Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2526221 | Axial involvement in the seronegative enthesopathy and arthropathy syndrome and its progre | 1989 Feb | We studied prospectively the clinical and radiographic features of sacroiliac and spinal involvement in 20 patients with seronegative enthesopathy and arthropathy. This group was compared with 25 patients with a polyarticular onset form of juvenile rheumatoid arthritis (JRA) and 28 with definite ankylosing spondylitis (AS) of juvenile onset. A significant increasing proportion of patients with seronegative enthesopathy and arthropathy developed back complaints and radiographic sacroiliitis fulfilling the diagnostic criteria for AS from the 3rd-5th year of disease (47.1-75.0%) and thereafter (92.3%). Back complaints were rarely seen in JRA and, furthermore, sacroiliitis of the AS type nerve occurring in this group. There were no significant differences between the group with seronegative enthesopathy and arthropathy and juvenile AS, either at onset or through the years. Clinical and radiographic assessment of axial involvement in children at risk should include a careful analysis of symptoms, periodical measurements of the spinal flexion and, starting from the 3rd year, radiographs of the pelvis. | |
| 3621684 | Humoral sensitivity to native collagen types I-VI in the arthritis of MRL/l mice. | 1987 Oct | The presence of immune reactivity to collagen in patients with rheumatoid arthritis as well as recent interest in the type II collagen-induced arthritis model have suggested a role for autoimmunity to collagen as a major disease mechanism. However, data concerning the occurrence of antibodies (AB) against the different types of collagen during a spontaneously occurring, histologically well-defined arthritis have been lacking. Sera from 48 MRL/l mice aged 5 to 25 weeks with spontaneously occurring hindlimb arthritis were obtained. Sera were tested for auto-AB against collagens utilizing highly purified native collage types I-VI. Significant levels of circulating AB against native collagen types I, III, and VI could not be detected in any age group. The greatest elevation of antibodies directed against type II collagen was found in 13- to 15-week-old mice. AB against type IV collagen were detected in slightly elevated levels with a maximum at 9-10 weeks. Most strikingly, AB against type V were markedly elevated after 19 weeks. The occurrence of high levels of AB against type V collagen, largely found in the pericellular matrix of smooth muscle cells, is associated with the late stage of disease characterized by histologically documented vasculitis. The results suggest that AB to collagen occur as a consequence of tissue destruction and that evidence for a pathogenetic role of AB in MRL/l arthritis is lacking. | |
| 3413289 | 99m-Tc HMDP bone scintigraphic findings of gouty arthropathy of both hands: extending soft | 1988 Jan | The 99mTc hydroxy methylene diphosphonate scintigraphic findings of both hands are correlated to the radiographic findings in a patient with a 30-year history of gouty arthropathy. Scintigraphic differentiation of the type of arthritis on the basis of uptake pattern is difficult. However, the findings of rheumatoid arthritis are confined to the joints and usually the involvement is symmetrical. With gout there is a tendency toward asymmetrical, bilateral, multifocal joint involvement with areas of intense abnormal uptake; because of the associated soft tissue swelling, the intense uptake usually extends beyond the involved joints. | |
| 1693443 | A highly conserved conformational idiotope on human IgM rheumatoid factor paraproteins of | 1990 | Human IgM rheumatoid factors have been classified into major (Wa) and minor (Po) idiotypically cross-reactive families on the basis of reactivity with polyclonal anti-idiotypic antisera. Extensive structural studies have revealed that RFs from the Wa CRI family have homologous light chains. The structural basis of this CRI however is not known. In this study we have defined a conformational idiotope requiring the association of the VH and VL of a number of RF from the Wa CRI family for its expression and which thus comprise part of the Wa CRI. A murine monoclonal antibody, G8 specific for the idiotope reacted with 67% of RFs from the Wa CRI family. G8 also reacted with one IgG2K paraprotein with unknown specificity suggesting that the idiotope per se does not confer RF reactivity. Comparative studies of G8 expression relative to previously described sequence-dependent heavy and light chain associated idiotopes suggest that G8 recognises a separate determinant. Furthermore, the G8 idiotope is found on RFs expressing the VHI subgroup of heavy chain. Study of G8 expression in polyclonal IgM in normal sera demonstrated that the idiotope is widely expressed in the population. However, significantly higher levels of IgM bearing G8 were detected in the sera of patients with rheumatoid arthritis. | |
