Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3291434 | [Roentgenmorphologic findings in systemic dermatoses]. | 1988 Mar 21 | Skeleton and soft tissue findings in systemic dermatoses sometimes allow early differentiation between diseases affecting the skin only and those involving other organs too. Rarely, ossious alterations can be detected even before any cutaneous manifestations have shown up. Apart from a tabular survey, we refer in detail to the frequency as well as the diagnostic value of ossious and soft tissue findings in dermatomyositis, lupus erythematosus, systemic sclerosis, psoriasis, Reiter's disease, sarcoidosis, neurofibromatosis (Recklinghausen's disease), histiocytosis X, and pretibial myxedema. Particular attention is paid to the problems of differential diagnosis with special regard to rheumatoid arthritis. | |
| 3660729 | [Complex-formation with hyaluronic acid as a cause of fibronectin heterogeneity in the syn | 1987 Jul | Heterogeneity of synovial fluid fibronectin was studied by means of Laurell cross-immunoelectrophoresis in patients with rheumatoid arthritis, posttraumatic synovitis and other arthropathies. Prior to hyaluronidase treatment all the synovial fluid samples exhibited the fibronectin heterogeneity, which disappeared after the action of hyaluronidase. The data obtained suggest that complexes of fibronectin and hyaluronic acid are responsible for physico-chemical heterogeneity of fibronectin in synovial fluid. | |
| 3022340 | Ultrasound guided percutaneous drainage of pericardial fluid with an indwelling catheter. | 1986 Oct | The technique of ultrasonographic guided percutaneous drainage of pericardial fluid, applied in three patients, is reported. The primary disease was synovial sarcoma, rheumatoid arthritis and prostatic carcinoma, respectively. Although three slightly different techniques and catheters were used all patients were sufficiently drained and the clinical symptoms promptly relieved. The catheters were left for drainage 3 months, 5 days and 14 days respectively. There were no major complications. One patient complained of transient palpitations. Percutaneous ultrasound-guided catheter drainage seems to be a safe method in patients with pericardial fluid where an indwelling catheter is considered. | |
| 2406340 | Distribution of antibodies against denatured collagen in AIDS risk groups and homosexual A | 1990 Feb 15 | Autoimmunity often precedes the onset of AIDS-related complex or AIDS, and a number of autoantibodies have been described in AIDS patients and persons at risk for AIDS. The presence of such antibodies provokes speculation that autoimmunity is a component of AIDS pathogenesis. We report evidence of an autoantibody (anticollagen) common to all homosexual AIDS patients studied. High titer serum reactivity against collagen was detected in all homosexual AIDS patients, and in HIV+ homosexuals (66%), HIV+ i.v. drug users (38%) HIV- homosexuals (32%), HIV+ transfusion recipients (22%), and HIV+ hemophiliacs (13%), but not in HIV- i.v. drug users, HIV- transfusion recipients, HIV- hemophiliacs, rheumatoid arthritis patients, or controls. Anticollagen reactivity does not correlate with serum IgG levels, so it is not merely a reflection of polyclonal B-cell activation. Titration of anticollagen positive sera typically revealed anticollagen antibody titers 100 times those of normal sera. Affinity purification and immunoblot analysis confirmed the antibody nature of the anticollagen reactivity. The anticollagen antibodies react preferentially with primary determinants of types I and III collagen revealed after heat denaturation. Similar antibodies occur infrequently in rheumatoid arthritis patients, more often on SLE, and frequently in graft vs host disease and lepromatous leprosy. Levels of anticollagen activity in HIV+ i.v. drug users and transfusion recipients correlate with serum beta 2-microglobulin levels, suggesting that those persons with anticollagen antibodies are at greater risk of developing AIDS. This correlation, the fact that anticollagen antibodies occurred in all homosexual AIDS patients tested, and the occurrence of antibodies against denatured collagen in immune disorders with features similar to AIDS suggest these antibodies may be related to disease progression. The association of anticollagen autoantibodies with AIDS and certain other infections and immune disorders may reflect common immunopathogenic features in the etiology of these disorders. | |
