Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1706901 | [A comparative study of serum complement (C3 and C4) in inflammatory joint diseases]. | 1990 | The third and the fourth fraction of the complement (C3 and C4), haptoglobin, fibrinogen, alpha 1-glycoprotein, alpha 2-macroglobulin and transferrin were examined in 692 patients with inflammatory joint disease--rheumatism, rheumatoid arthritis, ankylosing spondylarthritis, psoriatic arthritis, Reiter's syndrome, sacroiliitis [correction of sacroileitis], reactive arthritis, gout, osteoarthrosis and nosologically undefined arthritis in active or nonactive phase and in 60 healthy controls. The complement fractions studied show an increase of various degree and importance in almost all groups of patients in both phases studied. The relations between the complement fractions and the other acute phase indices show significant correlations between them and the other acute phase indices. C3 and to a certain degree C4 could be added to the acute phase reacting indices. Their place in the downgrade scale is as follows: fibrinogen, haptoglobin, alpha 1-glycoprotein, C3, C4, alpha 2-macroglobulin, transferrin. | |
| 2431585 | Reticular erythematous mucinosis syndrome in a patient with polyarthritis. | 1986 | A patient with seronegative oligoarthritis who developed the reticular erythematous mucinosis (REM) syndrome is described. This syndrome is considered to be a dermatological entity unrelated to systemic disorders. Aggravation of the rash by exposure to sunlight and a good response to anti-malarial agents suggest a relationship with rheumatological disorders, e.g. rheumatoid arthritis and systemic lupus erythematosus. Dermatologists consulted by a patient with the REM syndrome should be aware of the possibility of an associated rheumatological disease. | |
| 2691683 | Confounding features of the fibromyalgia syndrome: a current perspective of differential d | 1989 Nov | Patients eventually diagnosed as having the fibromyalgia syndrome often have symptoms which suggest alternate diagnoses such as peripheral neuropathy, spondylitis, metabolic myopathy, polymyalgia, early rheumatoid arthritis, early systemic lupus erythematosus or a chronic fatigue syndrome. Delay in diagnosis of fibromyalgia often proves costly and frustrating to the patient and may lead to inappropriate therapy. | |
| 2716388 | [Distal tubular renal acidosis associated with hyperglobulinemic purpura and Sjõgren's sy | 1989 Mar 18 | A 35-year-old female with a diagnosis of Waldenström's benign hypergammaglobulinemic purpura developed bilateral renal stones during the course of her disease. Evaluation disclosed type I distal tubular renal acidosis. In addition, the patient developed Sjögren's syndrome seven years later. The etiology and pathogenesis of renal tubular acidosis secondary to autoimmune disease are reviewed, and the exceptional occurrence of the three conditions in a single patient is commented. | |
| 3473637 | Tear fluid proteins in Sjögren's syndrome. | 1986 | Schirmer-I test, rose bengal staining and BUT in normals, keratoconjunctivitis sicca patients and patients with Sjögren's syndrome were compared with the results of lactoferrin, lysozyme and tear-specific prealbumin assays as diagnostic procedures for lacrimal gland function. The results suggest that all three major tear proteins, originating from the tear gland can serve as sensitive markers for lacrimal gland function. In clinical practice the simple immunodiffusion assay for lactoferrin could be a reliable alternative for the traditional diagnostic tests. | |
| 1927263 | Sjögren's syndrome in patients with multiple sclerosis. | 1991 Jul | Twenty female patients with clinically multiple sclerosis were evaluated with regard to a possible underlying Sjögren syndrome. Two patients (10%) demonstrated a clinical Sjögren syndrome which does not differ significantly from the prevalence in an unselected population. Dry eye-symptoms occurred among MS-patients and should be subjected to relevant diagnostic procedures. | |
