Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2810277 | IgA rheumatoid factor and IgA containing immune complexes in primary Sjögren's syndrome. | 1989 Sep | IgA rheumatoid factor (RF) and immune complexes containing IgA-IgG, C3-IgA, and C3-IgG from sera of patients with primary Sjögren's syndrome and controls were quantified by ELISA. Salivary tissue obtained from patients at the same time as serum was scored to simultaneously reflect lymphoplasmocytic infiltrate and fibrosis. Patients had significantly increased amounts of IgA RF and all complexes when compared to controls (p less than 0.0005). IgA-IgG complexes, thought to be IgG-IgA RF complexes, were inversely correlated to tissue pathology (p less than 0.001) and peripheral white blood cell counts. Additionally, IgA RF was inversely correlated to stimulated parotid flow. This suggests immune complex formation precedes tissue destruction or is associated with less destructive pathology in primary Sjögren's syndrome. | |
| 3426303 | Selective bone marrow involvement of lymphoplasmacytic cells secreting monoclonal IgA rheu | 1987 Dec | The clinical features and results of serological studies of a patient with Sjögren's syndrome, IgA kappa monoclonal gammopathy, and hyperviscosity syndrome are reported. The novel aspect of this case is the selective localisation to the bone marrow of lymphoplasmacytoid cells secreting IgA kappa morphologically identical to the cells infiltrating the salivary glands. The serum of the patient contained large amounts of immunoglobulin-anti-immunoglobulin immune complexes. By gel filtration chromatography it was shown that the immune complexes formed a peak of molecular weight 680 kilodaltons. The immune complexes were dissociable under acidic conditions. The immunoglobulin with rheumatoid activity was characterised as monoclonal IgA kappa protein. Treatment with plasmapheresis combined with immunosuppressive treatment with cyclophosphamide reduced the serum viscosity with concomitant clinical improvement. | |
| 2683009 | [Cartilage and synovial membrane]. | 1989 Jul | The synovial membrane acts on the cartilage at the levels of the synovial cells, the production of soluble factors and the cartilage components. The synovial membrane is at the same time a trophic, an immunologic and a defense organ. One does not oppose anymore the aspects found in normal synovium to those found in osteoarthritis and in rheumatoid arthritis. Synovial reactivity against the cartilage components is mediated by specific initiating mechanisms leading to an amplification process. Various soluble factors regulate this cooperation at the articular and the systemic levels. The dysregulation between these factors plays a role in the pathogenesis of joint diseases. | |
| 2627487 | [The state of muscle cramp disease]. | 1989 May | A 65-year-old man presented with daily, almost continuous muscle cramps and painless muscle contractions eight years after being diagnosed as having rheumatoid arthritis. Both cramps and contractions were present at rest, were accentuated by stress and disappeared during sleep. By night-fall the patient was plunged into an extremely disabling condition due to the continuous cramps present in the orofacial, trunk, neck and limb musculature. He even had difficulty speaking. EMG studies demonstrated that both cramps and painless contractions appeared synchronously in muscles innervated by different peripheral nerves. A state of central hyperexcitability is the probable cause of this clinical picture which has remained unchanged over the last six years. | |
| 3209792 | Ocular chrysiasis. | 1988 Dec | Elemental gold, administered parenterally and orally, is used to a moderate extent to treat rheumatoid arthritis, Sjögren's syndrome and nondisseminated lupus erythematosus. Deposition of gold salts are observable in ocular tissues during chrysotherapy. These tissues are the cornea, conjunctiva, skin, lens and retina. This case report describes ocular chrysiasis and discusses its clinical management. | |
| 3189350 | Using multiple cause of death coding in occupational mortality studies. | 1988 | Conventional occupational mortality analysis, using underlying cause of death coding, underestimates the contribution of those chronic diseases which are mentioned on the death certificate but which usually do not appear as underlying cause of death. Proportionate occupational mortality analysis, using all the mentioned causes on the Washington State male death records 1968-1984, identified an excess of rheumatoid arthritis in farmers, and asbestosis in plumbers, pipefitters, and steamfitters. | |
| 3684802 | Bilateral rupture of extensor pollicis longus. A case report. | 1987 Nov | Bilateral rupture of the extensor pollicis longus tendon is a rare entity. Most case studies in the literature have been reported in patients with an underlying systemic condition such as rheumatoid arthritis or following an episode of trauma. An interesting and unusual case is presented and theories concerning etiology, various operative techniques, and recent cases in the literature are discussed. | |
