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| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2649540 | Salivary gland fluid secretion during aging. | 1989 May | Salivary gland function is generally well-preserved in healthy older persons. Similar results are observed in the laboratory rat. Older people are, however, more likely to experience salivary disorders due to disease or its treatment. For many patients with remaining salivary gland parenchymal tissue, improved function may result from pharmacological therapy. | |
| 3655277 | Pulmonary involvement in primary biliary cirrhosis. | 1987 Aug | Four patients with primary biliary cirrhosis (PBC) and Sjogren's syndrome presented with pulmonary disease manifested by fever, cough, and dyspnea. One patient had obstructive lung disease secondary to an autoimmune process documented by immunofluorescent staining of lung parenchyma. The other three patients had interstitial lung disease, pulmonary nodules, and multiple granulomas of the lung, respectively. Primary biliary cirrhosis is a complex autoimmune syndrome involving a disorder of the secretory immune system and its epithelial end organs. These four cases suggest that, in addition to biliary, lacrimal, intestinal, renal tubular, and salivary epithelium, lung tissue also is a possible site for autoimmune involvement in PBC. | |
| 3300589 | Xerostomia. A neglected symptom. | 1987 Jul | Xerostomia, the subjective feeling of dry mouth caused by a severe reduction in the flow of saliva, is a common problem that is particularly prevalent among the aged. It has become increasingly evident that dry mouth is associated with a number of serious systemic conditions and diseases. Among these are the intake of commonly prescribed medications, autoimmune diseases, and irradiation to the head and neck. The diminution in the flow of saliva may profoundly affect oral health, disturb digestion and speech, and seriously impair the patient's quality of life. Food avoidance, nonabsorption of sublingually placed drugs, and noncompliance with medication may also result. Sialometry can be used to confirm the presence of dry mouth. Treatment is aimed at increasing the flow of saliva, when possible, or providing oral moisture by other means. | |
| 3473629 | Platelets in blood and salivary glands of patients with primary Sjögren's syndrome. | 1986 | Circulating platelets from 15 patients with primary Sjögren's syndrome (primary SS) and from 15 normal controls were enumerated and their aggregability determined. Blood platelet concentrations were within the normal range, except for two patients in whom they were slightly decreased. Platelet aggregation was enhanced in patients, when measured upon stimulation with epinephrine (p less than 0.05), ADP (p less than 0.01) and collagen (p less than 0.01). Plasma and saliva from 17 patients with primary SS and from 11 normal controls were examined for the platelet-specific release product beta-thromboglobulin (beta-TG). P-beta-TG was increased in the patients, although not significantly (p greater than 0.05). In saliva beta-TG was detected in 5 patients (11-150 ng/ml), but not in any of the controls. There was no correlation between levels of beta-TG in plasma and saliva. Lower lip minor salivary glands from 17 patients under evaluation for SS were examined for platelet accumulation. Indirect immuno-peroxidase staining with the monoclonal mouse anti-human platelet glycoprotein Ib antibody, showed platelet accumulation intravascularly in the inflamed areas. The combined results are in accordance with the hypothesis that platelet activation occurs in the salivary glands of patients with primary SS. | |
| 3296150 | Treatment of Sjögren's syndrome: an overview. | 1986 | This review focus on the double-blind clinical investigations in patients with Sjögren's syndrome and describe the historical developments. It is divided into two passages--systemic and topically treatment. | |
| 1850064 | [Scintigraphy in the diagnosis of salivary gland diseases]. | 1991 | An original method of sialoscintigraphy was used to investigate the structure and function of the unchanged salivary glands in 108 patients and in 192 patients with various diseases of the salivary glands (chronic interstitial sialadenitis, chronic parenchymatous sialadenitis, chronic sialadenitis, reactive-dystrophic diseases and tumors. The data obtained are of great importance for the diagnosis and differential diagnosis of salivary gland diseases as well as for the evaluation of effectiveness of therapeutic measures. | |
| 2406674 | Isolated trigeminal sensory neuropathy: a heterogeneous group of disorders. | 1990 Feb | Neuropathy affecting the face is a serious sign that warrants thorough and often multidisciplinary investigation. Patients with isolated trigeminal sensory neuropathy (TSN) should be monitored for connective tissue disease, and some may develop multiple sclerosis or paroxysmal trigeminal neuralgia. A patient with chronic isolated TSN and Sjôgren's syndrome, Raynaud's phenomenon, arthropathy, vitiligo, and evidence of other immune dysregulation is presented. The literature is reviewed with respect to the heterogeneous etiology of TSN, and an attempt is made to identify subgroups and to evaluate prognosis from details of the history and systemic disorder associations. | |