| 2190030 | [A case of mixed connective tissue disease complicated with malignant hypertension]. | 1990 Jan | This case was a 51-year-old woman, who had been diagnosed as having rheumatoid arthritis at some clinic and had been treated with both non-steroidal anti-inflammatory drugs and steroid 3 years before visiting our clinic. When she noticed a decrease in visual acuity and general fatigue in June 1985, she was referred to an ophthalmologist of our hospital, and found to have blood pressure of 240/150 mmHg and KW grade IV retinal findings. She was admitted in our department to examine and treat malignant hypertension. On admission, remarkable hypergammaglobulinemia (29.3%), arthralgia, arthral deformity and pericardial effusion were present thus, she was suspected to be suffering from malignant rheumatoid arthritis. Anti-nuclear antibody (64X), anti-nuclear ribonucleoprotein antibody (64X) and anti-RNase sensitive antibody of anti-extractable nuclear antigens (ENA) antibody (81920X) were positive, while anti-RNase resistant antibody of anti-ENA antibody was negative. Immunologically, her condition was consistent with mixed connective tissue disease (MCTD). Since urinary protein was positive and creatinine clearance was 46.0 ml/min, renal function was thought to be diminished. Her chest roentgenogram revealed cardiomegaly (CTR 67.5%) and an increase in pulmonary vascular shadow. An echocardiogram demonstrated the presence of pericardial effusion. Plasma renin activity was 3.3 ng/ml/h and it was suspected that an intrarenal ischemic change resulted in increased renin release from the juxta-glomerular apparatus, leading to the marked hypertension. Treatment was started with prednisolone 60 mg/day during 4 weeks.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2252102 | A clinicopathologic study of 34 cases of diffuse pulmonary hemorrhage with lung biopsy con | 1990 Dec | Based on a clinicopathologic study of 34 patients with biopsy-confirmed diffuse pulmonary hemorrhage (DPH), we present an approach to the differential diagnosis of DPH with attention to histologic features such as capillaritis and the importance of laboratory tests such as anticytoplasmic autoantibodies (ACPA). The following DPH syndromes were encountered: antibasement membrane antibody (ABMA) disease (four cases); idiopathic pulmonary hemorrhage (four cases); Wegener's granulomatosis (WG) (five cases); probable WG (six cases); systemic necrotizing vasculitis otherwise unclassified (three cases); systemic lupus erythematosus (two cases); rheumatoid arthritis (one case); seronegative juvenile rheumatoid arthritis (one case); IgA nephropathy (one case); idiopathic glomerulonephritis (two cases--one with and one without immune complexes); and unclassified pulmonary-renal syndromes (five cases). Capillaritis was found in lung biopsy samples from 30 of the 34 patients (88%) and included patients with every type of DPH syndrome. Serologic testing for ACPA was useful in the diagnosis of WG. Identification of ABMA in the serum, kidney, or lung was the defining feature for the diagnosis of ABMA-mediated disease. Subclassification of the cases could not be done solely on histologic grounds except for cases of WG that showed granulomatous inflammation, foci of necrosis, or vasculitis. Classification of the remaining cases required correlation with (a) clinical and laboratory data; (b) biopsy samples from other sites such as the kidney, nasal sinuses, or skin; and (c) results of immunofluorescence or electron microscopy of kidney or lung biopsy samples. | |
| 2783378 | Autoimmunity and B-cell dysfunction in chronic proliferative disorders of large granular l | 1989 Jan 1 | Clinical and laboratory findings of B-cell immune dysfunction were evaluated in ten patients with a large granular lymphocyte/natural killer cell proliferative disease (LGL/NK-PD). Increased immunoglobulin synthesis with autoantibody formation was documented: polyclonal hypergammaglobulinaemia (six patients), neutrophil autoantibody (one patient), antinuclear antibody (one patient), and rheumatoid factor (five patients). In addition, serum beta 2-microglobulin level was raised in seven patients, a benign monoclonal gammopathy was detected in one, and concurrent B-type hairy cell leukemia in another. Most patients experienced the complications of hemocytopenia, polyarthritis or rheumatoid arthritis, and immediate allergic reactions to drugs or environmental substances, rather than from symptoms of progressive LGL/NK-PD. A review of the literature confirms that an increased immunoglobulin production is common in LGL/NK-PD, and that patients are likely to develop multiple autoantibodies. The incapacity of proliferating, abnormal LGL/NK cells to suppress B-cell activation and immunoglobulin synthesis, documented by several in vitro studies, offers a pathogenetic explanation for these phenomena. This study shows that an anomalous B-cell function contributes greatly to the morbidity of disease in LGL/NK-PD, and points out the utility of investigating the LGL/NK cell system in patients with autoimmune pathologic characteristics of unclear origin. | |