| 1680801 | [Therapy strategies for Still's syndrome of adults (AOSD)]. | 1991 Jun | The differential diagnosis of seronegative polyarthritides are manyfold and can cause problems even for the routine rheumatologist. Together with the symptom "fever of unknown origin" an intensive diagnostic workup is often unavoidable. Five patients with this symptom combination are discussed who also had different typical manifestations of the adult onset Still's disease (AOSD). | |
| 2150367 | [Biopsy of the minor salivary glands in Sjögren's syndrome]. | 1990 Dec 15 | Twenty subjects, 17 females and 3 males, mean age 55.9, with Sjögren's syndrome (13 cases: classical or secondary form--7 cases: sicca syndrome) were submitted to biopsy of the minor salivary glands of the lower lip. The histopathological findings from the salivary glands and the clinical aspects of each patient were separately evaluated, in order to find a possible connection between the degree of glandular impairment and the severity of the disease. As a result of their findings, the authors conclude that the biopsy of the salivary glands, while constituting an important element for diagnosis, cannot be considered a determining factor for making a prognosis, or for therapy, because of the extreme polymorphism in the histopathological findings, and for the relative nature of the respondents with the severity of the clinical aspects. | |
| 2548366 | Nasal mucociliary clearance in Sjögren's syndrome. Dissociation in flow between sol and g | 1989 Jul | Nasal mucociliary clearance was measured with two methods in 8 patients with Sjögren's syndrome and in 6 normal subjects. The movement of two different tracers placed 1.5 cm posterior to the inferior turbinate tip was measured respectively. The transport rate of a 500 microns anion resin particle tagged with 99mTc was measured. The clearance of 10 microliters saline labelled with 99mTc was monitored and the clearance rate was calculated. Whereas the measurement with the particle method revealed the lowered transport rate in Sjögren's syndrome, measurement with the saline method did not reveal any difference in clearance rate between the two groups. Since the former method measures the transport of particle in the gel phase (the outer mucous layer) and the latter measures the clearance of both gel and sol (periciliary fluid) layers, it is postulated that there is a dissociation of flow between sol and gel layers in Sjögren's syndrome. | |
| 3355252 | Sarcoidosis in a patient presenting with clinical and histological features of primary Sjà | 1988 Feb | A patient presenting with bilateral enlargement of parotid and lacrimal glands, xerostomia, and keratoconjunctiva sicca, whose labial biopsy specimen showed changes consistent with Sjögren's syndrome, is described. The patient was initially misdiagnosed as having primary Sjögren's syndrome (SS). Subsequent investigations, however, performed to exclude an associated lymphoma or sarcoidosis, showed histological changes of the latter. The possibility that early infiltrates of the salivary glands in sarcoid may mimic those of SS is discussed. | |
| 2383067 | Primary Sjögren's syndrome presenting as a case of sarcoidosis and a suspected pancreatic | 1990 Jun | A 45 year old man, previously diagnosed as having sarcoid, presented with signs and symptoms of a pancreatic malignancy. An explorative laparotomy, however, showed only chronic pancreatitis. He was found to have a raised erythrocyte sedimentation rate, normocytic normochromic anaemia, renal insufficiency, hypergammaglobulinaemia, and a strongly positive rheumatoid factor and antinuclear antibody titre. Bilateral hilar lymph node enlargement was noted on chest x ray. Subsequently, the patient complained of xerostomia and keratoconjunctivitis sicca. Large lymphocytic infiltrates and a shift in the relative number of IgA bearing plasma cells in favour of IgG and IgM bearing plasma cells were seen in tissue obtained by sublabial salivary gland biopsy. A transbronchial lung biopsy and review of the biopsies of the pancreas, the lung, liver, and a lymph node all failed to show granulomatous disease. These findings strongly suggested a diagnosis of Sjögren's syndrome instead of sarcoidosis. This case shows the difficulty sometimes encountered in differentiating between sarcoid and systemic Sjögren's syndrome, and the value of a sublabial salivary gland biopsy. | |
