Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2675893 | Conjunctival cell glycoprotein pattern of healthy persons and of patients with primary Sjà | 1989 Aug | Formalin-fixed biopsies of conjunctival tissue from the lower fornix of 10 healthy persons and of 10 patients with primary Sjögren's syndrome (primary SS) were examined by light microscopy. Deparaffinized, rehydrated sections of 5 microns were incubated overnight, each with one of 15 different biotinylated lectins. Bound lectins were visualized using avidin-HRP-substrate complexes. Five lectins did not bind to conjunctival cells, and further six lectins bound in an unspecific manner to conjunctival cells of both healthy persons and of primary SS patients. Jacalin lectin bound selectively to goblet cells of all specimens. Peanut agglutinin (PNA) and wheat germ agglutinin (WGA) bound significantly stronger to basal conjunctival epithelial cells of patients with primary SS. This binding pattern may be of diagnostic value. | |
| 3180618 | Gallium-67 renal uptake in Sjogren's syndrome. | 1988 Sep | This case report describes a 61-year-old male with Sjogren's syndrome. Diffuse Ga-67 uptake in the kidneys was seen due to renal involvement with this disorder. Sjogren's syndrome should be considered in the differential diagnosis of diffuse bilateral Ga-67 accumulation in the kidneys. | |
| 3351029 | CT evaluation of mediastinal lymph nodes in primary Sjögren syndrome. | 1988 Mar | Computed tomography was used to evaluate mediastinal lymph nodes of 25 patients with primary Sjögren syndrome (pSS) and in 38 control subjects. Abnormally enlarged nodes, according to accepted CT criteria, were detected in four pSS patients and in 10 control subjects (differences not significant). The presence of enlarged mediastinal nodes did not correlate with peripheral lymphadenopathy, splenomegaly, parotid enlargement, or cryoglobulinemia in the pSS group. One pSS patient with pseudolymphoma and another with non-Hodgkin lymphoma did not have enlarged mediastinal lymph nodes. Our results suggest that the detection by CT of slightly enlarged mediastinal nodes, invisible in plain radiography, in pSS patients is of uncertain clinical significance. | |
| 2080396 | [Articular manifestations in Wegener's disease. Report of 13 cases]. | 1990 Dec | Seventeen cases of Wegener's granulomatosis have been reviewed in search of articular involvement. Articular symptoms were present in 13 cases (76 p. cent), and were inaugural in 9 cases (53 p. cent). Six of these patients experienced arthralgias, which were most often migratory, and were inaugural in 3 cases. Seven patients had arthritides, which were inaugural in 6 cases; they were fixed and additive in 6 of these 7 cases, making up a distal polyarthritis in 3 patients, and an oligoarthritis in the 3 other ones; they were transient and migratory in 1 case. The 3 cases of distal polyarthritis were inaugural and fulfilled the ARA criteria for rheumatoid arthritis; two of them were accompanied by nodules which were quite identical to rheumatoid ones. There was no axial involvement. Joint involvement was not destructive and had a favourable course under disease treatment. Myalgias were present in 3 cases, one of which simulated Horton's disease. Biological manifestations chiefly consisted of marked inflammatory changes. Antineutrophil cytoplasm antibodies were present in 11 out of 16 patients in whom they were searched; among 6 of these patients who had active disease, they were present in 5. The antibody level decreased as treatment reduced disease activity and suppressed joint involvement. Joint involvement in Wegener's granulomatosis seems to be the inconstant hallmark of disease activity. It requires no specific treatment. | |