| 2075370 | Measurement of complement activation products in patients with chronic rheumatic diseases. | 1990 | Measurement of the complement activation products C1s:C1-inh, C3bP and C5b-9 by ELISA in plasma samples from normals, rheumatoid arthritis (RA) and systemic lupus erythematosis (SLE) patients showed significantly elevated levels in the two patient groups (P less than 0.0001 for C1s:C1-inh, C3bP and C5b-9) compared to normals. In seropositive RA patients there were significant correlations between the levels of the three complement activation complexes and IgM-RF, IgG-RF and IgA-RF. However, IgM-RF did not interfere with any of the ELISA systems. Mean levels of C1s:C1-inh, C3bP and C5b-9 were the same in paired plasma and synovial fluids; however, C3bP levels in the paired samples did not correlate with one another by rank. Our conclusions are that: (a) elevated plasma levels of these complement activation products are detectable in rheumatic diseases; (b) plasma levels of these complement activation products are related to Rheumatoid factor (RF) levels in seropositive RA patients; and (c) IgM-RF does not influence these solid-phase ELISA procedures. | |
| 2962719 | Laboratory testing in arthritic disease. | 1988 Jan | Rheumatoid autoantibodies, acute phase reactants of inflammation, and other laboratory indices of the inflammatory response lack the specificity necessary to follow adequately the course of arthritic disease or the efficacy of their treatment regimens. Routine laboratory tests are better utilized to follow the potential complications of pharmacologic therapy. A review of the traditional laboratory tests used for the arthritides is presented. | |
| 2397630 | Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythema | 1990 Jul | Pediatric research has been limited regarding the neuropsychologic status in systemic lupus erythematosus (SLE) despite frequent involvement of the central nervous system early in the disease process. SLE is a multisystem autoimmune disorder which often presents with significant neuropsychiatric manifestations including objective neurologic findings and severe psychiatric symptoms. Neuropsychological evaluation provides an objective method for delineating changes in higher cortical functions. We studied 21 pediatric patients who met SLE criteria (12 moderate, 9 mild disease activity) and had no history of CNS damage unrelated to lupus. Mean age was 15.8 years; mean SLE duration at the time of the neuropsychological examination was 2.4 years. Comparison of these SLE patients to a contrast group of 11 patients with juvenile rheumatoid arthritis (JRA) revealed decreased complex problem solving ability for the SLE group. Individual, IQ-adjusted neuropsychological profile analysis yielded a significant difference in the number of specific neuropsychologic deficits for the 2 groups, with impairment rates of 43% for SLE and 18% for JRA. Longer duration of lupus was associated with lower cognitive status. Neuron-reactive antibody studies for IgG and IgM were negative. Results suggest that the prevalence of higher cortical impairment may be as great for younger individuals with lupus as has been documented for older populations. | |
| 3014039 | Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-depend | 1986 Jul 1 | HLA-DR4, Dw4-associated haplotypes associated with IDDM and JRA were compared using genomic DNA restriction fragment analysis to distinguish among DQ beta and alpha alleles linked to DR4. DQ beta polymorphisms that subdivide the HLA-DQw3 specificity into DQ3.1 and 3.2 alleles were identified. More than 90% of DR4+ IDDM patients express one of these alleles, DQ3.2; restriction enzyme mapping indicates that the presence of this allele also accounts for the genomic fragment patterns previously reported in IDDM. Furthermore, haplo-identical siblings of DQ3.2 IDDM patients also carry the DQ3.2 allele, regardless of clinical presentation. In contrast, DR4+ JRA patients show no allelic preference at DQ beta, implicating different HLA genetic contributions in these two DR4-associated diseases. | |