| 2767737 | Measurement of rheumatoid factor isotypes in the clinical laboratory. | 1989 Jul | In this study we assessed the clinical utility of measuring all major rheumatoid factor (RF) isotypes (IgG, IgA, and IgM) in the diagnostic immunology laboratory using an enzyme-linked immunoassay (ELISA). An improved method for IgG-RF was tested which employed a commercially available monoclonal anti-human IgG Fd antibody and did not require pepsin digestion of samples. We detected elevated levels of all three RF isotypes in a population of hospitalized rheumatoid arthritis patients (n = 109). We demonstrated a significant association between IgM and IgA RF which occurred in 36% of our subjects, while less than 6% had IgM + IgG RF or IgG + IgA RF. A comparison of the IgM ELISA with the Rheumaton revealed a statistically significant correlation (r = 0.65, p = 0.001). In addition, the two methodologies were equivalent in sensitivity (ELISA: 76%, Rheumaton: 78%). However, the ELISA procedure was more time consuming, costly, and required greater technical expertise. The following clinical and laboratory findings were significantly associated with RF isotypes: IgG RF and the presence of rheumatoid nodules (p = 0.03), elevated erythrocyte sedimentation rate (ESR) and IgG RF (p = 0.007), and elevated ESR and IgM RF (p = 0.0009). Our ELISA methodology did not provide significant advantages over existing techniques to justify its use as part of the routine laboratory assessment of rheumatoid factor. | |
| 3200113 | Follow-up study of lipid peroxides, superoxide dismutase and glutathione peroxidase in the | 1988 | Because reactive oxygen species (ROS) are generally believed to play an important role in tissue injury in rheumatoid arthritis, we examined the levels of lipid peroxides, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) in the synovial membrane, serum and liver of young (8 wk) and old (12 mo) mice with collagen-induced arthritis. In the synovial membrane, serum and liver, lipid peroxide levels of both young and old mice were increased beginning on the 3rd day after the onset of arthritis. SOD activity, which scavenges O2- and inhibits lipid peroxidation, rose markedly in the synovial membrane of young mice in parallel with the increase in lipid peroxide levels, but not so markedly in old mice. Liver GSH-Px activity, which metabolizes already formed lipid peroxides, also rose in young arthritic mice to a greater degree than in old mice. This study suggests that in inflammatory synovial lesions, lipid peroxides are generated due to an increase in ROS concentration, with resultant cytotoxicity, and that younger animals or humans can prevent this unfavorable reaction more effectively than aged ones by enzyme induction. The hypothesis that lipid peroxides formed in the oxidative lesions of the primary organ are released into the serum, trapped by the liver and metabolized there is further supported by the present study. | |
| 2218429 | Distribution of Gm allotypes in juvenile chronic arthritis. | 1990 | The immunoglobulin allotypes G1m(a), G1m(x), G2m(n), G3m(b) and Km(1) were determined in 76 Swedish patients with juvenile chronic arthritis (JCA). Eight of the patients had the systemic form of the disease. 37 belonged to the polyarticular and 31 to the oligoarticular subset. The frequency of the G1ma(x), G3m-b haplotype was significantly increased in the polyarticular subset but not in the oligoarticular subset, compared with the normal population (p less than 0.01). The polyarticular subset also differed from the oligoarticular subset with increased frequency (p less than 0.01) and higher levels (p less than 0.01) of IgM rheumatoid factor and a lower rate of remission (p less than 0.05). The few JCA patients in the systemic subset showed similar features as the polyarticular patients. The frequencies of G2m(n) and Km(1) did not deviate from the expected in any of the JCA subsets. | |