| 1857996 | [A case of primary Sjögren's syndrome presenting as osteomalacia secondary to renal tubul | 1991 Feb | We report a 43-year-old female with primary Sjögren's syndrome (SjS) who presented as osteomalacia due to distal renal tubular acidosis (RTA). Osteomalacia was thought to be a rare complication of RTA in SjS, although it had been often described in association with RTA in general. In 1979, she presented with dry mouth, parotid gland swelling and leg purpura. A diagnosis of primary SjS and hyperglobulinemic purpura was made on the basis of positive staining with Rose Bengal stain, sialography of the parotid gland and histological examination of the salivary gland of the lip. She was admitted to Jichi Medical School Hospital in March 1988 with chest pain. X-ray films revealed pseudofractures of bilateral ribs. Bone scanning showed abnormal multiple accumulation of RI on the same parts. Laboratory studies on admission revealed: GOT 50 IU/ml, GPT 9 IU/ml, ALP 190 IU/ml, LDH 301 IU/ml, BUN 11.0 mg/dl, creatinine 1.0 mg/dl, uric acid 2.7 mg/dl, total protein 7.4 g/dl (gamma globulin 22.3%), sodium 141 mEq/l, potassium 3.7 mEq/l, chloride 106 mEq/l, calcium 8.9 mg/dl, and phosphorus 2.4 mg/dl. Arterial blood gas studies on room air showed: PO2 96.7mmHg, PCO2 35.5mmHg, HCO3-19.1 mEq/l, PH 7.347 and base excess -5.4 mEq/l. The urinalysis showed: specific gravity 1.008, PH 7.0, and no protein and glucose. Immunologically, antinuclear antibody was positive at 1:640 with a speckled pattern. Anti-DNA antibody was negative. Antibodies to SS.A and SS.B were 1:64 and 1:32 respectively. Distal RTA was confirmed by the sodium bicarbonate and NH4Cl loading test.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2620522 | Type III membranoproliferative glomerulonephritis in primary Sjögren's syndrome. | 1989 Nov | Glomerulonephritis is a rare complication of primary Sjögren's syndrome. When glomerulonephritis does occur, it is usually due to membranous, focal proliferative, or membranoproliferative lesions. There have been fewer than 20 reported cases of glomerulonephritis in primary Sjögren's syndrome, only three of which have been membranoproliferative. We report a case of primary Sjögren's syndrome complicated by Type III membranoproliferative glomerulonephritis, a specific type of mesangiocapillary glomerulonephritis never before reported in this setting, and describe a clinical course terminating in rapidly progressive renal failure. | |
| 3239958 | Myopathy with unique ultrastructural feature in Marinesco-Sjögren syndrome. | 1988 Oct | We have investigated 3 children aged 6, 3, and 2 years, from 2 families, with the clinical features of Marinesco-Sjögren syndrome. Muscle biopsy specimens from all 3 were abnormal and showed small vacuoles and slight variation in fiber size. Electron microscopy revealed vacuolation and membranous whorls and, in particular, a unique dense membranous structure associated with nuclei. These cases emphasize the involvement of muscle in Marinesco-Sjögren syndrome and the importance of electron microscopy in differential diagnosis. | |
| 3250005 | Prospective studies on the progress of sicca symptoms in Sjögren's syndrome: subclinical | 1988 Jun | We evaluated prospectively twenty-two subjective sicca features in seventeen patients with Sjögren's syndrome (SS) including six patients with primary SS twice at a six-year interval. In the second evaluation in 1986, the frequency of sicca symptoms was increased for most items, and the mean number of positive symptoms was also increased in the patients compared with the results in 1980. In the first evaluation, three patients lacked any sicca symptoms, and were considered as subclinical SS. Sicca symptoms developed in all three of these patients later. A positive correlation between the number of sicca symptoms and the patients' age was also reconfirmed by the present study. Changes in sicca symptoms between the two evaluations were not correlated with objective findings of exocrine gland involvement determined at the time of diagnosis of SS. The lacrimal or salivary secretion and sialographic findings determined serially were relatively stable during whole observation period, except in some patients. The results indicate that both the symptoms and objective findings of glandular involvement progress very slowly in SS, although patients with subclinical disease eventually develop clinical SS. | |
