Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2781004 | Arthritis associated with HIV infection: radiographic manifestations. | 1989 Oct | Radiographs of symptomatic joints were retrospectively evaluated in 24 patients with inflammatory arthritis and human immunodeficiency virus (HIV) infection. Clinically, 20 patients had a seronegative arthritis including Reiter syndrome (54%), psoriatic arthritis (17%), and undifferentiated forms of spondyloarthropathy (13%). These patients were indistinguishable radiographically from patients with typical seronegative disorders except for the predominance of lower-extremity abnormalities. Four patients (17%) had a rheumatoidlike arthritis defined as acute symmetric polyarthritis (ASP). With the exception of extensive proliferative periostitis, ASP simulated classic rheumatoid arthritis. HIV-associated arthritis was manifest during various stages of HIV infection. It preceded acquired immunodeficiency syndrome in 64% of patients with stage IV HIV infection. Awareness of the coexistence of HIV infection in patients with the above-mentioned arthritides is important, since immunosuppressive therapy, commonly used in the treatment of arthritis, can have detrimental effects in patients with HIV infection. | |
| 2272120 | Amelioration by menadione of the experimental chronic immune arthritis in the rabbit. | 1990 Oct | The immunological induction of arthritis in the knee of the rabbit is well established as a model for human rheumatoid arthritis. It has the special advantage of allowing the development of the condition, and the effect of disease-modifying agents, to be followed. Attention has been focussed on the activity of glucose 6-phosphate dehydrogenase in the synovial lining cells since the fourfold elevation of this activity was shown to be fundamental in the human condition. An equal elevation of this activity has now been demonstrated in the rabbit model. Furthermore, it has been shown that the oral administration of menadione decreases this activity towards normality with a concomitant decrease in the degree of inflammation. | |
| 3760595 | Group G streptococcal infection of joints and joint prostheses. | 1986 Sep | Eight cases of septic arthritis caused by beta-haemolytic streptococci of Lancefield group G are presented and compared with others previously reported. Involvement of prosthetic joints is notable (25%) as is accompanying cellulitis (75%) which is probably related to the portal of entry of the organism. Other associated conditions were rheumatoid arthritis (38%) and malignant neoplastic disease (25%). Carriage of the group G streptococcus was detected in two of the eight patients. Serological tests for streptococcal antibodies were found to be less useful in the diagnosis of septic arthritis due to group G streptococci than culture of aspirated fluid. In the absence of endocarditis, which was not present in any of our patients, the prognosis appears to be good after treatment with appropriate antibiotics and open drainage of the joint. Both affected joint prostheses, however, required removal. | |
| 3086444 | Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from pati | 1986 Jul 1 | Approximately one-half of human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors (RF] from unrelated individuals with cryoglobulinemia coordinately express three cross-reactive idiotypic antigens (CRI). The CRI are detected with: 1) monoclonal antibody 17.109, which recognizes a conformation-dependent CRI on K-light chains; and 2) two rabbit anti-peptide antibodies that react with primary sequence-dependent CRI (PSL2 and PSL3) corresponding to the conserved second and third K-chain complementarity-determining regions, respectively. In the present experiments, the structural features of polyclonal RF autoantibodies from diverse patients with rheumatoid arthritis and from those with primary Sjögren's syndrome, and from seropositive elderly subjects without overt autoimmune diseases, were investigated with these three defined anti-CRI reagents. The pattern of expression of the CRI differed among patient groups. Only the RF autoantibodies from Sjögren's syndrome patients frequently displayed all three CRI. However, the RF from nearly every subject tested, including patients with rheumatoid arthritis, were enriched in the primary sequence-dependent PSL2-CRI as compared to RF-depleted Ig from the same subjects. Amino acid sequence analysis of monoclonal IgM-RF indicates that PSL2-CRI-positive light chains probably represent the products of a single Vk gene. Therefore, a proportion of the polyclonal RF from different autoimmune states may represent somatic variants of this germ-line RF Vk gene which retain the PSL2 sequence as a common element. | |