| 1953071 | [Massive hematuria and bladder perforation, complication of systemic amyloidosis]. | 1991 Sep | Secondary amyloidosis of the bladder is a rare cause of hematuria. When it presents, it is a life-threatening condition with a mortality rate of 60%. The diagnosis is based on the anatomopathological finding of amyloid deposits in extracellular interstitium. A case of massive hematuria in a patient with systemic amyloidosis secondary to long-standing rheumatoid arthritis is described. Like most of the cases reported elsewhere, the outcome was fatal. | |
| 1766994 | [Intrathoracic extramedullary hematopoiesis]. | 1991 Jan | The authors report on 29 cases of intrathoracic localization of extramedullary hematopoiesis. Out of them, 26 cases were confirmed by cytomorphologic examination of the aspirate specimens obtained by transtracheal biopsy of carina while in 3 cases the specimens for cytologic analysis were obtained by transthoracic fine needle aspiration of solitary shadows in the lung parenchyma. The cytomorphologic finding of the hematopoietic cells of the specimens obtained by transtracheal biopsy was unexpected in patients with an active pulmonary tuberculosis, primary bronchial carcinoma, broncho and pleuropneumonia, lung abscess, sarcoidosis, chronic bronchitis, rheumatoid arthritis as well as in patients with hemoptysis. | |
| 2606642 | Fatal aplastic anaemia following prolonged diclofenac use in an elderly patient. | 1989 Aug | Aplastic anaemia is recognised to occur following the use of some non-steroidal anti-inflammatory drugs. We report a case of fatal aplastic anaemia following prolonged administration of diclofenac in a 77 year old lady with rheumatoid arthritis. To our knowledge this is the first report of fatal aplastic anaemia associated with diclofenac use in an elderly patient. | |
| 2655152 | [Sonography of the shoulder]. | 1989 Mar | Sonography is a valuable method for the detection of rotator cuff tears. A high resolution transducer and an experienced examiner are necessary. The rotator cuff is not visible in large tears and has a convex outer border in small tears. Sonography reveals pathology of the subacromial bursa, joint effusions, inflammatory tissue in rheumatoid arthritis and often also bony erosions and tendon calcifications. Arthrography is still indicated in equivocal cases. Arthro-CT is the method of choice for the diagnosis of limbus and capsular pathology, but not for rotator cuff tears. MRI shows promising results in rotator cuff tears, but its role has not been definitively assessed. | |
| 2657693 | Assessment and management of chronic and recurrent pain in children with chronic diseases. | 1989 | This paper provides an overview to the assessment and management of chronic and recurrent pain in children with chronic diseases. Relevant clinical research studies are cited, and practical guidelines are provided for the differential assessment and management issues inherent in the comprehensive care of chronic and recurrent pain in children and adolescents with hemophilia, juvenile rheumatoid arthritis, sickle cell disease, and cancer. | |
| 3595012 | Reconstruction of the thumb basal joints. Development and current status of implant techni | 1987 Jul | The problems presented at the thumb basal joints differ in osteoarthritis and rheumatoid arthritis. Therefore, the proper treatment must be selected from several options including resection of the trapeziometacarpal joint with or without a convex or concave condylar implant and resection arthroplasty of the trapezium with or without a trapezium implant. Proper medialization of any basal thumb implant and stability over the scaphoid facet are essential for a good result. Balance of the entire thumb ray is critical and stabilization or fusion of the distal articulations of the thumb may also be considered. | |
| 1751862 | Psychiatric manifestation of systemic lupus erythematosus in Singapore. A cross-cultural c | 1991 Oct | In a case-control, cross-cultural study of the psychiatric morbidity of systemic lupus erythematosus in an Oriental population, 30 patients suffering from SLE and 29 controls with rheumatoid arthritis were interviewed. The SLE patients in Singapore exhibited greater psychiatric morbidity than their Western counterparts. Significant correlation was observed between psychiatric morbidity and the clinical disease activity. The patient's perception of the severity of arthritis, myalgia and dermatological lesions was an important aetiological factor. Culturally determined, disease-related psychological stresses also contributed to the psychopathology. | |
| 2065503 | Renal tubular dysfunction in primary Sjögren's syndrome: clinical studies in 27 patients. | 1991 Mar | Kidney involvement in Sjögren's syndrome (SS) including renal tubular disorders are well recognized but little is known about frequency and extent of such dysfunction in the general population of patients with primary SS, due to a lack of group studies. We studied 27 patients with primary SS and without other possible causes of tubular dysfunction. Increased urinary beta 2M excretion, due to proximal tubular dysfunction, was present in 26% of patients. Inadequate urine acidification after oral NH4 Cl, proving distal tubular dysfunction, was found in 12% of the patients studied. Concentrating ability, tested by thirst, was decreased in 44% of patients studied. Abnormal renal tubular tests correlated with presence of ANA (p = 0.05) but not with other clinical parameters. In conclusion demonstrable renal tubular dysfunctions occur in over half the patients with primary SS. Literature concerning this subject is discussed. | |