| 1940780 | Features of Sjögren's syndrome in patients with primary biliary cirrhosis. | 1991 Nov | Twenty-six consecutive patients with primary biliary cirrhosis (PBC) from northern Sweden were studied regarding the occurrence and features of Sjögren's syndrome (SS). In more than 50% of the patients the rose bengal dye test showed conjunctival and/or corneal staining. In six patients keratoconjunctivitis sicca (KCS) was present with positive rose bengal and Schirmer tests. In a further three patients only the results of the Schirmer tests were abnormal. Radiological findings of sialectasia were demonstrated in six patients, five of whom had KCS. Two of the seven patients who fulfilled our criteria for Sjögren's syndrome were HLA-B8 positive. A high prevalence of increased immune globulins and rheumatic factor was found, but this did not correlate with the presence of Sjögren's syndrome. Some features of Sjögren's syndrome were found in 73% of PBC patients, and keratoconjunctivitis sicca and/or sialectasia were found in 27% of PBC patients. This constitutes a high frequency of secondary manifestations of the liver disease. | |
| 2396875 | Hodgkin's disease occurring in primary Sjögren's syndrome. | 1990 Aug | A 57 year old woman with a 13 year history of mouth dryness, keratoconjunctivitis sicca, and recurrent bronchial infections presented with multiple lymphadenopathies. Histological diagnosis was Hodgkin's disease. B and T cell lymphomas are well known complications of Sjögren's syndrome. This case provides evidence that Hodgkin's disease may also be associated with this syndrome. | |
| 2310226 | Comparison of labial and sublingual salivary gland biopsies in the diagnosis of Sjögren's | 1990 Jan | This study was designed to compare labial and sublingual salivary gland biopsies in the diagnosis of Sjögren's syndrome (SS). Fourteen labial and 29 sublingual specimens were considered positive. There was a better correlation between infiltration of the ductal structure and the focus score in the sublingual salivary gland biopsy than in the labial salivary gland biopsy. Use of sublingual salivary gland biopsy as an additional diagnostic tool in SS is therefore suggested. | |
| 2736829 | Oral parameters for the diagnosis of Sjögren's syndrome. | 1989 Mar | Agreement is probably world wide in the medical profession that patient history is the most relevant part of the patient examination, but at the same time the most demanding part because there is no substitute to lack of knowledge and experience. These form the basis for an often subconscious process of selecting the most important pieces of information to help in decision making. We describe a stepwise forward discriminant analysis with a jackknife-validation in analysis of questionnaires as to diagnosis of Sjögren's syndrome. The second topic of current interest, also due to the need of generally acceptable criteria for diagnosis and classification, is the place of labial salivary gland (LSG) biopsy in such sets of criteria. In the histopathological part of our work we describe findings of a postmortem LSG study from the coroner's office. | |
| 3473646 | The effect of bromhexine on the kidney lesions in NZB-NZW-F1 mice. | 1986 | The NZB-NZW-F1 mice develop a clinical picture resembling SLE and an exocrinopathy resembling Sjögren's syndrome. Three groups of hybrids were treated from their 20th week of age for 10, 17 and 20 weeks (groups 1, 2, 3) with Bromhexine in two different concentrations--6 & 60 mg/kg and placebo. NMRJ mice treated with placebo acted as healthy controls. After the treatment the kidneys were examined by light microscopy. The kidneys exhibited lupus-like lesions. Animals treated with 60 mg/kg Bromhexine for 17 weeks had a significantly lower degree of changes than had the other hybrids. | |
| 1867927 | [Primary segmental sclerosing cholangitis associated with Sjögren's syndrome]. | 1991 May | We report the case of a patient with primary sclerosing cholangitis associated with Sjögren's syndrome and Raynaud's phenomenon, an uncommon association. The presence of periportal lymph nodes with features similar to those described in autoimmune diseases suggests an immune pathogenesis of the disease. The localized and segmentary involvement of the common duct is also an uncommon finding. The pathogenetic and therapeutic aspects are discussed. | |