| 1684619 | Sulfasalazine therapy in psoriatic arthritis: clinical and immunologic response. | 1991 Sep | Sulfasalazine therapy has been shown effective in rheumatoid arthritis and ankylosing spondylitis. We treated 10 patients with active polyarticular psoriatic arthritis with 2 g/day of sulfasalazine for 16 weeks. Significant improvement was seen in joint count score, morning stiffness, and patient/physician assessment of disease activity. Toxicity requiring drug cessation was seen in only 1 patient. Patients with psoriatic arthritis had elevated B cells and immunoglobulin levels which fell with sulfasalazine therapy. Minimal changes were seen in T cell subsets. Sulfasalazine appears to be an effective second line agent for the treatment of psoriatic arthritis. Its mechanism of action may in part relate to alteration of B cell number and function. | |
| 1670619 | Seronegative juvenile rheumatoid arthritis and mast cell-associated gastritis. | 1991 Jan | We describe 4 children with seronegative inflammatory arthritis who had persistent, severe nausea and abdominal pain over several months, in spite of vigorous medical therapy, including antacids and histamine H2 receptor antagonists. Endoscopy and biopsy of gastric and duodenal mucosa showed antral gastritis and an increased number of mast cells in 3 of the 4 patients. In the fourth patient, urinary histamine levels were elevated. These findings suggest an association between inflammatory arthritis and localized mast cell disease in some individuals. Further studies are needed to determine whether this association represents an independent syndrome or whether mast cell-related disease is secondary to long-term treatment with nonsteroidal antiinflammatory drugs in children with mild arthritis. | |
| 2359074 | Remitting, seronegative, symmetrical synovitis with pitting edema--13 additional cases. | 1990 May | The case histories of 13 elderly patients (8 men/5 women) with a relatively acute onset of a severe symmetrical synovitis affecting the flexor digitorum tendon sheaths and wrist joints with pitting edema of the dorsum of both hands are described. All were persistently seronegative for IgM rheumatoid factors and all went into complete remission without relapse. Asymptomatic residual flexion contractures of the fingers and wrists were a constant feature during remission. HLA-B7 was present in 15 of a total 23 reported cases (relative risk = 4.4). This condition, with its excellent prognosis, is differentiated from rheumatoid arthritis and polymyalgia rheumatica. | |
| 3746595 | Orbital and childhood sarcoidosis. | 1986 Jul | Orbital infiltration, anterior uveitis, disc edema, choroiditis, erythema nodosum, and polyarticular arthritis due to sarcoidosis occurred in a five-year-old child who presented with unilateral proptosis. Diagnosis was enhanced by computerized tomography of the orbit, and confirmed by synovial biopsy findings. This patient's course illustrates the importance of thorough and frequent ocular examinations in childhood uveitis associated with systemic disease and demonstrates an unusual finding of orbital sarcoidosis. Childhood sarcoid arthritis may be misdiagnosed as juvenile rheumatoid arthritis. Familiarity with the ocular and systemic findings may lead to the correct diagnosis. | |
| 2097892 | Chemotaxis of leukocytes from peripheral blood of patients with juvenile rheumatoid arthri | 1990 Sep | Spontaneous and stimulated migration of leukocytes from peripheral blood was studied in 15 patients with JRA and 15 controls. Cells from both groups showed equal migratory ability. However, in the presence of the activated serum of the JRA patients, there was a significant decrease in migration of leukocytes from JRA patients and from controls, suggesting the existence of a serum factor responsible for this chemotactic impairment. The effect of washing on the migration of these cells was also studied. A significant decrease could be observed in the spontaneous and stimulated migration of washed cells from both JRA patients and controls. | |
