Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3276169 | Characterization of immune cells in kidneys from patients with Sjogren's syndrome. | 1988 Jan | The association of interstitial nephritis, the most common renal lesion in Sjogren's syndrome, to the other manifestations of the disease is unclear. To begin to address this issue, the infiltrating cells in frozen kidney tissues from two patients with interstitial nephritis secondary to Sjogren's syndrome were characterized by indirect immunofluorescence. T cells predominated, the majority of which were helper/inducer cells (OKT4+). Both kidneys contained nodules of B cells. The increased proportion of OKT4+ T cells in salivary gland and in interstitial renal lesions of Sjogren's syndrome contrasts with some other forms of interstitial renal disease and suggests that the renal and salivary gland lesions have a similar pathogenesis. | |
| 3473630 | In vivo IgG deposits and reduced density of Langerhans cells in the surface epithelium of | 1986 | Intraepithelial IgG deposits have previously been demonstrated in epidermis and oral labial mucosal epithelium of patients with primary Sjögren's syndrome. IgG has been shown to be located to cell surface membranes predominantly of OKT6 positive Langerhans cells (LC), which moreover are decreased in number in epidermis of these patients. In biopsies of cervix uteri from 17 patients with primary Sjögren's syndrome and 21 controls, the mucosal membrane was examined with a direct immunofluorescence technique, for in vivo deposits of immunoglobulins, fibrinogen and C3c in the stratified squamous epithelium. Epithelial deposits of IgG, similar to that found in skin and oral labial mucosa, were demonstrated in 4/17 patients, but in none of the controls. No deposits of IgM, IgA, fibrinogen or C3c were found in the biopsies from either patients or controls. OKT6 positive mucosal LC were demonstrated with an indirect immunofluorescence technique, and enumerated in vertical sections. The density of epithelial LC was found to be decreased in patients (p less than 0.05) as compared to controls. No correlation was found between presence of IgG deposits and density of LC, in agreement with the findings in skin of these patients. | |
| 2332852 | Major salivary gland function in primary Sjögren's syndrome and its relationship to clini | 1990 Mar | Unstimulated and stimulated salivary secretions of both the parotid and submandibular/sublingual glands were studied in 64 patients with primary Sjögren's syndrome to define further salivary changes in this disorder. The stimulated flows of the submandibular/sublingual glands were below normal in 56 of 64 patients, while stimulated parotid flows were decreased in only 35. Compositional changes of the submandibular saliva paralleled changes of parotid saliva, and these data suggest that ductal electrolyte resorption is altered in the glands of patients. Finally, stimulated parotid flow rates correlated inversely with focus scores of the minor salivary gland biopsies. | |
| 3538930 | Epidermal Langerhans cells in patients with primary Sjögren's syndrome. | 1986 Aug | IgG-binding to the surface of Langerhans cells (LC) is a feature of primary Sjögren's syndrome and might be associated with qualitative and quantitative defects in LC. Fifteen patients with primary Sjögren's syndrome and 15 healthy controls had a punch biopsy performed from clinically unaffected skin. LC were enumerated in epidermal sheets by an immunoperoxidase technique, as well as demonstrated by immunofluorescence in vertical sections, which were furthermore examined for in vivo deposits of immunoglobulins, fibrinogen and C3. A significant (P less than 0.05) reduction in number of LC, measured on epidermal sheets, was found in patients as compared with controls. Examination of vertical sections did not reveal abnormalities in morphology or localisation of epidermal LC. Intraepidermal IgG deposits were demonstrated in 7/15 patients. In vivo deposits were not found in any of the controls. The density of epidermal LC was not correlated to the presence of intraepidermal IgG deposits. | |
| 2816623 | [Secondary amyloidosis of the bladder associated with Sjögren's syndrome: a case report]. | 1989 Sep | A 57-year-old woman visited the Mie University Hospital with the complaint of lower abdominal pain on December 2, 1987. Cystoscopic examination revealed a non-papillary tumor with a broad base in the left posterior wall. A diagnosis was made by biopsy of the bladder epithelium. Amyloid fibrils were confirmed in the biopsy specimen with polarization and electron microscopies. Symptomatic secondary amyloidosis of the bladder is very rare. To date, only 15 cases have been reported in the American and European literatures. This seems to be the first case reported in Japan. | |
| 2812479 | [Pseudo-Sjogren's syndrome in type IV hyperlipoproteinemia. Description of a clinical case | 1989 Sep | A case of type IV hyperlipoproteinemia, obesity, mild diastolic hypertension, xerostomia and bilateral parotid gland enlargement is described. The labial biopsy showed a fatty infiltration, but not inflammatory infiltrates. On the basis of these data, a diagnosis of pseudo-Sjögren's syndrome was made. | |