| 2181723 | [Visceral manifestations of primary Sjogren's syndrome]. | 1990 Feb 28 | The author briefly surveys the visceral manifestations of primary Sjögren's syndrome. Two patients are described where the clinical picture was dominated by symptoms from lungs and kidneys respectively. | |
| 2377938 | [The effect of bakumondo-to on salivary secretion in Sjögren syndrome]. | 1990 Feb | The effect of a traditional chinese medicine 'Bakumondô tô' was evaluated on salivary secretion in thirty-eight patients with Sjögren's syndrome (SjS) and the results were compared with a matchen control group of patients treated with Hochûekki-tô. Hochûekki-tô is also one of the traditional chinese medicine. Tsumura Bakumondô-tô and Tsumura Hochûekki-tô (extract granules) were used. Daily dose was 9g and 7.5g respectively. Before looking into the effects of Bakumondô-tô on salivary secretion, we must define the reliability of the gum test. To avoid of learning effect, three sequential gum tests were needed. At the second gum test and the third gum test, no increase of salivary secretion was observed. So, we performed at least three gum test in each the patients studied. We have reached the following conclusion. First, in the Bakumondô-tô group the salivary secretion was significantly increased from 8.2 +/- 1.1ml (m +/- SE) to 11.4 +/- 1.4ml. (p less than 0.005) Second, in the Bakumondô-tô group, the increase in salivary secretion was 3.16 +/- 0.78ml which was significantly more than the increase in control group. (p less than 0.005) Third, in the course of long-term observation, the salivary secretion in patients under Bakumondô-tô treatment gradually increased. (r = 0.7290) Fourth, the improvement of salivary secretion under Bakumondô-tô treatment was marked in stage I and stage II of sialographical abnormalities of the salivary gland. Finally, Bakumondô-tô was very useful for managing oral manifestations in patients with SjS. | |
| 3394100 | [Sjögren's syndrome in children]. | 1988 | The authors summed up the results of a many-year study of 13 children with Sjogren's diseases and syndrome, presented clinical characterization of patients, a course of this childhood pathology, some therapeutic problems and catamnestic data. An excerpt from a case history of a child with Sjogren's syndrome was given. Characteristic features of this childhood pathology were defined in comparison with adult patients. | |
| 2830654 | [Polyneuropathy disclosing primary Gougerot-Sjögren syndrome. Treatment by plasma exchang | 1987 | A 27 year-old woman presented with a sensory-motor polyneuropathy, right facial hypoesthesia and bilateral Adie syndrome. These led to the diagnosis of primary Gougerot-Sjögren syndrome. A 6 weeks therapy with corticoids brought no improvement. Frank improvement followed 12 plasmatic exchanges. | |
| 1778672 | Primary Sjögren's syndrome from the viewpoint of an internal physician. | 1991 Nov | The characteristics of primary Sjögren's syndrome are described on the basis of the follow-up of 65 patients with extraglandular symptoms at the onset and during the disease. The mean age of the patients at onset was 41.8 years and at the time of definite diagnosis was 45.8 years. Articular (32 cases), lacrimal (30 cases) and salivary (30 cases) manifestations were the most frequent initial symptoms. In only 22 of the 65 patients could Sjögren's syndrome be diagnosed at the onset. In most cases, the articular symptoms observed observed in 56 patients during the course corresponded to true polyarthritis, as verified by joint scintigraphy. Most frequently the wrists and ankles were affected. Chronic atrophic gastritis was found in 35 patients. In the young patients (13 cases), both the antrum and the corpus were affected more frequently than in the controls. In middle-aged patients (21 cases), atrophy of the antrum, and in the elderly (10 cases) atrophy of the corpus was more frequent than in the controls. All three types of chronic atrophic gastritis occurred in the disease. The decreased gastric acid secretion was characteristic of types A and AB gastritis, but the hypergastrinaemia only of type A. It was verified that chronic duodenitis and jejunitis occur in the disease. The pancreatic lesions were mild. Renal involvement was detected in 15 patients, vascular symptoms in 22 and lower-airway changes in 21. The variety of the different symptoms proved that primary Sjögren's syndrome can involve many organs. | |