| 2661988 | [A case of juvenile rheumatoid arthritis treated with thymopentin]. | 1989 Feb | The case of a ten year old girl with JRA presenting a systemic onset and resistant to non-steroid therapy is described. After one course of thymopentin the patient responded satisfactorily. After ten months from the beginning of treatment and a third course she is still doing well. The authors comment the modalities of therapy. | |
| 2930278 | Peripheral arthritis in the elderly: a hospital study. | 1989 Mar | One hundred consecutive patients admitted to an acute geriatric unit were examined for evidence of peripheral arthritis with recognised criteria used to define osteoarthritis, rheumatoid arthritis, pyrophosphate arthropathy, gout, and disorders of the shoulder joint. The presence of arthritis and its severity were related both to functional independence and to a recognition by the patient that joint problems were impairing independence. Seventy six patients had clinical peripheral arthritis; 48 had arthritis contributing to loss of function, and 19 of these did not volunteer evidence of their joint disease. The common occurrence of arthritic conditions in the elderly, with consequential disability and dependency, suggests that increased medical awareness may be required to prevent unnecessary morbidity. Our findings need confirmation in community based studies. | |
| 2367718 | [Selective deficiency of IgA in autoimmune diseases]. | 1990 Mar | A selective IgA deficiency (SD IgA) appears in a 0.15% of the population, being more frequent in autoimmune diseases. We present here eight patients presenting this association who were diagnosed at the Rheumatology Department during a period of eight years. Five patients suffered Juvenile Chronic Arthritis (JCA), two patients Rheumatoid Arthritis (RA) and one Systemic Lupus Erythematous (SLE). There were to cases of familiar deficiency. There was not a relationship between SD IgA and treatments used. There is an important association between SD IgA and JCA (4.27% prevalence). In the other two conditions, however, the association could be casual. | |
| 2739536 | [Reye's syndrome in an adult following therapy with salicylates in Still's disease]. | 1989 Jan | Reye's syndrome or encephalopathy with fatty infiltration of the liver occurs mainly in childhood and to a lesser degree in adult age. Salicylate may play a role in the pathogenesis of this syndrome. Still's disease is a form of juvenile rheumatoid arthritis very rare in the adult. A case is reported of a 39-year old woman who developed Reye's syndrome while on aspirin therapy for the treatment of a classical adult Still's disease. | |
| 3473647 | Editorial comments to the four sets of criteria for Sjögren's syndrome. | 1986 | The four most frequently used criteria for definition of Sjögren's syndrome--the Copenhagen, the Japanese, the Greek and the Californian criteria--are critically evaluated. The article focuses on the similarities and the dissimilarities as well as the advantages and the disadvantages between the various sets of criteria. | |
| 2623977 | [Preventive and therapeutic effect of estrogen administration in adjuvant arthritis]. | 1989 Nov | Using adjuvant arthritis as a model for human rheumatoid arthritis, we examined prophylactic and therapeutic effects for different doses of estrogen (0.5-5.0 mg estradiol 3x/week) in 40 male Long Evans rats compared to 16 control animals. More than 2.5 mg estradiol resulted in significantly reduced inflammatory activity, both in animals treated before or after induction of arthritis (Mann Whitney U-test, p less than 0.05). | |
| 2174536 | Interleukin-2 immunotherapy in children. | 1990 Dec | Immunotherapy with interleukin (IL)-2 possesses great potential in the treatment of immune-mediated diseases and cancers. However, only a few reports on a small number of children have appeared in the literature. From March 1988 to March 1989, 11 children and adolescents were treated with IL-2. They included 1 patient with hepatocellular carcinoma, 1 with hepatoblastoma, 6 with childhood atopic dermatitis, and 3 with juvenile rheumatoid arthritis. The dosages ranged from 10,000 to 50,000 U/kg every 8 hours by intravenous drip. The following side effects were observed: anorexia, fever, and chillness (100%), general malaise (82%), irritability (64%), diarrhea (100%), nausea and vomiting (73%), weight