| 2156070 | Sjögren's syndrome: no demonstrable association by serology of secondary Sjögren's syndr | 1990 Jan | The possible relationship between Sjögren's syndrome (SS) and cytomegalovirus (CMV) was examined using enzyme linked immunosorbent assay of serum antibodies. Patients with secondary SS did not have significantly different CMV antibodies compared with matched healthy controls. | |
| 2584673 | Primary biliary cirrhosis: management of an unusual case with severe xanthomata by hepatic | 1989 Dec | We report a patient with advanced primary biliary cirrhosis associated with Sjögren's syndrome, xanthelasma, and extensive, painful xanthomata involving cutaneous lipid deposits on her face, abdomen, hands, and buttocks and extensor surfaces over many joints. Despite conventional dietary and drug therapy, these lesions progressed rapidly over 3 years. There was symptomatic improvement of the xanthomata, but no objective amelioration of the xanthomatosis with the use of plasmapheresis over an 18-month period. Liver transplantation was undertaken for decompensated chronic liver disease and poor quality of life due to complications of xanthomatosis. Twelve months after transplantation, all xanthomata and xanthelasma and symptoms attributable to xanthomata had disappeared. Liver transplantation is a drastic but successful remedy for complications of abnormal lipid metabolism associated with primary biliary cirrhosis. | |
| 3049879 | [Articular manifestations of Behçet's disease. Apropos of 73 cases]. | 1988 | The authors report 73 cases of Behçet's disease with articular manifestations. Polyarthritis, generally considered to be rare, was found in 20.5 per cent of cases in this series. The unusual features are illustrated. Amongst them, two cases presented deforming and destructive lesions, which have been only exceptionally reported in the literature. A third case is unusual because of the association of Gougerot-Sjögren's syndrome with Behçet's disease and polyarthritis deformans. No cases of ankylosing spondylitis were observed. Lastly, the data of this series are compared with those of the literature. | |
| 3809786 | [Sicca syndrome with severe renal insufficiency]. | 1986 Nov | The interstitial nephritis associated with sicca syndrome is usually symptomless or responsible for mild renal impairment. The authors report five cases in which renal failure was severe, requiring haemodialysis in two patients. The physiopathological mechanisms and the treatment of interstitial nephritis in sicca syndrome are discussed. Corticosteroids improved renal function in three of these five patients. | |
| 1843851 | Sjögren's syndrome complicated by cryoglobulinaemia and acute renal failure. | 1991 Aug | A patient is described with Sjögren's syndrome and an IgM-kappa gammopathy. With time cryoglobulins, the cause of acute renal failure, could be detected. The kidney biopsy showed a proliferative glomerulonephritis as is frequently seen with mixed cryoglobulinaemia. Plasmapheresis and immunosuppression resulted in long-term improvement of kidney function. The differential diagnosis of acute renal failure of glomerular origin in a patient with Sjögren's syndrome is discussed. This case report illustrates once more the consequences of monoclonal B-cell lymphocyte activation in Sjögren's syndrome. | |
| 2012937 | Defects of the retinal pigment epithelium in scleroderma. | 1991 Apr | We completed ocular examination, including retinal fluoroangiography, in 19 unselected patients with diffuse systemic sclerosis (scleroderma) and compared the findings with those made in 50 consecutive patients with systemic lupus erythematosus, 18 with primary Sjögren's syndrome, 20 with mixed connective tissue disease, and 20 healthy women. Five of 19 scleroderma patients had atrophy of the retinal pigment epithelium (26.3%) while none of the controls and only four of the 88 (4.5%) patients with other connective tissue diseases (P less than 0.01) had this anomaly. Atrophy of the pigmented epithelium of the retina may occur in scleroderma as a result of damage of the choroidal plexus. | |
| 2332864 | Intravenous pulse methylprednisolone for the treatment of a child with Sjögren's nephropa | 1990 Mar | Six years after the onset of polyarthritis and after several episodes of recurrent parotitis, our patients developed the abrupt onset of renal insufficiency. Kidney histopathology showed interstitial and peritubular lymphocytic infiltration typical of Sjögren's nephropathy. Treatment with high dose intravenous methylprednisolone resulted in rapid and sustained normalization of kidney function. The favorable response of our patient to intravenous pulse corticosteroids suggests that this therapy is effective for the treatment of Sjögren's nephropathy. | |
| 2736830 | Histological criteria of Sjögren's syndrome in scleroderma. | 1989 Mar | 33 patients with scleroderma, xerostomia and xerophthalmia underwent biopsy of 3 to 5 labial salivary glands. Histological and ultrastructural study were systematically performed on the salivary gland specimen. In 27 patients, sclerosis was the main feature: it was an active fibrosis, with numerous secreting fibroblasts and degranulating mast cells. This fibrosis was located around capillaries and excretory ducts. It surrounded the acini, progressively destroying them. Lymphocytes were present but not very numerous. They were not grouped around the ducts but scattered in the fibrosis. 5 patients had similar fibrotic lesions but they also had numerous lymphocytes grouped in focus around excretory ducts as in primary Sjögren's syndrome. It is concluded that in scleroderma, xerostomia and xerophthalmia can be related either to a pure sclerotic process or to a 'common' secondary Sjögren's syndrome. | |