| 2011347 | Psoriatic arthritis of the temporomandibular joints with ankylosis. Literature review and | 1991 Mar | Psoriatic arthritis is currently defined as psoriasis associated with chronic, erosive inflammatory arthritis, which is seronegative for rheumatoid factor. A review of the etiology, pathogenesis, diagnosis, and treatment is accompanied by two unusual case reports of psoriatic arthritis affecting the temporomandibular joints with ankylosis. | |
| 1844691 | Applying survival methodology to adverse experience occurrences in controlled clinical tri | 1991 | On the basis of calculated cumulative hazard rates for initial occurrence of adverse experiences of patients following treatment for rheumatoid arthritis and osteoarthritis, a simple function is evolved that fits such cumulative hazard rate data very well. From this simple function, we obtain the estimated hazard rate in terms of two physically meaningful parameters. These two parameters can be used to describe the rate of occurrence of adverse experiences, and to convey the concept of risk of adverse experience associated with duration of exposure to a drug. The parameters are rho 1, which represents the risk of adverse experience at baseline, and rho 2, which defines the rate of occurrence of adverse experience immediately following drug administration. A method of estimating rho 1 and rho 2 is the maximum likelihood approach, and the estimated parameters are given for series of data referring to patients treated for arthritis. | |
| 3022758 | Characterization of rabbit genes for synovial cell collagenase. | 1986 Nov | To provide tools for understanding collagenase gene expression in rheumatoid arthritis, we have isolated and characterized genomic clones for rabbit synovial cell collagenase. These clones represent 2 types of collagenase gene, at least 1 of which is transcribed in synovial fibroblasts. By examining the rabbit genome in situ, we provide evidence that there are only 2 different synovial cell collagenase genes found in a haploid genome. Amplification of these genes is not a mechanism for collagenase messenger RNA induction by phorbol esters. | |
| 10149613 | Distal interphalangeal joint silicone interpositional arthroplasty: surgical technique and | 1991 Apr | Distal interphalangeal joint arthroplasty is effective in alleviating the pain of degenerative arthritis while preserving motion and stability. This procedure was undertaken as an alternative to arthrodesis for 17 women with osteoarthritis and 1 woman with rheumatoid arthritis. Silicone interpositional arthroplasty was performed in 31 digits of patients whose mean age was 58.3 years. The patients were evaluated at an average of 72.2 months (range, 12.6 to 123.1 months) after surgery. All patients reported that their primary preoperative symptom of pain was effectively eliminated by the procedure. At reevaluation, the active range of motion of the distal interphalangeal joint averaged 32.2 degrees and extension lag averaged 12.7 degrees . Lateral stability of the distal joint was present in all but one middle finger implant. Two implants were removed at 3 months postoperatively for wound problems and one at 31 months because of prothesis fracture. | |
| 2277134 | Management of patients and side effects during cyclosporine therapy for cutaneous disorder | 1990 Dec | Cyclosporine has been used in the experimental treatment of multiple inflammatory diseases of presumed autoimmune origin, including insulin-dependent diabetes mellitus, uveitis, rheumatoid arthritis, inflammatory bowel diseases, Graves' disease, and myasthenia gravis. In dermatology, the drug has been used successfully as primary therapy for psoriasis and psoriatic arthritis, alopecia areata, pyoderma gangrenosum, Behçet's disease, atopic dermatitis, and lichen planus. At a dose of 3 to 5 mg/kg per day, cyclosporine is well tolerated by most patients. However, because of concerns about its potential short- and long-term side effects, patients who use this drug require close monitoring. This review discusses appropriate clinical and laboratory evaluations, common and unusual side effects and their management, drugs that might alter the pharmacokinetics of cyclosporine metabolism, and criteria for dosage adjustments. | |
| 3592782 | Incidence and prevalence of juvenile chronic arthritis: a population survey. | 1987 Apr | In a population based epidemiological survey of juvenile chronic arthritis (JCA), performed in Western Sweden in 1983, an incidence of 12/100,000 was found. The estimated prevalence was 56/100,000. Subgroup distribution showed a preponderance of mono- and pauciarticular forms. The peak age of onset was between 0 and 4 years of age. Girls predominated over boys in a ratio of 3:2. Overall, 30% were antinuclear antibody (ANA) positive, 9% rheumatoid factor (RF) positive, and eye involvement occurred in 10% of the children. The results suggest differences in population based studies of JCA compared with previously reported hospital based series. | |