| 2648676 | [Clinical importance of changes in antibody immunity in gout]. | 1989 Jan | In 77 patients with gout (16 with acute attacks and 61 during an attack-free period), in 30 healthy subjects, 30 patients with IgM RF serum positive rheumatoid arthritis (RA) and 20 cases of IgM RF serum negative RA the authors examined serum values of 10 parameters of antibody immunity: IgA, IgG, IgM, IgD, IgE, beta-2 microglobulin (beta-2 MG), immunocomplexes (IK), IgM RF/LFT, IgM/RF/HAT and ANA/IF. Data obtained by quantitative analyses were processed by stepwise discrimination with the consecutive selection of characteristics significant for the differentiation of the investigated groups and by assessment of classification functions which make it possible to classify individuals selected at random. The authors consider the following particularly important from the clinical aspect: acute gouty attack--IgM RF serum positive RA (IK and beta-2 MG), attack-free stage of gout--healthy subjects (IgA, IgG, IgM, IgD, IK, IgE). IgM RF were detected in 5/77 patients with gout, ANA/IF not in a single patient. | |
| 3195528 | Nonsteroidal anti-inflammatory drug therapy in chronic childhood iridocyclitis. | 1988 Dec | The adjunctive use of nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of chronic iridocyclitis was evaluated in 14 patients, eight with juvenile rheumatoid arthritis and six with idiopathic iridocyclitis. In all patients, the activity of the iridocyclitis improved with the addition of NSAIDs to their treatment regimens, permitting reduction in the dose of corticosteroid drugs. These data suggest that NSAID therapy may have an adjunctive role in the treatment of chronic iridocyclitis in childhood. | |
| 2357502 | The effect of pressure gradient and thermolactyl control gloves in arthritic patients with | 1990 Jun | In this study the effect of pressure gradient gloves was compared with that of control gloves by eight patients with rheumatoid arthritis (RA) and diffusely and symmetrically swollen hands. In the morning at fixed times, grip strength, circumference of PIP joints and proximal phalanges, nocturnal pain and morning stiffness in the hands were measured. Significant improvement of circumference of PIP joints (P less than 0.001) and proximal phalanges (P less than 0.01) were found. On wearing the control gloves, some improvement was also found, but only the circumference of PIP joints decreased significantly (P less than 0.05). Nocturnal pain and morning stiffness diminished significantly on wearing both types of glove. Grip strength improved, but not significantly with both. No significant differences were detected between the effects of wearing the two types of glove. No correlation was found between the decreased swelling in the hands as measured by PIP joint circumference or circumference of the proximal phalanges and the decreased nocturnal pain or morning stiffness. This study provided no explanation for the beneficial effect of the gloves. It was shown that for some patients with painful and swollen hands, wearing gloves at night may give relief. | |
| 2660252 | New understandings of NSAID gastropathy. | 1989 | Non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy is a serious public health problem. The United States Food and Drug Administration has recently proposed strong class labelling for NSAIDS, warning of the risk of ulceration, bleeding and perforation associated with their use. The adaptation of the gastric mucosa in response to NSAID intake in volunteers does not seem to occur to the same extent in rheumatic patients. In an ongoing study of patients with osteo- or rheumatoid arthritis, currently in its fourth year, nabumetone has been shown to be relatively gastric sparing when compared with naproxen. Nabumetone is at least as effective as naproxen. Long-term studies are important as treatment of arthritis may involve prolonged use of NSAIDs. | |
| 3662638 | Yersinia specific immune complexes in the synovial fluid of patients with yersinia trigger | 1987 Jul | Yersinia specific immune complexes were demonstrated in the synovial fluid of three patients out of 12 with yersinia triggered reactive arthritis. They were not detectable in the synovial fluid of any of the 16 control patients, including nine with reactive arthritis triggered by factors other than yersiniae. Platelet reactive IgG was detectable in the synovial fluid of eight out of the 12 patients with yersinia triggered reactive arthritis and in three of the 16 control patients, all three having rheumatoid arthritis. An enzyme linked immunosorbent assay and a platelet 125I labelled staphylococcal protein A test were used to measure yersinia specific immune complexes and platelet reactive IgG respectively. The results obtained show for the first time the occurrence of bacterial antigens, derived from the causative strain, in the synovial fluid in yersinia triggered reactive arthritis. | |