| 3502073 | [Sicca syndrome associated with systemic lymphoproliferative disease. Clinico-pathologic a | 1987 | Clinical, histologic, and immunohistochemical studies were performed in 11 patients suffering from sicca syndrome with extraglandular lymphoid lesions (liver, spleen, lymph nodes and bone). Seven patients proved to have primary Sjögren's syndrome (SS), 3 had non Hodgkin's lymphoma (NHL) with glandular and extraglandular monoclonal B-cell infiltrates, and 1 had diffuse Castleman's disease (CD). Antibodies to nuclear and/or cytoplasmic ribonucleoproteins were found, by immunodiffusion, in sera from all patients with SS (anti-SSA/Ro in 7 cases and anti-SSB/La in 6). No patient with NHL or CD had evidence of circulating antibodies to these antigens as well as other soluble nuclear antigens. Our data suggests that antibodies to SSA/Ro and SSB/la are strongly associated with extraglandular lymphoid lesions in primary SS and may be useful in differentiating this condition from sicca complex with NHL. | |
| 2421565 | Immunoregulation with methisoprinol in Sjögren's syndrome. | 1986 Jan | In this work, we studied the therapeutic clinical efficacy and the immunoregulating effect of methisoprinol in 4 cases of primary SS and one case of secondary SS. After 12 weeks of treatment, no significant clinical improvement was detected in the glandular histology, in Schirmer's test and sialography. On the other hand, we have observed the following alterations: immunological changes characterized by an increase in the total population of T-lymphocytes (OKT3), a normalization and thereby a diminution in IgM, an increase in T-helper subpopulation (OKT4) in four cases and in T-suppressor subpopulation in one case. A noticeable fact was the best immunological response of the patient showing a negative histology, a functional alteration of the parotid and a short evolution of the syndrome. These findings support the hypothesis that methisoprinol can be an efficient coadjuvant in the treatment of primary Sjögren's syndrome in early stages when there is only functional alteration but no glandular atrophy. | |
| 1908698 | A novel autoantibody reactive with carbonic anhydrase in sera from patients with systemic | 1991 May | Carbonic anhydrase (CA) is an extremely basic zinc metalloenzyme with a wide phyletic distribution, and the enzyme is important for the regulation of acid-base status. A novel autoantibody reactive with carbonic anhydrase was demonstrated. Several different classes of CA are known in mammals. Using the immuno blotting method and and immun-dot analysis, we found this autoantibody to be reactive with CA in the sera from patients with Sjögren's syndrome (20.8%), including a patient with Sjögren's syndrome and renal tubular acidosis, and in patients with systemic lupus erythematosus (31.6%). The autoantibody varied in the extent of its cross-reactivity among human CA I (or B), human CA II (or C), bovine CA I, bovine CA II, rabbit CA, and dog CA. The titers continued to float and tended to parallel disease activity. Positive reactivity of autoantibody was observed on eccrine sweat glands and the distal tubules of the kidney by the indirect immunofluorescent method. | |
| 1695475 | CD5 positivity on peripheral blood B lymphocytes in patients with primary Sjögren's syndr | 1990 Mar | The increased number of the CD5+ (Leu 1) B cells in 9 of 17 patients with primary Sjögren's syndrome (SS) were found in this study. The percentage of CD5+ B cells that demonstrated an increased number of these cells was more than 45% in patients with pSS, and the normal level 26.3 +/- 8.8% in control subjects. The ratio of the CD5+ B cells was higher if the pSS was in the active stage. | |
| 2182171 | Venous leg ulcers and arthropathy. | 1990 Apr | Reduced ankle mobility impairs the venous muscle pump and this leads to an increase in mean venous pressure in the lower leg. We have previously shown that pressure-induced venous distension leads to cutaneous hypoxia which is caused by arteriolar vasoconstriction in response to a spinal reflex. The prolonged cutaneous hypoxia which is thus a consequence of sustained elevation of venous pressure is an important factor in the development of gravitational ulcers. It is postulated that the increased incidence of leg ulcers in patients with rheumatoid arthritis is the result of impairment of the efficiency of the venous muscle pump by reduced ankle mobility. Conversely, the elevation of venous blood pressure in patients with venous insufficiency may lead to arthropathy in the ankle. The hypothesis is presented that prolonged elevation of venous blood pressure causes injury to both the ankle joint and veins leading to chronic reciprocal damage to both. This explains the frequent association between arthropathy of the ankle and venous leg ulcers. |