| 2026798 | MR imaging of Sjögren syndrome: correlation with sialography and pathology. | 1991 May | Magnetic resonance (MR) imaging of the parotid glands were performed in 13 cases of Sjögren syndrome to assess if there are any typical MR features. The MR findings were compared with sialography and pathology results. Signal intensity ratios of parotid (minus background noise) to skeletal muscle (minus background noise) were measured in these 13 cases as well as in 10 normal controls. Both T1- and T2-weighted images showed multiple hypointense mixed with hyperintense foci (salt-and-pepper appearance) throughout the glands in the six Sjögren cases of intermediate severity (46%), inhomogeneous glands in five cases with early or advanced disease, and homogeneous glands in the remaining two cases with the earliest stage of disease. Mean intensity ratios in T2-weighted pulse sequences in patients with salt-and-pepper appearance and inhomogeneous glands were significantly smaller than those in normal controls (p less than 0.05 and p less than 0.001, respectively). Pathologic studies tend to indicate that focal lymphocytic aggregates associated with increased interlobular fibrosis are probably responsible for the hypointense foci and the decrease in intensity ratios. We think that the salt-and-pepper appearance is suggestive of Sjögren syndrome and that the decreased intensity ratios combined with a typical clinical picture may lead to a highly probable diagnosis of this disorder. | |
| 3394093 | [Stomatological manifestations in Sjögren's disease and syndrome]. | 1988 | For diagnosis of SS and SD and the detection of early stages of disease one should necessarily take into account the symptom complex of "major" (salivary gland enlargement, xerostomia, exacerbation of parotitis) and "minor" stomatological signs (multiple cervical caries, dry lips, perlèche, mycotic and herpetic stomatitis, lymphadenopathy). The initial, marked and late stages were defined according to a degree of expression of stomatological manifestations. The initial stage prevailed in SS, the late stage in SD. The chief method of examination were sialometry, sialography and minor salivary gland biopsy. Sialography was widely used as a less traumatic diagnostic procedure. In addition to common signs with SD, salivary gland involvement was characterized by changes typical of SS combined with rheumatic disease (sclerosis in sclerodermia, vasculitis in RA and SLE, nuclear pathology in SLE). | |
| 2855250 | [Assessment of viral factors in the etiopathogenesis of Sjögren's syndrome]. | 1988 | This study has been carried out in serums of 32 Sjögren's syndrome (SS) patients -16 primary and 16 secondary- who have been followed-up for 3 years in Hacettepe University Medicine Faculty Ophthalmology Department. The serum levels of cytomegalovirus (CMV) antibodies and the antibody titers of herpes simplex virus (HSV) type I has been determined by the ELISA test and the complement fixation method respectively. The viral factors that play a role in the pathogenesis of SS have been discussed in regard to the results of the study. | |
| 3498598 | Clinical manifestations in HLA-B27-positive patients. | 1987 | The clinical manifestations of rheumatic diseases have been studied in a population of 440 HLA-B27-positive patients. Fifty-eight per cent had peripheral joint involvement. After statistical analysis and clustering of characteristics, three patterns of peripheral joint involvement were found. They were referred to as the X, Y and Z type for mnemotechnical reasons. The X type includes male patients with sacroiliitis, spondylitis, uveitis and uni- or bilateral arthritis of hip and/or shoulder. Y type patients present sacroiliitis, pauci-articular asymmetrical joint involvement and tendinitis. Z type patients are characterized by sacroiliitis, polyarticular symmetrical joint involvement and a positive IgM rheumatoid factor. This classification enables a new approach to the pathology, diagnosis and therapy of the seronegative spondyloarthropathies. |