| 3496524 | [HLA-B27 associated spondyloarthritis in childhood]. | 1987 Apr | Ankylosing spondylitis, indefinite juvenile spondyloarthritis (JSA), reactive arthritides, psoriasis arthritis, arthritis of inflammatory bowel disease, and probably other rare diseases, such as the Behçet-syndrome, are sharing several distinctive features which discriminate them as a group from other arthritides, particularly from the rheumatoid arthritis in children (JRA) and adults. These distinctive features are: familial aggregation; association with HLA-B27; enthesopathy, sacroiliitis; predominance of Lower-Limb-arthritis; onset mostly after the age of 10 years, and typical manifestations of the skin and mucous membranes. Based on these characteristics and the probability of a later involvement of the spine, this group of diseases has been designated "HLA-B27-associated spondyloarthritides". Two thirds of all cases do not fit in any of the well-known spondyloarthritides. In this subgroup, designated as JSA, the disease begins usually with oligoarthritis and/or enthesopathy, and based on further clinical criteria it can early be distinguished from the JRA. The diagnosis of the other spondyloarthritides can be established primarily or later on follow-up, based on further characteristic symptoms and findings. In the differential diagnosis of arthritis in children, one third do have a spondyloarthritis and about one half do have JRA. This differentiation is of an important therapeutic and prognostic value, e.g. the slow-acting drugs are effective in JRA but not in spondyloarthritis, and in patients with axial manifestations, the early education and training for correct posture is important to prevent the development of kyphosis. | |
| 1918494 | Annular erythema associated with Sjögren's syndrome: a variant of systemic lupus erythema | 1991 Sep | We present a Burmese patient with widespread annular erythema associated with Sjögren's syndrome. Unlike previously described cases, the disease occurred in the setting of systemic lupus erythematosus. Photoprovocation testing revealed light sensitivity in the UVA range with elicitation of subacute cutaneous lupus erythematosus-like lesions. The presence of an erythema annulare centrifugum-like eruption should initiate the search for Sjögren's syndrome and systemic lupus erythematosus. | |
| 1881026 | Anti-Ro(SSA) and anti-La(SSB) antibodies in lupus erythematosus and Sjögren's syndrome. | 1991 Jun | Anti-Ro(SSA) and La(SSB) antibody determinations have become important serologic tests in the evaluation of lupus erythematosus and Sjögren's syndrome patients. These antibodies appear to identify a group of lupus patients with prominent skin diseases. Although much of the initial investigations regarding the value of these antibodies has been performed in the United States and Europe, preliminary studies suggest that the frequency of these antibodies in Japanese and other Oriental patients may be double that seen in American patients. This article will briefly review our knowledge of the molecular, immunogenetic and clinical features of the anti-Ro(SSA) and anti-La(SSB) antibody responses. | |
| 2183805 | Salivary gland echography in patients with Sjögren's syndrome. | 1990 Apr | Ultrasonographic examinations of salivary glands were performed on 24 patients with Sjögren's syndrome. On B-mode echographic images, the submandibular glands of 21 of the patients (88%) showed a heterogeneous pattern, whereas all of the control subjects had homogeneous patterns. This distinction was further confirmed by the results of the analysis of the histogram patterns of echo intensity and echo frequency of the submandibular glands, which showed that the width of the echo level at 0% and 10% of the maximum normalized frequency was significantly greater in patients with Sjögren's syndrome than in the control subjects. Similar histographic findings were present in the parotid glands, although the heterogeneous ultrasonographic pattern was observed in only 8 of the 24 patients (33%). These results indicate that ultrasonography may be useful in the evaluation of salivary gland involvement in patients with Sjögren's syndrome. | |
