 gm of the drug over 9 months. The case is also unusual because of the short course and low cumulative dose of drug received and because of the calcification of elastic fibers. The calcification of elastic fibers suggests that this case may represent an unusual variant of elastosis perforans serpiginosa or an overlap with pseudoxanthoma elasticum. All reported cases of D-penicillamine-induced elastosis perforans serpiginosa are reviewed, and histopathologic and electron microscopic findings are presented. The theoretic mechanisms of action of D-penicillamine on elastic tissue synthesis and morphology are discussed. | |
| 2070646 | Incomplete Reiter's syndrome in a black patient showing HLA B 27. | 1991 Apr | We report a case of incomplete Reiter's syndrome in a black patient, who was first incorrectly diagnosed as having rheumatoid arthritis. We discuss the challenge involved in diagnosing incomplete forms of the syndrome and the value of a positive HLA B 27 antigen level in black patients. | |
| 3628048 | [Viral arthritis in childhood]. | 1987 Jan | Many viruses can cause arthritis in children. Viral arthritis can mimic other rheumatic conditions as rheumatic fever, septic arthritis or juvenile rheumatoid arthritis. Usually viral arthritis is a self-limited disease; occasionally it may show a chronic course lasting several months. Rubella arthritis follows natural infection or vaccination; it looks the expression of a direct invasion of the synovial tissue by the virus. Hepatitis B arthritis is an immune-complex synovitis occurring during the prodromic stage of HBV infection. | |
| 1686281 | DNA analysis of HLA-DR, DQ and DP genes in pauciarticular juvenile rheumatoid arthritis. | 1991 Nov | HLA-DR, DQ, and DP alleles were determined by restriction fragment length polymorphism (RFLP) and oligonucleotide hybridization analysis in 50 Caucasian children with pauciarticular juvenile rheumatoid arthritis (PaJRA) and 82 controls. There was an increased frequency of DR5, DRw8, and DQw4, as well as individual DQ alpha and beta chains, DQA*0401 and DQB1*0402, respectively, in this group of patients. There was an absolute association between DRw8, DQw4, DQA1*0401, and DQB1*0402 in the patient population. HLA-DPw2.1 was also increased in frequency. There was little evidence of linkage disequilibrium found between DPw2.1 and DR5, DRw8, or DQw4. These MHC Class II associations were more characteristic of those patients with young age of onset (less than 5 years), rather than those with onset greater than or equal to 5 years of age. Our data confirmed the previous associations of HLA-DR5, DRw8, and DPw2.1 with PaJRA and suggested a new association for DQ alpha and beta genes in the clinical expression of this disease. | |
| 1941832 | Auranofin therapy for juvenile rheumatoid arthritis: results of the five-year open label e | 1991 Aug | Eighty-eight children with juvenile rheumatoid arthritis (JRA) who completed a double blind, randomized placebo controlled trial of oral gold were entered into an open label extension phase during which they received auranofin (AF) at a dosage of 0.15-0.2 mg/kg/day (9 mg/day maximum). Eleven (12.5%) patients completed 5 years of AF therapy; 77 (87.5%) did not. Fifteen (17%) of the 88 were in disease remission at the final visit. Mean duration of therapy for those who discontinued was 646 days. Parental/patient decision and insufficient therapeutic effect were the 2 most frequent reasons for early termination, followed by adverse effects. Though relatively well tolerated, AF provides adequate longterm management for only a small percentage of patients with JRA. | |
| 1845410 | Technetium-99m nanocolloid scintigraphy in rheumatic inflammation in children. | 1991 | Technetium-99m HSA (human serum albumin) is a nanometer-sized albumin-based inert colloid, which has a specific ability to accumulate in inflamed soft tissue lesions. With a particle size smaller than 30 nm, Tc-99m HSA spills into the extravascular space in the sites of inflammation because of the changed capillary permeability. The conventional tracer in joint scintigraphy, technetium-99m methylene diphosphonate (Tc-99m-MDP) is a boneseeking compound, which strongly accumulates in the epiphyseal area of growing bones. This makes the estimation of the inflammatory process in the joints of growing children difficult. The nanocolloid compound has not this disturbing tendency. This fact makes the joint scans more specific and the detection of inflammatory lesions is easier especially in children. In our study Tc-99m HSA is used for the detection of rheumatic inflammation in children with juvenile rheumatoid arthritis. We examined 24 children with juvenile rheumatoid arthritis, age 3-19 years, 20 girls and 4 boys, who all had clinically active inflammation in the joints or in the tendon sheets. The uptake pattern of nanocolloid parallels the severity of the inflammatory process in periarticular tissues and tendon sheets. In suspicious cases, the comparison with the contralateral area helps in the detection of the lesion. Therefore, when investigating paired joints, the scintigraphy of symmetrical parts is necessary. | |