| 2910685 | Sjogren's syndrome. Its contribution to neuropsychiatric syndrome in patients with primary | 1989 Jan | The neuropsychiatric status of patients with primary biliary cirrhosis (PBC) was contrasted to that of patients with PBC and accompanying Sjogren's syndrome and to a matched group of normal controls. The subjects with PBC + Sjogren's syndrome had a more profound impairment on a battery of psychometric tests than did the subjects with PBC alone. In addition, they more frequently met the criteria for a psychiatric diagnosis of anxiety disorder than did those with PBC alone. | |
| 3357471 | Assessment of a patient-completed questionnaire for keratoconjunctivitis sicca. | 1988 Apr 18 | A patient-completed questionnaire has been shown to be equivalent to an observer-administered format in discriminating between subjects with and without keratoconjunctivitis sicca. As well as saving time it can screen patients for the presence of keratoconjunctivitis sicca without the need for more specialized and/or invasive techniques. | |
| 3394097 | [Personality and psychopathology in patients with primary Sjögren's syndrome]. | 1988 | Twenty-one patients with primary Sjogrens' syndrome were investigated for hostility structure and psychiatric symptomatology. It was observed that they manifested high levels of hostility with an intropunitive direction in combination with highly scored delusional items of guilt and paranoid hostility. Acting-out hostility was in low levels. From the psychopathology point of view the majority of patients reported mainly depression and somatization, as well as anxiety and obsessive-compulsive symptoms. Unexpectedly paranoid symptoms were revealed in a substantial number of these patients. SS patients may present serious psychiatric symptoms and are in need of psychiatric help. | |
| 3314876 | Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthrit | 1987 Oct | We studied 10 patients who had arthritis of the knee joint, but no other signs of rheumatic disease. The clinical diagnosis of osteoarthritis was corroborated by arthroscopic evidence of characteristic cartilage degeneration. Signs of inflammation were confined to areas of the synovial membrane that lay near the cartilage; thus, the major part of the joint cavity was not affected. The intensity of the synovial inflammation varied within the areas involved, but was always most pronounced in regions rimming the cartilage. Biopsy samples selected from regions of intensely inflamed synovium contained foci of T lymphocytes, which were bordered by immunoglobulin-carrying B lymphocytes and plasma cells, as well as strongly HLA-DR positive dendritic-like cells adjoined to alpha Leu-3a+ T helper lymphocytes. In tissue samples taken from macroscopically noninflamed areas, only a few infiltrating lymphocytes were seen. Thus, the inflammatory synovial changes found in osteoarthritis appear to be anatomically restricted and of varied intensity but, when present, are microscopically indistinguishable from the changes that have been previously described as indicative of rheumatoid arthritis. | |
| 2302887 | Ankle arthroplasty. A comparative study of cemented metal and uncemented ceramic prosthese | 1990 Mar | From 1975 to 1980, total ankle arthroplasty was performed using a metal and polyethylene prosthesis on 30 ankles in 28 patients with painful arthritis. However, because loosening and sinking of the prosthesis were significant, a ceramic total prosthesis was designed in 1980 to be used without cement. Between 1980 and 1987, 39 ankles in 35 patients with osteoarthritis, rheumatoid arthritis, and hemophilic arthritis were replaced using the ceramic prosthesis. Out of 39 ankles, nine were replaced with cement and 30 without cement. The follow-up period for the cemented metal and ceramic cases ranged from 13.4 to 6.2 years, with an average of 8.1 years, and for uncemented ceramic cases from 1.2 to 6.4 years, with an average of 4.1 years. Based on a rating scale for ankle evaluation, 27% of the cemented cases and 67% of the uncemented cases are satisfactory. Five metal ankles and one ceramic ankle were reoperated upon, with one revision and five arthrodeses performed. Ceramic total ankle arthroplasty, performed without cement, has to date provided mostly excellent stable results. | |
| 2067879 | Meniscal-bearing unicompartmental knee arthroplasty. An 11-year clinical study. | 1991 May | From 1977 through 1987, 21 meniscal-bearing unicompartmental knee arthroplasties (UKAs) were performed on 20 patients in preference to a distal femoral or proximal tibial osteotomy for unicompartmental knee arthritis. Preoperative diagnoses were osteoarthritis (14 cases), posttraumatic arthritis (5 cases), and rheumatoid arthritis (1 case). Eighteen UKAs (7 lateral, 11 medial) were followed for 24 to 132 months (mean, 34). Using the New Jersey Orthopedic Hospital Knee Scoring Scale, good to excellent clinical results were found in 16 (89%) of the UKAs followed for at least two years. These scores represent significant improvement over preoperative evaluation, (paired t test, P less than or equal to .05). No statistical difference was noted in postoperative results between the lateral or medial arthroplasties (Student's t test, P less than or equal to .05). | |