| 2736825 | Parotid sialography and lip biopsy in the evaluation of oral component in Sjögren's syndr | 1989 Mar | In order to evaluate their sensitivity and specificity, parotid sialography (PS) and labial salivary gland biopsy were performed in 150 putative patients with Sjögren's syndrome (SS) (74 with SS alone and 76 with SS associated with other well-defined disorders). Although PS and LSGB strongly correlated to each other (Kendall's Tau 0.47, z = 7.78, p less than 0.0001), PS confirmed the diagnosis of SS in a significantly higher prevalence of patients with respect to LSGB (63% vs 37%, chi 2 = 18.25, p less than 0.001). When the sensitivity and specificity of PS and LSGB were calculated, PS showed a better sensitivity, and an only slightly lower specificity than LSGB (86% vs 70% and 78% vs 86% respectively). In conclusion, our study indicates that PS has been unduly overlooked in the past decades as a diagnostic tool for the salivary component of SS, and should be reconsidered as a potentially useful and relatively non-invasive procedure in the approach of patients with this disease. | |
| 3068363 | Ultrasonography and computer tomography of the salivary glands in the evaluation of Sjögr | 1988 Dec | Ultrasonography (US) and computed tomography (CT) were studied as noninvasive methods to determine salivary gland involvement and compared with parotid sialography in patients with Sjögren's syndrome (SS) and patients with only objective xerostomia and/or xerophthalmia. Patients with complaints of dry eyes and dry mouth but with no objective abnormalities served as controls. CT was not discriminative between the 2 groups. In contrast, US revealed decreased parotid gland echogenicity in most of the patients with SS, compared with only 1 patient in the group with sicca complaints only (p = 0.005). Our study suggests that US can be a useful, noninvasive method in the diagnostic investigation of patients with sicca complaints. | |
| 3555358 | Sjögren's syndrome. Association of cutaneous vasculitis with central nervous system disea | 1987 Jun | We describe a group of patients with Sjögren's syndrome, who commonly present to dermatologists with cutaneous manifestations of vasculitis. Two specific clinically recognizable forms of cutaneous vasculitis predominate: palpable purpura of the lower extremities (Waldenström's benign hypergammaglobulinemic purpura) and urticarialike vasculitis. Two pathologic types of cutaneous vasculopathy are demonstrated, one leukocytoclastic and the other mononuclear. The leukocytoclastic vasculopathy is associated with high titers of Ro(SS-A) and La(SS-B) autoantibodies (detected by gel double-diffusion techniques) and general serohyperreactivity. In marked contrast, the mononuclear vasculopathy is associated with low titers of Ro(SS-A) and La(SS-B) autoantibodies (detected by enzyme-linked immunosorbent assay but not gel double-diffusion techniques) and general serohyporeactivity. Approximately 70% of patients with Sjögren's syndrome and cutaneous vasculitis have also developed peripheral and/or central nervous system disease. The pathogenesis of the nervous system disease is unknown, but preliminary data suggest a vasculopathy. | |
| 3828546 | [Short-term tracheobronchial clearance in apparently pure Gougerot-Sjögren syndrome]. | 1986 Nov | Bronchopulmonary involvement in the Sjögren syndrome can lead to distal obstructive airway disease. This syndrome induces a decrease in secretions which become rare and thick, and consequently a slowing down of mucociliary activity. This activity, which can be estimated by tracheobronchial clearance studies, was investigated in seven non-smoking women (mean age = 56.7 yr) with the Sjögren syndrome but without patent distal bronchial impairment. After oral inhalation of radioactive particles labelled with 111In during spontaneous breathing (MMAD = 3 micrograms; sigma g = 1.4; energies gamma 173 and 247 keV, radioactive half-life = 2.8 days), the incorporated radioactivity was measured by a gamma-camera at the end of inhalation and then every 5 min throughout 90 min and 2, 4, 5, 6 and 24h thereafter. Biological decrease in radioactivity was exponential in form. Considering, as may authors do, the clearance of the tracheobronchial compartment to be completed within 24h, we calculated an initial biological period corresponding to the beginning of this clearance. It was equal to 101 +/- 27 min in 12 normal subjects. It was normal in three of our patients (T = 90, 91 and 101 min) and longer for the four others (T = 178, 203, 240 and 304 min). We hypothesize that three of these four patients with slow clearance and normal penetration index (tracheobronchial deposition/pulmonary deposition) had bronchiolar involvement, creating anomalies in the mucociliary escalator which were undetectable by clinical, radiological or functional examinations. These results argue in favour of strict pulmonary surveillance in patients with altered short-term clearances to enable early detection of bronchiolar disease. |