gain (82%), edema (82%), abdominal distension (73%), oliguria (82%), cough (91%), dyspnea (27%), pleural effusion (40%), hypotension (82%), skin eruption (82%), oral ulcer (18%), enlarged liver (73%) liver function abnormalities (82%), renal function impairment (36%), electrolyte imbalance (73%), anemia (91%), thrombocytopenia (54%), leukopenia (18%), and eosinophilia (73%). Immunologically, numbers of natural killer cells were increased and natural killer and lymphokine-activated killer cell activities were augmented after IL-2 treatment. There was a tendency for serum levels of IL-2 and receptor IL-2 to decrease, especially in patients with atopic eczema. Ten patients (91%) completed one course (9 to 12 days) of therapy, and the remaining patient interrupted the treatment because of intolerable adverse effects. Clinically, complete remission for 3 months was obtained in 1 juvenile rheumatoid arthritis patient, transient improvement (2 to 6 weeks) in all atopic dermatitis patients, minor response in the hepatoblastoma patient, and no response in the patient with hepatocellular carcinoma. | |
| 1957305 | [Psychological and social aspects of juvenile chronic arthritis]. | 1991 Oct | Juvenile rheumatoid arthritis (JRA) affects the physical, psychological and social development of children and adolescents. Illness characteristics such as visibility, pain and uncertainty may influence the development of independence and social adjustment. Children can suffer from growth deficiencies, school problems, social isolation, sometimes psychopathology. International research does not yield consensus on the incidence of psychopathology in chronically ill children. The psychosocial effects of the illness are partly determined by the ways the child and the family react to the illness and its physical consequences. The functioning of child and family ultimately depends upon the balance between burdens and strengths. Reciprocal influences between illness and daily living can be understood through modern psycho-neuroimmunologic theories. These concepts ask for a multidisciplinary team-approach for suitable, individualized care. | |
| 2768694 | Mucosal burn resulting from chewable aspirin: report of case. | 1989 Aug | A 4-year-old female patient with juvenile rheumatoid arthritis received a mucosal burn from chewable-aspirin therapy. She was given five chewable aspirin tablets before bedtime, and fell asleep before swallowing them. Mucosal burns from incomplete aspirin ingestion can be prevented by not administering aspirin at bedtime, and by cleaning the buccal vestibules with a cotton swab to ensure complete removal of all aspirin. | |
| 3754110 | Studies on the chronic phase of adjuvant arthritis: effect of SR 41319, a new diphosphonat | 1986 Jan | We studied the course of adjuvant arthritis in rats by measuring clinical, biochemical, and histological parameters on day 36 after induction (representing the secondary reaction) and on day 171, which is at the stage of permanent deformity. The effect of SR 41319, a new diphosphonate, was evaluated on days 36 and 171, after three weeks of treatment (days 14-35 inclusive). In the absence of treatment all the measured parameters were markedly abnormal on day 36, indicating the presence of lesions that were still evolving. On day 171 clinical parameters and the lesion histological index remained the same, whereas the biochemical parameters and disease activity histological index had returned to normal, indicating that the lesions at this stage although severe were not inflammatory and consequently not progressing. SR 41319 treatment reduced the severity and progression of the disease both on day 36 and on day 171. We conclude that SR 41319 may be a potentially useful drug for the treatment of rheumatoid arthritis. | |
| 1927047 | [Elaboration of clinico-laboratory criteria of the Mycoplasma variants of rheumatoid arthr | 1991 | To develop clinical and laboratory criteria for the differential diagnosis of Mycoplasma-induced arthritides in 78 children with documented rheumatic arthritis (RA), a comprehensive study involving microbiological, immunological, and clinical tools has been performed. Some specific signs of the clinical course of Mycoplasma-induced RA have been defined. However, a differential diagnosis of Mycoplasma-induced arthritis may be made on the basis of a comprehensive study of a patient. |