| 2179549 | Septic arthritis due to Listeria monocytogenes: report and review of the literature. | 1990 Jan | Septic arthritis due to Listeria monocytogenes is an uncommon infection amenable to antibiotic therapy along with open or closed drainage. We report successful antibiotic treatment of a prosthetic joint infection in a man with seropositive rheumatoid arthritis and present a review of the literature describing this specific infection. | |
| 2379343 | Primary Sjögren's syndrome: a subjective description of the disease. | 1990 May | Forty patients with primary Sjögren's syndrome were interviewed to clarify the onset and course of the disease. In 50% of the cases, the first subjective signs of disease were recorded at age 30 to 50 years. A large variation was, however, observed, and some patients even recalled symptoms as early as in childhood. About one third described the onset as sudden, whereas the rest described an insidious deterioration. Keratoconjunctivitis sicca was the most frequent debut symptom, followed by xerostomia and weariness. Regardless of age, extreme weariness was a major problem. Pain in joints and muscles tended to be more severe in younger patients; ocular and oral problems tended to be more severe the higher the age of debut. Finally, most patients eventually came to have more or less the same complex of symptoms, which could lead to a devastating condition affecting the patients not only physically but also psychically and socially. The large variety of symptoms could easily be overlooked or misinterpreted, and because the patients did not appear to be ill, diagnosis was first established after an average period of nine years. Most patients used artificial tears, and obtained significantly greater benefit from this remedy than from all other drugs. A certain familial disposition towards the disease was found. | |
| 3335571 | Disorders of the sacro-iliac joint in children. | 1988 Jan | The cases of seventeen children whose ages ranged from two to eighteen years and who were treated for a disorder of a sacro-iliac joint between 1975 and 1983 were reviewed retrospectively. Thirteen children were acutely ill, with a temperature of more than 38 degrees Celsius, and four had chronic symptoms that had persisted for three weeks to one year. Pain in the hip, thigh, and buttock was the most common symptom. Of the thirteen acutely ill patients, eleven had septic arthritis of a sacro-iliac joint, while one who had ankylosing spondylitis and one who had juvenile rheumatoid arthritis had acutely painful arthritis of a sacro-iliac joint. Of the four patients who had chronic symptoms, two had septic arthritis of a sacro-iliac joint; one, ankylosing spondylitis with sacro-iliac involvement; and one, eosinophilic granuloma of the ilium. Thus, thirteen patients had septic arthritis of a sacro-iliac joint and four had some other disorder. For the seventeen children who had acute or chronic symptoms, at admission the white blood-cell count ranged from 3,500 to 26,200 per cubic millimeter (average, 11,100 per cubic millimeter) and the sedimentation rate, as determined by the Westergren technique, ranged from twenty-two to sixty-five millimeters per hour (average, fifty millimeters per hour). Twelve of the plain radiographs of the seventeen patients were negative. The initial bone scans of all seventeen patients were positive in eleven and negative in six. Of these six, five had septic arthritis and one, juvenile rheumatoid arthritis. A computed tomographic scan was performed in four patients and was positive in all of them: three had septic arthritis and one had ankylosing spondylitis. Organisms were cultured successfully from blood, from material aspirated from the sacro-iliac joint, or from stool of all thirteen patients who had sepsis. The thirteen infections responded well to appropriate antibiotics, which were administered intravenously to seven patients and first intravenously and then orally to six. | |
| 2087417 | [Septic arthritis]. | 1990 Sep | Septic arthritis is a serious medical problem that should be promptly recognized and requires appropriate treatment to avoid permanent joint damage. The disease is caused by several different microorganisms but the most frequent in children and in adults is Staphylococcus aureus. Pathogenetic mechanism, general (antiblastic therapy, diabetes, rheumatoid arthritis) and local (intra-articular injections) promoting factors are discussed. Usefulness of laboratory and radiological investigations is debated. Finally indications for needle aspiration, adequate drainage as well as guide lines on general and local antibiotic therapy are reported. | |
| 2688658 | Immune complex formation between IgM rheumatoid factor and IgG generated by hyaluronic aci | 1989 Dec | Immunoglobulin inclusions are regularly detected in granulocytes obtained from the synovial fluid of rheumatoid arthritis (RA) patients. In contrast, granulocytes isolated from the blood of the same patients usually contain no immunoglobulin inclusions. Using the indirect granulocyte phagocytosis test (IGPT), we obtained evidence that this discrepancy can be explained by the finding that hyaluronic acid (HA), a component of synovial fluid, increases the avidity of rheumatoid factor (RF), resulting in the formation of IgG-IgM-RF complexes. The addition of HA to RA sera and subsequent testing by IGPT revealed an increased uptake of the induced immune complexes by these cells, which was dependent on the HA dose. Furthermore, supplementation of normal human serum with purified IgM-RF generated a positive IGPT result in a dose-dependent manner in the presence of HA. We conclude that HA, a component of synovial fluid, might facilitate immune complex formation in the joint cavity, resulting in the inflammatory reaction in the joints of RA patients. | |