| 3718014 | Immunoglobulin classes in plasma cells of the synovial membrane in chronic inflammatory jo | 1986 May | The histological features of the synovial membrane in rheumatoid arthritis (RA) are shared by other chronic inflammatory joint diseases, so that diagnostic differentiation is impossible. Examination of the immunoglobulin class in the plasma cells present in inflamed synovial membranes, however, has shown differences. Synovial membranes from 12 patients were seropositive RA, eight with seronegative RA, eight with ankylosing spondylitis, five with psoriatic arthritis, and three with Reiter's syndrome have been compared by peroxidase-antiperoxidase (PAP) staining for immunoglobulin classes on routinely paraffin wax embedded sections. There were no significant differences in the percentages of plasma cells containing IgG of IgA between the diseases studied. There were, however, significantly more plasma cells containing IgM in patients with seropositive RA (2-34%) compared with those with seronegative RA (0-10%; p less than 0.002) and with other chronic synovitides (0-9%; p less than 0.002). The results show that it is possible to distinguish seropositive RA from other chronic inflammatory joint diseases by PAP staining for immunoglobulin classes in the plasma cells present in the inflamed synovial membrane. | |
| 3488708 | Evaluation of rheumatic disorders in patients with primary biliary cirrhosis. | 1986 | Twenty-six consecutive patients with primary biliary cirrhosis (PBC) were subjected to clinical, radiological and serological assessment for evidence of rheumatic disease. Seven patients had asymptomatic liver disease, while the rest had symptoms indicating varying stages of advanced disease. Of the 18 patients with arthropathy, in 13 there was considered to be an association between the arthropathy and PBC as no other underlying causes could be discovered. In about half of the patients the symptoms were episodic, while the others had chronic pain. Usually both large and small joints were affected bilaterally. The joint symptoms had an average duration of 5 years, and had started in all patients after the onset of the liver disease. All 7 patients with arthritis fulfilled the criteria of the American Rheumatism Association for rheumatoid arthritis (RA). Five patients were classified as definite or classical RA. Circulating immune complexes were present in 35% of all patients, but there was no correlation with the presence of arthropathy. Seven patients were HLA-B27 positive, of whom 4 had arthritis. The investigation demonstrates that rheumatic disorders are common in PBC patients, whether or not they are symptomatic, and sometimes joint symptoms may even dominate the clinical picture. | |
| 1826647 | The distribution and functional properties of dendritic cells in patients with seronegativ | 1991 Apr | Dendritic cells (DC), potent antigen-presenting cells, are known to be increased in numbers in inflammatory lesions in rheumatoid arthritis and juvenile chronic arthritis. In this study, patients with seronegative arthritis were studied; the distribution and functional properties of DC enriched low density cells (LDC) from peripheral blood (PB) and synovial fluid (SF) were compared. The composition of LDC from both sources was similar, comprising approximately 30% DC, 60% monocytes with few T lymphocytes. SF was significantly enriched for LDC compared with paired peripheral blood (P less than 0.0001) or peripheral blood from healthy controls (P less than 0.001). In contrast, patient PB contained fewer LDC (P less than 0.05) overall than healthy controls. LDC from both sources were potent simulators of allogeneic PB T cells in a mixed leucocyte reaction (MLR), but in four out of 10 patients SF LDC were significantly more stimulatory. In autologous MLRs (AMLRs) SF T cells were not stimulated by either LDC population. This anergy of T cells was confined to the joint as patient PB T cells showed an AMLR response to PB LDC which was similar to that seen in cells from healthy controls. PB T cells also responded to SF LDC; in a minority of patients SF LDC caused significantly greater stimulation in AMLR than PB LDC and the possibility is discussed that this may represent presentation of antigen acquired in vivo. | |
| 2224401 | The sulphated glycosaminoglycan levels in synovial fluid aspirates in patients with acute | 1990 Oct | Proteoglycan levels were measured in a series of synovial fluid samples from patients with acute and chronic joint diseases using a modified chemical dye binding method. Levels found in 50 miscellaneous inflammatory arthritis fluids (mean = 173.2 +/- 90.9 micrograms/ml) were higher than found in either 50 with rheumatoid arthritis (96.3 +/- 31.3 micrograms/ml) or 50 with osteoarthritis (83.8 +/- 27.3 micrograms/ml). For comparison, proteoglycan levels were measured in 15 cadaver synovial fluids (98.9 +/- 44.2 micrograms/ml) and 12 synovial fluids from patients with sports injury (163.7 +/- 79.4 micrograms/ml). Patients were recruited into a trial where synovial fluid was aspirated as often as possible over a 6-month period during which the patients were followed using a number of well proven clinical parameters. No correlation was found between the degree of joint destruction as measured by X-ray damage and the concentration or total amount of proteoglycan in the synovial fluid. In addition, there was no correlation between the level or total amount of proteoglycan and any clinical parameter of disease activity. | |