| 1987506 | [Malignant B-cell lymphoma in a patient with primary Sjögren syndrome]. | 1991 Jan 6 | Authors report the case of a 42 years old female with primary Sjögren's syndrome in whom nine years after the beginning of her disease generalised swollen lymphatic nodes and enlargement of liver as well as a spleen has appeared. The simultaneous appearance of fever, loss of body weight and worsening of her general condition raised the possibility of an associated malignant lymphoproliferate disease. The histology of a lymph node proved the presence of a highly malignant form of B-cell lymphoma (CB NHL). Attention is drawn to the necessitate of regular control of patients with Sjögren's syndrome. Lymphadenopathy, the decrease of the immunoglobulin levels and autoantibody titer in the serum, as well as the predominance of monoclonal immunoglobulins point to the possibility of malignant transformation. With reference to the presented case a short review of the Sjögren's syndrome is given by the authors. | |
| 2044615 | Bilateral tonic pupils and polyneuropathy in Sjögren's syndrome: a common pathophysiologi | 1991 | One case associating tonic pupils and Sjögren's syndrome is reported. Neurophysiological examination also demonstrated a purely sensory neuropathy. This rare association raises the issue of a common process destroying the ciliary and spinal root ganglia in these patients. | |
| 3247707 | [Extracorporeal therapy (hemosorption, plasmapheresis) in the combined treatment of severe | 1988 | The clinical and laboratory efficacy of the combination of plasmapheresis, hemosorption disease. The combined Sjögren's disease. The combined intensive treatment led to improvement in the cases with disturbances of the peripherial and central nervous system, kidneys, blood vessels (Raynaud's syndrome), joints and muscles. The efficacy of this treatment is proved in cryoglobulinemic and hypergammaglobulinemic purpura and is comfirmed by the reliable decrease of the rheumatoid factor, circulating immune complexes. C-reactive protein and gamma globulins. A positive dynamics of the exocrine glands function and microcirculation is found. | |
| 3500380 | [Diagnostic procedure in suspected Sjögren syndrome]. | 1987 Sep | Basing on anamnestic and clinical findings in Sjögren's syndrome, methods of examination of the salivary glands are outlined. The flow rate and composition of the saliva, especially sodium and IgM contents, are important points of diagnosis. Serological methods are described, such as examination of antibodies to nuclear antigens and their subunits SS-A and SS-B. Labial salivary gland biopsy rounds off the diagnostic procedure. Patients with Sjögren's syndrome must be controlled regularly because of the above-average risk of developing non-Hodgkin lymphoma. | |
| 2885503 | Serological diagnosis of primary Sjögren's syndrome by means of human recombinant La (SS- | 1987 Jul 4 | Human recombinant La nucleoprotein was purified from cultures of Escherichia coli containing a vector with a 1.4 kilobase cDNA encoding La; the nucleoprotein was used to test for antinuclear antibodies (ANA) to La. Serum samples from 260 patients with autoimmune diseases associated with ANA and 100 healthy subjects were tested by an enzyme-linked immunosorbent assay (ELISA). Samples from 47 (94%) of 50 patients with primary Sjögren's syndrome and 1 (7%) of 14 patients with secondary Sjögren's syndrome reacted with the recombinant La. No reactivity was demonstrated in 196 patients with other ANA-associated autoimmune diseases or in 100 healthy subjects. The study confirms the high correlation between ANA, anti-La, and primary Sjögren's syndrome and shows how gene cloning can provide large quantities of human autoantigens for use in highly specific and sensitive diagnostic assays. | |
| 3601833 | Sjögren's syndrome. More than dry eyes and dry mouth. | 1987 Jul | Sjögren's syndrome is a complex disease state with multisystem manifestations. Two forms of the disease, primary and secondary, are recognized; the secondary form is more easily diagnosed because of its association with an already established rheumatic or autoimmune disease. Treatment consists of measures to prevent damage from ocular and oral dryness (sicca complex) and to minimize systemic manifestations. |