| 2204214 | [Viruses and arthritis]. | 1990 Jun 30 | A number of virus infections can induce acute, non-erosive arthritis. A thorough exploration of the patient's history and serological testing for viral infections are crucial to the diagnosis of virus-induced arthritis. Musculoskeletal involvement in infection with the HIV-virus is not a rare feature and will have to be considered more often in cases of acute arthritis, as the prevalence of HIV-infection is increasing. Whether chronic arthritis, like rheumatoid arthritis, is induced by viral infection, is still a subject of intensive research efforts. | |
| 2962727 | Juvenile rheumatoid arthritis. | 1988 Jan | The early diagnosis of JRA rests on the recognition of three distinct modes of onset that are important in preventing deformity, blindness, and even death. Systemic onset is characterized by typical systemic manifestations, particularly high spiking fever and the rheumatoid rash, polyarticular onset is noted by arthritis of more than four joints, and pauciarticular onset is distinguished by involvement of four joints or less, most often a knee initially. In JRA, fundamental to the heart of successful management is patient and parental education regarding both the nature of the disease and goals of therapy. Whereas the NSAIDs are adequate for the control of active disease in most patients, two key issues must be resolved. First, it is important to recognize that the choice of drug for the individual patient is frequently a matter of trial and error. Second, it is critical to prescribe antiinflammatory quantities of a given drug. The slow-acting (remittive) agents, such as intramuscular or oral gold, are reserved for patients with prolonged active polyarthritis, which affects 15 per cent of all patients with JRA. There are several drawbacks to the use of remittive agents. They must be tried for several months, often in the presence of rapidly developing joint limitation and erosions on radiograph, before their effectiveness can be determined. Also, when using these drugs, one must often follow a meticulously graduated dosage regimen, while carefully monitoring the patient for toxic and potentially lethal side effects. It follows, therefore, to never use these agents unless you are familiar with their administration and potential toxicity and to seek help from a specialist. | |
| 3758304 | Articular cartilage canals--a new pathogenetic mechanism in infectious arthritis. | 1986 Sep 15 | In experimentally-induced erysipelas polyarthritis, preexisting cartilage canals in articular cartilage play a crucial role during the very onset of the disease. This observation might have some implications for the pathogenesis of other infectious arthritides in young animals or even rheumatoid arthritis in man. | |
| 3593440 | Successful joint arthroplasty following Proteus morganii (Morganella morganii) septic arth | 1987 May | Proteus morganii (Morganella morganii) is an uncommon cause of septic arthritis. We describe a 53-year-old woman with severely deforming rheumatoid arthritis, who developed an indolent septic arthritis secondary to infection with this organism. She was treated with antibiotics and closed drainage, and subsequently, underwent successful arthroplasty. She continues to do well 4.5 years later. This patient's disease course shows that gram-negative septic arthritis, effectively treated, does not preclude successful total joint arthroplasty. | |
| 2103769 | [Amyloid arthropathy associated with multiple myeloma]. | 1990 Mar | Amyloidosis as a complication of patients afflicted with multiple myeloma only arose in 15% of the cases. The articular localization is particularly rare, the clinical findings being similar to rheumatoid arthritis. A case of amyloid arthritis associated to Bence-Jones myeloma, kappa type, is presented and the literature is reviewed. | |
| 1994914 | Spontaneous degenerative polyarthritis in male New Zealand black/KN mice. | 1991 Feb | Histopathologic studies and radiographic analysis revealed that male New Zealand black/KN (NZB/KN) mice develop degenerative polyarthritis in the joints of the forepaw and hindpaw beginning at age 2 months. Deposits of autoantibodies were observed on proliferating collagen fibers, nuclei of chondrocytes, and epidermal cells. Increases in the frequency of positivity for rheumatoid factor and anti-type II collagen antibodies and in the level of serum oxidation activity were noted in these mice. The joint disease in male NZB/KN mice was transferable to female NZB/KN mice and male BALB/c mice by intraperitoneal injection of spleen cells from the male NZB/KN mice. This animal model of arthritis will be extremely useful for analyzing not only the pathogenesis of rheumatoid arthritis, but also new strategies for its treatment, since NZB/KN mice, unlike MRL/lpr mice, do not develop severe lupus nephritis or lymph-adenopathy, and therefore have a longer survival period. |