| 3412023 | Identification of human herpesvirus 6-specific DNA sequences in two patients with non-Hodg | 1988 Aug | Human herpesvirus 6 (HHV-6) is a recently discovered virus which has not been causally linked to any particular disease. In order to investigate the possible role of this virus in the pathogenesis of lymphoid malignancies, we examined tissue samples from 117 patients for the presence of HHV-6-specific DNA sequences. Two cases of non-Hodgkin's lymphoma were found to be positive. One patient had a T cell lymphoma and a preceding history of angioimmunoblastic lymphadenopathy; the other had a B cell lymphoma occurring in the context of Sjögren's syndrome. HHV-6 has been isolated previously from a patient with angioimmunoblastic lymphadenopathy, and viral sequences have been identified in another patient with Sjögren's syndrome and B cell lymphoma. The relationship between HHV-6 and these conditions therefore warrants further investigation. | |
| 3064672 | [Tumors of the nasal cavity in human immunodeficiency virus infection. A case of polyclona | 1988 | HIV virus infection is frequently accompanied by polyclonal or monoclonal lymphoid proliferations. The authors report the first case of a tumour of the cavum in a Haitian subject with HIV infection. This large tumour was associated with parotid swelling and a buccal and ocular sicca syndrome. Histological examination revealed Sjögren type of lympho-epithelial infiltration in the parotid and salivary glands. Biopsy of the cavum demonstrated lymphoid hyperplasia without a monoclonal component. There was no lymphoid proliferation outside of the ear, nose and throat region. The various benign and malignant lymphoid proliferations observed during HIV infection are recalled. Their pathophysiology is discussed: role of EBV in B cell lymphoid proliferations, specific cytotoxicity against cells infected by HIV in T8 proliferations. | |
| 3297128 | Autoimmunity in 28 patients after allogeneic bone marrow transplantation: comparison with | 1987 May | The occurrence of autoantibodies in 28 long-term survivors of allogeneic bone marrow transplantation (BMT) (21 with chronic graft-versus-host disease) was compared with 48 cases of idiopathic Sjögren syndrome and 82 cases of scleroderma. Antinuclear, anti-smooth muscle, and anti-mitochondria antibodies occurred respectively in 80%, 82% and 14% of the post BMT cases. Anti-native DNA, anti-soluble nuclear antigen and anticentromere antibodies were not found. Antiepidermal antibodies were present in 14% of the cases but their pathological role is unclear. Although the clinical manifestations of chronic graft-versus-host disease are similar to Sjögren syndrome and scleroderma the autoantibody profile is significantly different. | |
| 3566825 | Acute transverse myelopathy successfully treated with plasmapheresis and prednisone in a p | 1987 Mar | We report a case of acute transverse myelopathy in a patient with primary Sjögren's syndrome of 3 years duration. Our patient's acute transverse myelopathy developed within 1 week and resulted in complete paraparesis below the mamillary level. Extensive laboratory investigation ruled out viral, bacterial, and fungal etiology, Guillain-Barré syndrome, poliomyelitis, and multiple sclerosis. At diagnosis, treatment was initiated immediately with prednisone (80 mg/day) and plasmapheresis, which was performed as a first-aid measure. Improvement was noted as early as 10 days after the start of therapy. Within 5 1/2 months of the first symptoms of paralysis, the patient walked without difficulty and returned to her normal activities. A causal relationship between plasmapheresis/prednisone therapy and recovery has not been proven but merits further consideration. | |
| 1910997 | Salivary SPECT and factor analysis in Sjögren's syndrome. | 1991 Sep | Salivary SPECT and factor analysis in Sjögren's syndrome were performed in 17 patients and 6 volunteers as controls. The ability of SPECT to detect small differences in the level of uptake can be used to separate glands from background even when uptake is reduced as in the patients with Sjögren's syndrome. In control and probable Sjögren's syndrome groups the uptake ratio of the submandibular gland to parotid gland on salivary SPECT (S/P ratio) was less than 1.0. However, in the definite Sjögren's syndrome group, the ratio was more than 1.0. Moreover, the ratio in all patients with sialectasia, which is characteristic of Sjögren's syndrome, was more than 1.0. Salivary factor analysis of normal parotid glands showed slowly increasing patterns of uptake and normal submandibular glands had rapidly increasing patterns of uptake. However, in the definite Sjögren's syndrome group, the factor analysis patterns were altered, with slowly increasing patterns dominating both in the parotid and submandibular glands. These results suggest that the S/P ratio in salivary SPECT and salivary factor analysis provide additional radiologic criteria in diagnosing Sjögren's syndrome. |