| 2145213 | Elevated synovial tissue concentration of the common acute lymphoblastic leukaemia antigen | 1990 Sep | The cell-surface neutral endopeptidase 3.4.24.11 (NEP) activity of the common acute lymphoblastic leukaemia antigen (CALLA) cleaves diverse peptide mediators at specific sites and it has been postulated that it regulates immune responses. The concentration of NEP was quantified in detergent extracts of synovial tissues by the percentage hydrolysis of [3H-D-Ala]-Leu enkephalin/hr/100 mg of tissue. The synovial tissue concentration of NEP was higher in all patients with rheumatoid arthritis (n = 7; group mean +/- SD = 29.4 +/- 20.2%), and was higher with degenerative joint disease (n = 6 of 8; group mean +/- SD = 11.9 +/- 10.4%) than with traumatic arthropathy (n = 3; 1.1 +/- 0.7%). The lack of direct relationship between synovial tissue NEP concentration and leukocytic infiltration suggests that the cellular source of NEP may be synoviocytes or fibroblasts, and that NEP may have distinctive pathogenetic roles in human arthritis. | |
| 2528286 | Social support and adjustment in chronically ill and handicapped children. | 1989 Apr | The relationship between social support and adjustment was investigated in children with a chronic physical illness or handicap. Mothers of 153 children with juvenile diabetes, juvenile rheumatoid arthritis, chronic obesity, spina bifida, or cerebral palsy reported on these children's family support, peer support, externalizing behavior problems, and internalizing behavior problems. Children reported as having high social support from both family and peers showed a significantly better adjustment than those with high social support from only one of these sources. Chronically ill or physically handicapped children without high support from both family and peers were reported to have significantly more behavior problems than children in general. Both family and peer support contributed negatively and independently to the variance in externalizing behavior problems, whereas only peer support did so for internalizing behavior problems. There were no interactions between type of support and either sex or age in predicting adjustment. | |
| 3794972 | Subcutaneous palisading granulomas (benign rheumatoid nodules) in children. | 1986 Dec | Subcutaneous palisading granulomas (SPG), also known as benign rheumatoid nodules, occur in otherwise healthy children. Although these lesions have the same histology as rheumatoid nodules in adults, subcutaneous granuloma annulare, and diabetic lipoidicum, they appear to represent a distinct clinicopathologic entity. We reviewed our experience with 17 cases of SPG. All patients presented with one or more painless, nonmobile, subcutaneous nodules. Lower extremity involvement was most common, but lesions presented in the upper extremities and scalp as well. There were 14 girls and three boys ranging in age from 10 months to 15 2/12 years (mean, 4 5/12 years) at the time of diagnosis. Past medical histories were negative. Laboratory and radiologic studies were normal except for one child with an elevated erythrocyte sedimentation rate (ESR). The follow-up period ranged from 6 months to 14 10/12 years (mean, 4 11/12 years). Subsequent new lesions developed in nearly two thirds of the patients. In the one child with an initially elevated ESR, rheumatoid arthritis developed. All others were alive and well except for one who died in a motor vehicle accident without evidence of further disease. Preoperative diagnosis was correct in only three patients. Excisional biopsy was performed in all cases. However, one child had received prior radiation therapy, one received topical steroid therapy, and three patients had subsequent lesions excised. All subsequent lesions not surgically excised underwent spontaneous involution.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1780917 | Sjögren's syndrome and pregnancy. | 1991 Jul | We analyzed 117 histories of pregnancy obtained from 40 female patients with Sjögren's syndrome (SS) including 13 patients with primary SS and 27 patients with secondary SS. The frequency of spontaneous abortions did not differ in the 40 patients and those with primary SS compared with 129 healthy women. However, both spontaneous abortions and premature deliveries were significantly more frequent in the SS patients with systemic lupus erythematosus (SLE). Anti-SS-A and anti-SS-B antibodies were not associated with the outcomes of pregnancy although spontaneous abortions were more frequent in secondary SS patients with false positive serological tests for syphilis, anti-erythrocyte antibodies, thrombocytopenia or prolonged activated partial thromboplastin time. Neither congenital anomalies nor connective tissue disease was found in the 77 neonates of the patients. We concluded that SS does not influence the outcome of pregnancy except in patients with SLE or those with serological and hematological abnormalities related to lupus anticoagulants or antiphospholipid antibodies. |