| 3960772 | Bipolar implant shoulder arthroplasty. | 1986 Mar | A bipolar implant was designed by the author in 1975 for reconstruction of the severely arthritic shoulder. It has the advantage of not requiring glenoidal component fixation, but still provides an artificial joint interface. The ball of the humeral intramedullary stemmed component articulates with a polyethylene bearing within the glenoid cup component. This bipolar prosthesis was implanted in 15 shoulders of patients who presented severe arthritic shoulder disabilities. The follow up period averaged 41 months. Nine patients had rheumatoid arthritis, and five had osteoarthritis; all presented with severe pain and joint crepitation with loss of motion. A "shoulder score" system, based on the rating of pain, activities of daily living and range of motion, was devised to categorize the results obtained. Patients obtained greatly improved range of motion with good to excellent pain relief and very good functional restoration. Radiographically, the implant was well tolerated and there was no stem loosening. This procedure appears to be safe and efficacious for use in the severely arthritic shoulder. | |
| 2022363 | [The suppressive effect of HLA-DQw6 genes on collagen-induced arthritis in mice]. | 1991 Feb | We investigated the effect of HLA-DQw6 genes on collagen-induced arthritis (CIA) in mice, based on our previous observation that the frequency of HLA-DR4-Dw15-DQw4 haplotype was increased in the patients with rheumatoid arthritis (RA) in the Japanese whereas the frequency of HLA-DR2-Dw12-DQw6 was decreased in them significantly. We utilized the HLA-DQw6 genes of transgenic C57BL/6 mice (DQw6-B6) and their F1 progenies with or without DQw6 genes derived from the matings between DBA/1 mice and HLA-DQw6 hemizygous transgenic DQw6-B6 mice. Mice were immunized with bovine type II collagen (C II) followed by boost immunization 3 weeks later. The development of arthritis was observed and the levels of IgG specific to C II were evaluated on ELISA every week until 10 weeks after the first immunization. The incidence of arthritic mice in DQw6(+)-F1 decreased significantly (P less than 0.05) as compared with that in DQw6(-)-F1 42.9% vs. 80.0%). The incidence of arthritic limbs in DQw6(+)-F1 decreased significantly (P less than 0.01) as compared with that in DQw6(-)-F1 (30.2% vs. 58.3%). The level of IgG specific to C II on the 5th week in DQw6(+)-F1 decreased significantly (P less than 0.01) as compared with that in DQw6(-)-F1 (218.6 +/- 39.2 micrograms/ml, mean +/- SEM, n = 21 vs. 431.3 +/- 58.8 micrograms/ml, mean +/- SEM, n = 20). Thus these results suggested that HLA-DQw6 genes suppressed the development of CIA most likely due to the reduction of the production of IgG specific to type II collagen. | |
| 3499909 | Pharmacological properties of the novel non-steroidal antiinflammatory agent N-methoxy-3-( | 1987 Aug | The antiinflammatory activity of the novel pyrrolidin-2-one derivative N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-o ne (E-5110) was investigated and compared with those of indomethacin and piroxicam in various antiinflammatory, analgesic and antipyretic animal models. The acute antiinflammatory activity of E-5110 on the carrageenin paw edema was similar to that of indomethacin, and half that of piroxicam. The chronic inflammatory responses in established adjuvant- and type II collagen-induced arthritis, which are widely used models of rheumatoid arthritis, were suppressed as effectively by E-5110 as by indomethacin and piroxicam. E-5110 decreased the pleural exudate volume and inhibited leucocyte infiltration in a reversed passive Arthus reaction more potently than indomethacin, suggesting that mediators other than prostaglandin E2 may play an important role in this inflammatory process. The analgesic potency of E-5110 against inflammatory pain was similar to that of indomethacin or piroxicam, but the antipyretic activity of E-5110 was more potent than that of the reference drugs. The ulcerogenic effect of E-5110 on rat gastric mucosa was less than those of indomethacin and piroxicam. In conclusion, E-5110 is a very potent antiinflammatory compound acting against various types of inflammation, and has a favorable therapeutic index. |